{"id":"https://openalex.org/W7214635285","doi":"https://doi.org/10.7150/thno.138283","title":"Harnessing ultrasound-responsive technologies for precision periodontitis therapy: a perspective","display_name":"Harnessing ultrasound-responsive technologies for precision periodontitis therapy: a perspective","publication_year":2026,"publication_date":"2026-09-09","ids":{"openalex":"https://openalex.org/W7214635285","doi":"https://doi.org/10.7150/thno.138283","pmid":"https://pubmed.ncbi.nlm.nih.gov/42910162","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13685042"},"language":"en","primary_location":{"id":"doi:10.7150/thno.138283","doi":"https://doi.org/10.7150/thno.138283","is_oa":true,"landing_page_url":"https://doi.org/10.7150/thno.138283","pdf_url":null,"source":{"id":"https://openalex.org/S2482500137","display_name":"Theranostics","issn_l":"1838-7640","issn":["1838-7640"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317973","host_organization_name":"Ivyspring International Publisher","host_organization_lineage":["https://openalex.org/P4310317973"],"host_organization_lineage_names":["Ivyspring International Publisher"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Theranostics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.7150/thno.138283","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100937238","display_name":"Chao Xing","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210105608","display_name":"ShenZhen People\u2019s Hospital","ror":"https://ror.org/01hcefx46","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105608"]},{"id":"https://openalex.org/I4210134759","display_name":"Shenzhen Bao'an District People's Hospital","ror":"https://ror.org/04dkfar71","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210134759"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chao Xing","raw_affiliation_strings":["Department of Stomatology, The People's Hospital of Baoan Shenzhen, No. 118 Longjing Road, Baoan District, Shenzhen, Guangdong 518101, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Stomatology, The People's Hospital of Baoan Shenzhen, No. 118 Longjing Road, Baoan District, Shenzhen, Guangdong 518101, China","institution_ids":["https://openalex.org/I4210105608","https://openalex.org/I4210134759"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001734860","display_name":"Saleh Muhammad","orcid":"https://orcid.org/0000-0003-4472-6981","observed_orcids":["https://orcid.org/0000-0003-4472-6981"]},"institutions":[{"id":"https://openalex.org/I204983213","display_name":"Harbin Institute of Technology","ror":"https://ror.org/01yqg2h08","country_code":"CN","type":"education","lineage":["https://openalex.org/I204983213"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Sibtain Muhammad","raw_affiliation_strings":["School of Science, College of Frontier Sciences, Harbin Institute of Technology, Shenzhen, 518055, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Science, College of Frontier Sciences, Harbin Institute of Technology, Shenzhen, 518055, China","institution_ids":["https://openalex.org/I204983213"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5153375539","display_name":"Bing Guo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204983213","display_name":"Harbin Institute of Technology","ror":"https://ror.org/01yqg2h08","country_code":"CN","type":"education","lineage":["https://openalex.org/I204983213"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Bing Guo","raw_affiliation_strings":["School of Science, College of Frontier Sciences, Harbin Institute of Technology, Shenzhen, 518055, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Science, College of Frontier Sciences, Harbin Institute of Technology, Shenzhen, 518055, China","institution_ids":["https://openalex.org/I204983213"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5153375539"],"corresponding_institution_ids":["https://openalex.org/I204983213"],"apc_list":{"value":2500,"currency":"AUD","value_usd":1671},"apc_paid":{"value":2500,"currency":"AUD","value_usd":1671},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.6626539,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"16","issue":"16","first_page":"9434","last_page":"9483"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":0.5449000000953674,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":0.5449000000953674,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11570","display_name":"Periodontal Regeneration and Treatments","score":0.2754000127315521,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":0.03180000185966492,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/periodontitis","display_name":"periodontitis","score":0.9879999756813049},{"id":"https://openalex.org/keywords/sonodynamic-therapy","display_name":"sonodynamic therapy","score":0.9409999847412109},{"id":"https://openalex.org/keywords/piezoelectric-materials","display_name":"piezoelectric materials","score":0.9959999918937683},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.8479999899864197},{"id":"https://openalex.org/keywords/acoustic-cavitation","display_name":"acoustic cavitation","score":0.9729999899864197},{"id":"https://openalex.org/keywords/biofilm-degradation","display_name":"biofilm degradation","score":0.6970000267028809},{"id":"https://openalex.org/keywords/alveolar-bone-loss","display_name":"alveolar bone loss","score":0.859000027179718},{"id":"https://openalex.org/keywords/periodontal-regeneration","display_name":"periodontal regeneration","score":0.8149999976158142},{"id":"https://openalex.org/keywords/injectable-hydrogel","display_name":"injectable hydrogel","score":0.9769999980926514},{"id":"https://openalex.org/keywords/tissue-engineering-scaffolds","display_name":"tissue engineering scaffolds","score":0.7689999938011169},{"id":"https://openalex.org/keywords/drug-delivery","display_name":"drug delivery","score":0.4429999887943268},{"id":"https://openalex.org/keywords/antibacterial-activity","display_name":"antibacterial activity","score":0.6259999871253967},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.5080000162124634}],"concepts":[{"id":"https://openalex.org/C12713177","wikidata":"https://www.wikidata.org/wiki/Q1900281","display_name":"Perspective (graphical)","level":2,"score":0.7293000221252441},{"id":"https://openalex.org/C2780385504","wikidata":"https://www.wikidata.org/wiki/Q520127","display_name":"Periodontitis","level":2,"score":0.4961000084877014},{"id":"https://openalex.org/C163763905","wikidata":"https://www.wikidata.org/wiki/Q17075943","display_name":"Precision medicine","level":2,"score":0.4555000066757202},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4180000126361847},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.37560001015663147},{"id":"https://openalex.org/C112930515","wikidata":"https://www.wikidata.org/wiki/Q4389547","display_name":"Risk analysis (engineering)","level":1,"score":0.32760000228881836},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.29429998993873596},{"id":"https://openalex.org/C55587333","wikidata":"https://www.wikidata.org/wiki/Q1133029","display_name":"Engineering ethics","level":1,"score":0.28760001063346863},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.27250000834465027},{"id":"https://openalex.org/C207267971","wikidata":"https://www.wikidata.org/wiki/Q120208","display_name":"Emerging technologies","level":2,"score":0.27140000462532043},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.26350000500679016},{"id":"https://openalex.org/C19527891","wikidata":"https://www.wikidata.org/wiki/Q1120908","display_name":"Medical physics","level":1,"score":0.2614000141620636},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.25220000743865967}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010518","descriptor_name":"Periodontitis","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D014464","descriptor_name":"Ultrasonic Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018441","descriptor_name":"Biofilms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.7150/thno.138283","doi":"https://doi.org/10.7150/thno.138283","is_oa":true,"landing_page_url":"https://doi.org/10.7150/thno.138283","pdf_url":null,"source":{"id":"https://openalex.org/S2482500137","display_name":"Theranostics","issn_l":"1838-7640","issn":["1838-7640"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317973","host_organization_name":"Ivyspring International Publisher","host_organization_lineage":["https://openalex.org/P4310317973"],"host_organization_lineage_names":["Ivyspring International Publisher"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Theranostics","raw_type":"journal-article"},{"id":"pmid:42910162","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42910162","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Theranostics","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13685042","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13685042/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Theranostics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.7150/thno.138283","doi":"https://doi.org/10.7150/thno.138283","is_oa":true,"landing_page_url":"https://doi.org/10.7150/thno.138283","pdf_url":null,"source":{"id":"https://openalex.org/S2482500137","display_name":"Theranostics","issn_l":"1838-7640","issn":["1838-7640"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317973","host_organization_name":"Ivyspring International Publisher","host_organization_lineage":["https://openalex.org/P4310317973"],"host_organization_lineage_names":["Ivyspring International Publisher"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Theranostics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":1,"referenced_works":["https://openalex.org/W1503380065"],"related_works":["https://openalex.org/W7169661565","https://openalex.org/W4415162100","https://openalex.org/W7169520941","https://openalex.org/W7163152040","https://openalex.org/W4415832000","https://openalex.org/W4293005011","https://openalex.org/W4415831884","https://openalex.org/W7160873079","https://openalex.org/W4415914021","https://openalex.org/W7148722055"],"abstract_inverted_index":{"Periodontitis":[0],"disease":[1],"normally":[2],"shows":[3],"oxidative":[4,92],"stress,":[5],"immunological":[6,113],"dysregulation,":[7],"alteration":[8],"of":[9,161],"the":[10,24,124],"periodontal":[11,63],"bacterial":[12],"ecology,":[13],"and":[14,37,70,88,115,140,151,163,184,189,193],"persistent":[15],"alveolar":[16],"bone":[17,117],"loss.":[18,31],"These":[19],"mechanisms":[20],"aggravate":[21],"problems":[22],"across":[23],"body":[25],"in":[26,61,105],"conjunction":[27],"with":[28,173],"causing":[29],"tooth":[30],"The-state-of-the-art":[32],"therapies":[33],"using":[34],"antimicrobial":[35],"agents":[36],"mechanical":[38,99],"debridement":[39],"often":[40],"fail":[41],"to":[42,58,122,169],"regulate":[43],"immune":[44],"signaling,":[45],"clear":[46],"infection,":[47],"or":[48],"repair":[49],"tissue.":[50],"Most":[51],"recently,":[52],"ultrasound-responsive":[53],"materials":[54,130],"have":[55],"stood":[56],"out":[57,158],"show":[59],"advantages":[60],"restoring":[62],"balance,":[64],"which":[65,85,142],"include":[66],"two":[67],"types":[68],"(piezoelectric":[69],"sonodynamic":[71,74,164],"materials).":[72],"For":[73,94],"materials,":[75,96],"they":[76,97],"generate":[77],"reactive":[78],"oxygen":[79],"species":[80],"(ROS)":[81],"via":[82],"acoustic":[83],"cavitation,":[84],"degrades":[86],"biofilms":[87],"disables":[89],"microorganisms":[90],"through":[91],"damage.":[93],"piezoelectric":[95,162],"convert":[98],"stress":[100],"into":[101,133],"electrical":[102],"polarization,":[103],"resulting":[104],"surface":[106],"charges":[107],"that":[108,159],"drive":[109],"redox":[110],"processes,":[111],"affect":[112],"responses,":[114],"stimulate":[116],"growth.":[118],"Importantly,":[119],"we":[120,156],"highlight,":[121],"improve":[123],"periodontitis":[125],"treatment":[126],"outcomes,":[127],"how":[128],"these":[129],"are":[131,187,197],"incorporated":[132],"platforms":[134],"such":[135,178],"as":[136,144,179],"injectable":[137],"hydrogels,":[138],"membranes,":[139],"scaffolds,":[141],"serve":[143],"carrier":[145],"matrices":[146],"for":[147,199],"placing":[148],"active":[149],"medicines":[150],"improving":[152],"spatiotemporal":[153],"control.":[154],"Also,":[155],"point":[157],"integration":[160],"technologies":[165],"provides":[166],"a":[167],"way":[168],"combine":[170],"antibacterial":[171],"activity":[172],"regeneration":[174],"stimuli.":[175],"Moreover,":[176],"challenges":[177],"material":[180],"stability,":[181],"activation":[182],"accuracy,":[183],"clinical":[185],"translation":[186],"there":[188],"greater":[190],"mechanistic":[191],"understanding":[192],"rigorous":[194],"design":[195],"criteria":[196],"required":[198],"further":[200],"development.":[201]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-09-29T00:00:00"}
