{"id":"https://openalex.org/W7214657246","doi":"https://doi.org/10.64898/2026.09.26.754256","title":"A draft atlas of the human plasma proteome at isoform resolution","display_name":"A draft atlas of the human plasma proteome at isoform resolution","publication_year":2026,"publication_date":"2026-09-28","ids":{"openalex":"https://openalex.org/W7214657246","doi":"https://doi.org/10.64898/2026.09.26.754256"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.26.754256","doi":"https://doi.org/10.64898/2026.09.26.754256","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.26.754256","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/28/2026.09.26.754256.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/28/2026.09.26.754256.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000874953","display_name":"Boris M. Z\u00fchlke","orcid":"https://orcid.org/0000-0001-5527-2626","observed_orcids":["https://orcid.org/0000-0001-5527-2626"]},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Boris Martin Z\u00fchlke","raw_affiliation_strings":["Institute of Biochemistry, Charit\u00e9 - University Medical Center Berlin, Berlin, Germany"],"raw_orcid":"https://orcid.org/0000-0001-5527-2626","affiliations":[{"raw_affiliation_string":"Institute of Biochemistry, Charit\u00e9 - University Medical Center Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035096876","display_name":"Torsten Schwecke","orcid":"https://orcid.org/0000-0002-9439-3508","observed_orcids":["https://orcid.org/0000-0002-9439-3508"]},"institutions":[{"id":"https://openalex.org/I4210139777","display_name":"Berlin Institute of Health at Charit\u00e9 - Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/0493xsw21","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210139777","https://openalex.org/I7877124"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Torsten Schwecke","raw_affiliation_strings":["Core Facility for High-Throughput Mass Spectrometry, Institute of Biochemistry, Charit\u00e9 - University Medical Center Berlin, Berlin, Germany","Institute of Biochemistry, Charit\u00e9 - University Medical Center Berlin, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Core Facility for High-Throughput Mass Spectrometry, Institute of Biochemistry, Charit\u00e9 - University Medical Center Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I4210139777","https://openalex.org/I7877124"]},{"raw_affiliation_string":"Institute of Biochemistry, Charit\u00e9 - University Medical Center Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035023466","display_name":"Tal Shapira","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210142260","display_name":"Max Planck Institute for Molecular Genetics","ror":"https://ror.org/03ate3e03","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210142260"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Tal Weizmann Shapira","raw_affiliation_strings":["Department of Computational Molecular Biology, Max Planck Institute for Molecular Genetics, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computational Molecular Biology, Max Planck Institute for Molecular Genetics, Berlin, Germany","institution_ids":["https://openalex.org/I4210142260"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064389291","display_name":"Agathe Niewienda","orcid":"https://orcid.org/0000-0002-0993-1026","observed_orcids":["https://orcid.org/0000-0002-0993-1026"]},"institutions":[{"id":"https://openalex.org/I4210139777","display_name":"Berlin Institute of Health at Charit\u00e9 - Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/0493xsw21","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210139777","https://openalex.org/I7877124"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Agathe Niewienda","raw_affiliation_strings":["Core Facility for High-Throughput Mass Spectrometry, Institute of Biochemistry, Charit\u00e9 - University Medical Center Berlin, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Core Facility for High-Throughput Mass Spectrometry, Institute of Biochemistry, Charit\u00e9 - University Medical Center Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I4210139777","https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079252154","display_name":"Anyi Yang","orcid":"https://orcid.org/0000-0002-6275-6095","observed_orcids":["https://orcid.org/0000-0002-6275-6095","https://orcid.org/0009-0000-0487-7959"]},"institutions":[{"id":"https://openalex.org/I4210142260","display_name":"Max Planck Institute for Molecular Genetics","ror":"https://ror.org/03ate3e03","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210142260"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Anyi Yang","raw_affiliation_strings":["Department of Computational Molecular Biology, Max Planck Institute for Molecular Genetics, Berlin, Germany","Institute of Biochemistry, Charit\u00e9 - University Medical Center Berlin, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computational Molecular Biology, Max Planck Institute for Molecular Genetics, Berlin, Germany","institution_ids":["https://openalex.org/I4210142260"]},{"raw_affiliation_string":"Institute of Biochemistry, Charit\u00e9 - University Medical Center Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063967506","display_name":"Fatma Amari","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Fatma Amari","raw_affiliation_strings":["Institute of Biochemistry, Charit\u00e9 - University Medical Center Berlin, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biochemistry, Charit\u00e9 - University Medical Center Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022648899","display_name":"Kathrin Textoris\u2010Taube","orcid":"https://orcid.org/0000-0002-1224-8236","observed_orcids":["https://orcid.org/0000-0002-1224-8236"]},"institutions":[{"id":"https://openalex.org/I4210139777","display_name":"Berlin Institute of Health at Charit\u00e9 - Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/0493xsw21","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210139777","https://openalex.org/I7877124"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Kathrin Textoris-Taube","raw_affiliation_strings":["Core Facility for High-Throughput Mass Spectrometry, Institute of Biochemistry, Charit\u00e9 - University Medical Center Berlin, Berlin, Germany","Institute of Biochemistry, Charit\u00e9 - University Medical Center Berlin, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Core Facility for High-Throughput Mass Spectrometry, Institute of Biochemistry, Charit\u00e9 - University Medical Center Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I4210139777","https://openalex.org/I7877124"]},{"raw_affiliation_string":"Institute of Biochemistry, Charit\u00e9 - University Medical Center Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019424018","display_name":"Ludwig Roman Sinn","orcid":"https://orcid.org/0000-0003-4692-0681","observed_orcids":["https://orcid.org/0000-0003-4692-0681"]},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ludwig Roman Sinn","raw_affiliation_strings":["Institute of Biochemistry, Charit\u00e9 - University Medical Center Berlin, Berlin, Germany"],"raw_orcid":"https://orcid.org/0000-0003-4692-0681","affiliations":[{"raw_affiliation_string":"Institute of Biochemistry, Charit\u00e9 - University Medical Center Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059282020","display_name":"Karola Lehmann","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Karola Lehmann","raw_affiliation_strings":["Proteome Factory AG, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Proteome Factory AG, Berlin, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040090614","display_name":"Christoph Gille","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christoph Gille","raw_affiliation_strings":["Institute of Biochemistry, Charit\u00e9 - University Medical Center Berlin, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biochemistry, Charit\u00e9 - University Medical Center Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009628707","display_name":"Martin Vingron","orcid":"https://orcid.org/0000-0002-1765-4241","observed_orcids":["https://orcid.org/0000-0002-1765-4241","https://orcid.org/0000-0003-1064-3571"]},"institutions":[{"id":"https://openalex.org/I4210142260","display_name":"Max Planck Institute for Molecular Genetics","ror":"https://ror.org/03ate3e03","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210142260"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Martin Vingron","raw_affiliation_strings":["Department of Computational Molecular Biology, Max Planck Institute for Molecular Genetics, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computational Molecular Biology, Max Planck Institute for Molecular Genetics, Berlin, Germany","institution_ids":["https://openalex.org/I4210142260"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067796654","display_name":"Michael M\u00fclleder","orcid":"https://orcid.org/0000-0001-9792-3861","observed_orcids":["https://orcid.org/0000-0001-9792-3861"]},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Michael M\u00fclleder","raw_affiliation_strings":["Institute of Biochemistry, Charit\u00e9 - University Medical Center Berlin, Berlin, Germany"],"raw_orcid":"https://orcid.org/0000-0001-9792-3861","affiliations":[{"raw_affiliation_string":"Institute of Biochemistry, Charit\u00e9 - University Medical Center Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070892021","display_name":"Markus Ralser","orcid":"https://orcid.org/0000-0001-9535-7413","observed_orcids":["https://orcid.org/0000-0001-9535-7413"]},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Markus Ralser","raw_affiliation_strings":["Institute of Biochemistry, Charit\u00e9 - University Medical Center Berlin, Berlin, Germany"],"raw_orcid":"https://orcid.org/0000-0001-9535-7413","affiliations":[{"raw_affiliation_string":"Institute of Biochemistry, Charit\u00e9 - University Medical Center Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5070892021"],"corresponding_institution_ids":["https://openalex.org/I7877124"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10683","display_name":"Mass Spectrometry Techniques and Applications","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12867","display_name":"Advanced Biosensing Techniques and Applications","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/plasma-proteome","display_name":"plasma proteome","score":0.8999999761581421},{"id":"https://openalex.org/keywords/proteoforms","display_name":"proteoforms","score":0.9700000286102295},{"id":"https://openalex.org/keywords/albumin","display_name":"albumin","score":0.6660000085830688},{"id":"https://openalex.org/keywords/coagulation-factors","display_name":"coagulation factors","score":0.9980000257492065},{"id":"https://openalex.org/keywords/olink","display_name":"Olink","score":0.6430000066757202},{"id":"https://openalex.org/keywords/somascan","display_name":"SomaScan","score":0.9800000190734863},{"id":"https://openalex.org/keywords/low-abundance-proteins","display_name":"low-abundance proteins","score":0.7350000143051147},{"id":"https://openalex.org/keywords/biomarker-discovery","display_name":"biomarker discovery","score":0.9330000281333923}],"concepts":[{"id":"https://openalex.org/C104397665","wikidata":"https://www.wikidata.org/wiki/Q860947","display_name":"Proteome","level":2,"score":0.7019000053405762},{"id":"https://openalex.org/C3020134792","wikidata":"https://www.wikidata.org/wiki/Q79749","display_name":"Human plasma","level":2,"score":0.6758000254631042},{"id":"https://openalex.org/C158163496","wikidata":"https://www.wikidata.org/wiki/Q5937310","display_name":"Human Protein Atlas","level":4,"score":0.6546000242233276},{"id":"https://openalex.org/C50476208","wikidata":"https://www.wikidata.org/wiki/Q898861","display_name":"Isoelectric focusing","level":3,"score":0.631600022315979},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5939000248908997},{"id":"https://openalex.org/C96294017","wikidata":"https://www.wikidata.org/wiki/Q308708","display_name":"Isoelectric point","level":3,"score":0.5734999775886536},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5457000136375427},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.505299985408783},{"id":"https://openalex.org/C162356407","wikidata":"https://www.wikidata.org/wiki/Q180809","display_name":"Mass spectrometry","level":2,"score":0.4332999885082245},{"id":"https://openalex.org/C94795543","wikidata":"https://www.wikidata.org/wiki/Q3813754","display_name":"Human proteome project","level":4,"score":0.3953000009059906},{"id":"https://openalex.org/C2911029443","wikidata":"https://www.wikidata.org/wiki/Q21296145","display_name":"Human proteins","level":3,"score":0.3831000030040741},{"id":"https://openalex.org/C31827203","wikidata":"https://www.wikidata.org/wiki/Q874296","display_name":"Tandem mass spectrometry","level":3,"score":0.36809998750686646},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3589000105857849},{"id":"https://openalex.org/C53345823","wikidata":"https://www.wikidata.org/wiki/Q5531554","display_name":"Gene isoform","level":3,"score":0.3319999873638153},{"id":"https://openalex.org/C2910669755","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide mapping","level":4,"score":0.32089999318122864},{"id":"https://openalex.org/C146543888","wikidata":"https://www.wikidata.org/wiki/Q425056","display_name":"Blood proteins","level":2,"score":0.3176000118255615},{"id":"https://openalex.org/C111684460","wikidata":"https://www.wikidata.org/wiki/Q334848","display_name":"Complement system","level":3,"score":0.3093000054359436},{"id":"https://openalex.org/C112313634","wikidata":"https://www.wikidata.org/wiki/Q7886648","display_name":"Complement (music)","level":5,"score":0.3059999942779541},{"id":"https://openalex.org/C202264299","wikidata":"https://www.wikidata.org/wiki/Q905695","display_name":"UniProt","level":3,"score":0.27469998598098755},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2565999925136566}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.09.26.754256","doi":"https://doi.org/10.64898/2026.09.26.754256","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.26.754256","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/28/2026.09.26.754256.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.09.26.754256","doi":"https://doi.org/10.64898/2026.09.26.754256","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.26.754256","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/28/2026.09.26.754256.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.5683000087738037,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2920619578","display_name":null,"funder_award_id":"533770413","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G4211186545","display_name":"HybridMassenspektrometer mit Fl\u00fcssigkeitschromatographieSystem","funder_award_id":"492697668","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G6614358020","display_name":null,"funder_award_id":"031L0220","funder_id":"https://openalex.org/F4320321114","funder_display_name":"Bundesministerium f\u00fcr Bildung und Forschung"}],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320321114","display_name":"Bundesministerium f\u00fcr Bildung und Forschung","ror":"https://ror.org/04pz7b180"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7214657246.pdf","grobid_xml":"https://content.openalex.org/works/W7214657246.grobid-xml"},"referenced_works_count":58,"referenced_works":["https://openalex.org/W1606423922","https://openalex.org/W1750773183","https://openalex.org/W1866421377","https://openalex.org/W1971280282","https://openalex.org/W1988586390","https://openalex.org/W2005948867","https://openalex.org/W2015159529","https://openalex.org/W2026370517","https://openalex.org/W2037199116","https://openalex.org/W2067098972","https://openalex.org/W2068565992","https://openalex.org/W2153349010","https://openalex.org/W2154798437","https://openalex.org/W2161811833","https://openalex.org/W2170776626","https://openalex.org/W2302629258","https://openalex.org/W2480274514","https://openalex.org/W2607310450","https://openalex.org/W2806017611","https://openalex.org/W2943223113","https://openalex.org/W2951021236","https://openalex.org/W2967091052","https://openalex.org/W2977866395","https://openalex.org/W2991106430","https://openalex.org/W2999283618","https://openalex.org/W3043870236","https://openalex.org/W3108232640","https://openalex.org/W3175993123","https://openalex.org/W3207607557","https://openalex.org/W3208196257","https://openalex.org/W3212853007","https://openalex.org/W4206665973","https://openalex.org/W4229449181","https://openalex.org/W4242416368","https://openalex.org/W4284897468","https://openalex.org/W4308634875","https://openalex.org/W4386462271","https://openalex.org/W4387344289","https://openalex.org/W4387344358","https://openalex.org/W4387354365","https://openalex.org/W4397008527","https://openalex.org/W4400880400","https://openalex.org/W4403853942","https://openalex.org/W4403948113","https://openalex.org/W4404458588","https://openalex.org/W4406001359","https://openalex.org/W4408403697","https://openalex.org/W4409118908","https://openalex.org/W4410138743","https://openalex.org/W4411077234","https://openalex.org/W4412049043","https://openalex.org/W4414747563","https://openalex.org/W4415033766","https://openalex.org/W4415648691","https://openalex.org/W7116670300","https://openalex.org/W7118196334","https://openalex.org/W7170375248","https://openalex.org/W7208720157"],"related_works":["https://openalex.org/W2002396315","https://openalex.org/W7163042303","https://openalex.org/W2142286883","https://openalex.org/W2726661837","https://openalex.org/W4300118986","https://openalex.org/W2597203431","https://openalex.org/W2072244397","https://openalex.org/W7098691942","https://openalex.org/W2133112773","https://openalex.org/W1983225260"],"abstract_inverted_index":{"Abstract":[0],"Key":[1],"plasma":[2,55,67,105,113,175,245],"protein,":[3,133],"including":[4],"albumin,":[5],"complement":[6,183],"system":[7],"proteins,":[8],"and":[9,15,36,72,91,177,184,194,226,247,260],"coagulation":[10],"factors":[11],"circulate":[12,115],"in":[13,163,180,220,231],"biochemically":[14],"functionally":[16],"distinct":[17,119],"isoforms,":[18],"or":[19],"proteoforms.":[20,233],"Despite":[21],"the":[22,48,53,93,103,139,149,159,167,172,192,221,243],"importance":[23],"of":[24,47,52,102,121,129,141,158,223,242],"these":[25,78,203],"proteoforms":[26,131],"being":[27],"widely":[28],"accepted,":[29],"they":[30],"are":[31],"challenging":[32],"to":[33,69,200,214],"resolve":[34],"systematically,":[35],"as":[37,198],"a":[38,43,97,127],"consequence,":[39],"we":[40,58,123],"still":[41],"lack":[42],"more":[44],"complete":[45],"picture":[46],"total":[49,160],"proteoform":[50,99,169,216,240,250],"diversity":[51,170,241,251],"human":[54,104,244],"proteome.":[56,106],"Here,":[57],"generated":[59],"3,114":[60],"intact":[61],"protein":[62,151,161],"fractions":[63,79],"by":[64,80],"extensively":[65],"separating":[66],"according":[68,199],"isoelectric":[70],"point":[71],"molecular":[73],"weight.":[74],"We":[75,107,165],"then":[76],"analysed":[77],"liquid":[81],"chromatography":[82],"data-independent":[83],"acquisition":[84],"mass":[85,162],"spectrometry":[86],"(DIA-MS)":[87],"upon":[88],"tryptic":[89],"digestions,":[90],"combined":[92],"resultant":[94],"data":[95,188,237],"into":[96],"multidimensional,":[98],"resolved":[100],"atlas":[101,146],"report":[108],"that":[109,148,249],"5,077":[110],"unequivocally":[111],"detected":[112],"proteins":[114,176,211,225],"at":[116,134],"least":[117],"179,049":[118],"proteoforms,":[120,144],"which":[122,229],"detect":[124,166],"44,083,":[125],"with":[126,212],"median":[128],"11":[130],"per":[132],"high":[135],"confidence.":[136],"Substantially":[137],"increasing":[138],"number":[140],"experimentally":[142],"confirmed":[143],"our":[145,187,201,236],"implies":[147,248],"canonical":[150],"forms":[152],"account":[153],"for":[154,208,257],"less":[155],"than":[156],"half":[157],"plasma.":[164],"greatest":[168],"among":[171],"most":[173],"abundant":[174,210],"those":[178,228],"functioning":[179],"nutrient":[181],"transport,":[182],"coagulation.":[185],"Finally,":[186],"clarifies":[189],"discrepancies":[190],"between":[191],"Olink":[193],"SomaScan":[195],"proteomic":[196],"platforms,":[197],"atlas,":[202],"techniques":[204],"provide":[205],"correlated":[206],"values":[207],"relatively":[209],"low":[213],"medium":[215],"diversity,":[217],"but":[218],"struggle":[219],"quantification":[222],"low-abundant":[224],"on":[227],"exist":[230],"many":[232],"In":[234],"sum,":[235],"reveals":[238],"extensive":[239],"proteome,":[246],"represents":[252],"an":[253],"enormous":[254],"untapped":[255],"reservoir":[256],"biomedical":[258],"research":[259],"biomarker":[261],"discovery.":[262]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-09-29T00:00:00"}
