{"id":"https://openalex.org/W7214664294","doi":"https://doi.org/10.7150/thno.135691","title":"Hybrid exosome\u2013liposome nanovesicles as delivery platforms for therapeutic applications: merging the best of both worlds","display_name":"Hybrid exosome\u2013liposome nanovesicles as delivery platforms for therapeutic applications: merging the best of both worlds","publication_year":2026,"publication_date":"2026-09-18","ids":{"openalex":"https://openalex.org/W7214664294","doi":"https://doi.org/10.7150/thno.135691","pmid":"https://pubmed.ncbi.nlm.nih.gov/42909294","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13684820"},"language":"en","primary_location":{"id":"doi:10.7150/thno.135691","doi":"https://doi.org/10.7150/thno.135691","is_oa":true,"landing_page_url":"https://doi.org/10.7150/thno.135691","pdf_url":"https://www.thno.org/v16p9261.pdf","source":{"id":"https://openalex.org/S2482500137","display_name":"Theranostics","issn_l":"1838-7640","issn":["1838-7640"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317973","host_organization_name":"Ivyspring International Publisher","host_organization_lineage":["https://openalex.org/P4310317973"],"host_organization_lineage_names":["Ivyspring International Publisher"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Theranostics","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.thno.org/v16p9261.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100613423","display_name":"Jian Yu","orcid":"https://orcid.org/0000-0001-8449-8739","observed_orcids":["https://orcid.org/0000-0001-8449-8739"]},"institutions":[{"id":"https://openalex.org/I4210099028","display_name":"Fourth Affiliated Hospital of China Medical University","ror":"https://ror.org/012sz4c50","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099028"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jian Yu","raw_affiliation_strings":["Department of Neurosurgery, The Fourth Affiliated Hospital of China Medical University, No. 4 Chongshandong Road, Shenyang, 110032, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, The Fourth Affiliated Hospital of China Medical University, No. 4 Chongshandong Road, Shenyang, 110032, China","institution_ids":["https://openalex.org/I4210099028"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5153329342","display_name":"Lujiao Yu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140515","display_name":"First Hospital of China Medical University","ror":"https://ror.org/04wjghj95","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140515"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Lujiao Yu","raw_affiliation_strings":["Department of Geriatrics, The First Hospital of China Medical University, No. 155 North Nanjing Street, Shenyang, 110001, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Geriatrics, The First Hospital of China Medical University, No. 155 North Nanjing Street, Shenyang, 110001, China","institution_ids":["https://openalex.org/I4210140515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101531818","display_name":"Fei Ren","orcid":"https://orcid.org/0000-0003-4100-8845","observed_orcids":["https://orcid.org/0000-0003-4100-8845"]},"institutions":[{"id":"https://openalex.org/I4210140515","display_name":"First Hospital of China Medical University","ror":"https://ror.org/04wjghj95","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140515"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Fei Ren","raw_affiliation_strings":["Department of Geriatrics, The First Hospital of China Medical University, No. 155 North Nanjing Street, Shenyang, 110001, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Geriatrics, The First Hospital of China Medical University, No. 155 North Nanjing Street, Shenyang, 110001, China","institution_ids":["https://openalex.org/I4210140515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025084104","display_name":"Kai Cui","orcid":"https://orcid.org/0000-0002-6566-679X","observed_orcids":["https://orcid.org/0000-0002-6566-679X"]},"institutions":[{"id":"https://openalex.org/I4210099028","display_name":"Fourth Affiliated Hospital of China Medical University","ror":"https://ror.org/012sz4c50","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099028"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kai Cui","raw_affiliation_strings":["Department of Orthopaedics, The Fourth Affiliated Hospital of China Medical University, No. 4 Chongshandong Road, Shenyang, 110032, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedics, The Fourth Affiliated Hospital of China Medical University, No. 4 Chongshandong Road, Shenyang, 110032, China","institution_ids":["https://openalex.org/I4210099028"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5153293848","display_name":"Gongping Sun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210099028","display_name":"Fourth Affiliated Hospital of China Medical University","ror":"https://ror.org/012sz4c50","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099028"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Gongping Sun","raw_affiliation_strings":["Department of General Surgery, The Fourth Affiliated Hospital of China Medical University, No. 4 Chongshandong Road, Shenyang, 110032, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Surgery, The Fourth Affiliated Hospital of China Medical University, No. 4 Chongshandong Road, Shenyang, 110032, China","institution_ids":["https://openalex.org/I4210099028"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5153270384","display_name":"Hong Pan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210099028","display_name":"Fourth Affiliated Hospital of China Medical University","ror":"https://ror.org/012sz4c50","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099028"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hong Pan","raw_affiliation_strings":["Department of Radiation Oncology, The Fourth Affiliated Hospital of China Medical University, No. 4 Chongshandong Road, Shenyang, 110032, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, The Fourth Affiliated Hospital of China Medical University, No. 4 Chongshandong Road, Shenyang, 110032, China","institution_ids":["https://openalex.org/I4210099028"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5100613423","https://openalex.org/A5101531818","https://openalex.org/A5153329342"],"corresponding_institution_ids":["https://openalex.org/I4210099028","https://openalex.org/I4210140515"],"apc_list":{"value":2500,"currency":"AUD","value_usd":1671},"apc_paid":{"value":2500,"currency":"AUD","value_usd":1671},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.40599874,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"16","issue":"16","first_page":"9261","last_page":"9276"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.8442000150680542,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.8442000150680542,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.15469999611377716,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/exosomes","display_name":"exosomes","score":0.9869999885559082},{"id":"https://openalex.org/keywords/liposomes","display_name":"liposomes","score":0.9980000257492065},{"id":"https://openalex.org/keywords/drug-delivery","display_name":"drug delivery","score":0.8240000009536743},{"id":"https://openalex.org/keywords/passive-loading","display_name":"passive loading","score":0.8029999732971191},{"id":"https://openalex.org/keywords/active-loading","display_name":"active loading","score":0.9980000257492065},{"id":"https://openalex.org/keywords/drug-loading-capacity","display_name":"drug loading capacity","score":0.6650000214576721},{"id":"https://openalex.org/keywords/homologous-targeting","display_name":"homologous targeting","score":0.7200000286102295},{"id":"https://openalex.org/keywords/biocompatibility","display_name":"biocompatibility","score":0.699999988079071},{"id":"https://openalex.org/keywords/immunogenicity","display_name":"immunogenicity","score":0.7900000214576721},{"id":"https://openalex.org/keywords/mass-production","display_name":"mass production","score":0.6710000038146973}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5266000032424927},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.36730000376701355},{"id":"https://openalex.org/C26517878","wikidata":"https://www.wikidata.org/wiki/Q228039","display_name":"Key (lock)","level":2,"score":0.2840000092983246},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.2793999910354614},{"id":"https://openalex.org/C15083742","wikidata":"https://www.wikidata.org/wiki/Q261659","display_name":"Nanomedicine","level":3,"score":0.24699999392032623},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.24690000712871552},{"id":"https://openalex.org/C2983812674","wikidata":"https://www.wikidata.org/wiki/Q134808","display_name":"Delivery system","level":2,"score":0.2313999980688095},{"id":"https://openalex.org/C126511603","wikidata":"https://www.wikidata.org/wiki/Q1261145","display_name":"Targeted drug delivery","level":3,"score":0.21279999613761902},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.19670000672340393},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.19619999825954437}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004337","descriptor_name":"Drug Carriers","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008081","descriptor_name":"Liposomes","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055354","descriptor_name":"Exosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D055354","descriptor_name":"Exosomes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.7150/thno.135691","doi":"https://doi.org/10.7150/thno.135691","is_oa":true,"landing_page_url":"https://doi.org/10.7150/thno.135691","pdf_url":"https://www.thno.org/v16p9261.pdf","source":{"id":"https://openalex.org/S2482500137","display_name":"Theranostics","issn_l":"1838-7640","issn":["1838-7640"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317973","host_organization_name":"Ivyspring International Publisher","host_organization_lineage":["https://openalex.org/P4310317973"],"host_organization_lineage_names":["Ivyspring International Publisher"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Theranostics","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13684820","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13684820/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13684820/pdf/thnov16p9261.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Theranostics","raw_type":"Text"},{"id":"pmid:42909294","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42909294","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Theranostics","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.7150/thno.135691","doi":"https://doi.org/10.7150/thno.135691","is_oa":true,"landing_page_url":"https://doi.org/10.7150/thno.135691","pdf_url":"https://www.thno.org/v16p9261.pdf","source":{"id":"https://openalex.org/S2482500137","display_name":"Theranostics","issn_l":"1838-7640","issn":["1838-7640"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317973","host_organization_name":"Ivyspring International Publisher","host_organization_lineage":["https://openalex.org/P4310317973"],"host_organization_lineage_names":["Ivyspring International Publisher"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Theranostics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7214664294.pdf","grobid_xml":"https://content.openalex.org/works/W7214664294.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4284973969","https://openalex.org/W4312221218","https://openalex.org/W4416642969","https://openalex.org/W4379285374","https://openalex.org/W4393391116","https://openalex.org/W4394566239","https://openalex.org/W7118016856","https://openalex.org/W6888821559","https://openalex.org/W4401283735","https://openalex.org/W7117552991"],"abstract_inverted_index":{"Exosomes":[0],"are":[1,42,68,136],"increasingly":[2,71],"employed":[3],"to":[4,13,24,36],"treat":[5],"various":[6,134],"diseases":[7,135],"because":[8],"of":[9,17,102,115,129],"their":[10,25,106],"remarkable":[11],"ability":[12],"enhance":[14],"the":[15,80,99,112],"stability":[16],"encapsulated":[18],"cargoes.":[19],"This":[20],"capability":[21],"is":[22],"attributed":[23],"outstanding":[26],"homologous":[27],"targeting,":[28],"desirable":[29],"biocompatibility,":[30],"and":[31,53,92,105,122,126],"low":[32],"immunogenicity,":[33],"thereby":[34],"contributing":[35],"improved":[37],"therapeutic":[38,75],"outcomes.":[39],"Nevertheless,":[40],"exosomes":[41,88,121],"constrained":[43],"by":[44],"some":[45],"limitations,":[46,67],"including":[47],"poor":[48],"loading":[49,86,91],"capacity,":[50],"inherent":[51],"heterogeneity,":[52],"challenges":[54,125],"in":[55,74,108,132],"large-scale":[56],"production.":[57],"Consequently,":[58],"hybrid":[59,103,130],"exosome-liposome":[60],"(EL)":[61],"systems,":[62],"which":[63],"can":[64],"circumvent":[65],"these":[66,116],"playing":[69],"an":[70],"crucial":[72],"role":[73],"applications.":[76],"Herein,":[77],"we":[78],"introduce":[79],"two":[81],"primary":[82],"strategies":[83],"for":[84],"drug":[85,109],"into":[87],"--":[89],"passive":[90],"active":[93],"loading.":[94],"We":[95],"further":[96],"elaborate":[97],"on":[98],"fabrication":[100],"methods":[101],"ELs":[104,131],"applications":[107],"delivery,":[110],"highlighting":[111],"innate":[113],"advantages":[114],"state-of-the-art":[117],"nanovesicles":[118],"over":[119],"conventional":[120],"liposomes.":[123],"Major":[124],"future":[127],"perspectives":[128],"treating":[133],"also":[137],"discussed.":[138]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-09-29T00:00:00"}