{"id":"https://openalex.org/W7214668208","doi":"https://doi.org/10.64898/2026.09.27.754813","title":"Alternative oxidase in trypanosomatids","display_name":"Alternative oxidase in trypanosomatids","publication_year":2026,"publication_date":"2026-09-28","ids":{"openalex":"https://openalex.org/W7214668208","doi":"https://doi.org/10.64898/2026.09.27.754813"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.27.754813","doi":"https://doi.org/10.64898/2026.09.27.754813","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.27.754813","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/28/2026.09.27.754813.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/28/2026.09.27.754813.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065503951","display_name":"Krist\u00edna Z\u00e1honov\u00e1","orcid":"https://orcid.org/0000-0002-5766-0267","observed_orcids":["https://orcid.org/0000-0002-5766-0267"]},"institutions":[{"id":"https://openalex.org/I154425047","display_name":"University of Alberta","ror":"https://ror.org/0160cpw27","country_code":"CA","type":"education","lineage":["https://openalex.org/I154425047"]},{"id":"https://openalex.org/I187293425","display_name":"University of Ostrava","ror":"https://ror.org/00pyqav47","country_code":"CZ","type":"education","lineage":["https://openalex.org/I187293425"]},{"id":"https://openalex.org/I202391551","display_name":"Czech Academy of Sciences","ror":"https://ror.org/053avzc18","country_code":"CZ","type":"government","lineage":["https://openalex.org/I202391551"]},{"id":"https://openalex.org/I21250087","display_name":"Charles University","ror":"https://ror.org/024d6js02","country_code":"CZ","type":"education","lineage":["https://openalex.org/I21250087"]},{"id":"https://openalex.org/I4210161358","display_name":"Institute of Parasitology","ror":"https://ror.org/05rhyza23","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I202391551","https://openalex.org/I4210161358","https://openalex.org/I4210164740"]},{"id":"https://openalex.org/I4210164740","display_name":"Czech Academy of Sciences, Biology Centre","ror":"https://ror.org/05pq4yn02","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I202391551","https://openalex.org/I4210164740"]}],"countries":["CA","CZ"],"is_corresponding":false,"raw_author_name":"Krist\u00edna Z\u00e1honov\u00e1","raw_affiliation_strings":["Department of Parasitology, Faculty of Science, Charles University, BIOCEV, Vestec, Czechia","Division of Infectious Diseases, Department of Medicine, University of Alberta, Edmonton, Canada","Institute of Parasitology, Biology Centre, Czech Academy of Sciences, \u010cesk\u00e9 Bud\u011bjovice, Czechia","Life Science Research Centre, Faculty of Science, University of Ostrava, Ostrava, Czechia"],"raw_orcid":"https://orcid.org/0000-0002-5766-0267","affiliations":[{"raw_affiliation_string":"Department of Parasitology, Faculty of Science, Charles University, BIOCEV, Vestec, Czechia","institution_ids":["https://openalex.org/I21250087"]},{"raw_affiliation_string":"Division of Infectious Diseases, Department of Medicine, University of Alberta, Edmonton, Canada","institution_ids":["https://openalex.org/I154425047"]},{"raw_affiliation_string":"Institute of Parasitology, Biology Centre, Czech Academy of Sciences, \u010cesk\u00e9 Bud\u011bjovice, Czechia","institution_ids":["https://openalex.org/I202391551","https://openalex.org/I4210161358","https://openalex.org/I4210164740"]},{"raw_affiliation_string":"Life Science Research Centre, Faculty of Science, University of Ostrava, Ostrava, Czechia","institution_ids":["https://openalex.org/I187293425"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008204893","display_name":"Ond\u0159ej Gahura","orcid":"https://orcid.org/0000-0002-2925-4763","observed_orcids":["https://orcid.org/0000-0002-2925-4763"]},"institutions":[{"id":"https://openalex.org/I202391551","display_name":"Czech Academy of Sciences","ror":"https://ror.org/053avzc18","country_code":"CZ","type":"government","lineage":["https://openalex.org/I202391551"]},{"id":"https://openalex.org/I4210161358","display_name":"Institute of Parasitology","ror":"https://ror.org/05rhyza23","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I202391551","https://openalex.org/I4210161358","https://openalex.org/I4210164740"]},{"id":"https://openalex.org/I4210164740","display_name":"Czech Academy of Sciences, Biology Centre","ror":"https://ror.org/05pq4yn02","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I202391551","https://openalex.org/I4210164740"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Ond\u0159ej Gahura","raw_affiliation_strings":["Institute of Parasitology, Biology Centre, Czech Academy of Sciences, \u010cesk\u00e9 Bud\u011bjovice, Czechia"],"raw_orcid":"https://orcid.org/0000-0002-2925-4763","affiliations":[{"raw_affiliation_string":"Institute of Parasitology, Biology Centre, Czech Academy of Sciences, \u010cesk\u00e9 Bud\u011bjovice, Czechia","institution_ids":["https://openalex.org/I202391551","https://openalex.org/I4210161358","https://openalex.org/I4210164740"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5143839252","display_name":"Katar\u00edna Benedikov\u00e1","orcid":"https://orcid.org/0009-0002-2621-4835","observed_orcids":["https://orcid.org/0009-0002-2621-4835"]},"institutions":[{"id":"https://openalex.org/I74788687","display_name":"Comenius University Bratislava","ror":"https://ror.org/0587ef340","country_code":"SK","type":"education","lineage":["https://openalex.org/I74788687"]}],"countries":["SK"],"is_corresponding":false,"raw_author_name":"Katar\u00edna Benedikov\u00e1","raw_affiliation_strings":["Faculty of Natural Sciences, Comenius University, Bratislava, Slovakia"],"raw_orcid":"https://orcid.org/0009-0002-2621-4835","affiliations":[{"raw_affiliation_string":"Faculty of Natural Sciences, Comenius University, Bratislava, Slovakia","institution_ids":["https://openalex.org/I74788687"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5117094003","display_name":"Nat\u00e1lia Trusina","orcid":"https://orcid.org/0009-0008-8372-1490","observed_orcids":["https://orcid.org/0009-0008-8372-1490"]},"institutions":[{"id":"https://openalex.org/I74788687","display_name":"Comenius University Bratislava","ror":"https://ror.org/0587ef340","country_code":"SK","type":"education","lineage":["https://openalex.org/I74788687"]}],"countries":["SK"],"is_corresponding":false,"raw_author_name":"Nat\u00e1lia Trusina","raw_affiliation_strings":["Faculty of Natural Sciences, Comenius University, Bratislava, Slovakia"],"raw_orcid":"https://orcid.org/0009-0008-8372-1490","affiliations":[{"raw_affiliation_string":"Faculty of Natural Sciences, Comenius University, Bratislava, Slovakia","institution_ids":["https://openalex.org/I74788687"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091532434","display_name":"Elora Kalita","orcid":"https://orcid.org/0000-0002-0799-7486","observed_orcids":["https://orcid.org/0000-0002-0799-7486"]},"institutions":[{"id":"https://openalex.org/I187293425","display_name":"University of Ostrava","ror":"https://ror.org/00pyqav47","country_code":"CZ","type":"education","lineage":["https://openalex.org/I187293425"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Elora Kalita","raw_affiliation_strings":["Life Science Research Centre, Faculty of Science, University of Ostrava, Ostrava, Czechia"],"raw_orcid":"https://orcid.org/0000-0002-0799-7486","affiliations":[{"raw_affiliation_string":"Life Science Research Centre, Faculty of Science, University of Ostrava, Ostrava, Czechia","institution_ids":["https://openalex.org/I187293425"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090435475","display_name":"\u013dubom\u00edra Chmelov\u00e1","orcid":"https://orcid.org/0009-0005-5457-3570","observed_orcids":["https://orcid.org/0009-0005-5457-3570"]},"institutions":[{"id":"https://openalex.org/I187293425","display_name":"University of Ostrava","ror":"https://ror.org/00pyqav47","country_code":"CZ","type":"education","lineage":["https://openalex.org/I187293425"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"\u013dubom\u00edra Chmelov\u00e1","raw_affiliation_strings":["Life Science Research Centre, Faculty of Science, University of Ostrava, Ostrava, Czechia"],"raw_orcid":"https://orcid.org/0009-0005-5457-3570","affiliations":[{"raw_affiliation_string":"Life Science Research Centre, Faculty of Science, University of Ostrava, Ostrava, Czechia","institution_ids":["https://openalex.org/I187293425"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029324201","display_name":"Ingrid \u0160kodov\u00e1\u2010Sver\u00e1kov\u00e1","orcid":"https://orcid.org/0000-0002-4004-3377","observed_orcids":["https://orcid.org/0000-0002-4004-3377"]},"institutions":[{"id":"https://openalex.org/I187293425","display_name":"University of Ostrava","ror":"https://ror.org/00pyqav47","country_code":"CZ","type":"education","lineage":["https://openalex.org/I187293425"]},{"id":"https://openalex.org/I202391551","display_name":"Czech Academy of Sciences","ror":"https://ror.org/053avzc18","country_code":"CZ","type":"government","lineage":["https://openalex.org/I202391551"]},{"id":"https://openalex.org/I4210161358","display_name":"Institute of Parasitology","ror":"https://ror.org/05rhyza23","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I202391551","https://openalex.org/I4210161358","https://openalex.org/I4210164740"]},{"id":"https://openalex.org/I4210164740","display_name":"Czech Academy of Sciences, Biology Centre","ror":"https://ror.org/05pq4yn02","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I202391551","https://openalex.org/I4210164740"]},{"id":"https://openalex.org/I74788687","display_name":"Comenius University Bratislava","ror":"https://ror.org/0587ef340","country_code":"SK","type":"education","lineage":["https://openalex.org/I74788687"]}],"countries":["CZ","SK"],"is_corresponding":false,"raw_author_name":"Ingrid \u0160kodov\u00e1-Sver\u00e1kov\u00e1","raw_affiliation_strings":["Faculty of Natural Sciences, Comenius University, Bratislava, Slovakia","Institute of Parasitology, Biology Centre, Czech Academy of Sciences, \u010cesk\u00e9 Bud\u011bjovice, Czechia","Life Science Research Centre, Faculty of Science, University of Ostrava, Ostrava, Czechia"],"raw_orcid":"https://orcid.org/0000-0002-4004-3377","affiliations":[{"raw_affiliation_string":"Faculty of Natural Sciences, Comenius University, Bratislava, Slovakia","institution_ids":["https://openalex.org/I74788687"]},{"raw_affiliation_string":"Institute of Parasitology, Biology Centre, Czech Academy of Sciences, \u010cesk\u00e9 Bud\u011bjovice, Czechia","institution_ids":["https://openalex.org/I202391551","https://openalex.org/I4210161358","https://openalex.org/I4210164740"]},{"raw_affiliation_string":"Life Science Research Centre, Faculty of Science, University of Ostrava, Ostrava, Czechia","institution_ids":["https://openalex.org/I187293425"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017181527","display_name":"Alena Z\u0131\u0301kov\u00e1","orcid":"https://orcid.org/0000-0002-8686-0225","observed_orcids":["https://orcid.org/0000-0002-8686-0225"]},"institutions":[{"id":"https://openalex.org/I202391551","display_name":"Czech Academy of Sciences","ror":"https://ror.org/053avzc18","country_code":"CZ","type":"government","lineage":["https://openalex.org/I202391551"]},{"id":"https://openalex.org/I4210161358","display_name":"Institute of Parasitology","ror":"https://ror.org/05rhyza23","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I202391551","https://openalex.org/I4210161358","https://openalex.org/I4210164740"]},{"id":"https://openalex.org/I4210164740","display_name":"Czech Academy of Sciences, Biology Centre","ror":"https://ror.org/05pq4yn02","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I202391551","https://openalex.org/I4210164740"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Alena Z\u00edkov\u00e1","raw_affiliation_strings":["Institute of Parasitology, Biology Centre, Czech Academy of Sciences, \u010cesk\u00e9 Bud\u011bjovice, Czechia"],"raw_orcid":"https://orcid.org/0000-0002-8686-0225","affiliations":[{"raw_affiliation_string":"Institute of Parasitology, Biology Centre, Czech Academy of Sciences, \u010cesk\u00e9 Bud\u011bjovice, Czechia","institution_ids":["https://openalex.org/I202391551","https://openalex.org/I4210161358","https://openalex.org/I4210164740"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042826449","display_name":"Vyacheslav Yurchenko","orcid":"https://orcid.org/0000-0003-4765-3263","observed_orcids":["https://orcid.org/0000-0003-4765-3263"]},"institutions":[{"id":"https://openalex.org/I187293425","display_name":"University of Ostrava","ror":"https://ror.org/00pyqav47","country_code":"CZ","type":"education","lineage":["https://openalex.org/I187293425"]}],"countries":["CZ"],"is_corresponding":true,"raw_author_name":"Vyacheslav Yurchenko","raw_affiliation_strings":["Life Science Research Centre, Faculty of Science, University of Ostrava, Ostrava, Czechia"],"raw_orcid":"https://orcid.org/0000-0003-4765-3263","affiliations":[{"raw_affiliation_string":"Life Science Research Centre, Faculty of Science, University of Ostrava, Ostrava, Czechia","institution_ids":["https://openalex.org/I187293425"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5042826449"],"corresponding_institution_ids":["https://openalex.org/I187293425"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10890","display_name":"Trypanosoma species research and implications","score":0.8432999849319458,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10890","display_name":"Trypanosoma species research and implications","score":0.8432999849319458,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.11879999935626984,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11879","display_name":"Protist diversity and phylogeny","score":0.0142000000923872,"subfield":{"id":"https://openalex.org/subfields/1105","display_name":"Ecology, Evolution, Behavior and Systematics"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alternative-oxidase","display_name":"alternative oxidase","score":1.0},{"id":"https://openalex.org/keywords/trypanosomatids","display_name":"trypanosomatids","score":0.9940000176429749},{"id":"https://openalex.org/keywords/kinetoplastids","display_name":"kinetoplastids","score":0.8370000123977661},{"id":"https://openalex.org/keywords/mitochondrial-electron-transport-chain","display_name":"mitochondrial electron transport chain","score":0.9419999718666077},{"id":"https://openalex.org/keywords/redox-homeostasis","display_name":"redox homeostasis","score":0.8019999861717224},{"id":"https://openalex.org/keywords/phylogenetic-relationships","display_name":"phylogenetic relationships","score":0.5559999942779541},{"id":"https://openalex.org/keywords/comparative-genomics","display_name":"comparative genomics","score":0.8169999718666077}],"concepts":[{"id":"https://openalex.org/C2778858093","wikidata":"https://www.wikidata.org/wiki/Q24721080","display_name":"Alternative oxidase","level":3,"score":0.871399998664856},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7075999975204468},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.6572999954223633},{"id":"https://openalex.org/C193252679","wikidata":"https://www.wikidata.org/wiki/Q242125","display_name":"Phylogenetic tree","level":3,"score":0.6078000068664551},{"id":"https://openalex.org/C90132467","wikidata":"https://www.wikidata.org/wiki/Q171184","display_name":"Phylogenetics","level":3,"score":0.43650001287460327},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.42890000343322754},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4205000102519989},{"id":"https://openalex.org/C38485361","wikidata":"https://www.wikidata.org/wiki/Q576379","display_name":"Oxidase test","level":3,"score":0.41290000081062317},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.4016999900341034},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.38989999890327454},{"id":"https://openalex.org/C3020377403","wikidata":"https://www.wikidata.org/wiki/Q211016","display_name":"Respiratory chain","level":3,"score":0.35589998960494995},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.3508000075817108},{"id":"https://openalex.org/C166393388","wikidata":"https://www.wikidata.org/wiki/Q856529","display_name":"Molecular evolution","level":4,"score":0.3357999920845032},{"id":"https://openalex.org/C199216141","wikidata":"https://www.wikidata.org/wiki/Q4995178","display_name":"Conserved sequence","level":4,"score":0.3314000070095062},{"id":"https://openalex.org/C105176652","wikidata":"https://www.wikidata.org/wiki/Q1147112","display_name":"Comparative genomics","level":5,"score":0.30970001220703125},{"id":"https://openalex.org/C45484198","wikidata":"https://www.wikidata.org/wiki/Q827246","display_name":"Sequence alignment","level":4,"score":0.2874000072479248},{"id":"https://openalex.org/C24586158","wikidata":"https://www.wikidata.org/wiki/Q27075","display_name":"Mitochondrial DNA","level":3,"score":0.28200000524520874},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.2806999981403351},{"id":"https://openalex.org/C2775859393","wikidata":"https://www.wikidata.org/wiki/Q28746","display_name":"Flavin adenine dinucleotide","level":4,"score":0.2768999934196472},{"id":"https://openalex.org/C66517615","wikidata":"https://www.wikidata.org/wiki/Q912751","display_name":"Cellular respiration","level":3,"score":0.27410000562667847},{"id":"https://openalex.org/C57600042","wikidata":"https://www.wikidata.org/wiki/Q227564","display_name":"Oxidative phosphorylation","level":2,"score":0.26820001006126404},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.2639000117778778},{"id":"https://openalex.org/C75385678","wikidata":"https://www.wikidata.org/wiki/Q4896390","display_name":"Inner mitochondrial membrane","level":3,"score":0.25589999556541443}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.09.27.754813","doi":"https://doi.org/10.64898/2026.09.27.754813","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.27.754813","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/28/2026.09.27.754813.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.09.27.754813","doi":"https://doi.org/10.64898/2026.09.27.754813","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.27.754813","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/28/2026.09.27.754813.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G4322017794","display_name":null,"funder_award_id":"90254","funder_id":"https://openalex.org/F4320323641","funder_display_name":"Vedeck\u00e1 Grantov\u00e1 Agent\u00fara M\u0160VVa\u0160 SR a SAV"},{"id":"https://openalex.org/G913688142","display_name":"Mapovanie evolu\u010dnej trajekt\u00f3rie bioenergetiky u monoxenick\u00fdch druhov tryapnozomat\u00edd","funder_award_id":"1/0709/26","funder_id":"https://openalex.org/F4320323641","funder_display_name":"Vedeck\u00e1 Grantov\u00e1 Agent\u00fara M\u0160VVa\u0160 SR a SAV"}],"funders":[{"id":"https://openalex.org/F4320323641","display_name":"Vedeck\u00e1 Grantov\u00e1 Agent\u00fara M\u0160VVa\u0160 SR a SAV","ror":"https://ror.org/044gwpv05"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7214668208.pdf","grobid_xml":"https://content.openalex.org/works/W7214668208.grobid-xml"},"referenced_works_count":1,"referenced_works":["https://openalex.org/W7172486515"],"related_works":["https://openalex.org/W2060322429","https://openalex.org/W4385623820","https://openalex.org/W2596161220","https://openalex.org/W7133052281","https://openalex.org/W4407835822","https://openalex.org/W2337800756","https://openalex.org/W2037813024","https://openalex.org/W2124957081","https://openalex.org/W2110952238","https://openalex.org/W2626012511"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Alternative":[2],"oxidase":[3,9,212],"(AOX)":[4],"is":[5],"a":[6,32,91,126,132,219,227,239,277,306],"mitochondrial":[7,41,186,272,297],"terminal":[8,211],"that":[10,108,147,179,252,285],"provides":[11,238],"an":[12,54,289],"alternative":[13,246,290],"route":[14],"for":[15,141,166,245,308],"electron":[16,42,267],"transfer,":[17],"contributing":[18],"to":[19,48,270],"respiratory":[20,266,298],"flexibility":[21,231],"and":[22,62,78,83,110,136,157,170,182,194,201,232,242,254,304],"redox":[23,233],"homeostasis":[24],"under":[25],"stress":[26],"conditions.":[27],"In":[28,46],"trypanosomatids,":[29],"AOX":[30,82,109,124,152,180,199,206,224,253,264],"displays":[31],"highly":[33],"uneven":[34],"distribution":[35,93],"associated":[36],"with":[37,99,185,205,260],"extensive":[38],"diversification":[39],"of":[40,81,94,173,315],"transport":[43],"chains":[44],"(ETCs).":[45],"addition":[47],"canonical":[49,220],"AOX,":[50],"many":[51],"trypanosomatids":[52],"encode":[53],"enigmatic":[55],"AOX-like":[56],"protein":[57,283],"(AOX-L),":[58],"whose":[59],"evolutionary":[60,72,114,241],"origin":[61],"functional":[63,79,243],"significance":[64],"remain":[65],"unresolved.":[66],"Results":[67],"Here,":[68],"we":[69],"investigated":[70],"the":[71,150,162,209,312],"distribution,":[73],"phylogenetic":[74,134],"relationships,":[75],"structural":[76],"conservation,":[77],"divergence":[80],"AOX-L":[84,111,130,148,255,275],"across":[85],"euglenozoans.":[86],"Comparative":[87],"genomic":[88],"analyses":[89,106,172],"revealed":[90,146],"patchy":[92],"both":[95],"proteins":[96,259],"among":[97],"kinetoplastids,":[98],"multiple":[100],"independent":[101,117],"losses":[102],"during":[103,301],"evolution.":[104],"Phylogenetic":[105],"demonstrated":[107],"represent":[112],"distinct":[113,258],"lineages,":[115],"indicating":[116],"origins":[118],"rather":[119],"than":[120],"duplication-derived":[121],"divergence.":[122],"While":[123],"showed":[125,178],"conserved":[127,279],"eukaryotic":[128,302],"origin,":[129],"occupied":[131],"separate":[133],"position":[135],"lacked":[137,161],"key":[138],"residues":[139],"required":[140],"ubiquinol":[142],"oxidation.":[143],"Structural":[144],"modelling":[145],"retained":[149],"characteristic":[151],"fold,":[153],"predicted":[154,262],"membrane":[155],"association,":[156],"dimeric":[158],"organization,":[159],"but":[160,280],"catalytic":[163],"architecture":[164],"necessary":[165],"enzymatic":[167,202],"activity.":[168],"Transcriptomic":[169],"biochemical":[171],"four":[174],"AOX-containing":[175],"trypanosomatid":[176],"species":[177,217],"expression":[181,200],"activity":[183],"correlated":[184],"ETC":[187,221],"organization.":[188],"Species":[189],"lacking":[190],"cytochrome-dependent":[191],"complexes":[192],"III":[193],"IV":[195],"displayed":[196],"substantially":[197],"higher":[198],"activity,":[203,225],"consistent":[204],"functioning":[207],"as":[208],"primary":[210],"in":[213,229,248],"these":[214],"lineages.":[215],"Conversely,":[216],"retaining":[218],"exhibited":[222],"lower":[223],"suggesting":[226],"role":[228],"metabolic":[230],"regulation.":[234],"Conclusions":[235],"Our":[236],"study":[237],"comprehensive":[240],"framework":[244],"oxidases":[247],"trypanosomatids.":[249],"We":[250],"demonstrate":[251],"are":[256],"evolutionarily":[257],"different":[261],"functions:":[263],"maintains":[265],"flow":[268],"according":[269],"lineage-specific":[271],"requirements,":[273],"whereas":[274],"represents":[276],"structurally":[278],"catalytically":[281],"inactive":[282],"family":[284],"may":[286],"have":[287],"acquired":[288],"regulatory":[291],"role.":[292],"These":[293],"findings":[294],"highlight":[295],"how":[296],"components":[299],"diversify":[300],"evolution":[303],"provide":[305],"basis":[307],"future":[309],"investigations":[310],"into":[311],"biological":[313],"function":[314],"AOX-L.":[316]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-09-29T00:00:00"}