{"id":"https://openalex.org/W7214644201","doi":"https://doi.org/10.64898/2026.09.25.748507","title":"PDLIM5 Modulates YAP1 Localisation and Fibrogenic Gene Expression in Hepatic Stellate Cells","display_name":"PDLIM5 Modulates YAP1 Localisation and Fibrogenic Gene Expression in Hepatic Stellate Cells","publication_year":2026,"publication_date":"2026-09-28","ids":{"openalex":"https://openalex.org/W7214644201","doi":"https://doi.org/10.64898/2026.09.25.748507"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.25.748507","doi":"https://doi.org/10.64898/2026.09.25.748507","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.25.748507","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/28/2026.09.25.748507.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/28/2026.09.25.748507.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053885184","display_name":"Kara Simpson","orcid":"https://orcid.org/0000-0001-7950-5703","observed_orcids":["https://orcid.org/0000-0001-7950-5703"]},"institutions":[{"id":"https://openalex.org/I11983389","display_name":"Manchester Metropolitan University","ror":"https://ror.org/02hstj355","country_code":"GB","type":"education","lineage":["https://openalex.org/I11983389"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Kara Worsley","raw_affiliation_strings":["School of Biological and Chemical Sciences, Faculty of Science and Engineering, Manchester Metropolitan University, Manchester, UK"],"raw_orcid":"https://orcid.org/0000-0001-7950-5703","affiliations":[{"raw_affiliation_string":"School of Biological and Chemical Sciences, Faculty of Science and Engineering, Manchester Metropolitan University, Manchester, UK","institution_ids":["https://openalex.org/I11983389"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009026635","display_name":"Dina I. Abdelmottaleb","orcid":"https://orcid.org/0000-0002-8810-911X","observed_orcids":["https://orcid.org/0000-0002-8810-911X"]},"institutions":[{"id":"https://openalex.org/I11983389","display_name":"Manchester Metropolitan University","ror":"https://ror.org/02hstj355","country_code":"GB","type":"education","lineage":["https://openalex.org/I11983389"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Dina Abdelmottaleb","raw_affiliation_strings":["School of Biological and Chemical Sciences, Faculty of Science and Engineering, Manchester Metropolitan University, Manchester, UK"],"raw_orcid":"https://orcid.org/0000-0002-8810-911X","affiliations":[{"raw_affiliation_string":"School of Biological and Chemical Sciences, Faculty of Science and Engineering, Manchester Metropolitan University, Manchester, UK","institution_ids":["https://openalex.org/I11983389"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033894595","display_name":"Lana Ibrahim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I11983389","display_name":"Manchester Metropolitan University","ror":"https://ror.org/02hstj355","country_code":"GB","type":"education","lineage":["https://openalex.org/I11983389"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Lana Ibrahim","raw_affiliation_strings":["School of Biological and Chemical Sciences, Faculty of Science and Engineering, Manchester Metropolitan University, Manchester, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biological and Chemical Sciences, Faculty of Science and Engineering, Manchester Metropolitan University, Manchester, UK","institution_ids":["https://openalex.org/I11983389"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5137296423","display_name":"Elliot Jennings","orcid":"https://orcid.org/0009-0000-7285-4572","observed_orcids":["https://orcid.org/0009-0000-7285-4572"]},"institutions":[{"id":"https://openalex.org/I11983389","display_name":"Manchester Metropolitan University","ror":"https://ror.org/02hstj355","country_code":"GB","type":"education","lineage":["https://openalex.org/I11983389"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Elliot F Jennings","raw_affiliation_strings":["School of Biological and Chemical Sciences, Faculty of Science and Engineering, Manchester Metropolitan University, Manchester, UK"],"raw_orcid":"https://orcid.org/0009-0000-7285-4572","affiliations":[{"raw_affiliation_string":"School of Biological and Chemical Sciences, Faculty of Science and Engineering, Manchester Metropolitan University, Manchester, UK","institution_ids":["https://openalex.org/I11983389"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5153238979","display_name":"Hayato Kakinuma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I11983389","display_name":"Manchester Metropolitan University","ror":"https://ror.org/02hstj355","country_code":"GB","type":"education","lineage":["https://openalex.org/I11983389"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Hayato Kakinuma","raw_affiliation_strings":["School of Biological and Chemical Sciences, Faculty of Science and Engineering, Manchester Metropolitan University, Manchester, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biological and Chemical Sciences, Faculty of Science and Engineering, Manchester Metropolitan University, Manchester, UK","institution_ids":["https://openalex.org/I11983389"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5153285890","display_name":"Joel Malungu Makopa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I11983389","display_name":"Manchester Metropolitan University","ror":"https://ror.org/02hstj355","country_code":"GB","type":"education","lineage":["https://openalex.org/I11983389"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Joel Malungu Makopa","raw_affiliation_strings":["School of Biological and Chemical Sciences, Faculty of Science and Engineering, Manchester Metropolitan University, Manchester, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biological and Chemical Sciences, Faculty of Science and Engineering, Manchester Metropolitan University, Manchester, UK","institution_ids":["https://openalex.org/I11983389"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5153264456","display_name":"Anna Meier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I11983389","display_name":"Manchester Metropolitan University","ror":"https://ror.org/02hstj355","country_code":"GB","type":"education","lineage":["https://openalex.org/I11983389"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Anna Meier","raw_affiliation_strings":["School of Biological and Chemical Sciences, Faculty of Science and Engineering, Manchester Metropolitan University, Manchester, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biological and Chemical Sciences, Faculty of Science and Engineering, Manchester Metropolitan University, Manchester, UK","institution_ids":["https://openalex.org/I11983389"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5153360693","display_name":"Rabea P\u00e4tzold","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I11983389","display_name":"Manchester Metropolitan University","ror":"https://ror.org/02hstj355","country_code":"GB","type":"education","lineage":["https://openalex.org/I11983389"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Rabea P\u00e4tzold","raw_affiliation_strings":["School of Biological and Chemical Sciences, Faculty of Science and Engineering, Manchester Metropolitan University, Manchester, UK"],"raw_orcid":"https://orcid.org/0000-0001-9473-9647","affiliations":[{"raw_affiliation_string":"School of Biological and Chemical Sciences, Faculty of Science and Engineering, Manchester Metropolitan University, Manchester, UK","institution_ids":["https://openalex.org/I11983389"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041227147","display_name":"Lindsay Birchall","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Lindsay Birchall","raw_affiliation_strings":["Division of Integrative Physiology, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, M13 9PT, UK, UK","Manchester Cell-Matrix Centre, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, M13 9PT, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Integrative Physiology, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, M13 9PT, UK, UK","institution_ids":["https://openalex.org/I28407311"]},{"raw_affiliation_string":"Manchester Cell-Matrix Centre, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, M13 9PT, UK","institution_ids":["https://openalex.org/I28407311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089680660","display_name":"Varinder Singh Athwal","orcid":"https://orcid.org/0000-0002-1684-721X","observed_orcids":["https://orcid.org/0000-0002-1684-721X"]},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]},{"id":"https://openalex.org/I4210092852","display_name":"Manchester University NHS Foundation Trust","ror":"https://ror.org/00he80998","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210092852"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Varinder S Athwal","raw_affiliation_strings":["Division of GI Medicine and Surgery, Manchester University NHS Foundation Trust Hospitals, Manchester, UK","Division of Integrative Physiology, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, M13 9PT, UK, UK","Manchester Cell-Matrix Centre, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, M13 9PT, UK"],"raw_orcid":"https://orcid.org/0000-0002-1684-721X","affiliations":[{"raw_affiliation_string":"Division of GI Medicine and Surgery, Manchester University NHS Foundation Trust Hospitals, Manchester, UK","institution_ids":["https://openalex.org/I4210092852"]},{"raw_affiliation_string":"Division of Integrative Physiology, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, M13 9PT, UK, UK","institution_ids":["https://openalex.org/I28407311"]},{"raw_affiliation_string":"Manchester Cell-Matrix Centre, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, M13 9PT, UK","institution_ids":["https://openalex.org/I28407311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044786704","display_name":"Elliot J. Jokl","orcid":"https://orcid.org/0000-0003-2556-3777","observed_orcids":["https://orcid.org/0000-0003-2556-3777"]},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Elliot Jokl","raw_affiliation_strings":["Division of Integrative Physiology, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, M13 9PT, UK, UK","Manchester Cell-Matrix Centre, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, M13 9PT, UK"],"raw_orcid":"https://orcid.org/0000-0003-2556-3777","affiliations":[{"raw_affiliation_string":"Division of Integrative Physiology, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, M13 9PT, UK, UK","institution_ids":["https://openalex.org/I28407311"]},{"raw_affiliation_string":"Manchester Cell-Matrix Centre, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, M13 9PT, UK","institution_ids":["https://openalex.org/I28407311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008313590","display_name":"Tristan R. McKay","orcid":"https://orcid.org/0000-0002-9128-9115","observed_orcids":["https://orcid.org/0000-0002-9128-9115"]},"institutions":[{"id":"https://openalex.org/I11983389","display_name":"Manchester Metropolitan University","ror":"https://ror.org/02hstj355","country_code":"GB","type":"education","lineage":["https://openalex.org/I11983389"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Tristan Mckay","raw_affiliation_strings":["School of Biological and Chemical Sciences, Faculty of Science and Engineering, Manchester Metropolitan University, Manchester, UK"],"raw_orcid":"https://orcid.org/0000-0002-9128-9115","affiliations":[{"raw_affiliation_string":"School of Biological and Chemical Sciences, Faculty of Science and Engineering, Manchester Metropolitan University, Manchester, UK","institution_ids":["https://openalex.org/I11983389"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049938896","display_name":"Karen Piper Hanley","orcid":"https://orcid.org/0000-0001-9473-9647","observed_orcids":["https://orcid.org/0000-0001-9473-9647"]},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Karen Piper Hanley","raw_affiliation_strings":["Division of Integrative Physiology, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, M13 9PT, UK, UK","Manchester Cell-Matrix Centre, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, M13 9PT, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Integrative Physiology, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, M13 9PT, UK, UK","institution_ids":["https://openalex.org/I28407311"]},{"raw_affiliation_string":"Manchester Cell-Matrix Centre, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, M13 9PT, UK","institution_ids":["https://openalex.org/I28407311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053193005","display_name":"Jonathan D. Humphries","orcid":"https://orcid.org/0000-0002-8953-7079","observed_orcids":["https://orcid.org/0000-0002-8953-7079"]},"institutions":[{"id":"https://openalex.org/I11983389","display_name":"Manchester Metropolitan University","ror":"https://ror.org/02hstj355","country_code":"GB","type":"education","lineage":["https://openalex.org/I11983389"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jonathan D. Humphries","raw_affiliation_strings":["School of Biological and Chemical Sciences, Faculty of Science and Engineering, Manchester Metropolitan University, Manchester, UK"],"raw_orcid":"https://orcid.org/0000-0002-8953-7079","affiliations":[{"raw_affiliation_string":"School of Biological and Chemical Sciences, Faculty of Science and Engineering, Manchester Metropolitan University, Manchester, UK","institution_ids":["https://openalex.org/I11983389"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5157697974","display_name":"J.P. Pritchett","orcid":"https://orcid.org/0000-0003-2620-7061","observed_orcids":["https://orcid.org/0000-0003-2620-7061"]},"institutions":[{"id":"https://openalex.org/I11983389","display_name":"Manchester Metropolitan University","ror":"https://ror.org/02hstj355","country_code":"GB","type":"education","lineage":["https://openalex.org/I11983389"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"James Pritchett","raw_affiliation_strings":["School of Biological and Chemical Sciences, Faculty of Science and Engineering, Manchester Metropolitan University, Manchester, UK"],"raw_orcid":"https://orcid.org/0000-0003-2620-7061","affiliations":[{"raw_affiliation_string":"School of Biological and Chemical Sciences, Faculty of Science and Engineering, Manchester Metropolitan University, Manchester, UK","institution_ids":["https://openalex.org/I11983389"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5157697974"],"corresponding_institution_ids":["https://openalex.org/I11983389"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.8579000234603882,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.8579000234603882,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12065","display_name":"Hippo pathway signaling and YAP/TAZ","score":0.13940000534057617,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pdlim5","display_name":"PDLIM5","score":1.0},{"id":"https://openalex.org/keywords/yap","display_name":"YAP","score":0.9919999837875366},{"id":"https://openalex.org/keywords/hepatic-stellate-cells","display_name":"hepatic stellate cells","score":0.9850000143051147},{"id":"https://openalex.org/keywords/liver-fibrosis","display_name":"liver fibrosis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/mechanotransduction","display_name":"mechanotransduction","score":0.7599999904632568},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.5920000076293945},{"id":"https://openalex.org/keywords/collagen-1a1","display_name":"collagen 1A1","score":0.7590000033378601},{"id":"https://openalex.org/keywords/stress-fibers","display_name":"stress fibers","score":0.8069999814033508},{"id":"https://openalex.org/keywords/hepatic-stellate-cell-activation","display_name":"hepatic stellate cell activation","score":0.6510000228881836},{"id":"https://openalex.org/keywords/fibrogenic-gene-expression","display_name":"fibrogenic gene expression","score":0.8119999766349792}],"concepts":[{"id":"https://openalex.org/C176891718","wikidata":"https://www.wikidata.org/wiki/Q1997459","display_name":"Hepatic stellate cell","level":2,"score":0.8019999861717224},{"id":"https://openalex.org/C2780219982","wikidata":"https://www.wikidata.org/wiki/Q17544238","display_name":"YAP1","level":4,"score":0.733299970626831},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7077000141143799},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.6363999843597412},{"id":"https://openalex.org/C154428179","wikidata":"https://www.wikidata.org/wiki/Q24721050","display_name":"PDZ domain","level":2,"score":0.5450000166893005},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5217999815940857},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4620000123977661},{"id":"https://openalex.org/C137738243","wikidata":"https://www.wikidata.org/wiki/Q189092","display_name":"Cell migration","level":3,"score":0.44279998540878296},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.4207000136375427},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.39469999074935913},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3571999967098236},{"id":"https://openalex.org/C195687474","wikidata":"https://www.wikidata.org/wiki/Q409715","display_name":"Integrin","level":3,"score":0.3463999927043915},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.34119999408721924},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3276999890804291},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.3248000144958496},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.32179999351501465},{"id":"https://openalex.org/C6929976","wikidata":"https://www.wikidata.org/wiki/Q3771881","display_name":"Regulator","level":3,"score":0.3190999925136566},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.31859999895095825},{"id":"https://openalex.org/C190672674","wikidata":"https://www.wikidata.org/wiki/Q3866591","display_name":"Decellularization","level":3,"score":0.3118000030517578},{"id":"https://openalex.org/C76419328","wikidata":"https://www.wikidata.org/wiki/Q74419","display_name":"Epithelial\u2013mesenchymal transition","level":4,"score":0.31049999594688416},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.30250000953674316},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.3012000024318695},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.3009999990463257},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.2856999933719635},{"id":"https://openalex.org/C2993667909","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Hepatic fibrosis","level":3,"score":0.2808000147342682},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.2768000066280365},{"id":"https://openalex.org/C195521686","wikidata":"https://www.wikidata.org/wiki/Q17152676","display_name":"Liver cytology","level":3,"score":0.27300000190734863},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.26190000772476196},{"id":"https://openalex.org/C27153228","wikidata":"https://www.wikidata.org/wiki/Q3787274","display_name":"Transcriptional regulation","level":4,"score":0.2612999975681305},{"id":"https://openalex.org/C85789140","wikidata":"https://www.wikidata.org/wiki/Q187640","display_name":"Cell adhesion","level":3,"score":0.26109999418258667}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.09.25.748507","doi":"https://doi.org/10.64898/2026.09.25.748507","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.25.748507","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/28/2026.09.25.748507.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.09.25.748507","doi":"https://doi.org/10.64898/2026.09.25.748507","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.25.748507","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/28/2026.09.25.748507.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6240000128746033}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320319985","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67"},{"id":"https://openalex.org/F4320320157","display_name":"British Society for Cell Biology","ror":"https://ror.org/01s0z9h22"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7214644201.pdf","grobid_xml":"https://content.openalex.org/works/W7214644201.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W1811064827","https://openalex.org/W1965588383","https://openalex.org/W1993891700","https://openalex.org/W1996420367","https://openalex.org/W2003331504","https://openalex.org/W2008132884","https://openalex.org/W2012349920","https://openalex.org/W2032019813","https://openalex.org/W2040992047","https://openalex.org/W2063208689","https://openalex.org/W2088071075","https://openalex.org/W2100641053","https://openalex.org/W2101244168","https://openalex.org/W2101749257","https://openalex.org/W2121353065","https://openalex.org/W2131936721","https://openalex.org/W2137889544","https://openalex.org/W2146337514","https://openalex.org/W2154530183","https://openalex.org/W2159196011","https://openalex.org/W2165062244","https://openalex.org/W2166582753","https://openalex.org/W2167279371","https://openalex.org/W2167978765","https://openalex.org/W2316381998","https://openalex.org/W2508686416","https://openalex.org/W2613180696","https://openalex.org/W2761533297","https://openalex.org/W2781527068","https://openalex.org/W2899878476","https://openalex.org/W3022772558","https://openalex.org/W3037011268","https://openalex.org/W3130337078","https://openalex.org/W4205884987","https://openalex.org/W4282976493","https://openalex.org/W4362705656","https://openalex.org/W4380050135","https://openalex.org/W4386318431","https://openalex.org/W4388673548","https://openalex.org/W4409781232"],"related_works":["https://openalex.org/W3159935709","https://openalex.org/W4383377473","https://openalex.org/W2320438180","https://openalex.org/W2154530183","https://openalex.org/W2558486683","https://openalex.org/W7171671355","https://openalex.org/W2908870216","https://openalex.org/W4391821923","https://openalex.org/W4398220631","https://openalex.org/W7162698601"],"abstract_inverted_index":{"Abstract":[0],"Hepatic":[1],"stellate":[2],"cells":[3,179],"(HSCs)":[4],"are":[5,70],"the":[6,39,45,55,86,119,150,244],"key":[7],"cellular":[8],"drivers":[9],"of":[10,47,121,248],"liver":[11,14,122,249],"fibrosis.":[12,123,250],"During":[13],"injury":[15],"and":[16,24,43,54,88,111,133,138,145,148,174,185,191,194,208,232,238,246],"chronic":[17],"inflammation":[18],"HSCs":[19,110,129,147,237],"adopt":[20],"an":[21,181],"activated":[22],"phenotype":[23],"secrete":[25],"fibrotic":[26,40,131,209],"extracellular":[27],"matrix":[28],"(ECM)":[29],"components":[30],"such":[31],"as":[32],"collagen":[33],"I.":[34],"Mechanical":[35],"cues":[36,69],"derived":[37],"from":[38],"ECM":[41,171],"drive":[42],"support":[44,180,223],"activation":[46],"HSCs,":[48],"via":[49],"mechanisms":[50],"that":[51,76,84,240],"involve":[52],"integrins":[53],"mechano-sensitive":[56],"transcriptional":[57],"regulator":[58],"YAP1.":[59,186],"It":[60],"is":[61,82,107],"not":[62],"yet":[63],"well":[64],"understood":[65],"how":[66],"external":[67],"mechanical":[68],"translated":[71],"into":[72],"a":[73,167,224],"molecular":[74],"response":[75],"alters":[77],"YAP1":[78,96,114,205,230],"nuclear":[79,206],"shuttling.":[80],"There":[81],"evidence":[83],"suggests":[85],"PDZ":[87],"LIM":[89],"domain":[90],"protein":[91,125,139],"(PDLIM)":[92],"5":[93],"can":[94],"regulate":[95],"shuttling":[97],"in":[98,109,118,128,130,169,177,200,217,228,236],"human":[99,132,144],"epithelial":[100],"cells.":[101,219],"We":[102,187],"therefore":[103],"investigated":[104],"whether":[105],"PDLIM5":[106,124,136,156,184,199,203,227,241],"expressed":[108,141],"contributes":[112],"to":[113,197],"associated":[115],"HSC":[116,152,170],"mechano-activation":[117],"context":[120],"was":[126],"detected":[127],"mouse":[134,146],"liver.":[135],"transcript":[137],"were":[140],"by":[142,149],"primary":[143],"immortalised":[151],"LX-2":[153,178,218],"cell":[154],"line.":[155],"colocalised":[157],"with":[158],"integrin":[159],"adhesion":[160],"complexes":[161],"at":[162],"actin":[163],"stress":[164],"fibres":[165],"suggesting":[166],"role":[168,225],"adhesion.":[172],"Co-immunoprecipitation":[173],"proximity":[175],"ligation":[176],"association":[182],"between":[183],"used":[188],"pharmacological":[189],"(paclitaxel)":[190],"genetic":[192],"(siRNA":[193],"CRISPRi)":[195],"approaches":[196],"inhibit":[198],"HSCs.":[201],"Inhibiting":[202],"reduced":[204],"localisation":[207,231],"gene":[210,234],"(":[211],"COL1A1":[212],",":[213],"ACTA2":[214],")":[215],"expression":[216,235],"Overall,":[220],"these":[221],"data":[222],"for":[226],"regulating":[229],"fibrogenic":[233],"suggest":[239],"may":[242],"influence":[243],"development":[245],"maintenance":[247]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-09-29T00:00:00"}
