{"id":"https://openalex.org/W7214639976","doi":"https://doi.org/10.64898/2026.09.25.751968","title":"Accessing Enzyme Kinetic Data and Prediction Methods at Scale","display_name":"Accessing Enzyme Kinetic Data and Prediction Methods at Scale","publication_year":2026,"publication_date":"2026-09-28","ids":{"openalex":"https://openalex.org/W7214639976","doi":"https://doi.org/10.64898/2026.09.25.751968"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.25.751968","doi":"https://doi.org/10.64898/2026.09.25.751968","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.25.751968","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/28/2026.09.25.751968.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/28/2026.09.25.751968.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5120502223","display_name":"Saleh Alwer","orcid":"https://orcid.org/0009-0008-3780-7445","observed_orcids":["https://orcid.org/0009-0008-3780-7445"]},"institutions":[{"id":"https://openalex.org/I188760350","display_name":"Ollscoil na Gaillimhe \u2013 University of Galway","ror":"https://ror.org/03bea9k73","country_code":"IE","type":"education","lineage":["https://openalex.org/I188760350"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Saleh Alwer","raw_affiliation_strings":["Digital Metabolic Twin Centre, University of Galway, University Road, Galway H91 TK33, Ireland","Institute for Clinical Trials, University of Galway, University Road, Galway H91 TK33, Ireland","School of Medicine, College of Medicine and Health, University of Galway, University Road, Galway H91 TK33, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Digital Metabolic Twin Centre, University of Galway, University Road, Galway H91 TK33, Ireland","institution_ids":["https://openalex.org/I188760350"]},{"raw_affiliation_string":"Institute for Clinical Trials, University of Galway, University Road, Galway H91 TK33, Ireland","institution_ids":["https://openalex.org/I188760350"]},{"raw_affiliation_string":"School of Medicine, College of Medicine and Health, University of Galway, University Road, Galway H91 TK33, Ireland","institution_ids":["https://openalex.org/I188760350"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092254230","display_name":"Hugues Escoffier","orcid":"https://orcid.org/0000-0002-3525-7661","observed_orcids":["https://orcid.org/0000-0002-3525-7661"]},"institutions":[{"id":"https://openalex.org/I186903577","display_name":"University of Luxembourg","ror":"https://ror.org/036x5ad56","country_code":"LU","type":"education","lineage":["https://openalex.org/I186903577"]}],"countries":["LU"],"is_corresponding":false,"raw_author_name":"Hugues Escoffier","raw_affiliation_strings":["Department of Health, Medicine and Life Sciences, Faculty of Science, Technology and Medicine, University of Luxembourg, 6 avenue du Swing, L-4367 Belvaux, Luxembourg"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Health, Medicine and Life Sciences, Faculty of Science, Technology and Medicine, University of Luxembourg, 6 avenue du Swing, L-4367 Belvaux, Luxembourg","institution_ids":["https://openalex.org/I186903577"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5140621769","display_name":"Karim Taha","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]},{"id":"https://openalex.org/I4210126213","display_name":"Cluster of Excellence on Plant Sciences","ror":"https://ror.org/034waa237","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I149899117","https://openalex.org/I171892758","https://openalex.org/I180923762","https://openalex.org/I4210126213","https://openalex.org/I4210141639","https://openalex.org/I44260953"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Karim Taha","raw_affiliation_strings":["Institute for Plant Sciences and Cluster of Excellence on Plant Sciences (CEPLAS), University of Cologne, Z\u00fclpicher Strasse 47b, 50674 Cologne, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Plant Sciences and Cluster of Excellence on Plant Sciences (CEPLAS), University of Cologne, Z\u00fclpicher Strasse 47b, 50674 Cologne, Germany","institution_ids":["https://openalex.org/I180923762","https://openalex.org/I4210126213"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084372867","display_name":"Veda Sheersh Boorla","orcid":"https://orcid.org/0000-0003-0084-3975","observed_orcids":["https://orcid.org/0000-0003-0084-3975"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Veda Boorla","raw_affiliation_strings":["Department of Chemical Engineering, The Pennsylvania State University, University Park, PA 16802, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, The Pennsylvania State University, University Park, PA 16802, USA","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077674509","display_name":"Han Yu","orcid":"https://orcid.org/0000-0002-3520-1828","observed_orcids":["https://orcid.org/0000-0002-3520-1828"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210145761","display_name":"Shenzhen Institutes of Advanced Technology","ror":"https://ror.org/04gh4er46","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210145761"]},{"id":"https://openalex.org/I4405273091","display_name":"Shenzhen Institute of Synthetic Biology","ror":"https://ror.org/058rt6c45","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405273091"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Han Yu","raw_affiliation_strings":["Center for Synthetic Biochemistry, Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Synthetic Biochemistry, Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210145761","https://openalex.org/I4405273091"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5140656138","display_name":"Somtirtha Santra","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Somtirtha Santra","raw_affiliation_strings":["Department of Chemical Engineering, The Pennsylvania State University, University Park, PA 16802, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, The Pennsylvania State University, University Park, PA 16802, USA","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5126696906","display_name":"Zechen Wang","orcid":"https://orcid.org/0000-0003-4554-133X","observed_orcids":["https://orcid.org/0000-0003-4554-133X","https://orcid.org/0009-0007-6064-0375"]},"institutions":[{"id":"https://openalex.org/I172675005","display_name":"Nanyang Technological University","ror":"https://ror.org/02e7b5302","country_code":"SG","type":"education","lineage":["https://openalex.org/I172675005"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Zechen Wang","raw_affiliation_strings":["College of Computing and Data Science, Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Computing and Data Science, Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798, Singapore","institution_ids":["https://openalex.org/I172675005"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5140719276","display_name":"Chidi Egwu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I188760350","display_name":"Ollscoil na Gaillimhe \u2013 University of Galway","ror":"https://ror.org/03bea9k73","country_code":"IE","type":"education","lineage":["https://openalex.org/I188760350"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Chidi Egwu","raw_affiliation_strings":["Digital Metabolic Twin Centre, University of Galway, University Road, Galway H91 TK33, Ireland","Institute for Clinical Trials, University of Galway, University Road, Galway H91 TK33, Ireland","School of Medicine, College of Medicine and Health, University of Galway, University Road, Galway H91 TK33, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Digital Metabolic Twin Centre, University of Galway, University Road, Galway H91 TK33, Ireland","institution_ids":["https://openalex.org/I188760350"]},{"raw_affiliation_string":"Institute for Clinical Trials, University of Galway, University Road, Galway H91 TK33, Ireland","institution_ids":["https://openalex.org/I188760350"]},{"raw_affiliation_string":"School of Medicine, College of Medicine and Health, University of Galway, University Road, Galway H91 TK33, Ireland","institution_ids":["https://openalex.org/I188760350"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047508711","display_name":"Abraham Osinuga","orcid":"https://orcid.org/0000-0002-2587-8704","observed_orcids":["https://orcid.org/0000-0002-2587-8704"]},"institutions":[{"id":"https://openalex.org/I114395901","display_name":"University of Nebraska\u2013Lincoln","ror":"https://ror.org/043mer456","country_code":"US","type":"education","lineage":["https://openalex.org/I114395901"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Abraham Osinuga","raw_affiliation_strings":["Department of Chemical and Biomolecular Engineering, University of Nebraska\u2013Lincoln, Lincoln, NE 68588, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical and Biomolecular Engineering, University of Nebraska\u2013Lincoln, Lincoln, NE 68588, USA","institution_ids":["https://openalex.org/I114395901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043163658","display_name":"Supantha Dey","orcid":"https://orcid.org/0000-0003-1957-4613","observed_orcids":["https://orcid.org/0000-0003-1957-4613"]},"institutions":[{"id":"https://openalex.org/I173911158","display_name":"Iowa State University","ror":"https://ror.org/04rswrd78","country_code":"US","type":"education","lineage":["https://openalex.org/I173911158"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Supantha Dey","raw_affiliation_strings":["Department of Chemical and Biological Engineering, Iowa State University, Ames, IA 50011, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical and Biological Engineering, Iowa State University, Ames, IA 50011, USA","institution_ids":["https://openalex.org/I173911158"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5138532375","display_name":"Vaishnavey Srinivasan Raghunath","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173911158","display_name":"Iowa State University","ror":"https://ror.org/04rswrd78","country_code":"US","type":"education","lineage":["https://openalex.org/I173911158"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vaishnavey Srinivasan Raghunath","raw_affiliation_strings":["Department of Chemical and Biological Engineering, Iowa State University, Ames, IA 50011, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical and Biological Engineering, Iowa State University, Ames, IA 50011, USA","institution_ids":["https://openalex.org/I173911158"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107201245","display_name":"Farid Zare","orcid":"https://orcid.org/0009-0000-8065-0422","observed_orcids":["https://orcid.org/0009-0000-8065-0422"]},"institutions":[{"id":"https://openalex.org/I188760350","display_name":"Ollscoil na Gaillimhe \u2013 University of Galway","ror":"https://ror.org/03bea9k73","country_code":"IE","type":"education","lineage":["https://openalex.org/I188760350"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Farid Zare","raw_affiliation_strings":["Digital Metabolic Twin Centre, University of Galway, University Road, Galway H91 TK33, Ireland","Institute for Clinical Trials, University of Galway, University Road, Galway H91 TK33, Ireland","School of Medicine, College of Medicine and Health, University of Galway, University Road, Galway H91 TK33, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Digital Metabolic Twin Centre, University of Galway, University Road, Galway H91 TK33, Ireland","institution_ids":["https://openalex.org/I188760350"]},{"raw_affiliation_string":"Institute for Clinical Trials, University of Galway, University Road, Galway H91 TK33, Ireland","institution_ids":["https://openalex.org/I188760350"]},{"raw_affiliation_string":"School of Medicine, College of Medicine and Health, University of Galway, University Road, Galway H91 TK33, Ireland","institution_ids":["https://openalex.org/I188760350"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5120780180","display_name":"Jack McGoldrick","orcid":"https://orcid.org/0009-0000-2106-4159","observed_orcids":["https://orcid.org/0009-0000-2106-4159"]},"institutions":[{"id":"https://openalex.org/I188760350","display_name":"Ollscoil na Gaillimhe \u2013 University of Galway","ror":"https://ror.org/03bea9k73","country_code":"IE","type":"education","lineage":["https://openalex.org/I188760350"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Jack McGoldrick","raw_affiliation_strings":["Digital Metabolic Twin Centre, University of Galway, University Road, Galway H91 TK33, Ireland","Institute for Clinical Trials, University of Galway, University Road, Galway H91 TK33, Ireland","School of Medicine, College of Medicine and Health, University of Galway, University Road, Galway H91 TK33, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Digital Metabolic Twin Centre, University of Galway, University Road, Galway H91 TK33, Ireland","institution_ids":["https://openalex.org/I188760350"]},{"raw_affiliation_string":"Institute for Clinical Trials, University of Galway, University Road, Galway H91 TK33, Ireland","institution_ids":["https://openalex.org/I188760350"]},{"raw_affiliation_string":"School of Medicine, College of Medicine and Health, University of Galway, University Road, Galway H91 TK33, Ireland","institution_ids":["https://openalex.org/I188760350"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072421019","display_name":"Jan-Niklas Weder","orcid":"https://orcid.org/0000-0003-2388-7049","observed_orcids":["https://orcid.org/0000-0003-2388-7049"]},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]},{"id":"https://openalex.org/I4210126213","display_name":"Cluster of Excellence on Plant Sciences","ror":"https://ror.org/034waa237","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I149899117","https://openalex.org/I171892758","https://openalex.org/I180923762","https://openalex.org/I4210126213","https://openalex.org/I4210141639","https://openalex.org/I44260953"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Jan-Niklas Weder","raw_affiliation_strings":["Institute for Plant Sciences and Cluster of Excellence on Plant Sciences (CEPLAS), University of Cologne, Z\u00fclpicher Strasse 47b, 50674 Cologne, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Plant Sciences and Cluster of Excellence on Plant Sciences (CEPLAS), University of Cologne, Z\u00fclpicher Strasse 47b, 50674 Cologne, Germany","institution_ids":["https://openalex.org/I180923762","https://openalex.org/I4210126213"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5151618758","display_name":"Eduard Kerkhoven","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800139495","display_name":"Science for Life Laboratory","ror":"https://ror.org/04ev03g22","country_code":"SE","type":"facility","lineage":["https://openalex.org/I2800139495"]},{"id":"https://openalex.org/I2801134892","display_name":"Novo Nordisk Foundation","ror":"https://ror.org/04txyc737","country_code":"DK","type":"facility","lineage":["https://openalex.org/I2801134892"]},{"id":"https://openalex.org/I66862912","display_name":"Chalmers University of Technology","ror":"https://ror.org/040wg7k59","country_code":"SE","type":"education","lineage":["https://openalex.org/I66862912"]},{"id":"https://openalex.org/I96673099","display_name":"Technical University of Denmark","ror":"https://ror.org/04qtj9h94","country_code":"DK","type":"education","lineage":["https://openalex.org/I96673099"]}],"countries":["DK","SE"],"is_corresponding":false,"raw_author_name":"Eduard Kerkhoven","raw_affiliation_strings":["Department of Life Sciences, Chalmers University of Technology, SE-412 96 Gothenburg, Sweden","Science for Life Laboratory (SciLifeLab), 412 96 Gothenburg, Sweden","The Novo Nordisk Foundation Biotechnology Research Institute for the Green Transition, Technical University of Denmark, 2800 Kgs. Lyngby, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Life Sciences, Chalmers University of Technology, SE-412 96 Gothenburg, Sweden","institution_ids":["https://openalex.org/I66862912"]},{"raw_affiliation_string":"Science for Life Laboratory (SciLifeLab), 412 96 Gothenburg, Sweden","institution_ids":["https://openalex.org/I2800139495"]},{"raw_affiliation_string":"The Novo Nordisk Foundation Biotechnology Research Institute for the Green Transition, Technical University of Denmark, 2800 Kgs. Lyngby, Denmark","institution_ids":["https://openalex.org/I2801134892","https://openalex.org/I96673099"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108899584","display_name":"Xiaozhou Luo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210145761","display_name":"Shenzhen Institutes of Advanced Technology","ror":"https://ror.org/04gh4er46","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210145761"]},{"id":"https://openalex.org/I4405273091","display_name":"Shenzhen Institute of Synthetic Biology","ror":"https://ror.org/058rt6c45","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405273091"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaozhou Luo","raw_affiliation_strings":["Center for Synthetic Biochemistry, Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Synthetic Biochemistry, Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210145761","https://openalex.org/I4405273091"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083581014","display_name":"Costas D. Maranas","orcid":"https://orcid.org/0000-0002-1508-1398","observed_orcids":["https://orcid.org/0000-0002-1508-1398"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Costas D. Maranas","raw_affiliation_strings":["Department of Chemical Engineering, The Pennsylvania State University, University Park, PA 16802, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, The Pennsylvania State University, University Park, PA 16802, USA","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5153394120","display_name":"Liangzhen Zheng","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Liangzhen Zheng","raw_affiliation_strings":["Shanghai Zelixir Biotech Co. Ltd., Shanghai 201210, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Zelixir Biotech Co. Ltd., Shanghai 201210, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009119354","display_name":"Ulrike Wittig","orcid":"https://orcid.org/0000-0002-9077-5664","observed_orcids":["https://orcid.org/0000-0002-9077-5664"]},"institutions":[{"id":"https://openalex.org/I71030271","display_name":"Heidelberg Institute for Theoretical Studies","ror":"https://ror.org/01f7bcy98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I102335020","https://openalex.org/I1305996414","https://openalex.org/I223822909","https://openalex.org/I71030271"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ulrike Wittig","raw_affiliation_strings":["Scientific Databases and Visualization Group, Heidelberg Institute for Theoretical Studies (HITS gGmbH), Schloss-Wolfsbrunnenweg 35, 69118 Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Scientific Databases and Visualization Group, Heidelberg Institute for Theoretical Studies (HITS gGmbH), Schloss-Wolfsbrunnenweg 35, 69118 Heidelberg, Germany","institution_ids":["https://openalex.org/I71030271"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5153281791","display_name":"Ratul Chowdhury","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173911158","display_name":"Iowa State University","ror":"https://ror.org/04rswrd78","country_code":"US","type":"education","lineage":["https://openalex.org/I173911158"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ratul Chowdhury","raw_affiliation_strings":["Department of Chemical and Biological Engineering, Iowa State University, Ames, IA 50011, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical and Biological Engineering, Iowa State University, Ames, IA 50011, USA","institution_ids":["https://openalex.org/I173911158"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089064325","display_name":"Rajib Saha","orcid":"https://orcid.org/0000-0002-2974-0243","observed_orcids":["https://orcid.org/0000-0002-2974-0243"]},"institutions":[{"id":"https://openalex.org/I114395901","display_name":"University of Nebraska\u2013Lincoln","ror":"https://ror.org/043mer456","country_code":"US","type":"education","lineage":["https://openalex.org/I114395901"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rajib Saha","raw_affiliation_strings":["Department of Chemical and Biomolecular Engineering, University of Nebraska\u2013Lincoln, Lincoln, NE 68588, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical and Biomolecular Engineering, University of Nebraska\u2013Lincoln, Lincoln, NE 68588, USA","institution_ids":["https://openalex.org/I114395901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039157038","display_name":"Nadine T\u00f6pfer","orcid":"https://orcid.org/0000-0002-3027-5799","observed_orcids":["https://orcid.org/0000-0002-3027-5799"]},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]},{"id":"https://openalex.org/I4210126213","display_name":"Cluster of Excellence on Plant Sciences","ror":"https://ror.org/034waa237","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I149899117","https://openalex.org/I171892758","https://openalex.org/I180923762","https://openalex.org/I4210126213","https://openalex.org/I4210141639","https://openalex.org/I44260953"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Nadine T\u00f6pfer","raw_affiliation_strings":["Institute for Plant Sciences and Cluster of Excellence on Plant Sciences (CEPLAS), University of Cologne, Z\u00fclpicher Strasse 47b, 50674 Cologne, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Plant Sciences and Cluster of Excellence on Plant Sciences (CEPLAS), University of Cologne, Z\u00fclpicher Strasse 47b, 50674 Cologne, Germany","institution_ids":["https://openalex.org/I180923762","https://openalex.org/I4210126213"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050871083","display_name":"Thomas Sauter","orcid":"https://orcid.org/0000-0001-8225-2954","observed_orcids":["https://orcid.org/0000-0001-8225-2954"]},"institutions":[{"id":"https://openalex.org/I186903577","display_name":"University of Luxembourg","ror":"https://ror.org/036x5ad56","country_code":"LU","type":"education","lineage":["https://openalex.org/I186903577"]}],"countries":["LU"],"is_corresponding":false,"raw_author_name":"Thomas Sauter","raw_affiliation_strings":["Department of Health, Medicine and Life Sciences, Faculty of Science, Technology and Medicine, University of Luxembourg, 6 avenue du Swing, L-4367 Belvaux, Luxembourg"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Health, Medicine and Life Sciences, Faculty of Science, Technology and Medicine, University of Luxembourg, 6 avenue du Swing, L-4367 Belvaux, Luxembourg","institution_ids":["https://openalex.org/I186903577"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069362994","display_name":"Ronan M. T. Fleming","orcid":"https://orcid.org/0000-0001-5346-9812","observed_orcids":["https://orcid.org/0000-0001-5346-9812"]},"institutions":[{"id":"https://openalex.org/I188760350","display_name":"Ollscoil na Gaillimhe \u2013 University of Galway","ror":"https://ror.org/03bea9k73","country_code":"IE","type":"education","lineage":["https://openalex.org/I188760350"]}],"countries":["IE"],"is_corresponding":true,"raw_author_name":"Ronan M. T. Fleming","raw_affiliation_strings":["Digital Metabolic Twin Centre, University of Galway, University Road, Galway H91 TK33, Ireland","Institute for Clinical Trials, University of Galway, University Road, Galway H91 TK33, Ireland","School of Medicine, College of Medicine and Health, University of Galway, University Road, Galway H91 TK33, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Digital Metabolic Twin Centre, University of Galway, University Road, Galway H91 TK33, Ireland","institution_ids":["https://openalex.org/I188760350"]},{"raw_affiliation_string":"Institute for Clinical Trials, University of Galway, University Road, Galway H91 TK33, Ireland","institution_ids":["https://openalex.org/I188760350"]},{"raw_affiliation_string":"School of Medicine, College of Medicine and Health, University of Galway, University Road, Galway H91 TK33, Ireland","institution_ids":["https://openalex.org/I188760350"]}]}],"institutions":[],"countries_distinct_count":8,"institutions_distinct_count":16,"corresponding_author_ids":["https://openalex.org/A5069362994"],"corresponding_institution_ids":["https://openalex.org/I188760350"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9726999998092651,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9726999998092651,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.009100000374019146,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.006500000134110451,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/enzyme-kinetics","display_name":"enzyme kinetics","score":0.7459999918937683},{"id":"https://openalex.org/keywords/open-source-platform","display_name":"open-source platform","score":0.6690000295639038},{"id":"https://openalex.org/keywords/binding-site-prediction","display_name":"binding site prediction","score":0.6940000057220459},{"id":"https://openalex.org/keywords/metabolic-modeling","display_name":"metabolic modeling","score":0.5669999718666077},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.777999997138977}],"concepts":[{"id":"https://openalex.org/C2777655017","wikidata":"https://www.wikidata.org/wiki/Q1501161","display_name":"Toolbox","level":2,"score":0.6481999754905701},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6150000095367432},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.6140000224113464},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.5458999872207642},{"id":"https://openalex.org/C124304363","wikidata":"https://www.wikidata.org/wiki/Q673661","display_name":"Abstraction","level":2,"score":0.5285999774932861},{"id":"https://openalex.org/C2777904410","wikidata":"https://www.wikidata.org/wiki/Q7397","display_name":"Software","level":2,"score":0.4966000020503998},{"id":"https://openalex.org/C2778755073","wikidata":"https://www.wikidata.org/wiki/Q10858537","display_name":"Scale (ratio)","level":2,"score":0.47029998898506165},{"id":"https://openalex.org/C176217482","wikidata":"https://www.wikidata.org/wiki/Q860554","display_name":"Metric (unit)","level":2,"score":0.45489999651908875},{"id":"https://openalex.org/C103278499","wikidata":"https://www.wikidata.org/wiki/Q254465","display_name":"Similarity (geometry)","level":3,"score":0.43630000948905945},{"id":"https://openalex.org/C135889238","wikidata":"https://www.wikidata.org/wiki/Q46276","display_name":"Kinetic energy","level":2,"score":0.41999998688697815},{"id":"https://openalex.org/C113843644","wikidata":"https://www.wikidata.org/wiki/Q901882","display_name":"Interface (matter)","level":4,"score":0.33709999918937683},{"id":"https://openalex.org/C191015642","wikidata":"https://www.wikidata.org/wiki/Q1132459","display_name":"Fragmentation (computing)","level":2,"score":0.32589998841285706},{"id":"https://openalex.org/C2993927895","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolic activity","level":2,"score":0.2971000075340271},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.296999990940094},{"id":"https://openalex.org/C18762648","wikidata":"https://www.wikidata.org/wiki/Q42213","display_name":"Work (physics)","level":2,"score":0.28130000829696655},{"id":"https://openalex.org/C2777289219","wikidata":"https://www.wikidata.org/wiki/Q7632154","display_name":"Substrate (aquarium)","level":2,"score":0.26489999890327454},{"id":"https://openalex.org/C67186912","wikidata":"https://www.wikidata.org/wiki/Q367664","display_name":"Data modeling","level":2,"score":0.2597000002861023},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.2574000060558319},{"id":"https://openalex.org/C147358964","wikidata":"https://www.wikidata.org/wiki/Q1200992","display_name":"Abstraction layer","level":3,"score":0.25270000100135803},{"id":"https://openalex.org/C13926793","wikidata":"https://www.wikidata.org/wiki/Q3507155","display_name":"Group method of data handling","level":2,"score":0.25130000710487366}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.09.25.751968","doi":"https://doi.org/10.64898/2026.09.25.751968","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.25.751968","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/28/2026.09.25.751968.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.09.25.751968","doi":"https://doi.org/10.64898/2026.09.25.751968","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.25.751968","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/28/2026.09.25.751968.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7214639976.pdf","grobid_xml":"https://content.openalex.org/works/W7214639976.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W2048465561","https://openalex.org/W2764202526","https://openalex.org/W2766958291","https://openalex.org/W2903357856","https://openalex.org/W2950954328","https://openalex.org/W3035965352","https://openalex.org/W3105895642","https://openalex.org/W3129727011","https://openalex.org/W3177500196","https://openalex.org/W3207760869","https://openalex.org/W4283032119","https://openalex.org/W4327550249","https://openalex.org/W4384023735","https://openalex.org/W4387761568","https://openalex.org/W4389546039","https://openalex.org/W4390971823","https://openalex.org/W4401715368","https://openalex.org/W4401839090","https://openalex.org/W4402297934","https://openalex.org/W4404458588","https://openalex.org/W4408055216","https://openalex.org/W4408601309","https://openalex.org/W4411622985","https://openalex.org/W4412345718","https://openalex.org/W6966644599","https://openalex.org/W7125430375","https://openalex.org/W7142036280","https://openalex.org/W7155909090","https://openalex.org/W7168042727","https://openalex.org/W7213419845"],"related_works":["https://openalex.org/W4404022106","https://openalex.org/W7171569316","https://openalex.org/W7220958323","https://openalex.org/W4417429841","https://openalex.org/W7136214136","https://openalex.org/W4401526016","https://openalex.org/W1599545777","https://openalex.org/W4402640682","https://openalex.org/W7126228347","https://openalex.org/W4416936388"],"abstract_inverted_index":{"SUMMARY":[0],"Enzyme":[1],"kinetic":[2,50,105],"parameters":[3],"inform":[4],"metabolic":[5,151],"models,":[6],"yet":[7],"experimental":[8],"measurements":[9],"are":[10],"sparse.":[11],"A":[12,76,95],"growing":[13],"body":[14],"of":[15,70],"work":[16],"predicts":[17],"them":[18],"from":[19],"protein":[20],"and":[21,66,81,86,113,121,124,145,153],"substrate":[22],"features,":[23],"but":[24],"software":[25],"fragmentation":[26],"hinders":[27],"adoption,":[28],"so":[29],"downstream":[30],"tools":[31],"lock":[32],"into":[33],"the":[34,67,125,131],"most":[35],"accessible":[36,54],"method.":[37],"We":[38],"present":[39],"OpenKinetics":[40],"Predictor":[41],"(":[42,99],"predictor.openkinetics.org":[43],"),":[44],"an":[45,122,141],"open-source":[46],"platform":[47,59],"integrating":[48],"thirteen":[49],"parameter":[51],"prediction":[52,82],"methods":[53],"via":[55],"one":[56],"interface.":[57],"The":[58],"optionally":[60],"reports":[61],"similarity":[62],"between":[63],"query":[64],"proteins":[65],"training":[68],"data":[69,97,154],"each":[71],"method":[72],"to":[73],"provide":[74],"context.":[75],"shared":[77],"framework":[78],"for":[79],"featurisation":[80],"keeps":[83],"it":[84],"extensible,":[85],"independent":[87],"parties,":[88],"including":[89],"original":[90],"authors,":[91],"contributed":[92],"many":[93],"methods.":[94],"paired":[96],"portal":[98],"data.openkinetics.org":[100],")":[101],"exposes":[102],"a":[103,118,135],"curated":[104],"dataset":[106],"with":[107,150],"precomputed":[108],"embeddings,":[109],"predicted":[110],"binding":[111],"sites,":[112],"standardised":[114],"splits.":[115],"Both":[116],"offer":[117],"web":[119],"interface":[120],"API,":[123],"GECKO":[126],"modelling":[127],"toolbox":[128],"already":[129],"calls":[130],"predictor":[132],"API.":[133],"As":[134],"case":[136],"study,":[137],"we":[138],"predict":[139],"across":[140],"E.":[142],"coli":[143],"model":[144],"find":[146],"inter-predictor":[147],"agreement":[148],"varies":[149],"context":[152],"availability.":[155]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-09-29T00:00:00"}