{"id":"https://openalex.org/W7214634428","doi":"https://doi.org/10.64898/2026.09.24.754267","title":"Targeting ALCAT1 Ameliorates Cardiomyopathy in Barth Syndrome","display_name":"Targeting ALCAT1 Ameliorates Cardiomyopathy in Barth Syndrome","publication_year":2026,"publication_date":"2026-09-28","ids":{"openalex":"https://openalex.org/W7214634428","doi":"https://doi.org/10.64898/2026.09.24.754267","pmid":"https://pubmed.ncbi.nlm.nih.gov/42856204","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13648465"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.24.754267","doi":"https://doi.org/10.64898/2026.09.24.754267","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.24.754267","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/28/2026.09.24.754267.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/28/2026.09.24.754267.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035834837","display_name":"Jun Zhang","orcid":"https://orcid.org/0000-0002-8489-3699","observed_orcids":["https://orcid.org/0000-0002-8489-3699","https://orcid.org/0009-0007-3285-2370"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]},{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jun Zhang","raw_affiliation_strings":["Department of Medicine, Physiology and Biophysics, University of California, Irvine, School of Medicine, Irvine, CA 92697, USA","Sam and Ann Barshop Institute for Longevity and Aging Studies, Department of Pharmacology, UT Health San Antonio, San Antonio, TX 78229, USA"],"raw_orcid":"https://orcid.org/0000-0002-8489-3699","affiliations":[{"raw_affiliation_string":"Department of Medicine, Physiology and Biophysics, University of California, Irvine, School of Medicine, Irvine, CA 92697, USA","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"Sam and Ann Barshop Institute for Longevity and Aging Studies, Department of Pharmacology, UT Health San Antonio, San Antonio, TX 78229, USA","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045753556","display_name":"Qianqian Ye","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]},{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qianqian Ye","raw_affiliation_strings":["Department of Medicine, Physiology and Biophysics, University of California, Irvine, School of Medicine, Irvine, CA 92697, USA","Sam and Ann Barshop Institute for Longevity and Aging Studies, Department of Pharmacology, UT Health San Antonio, San Antonio, TX 78229, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Physiology and Biophysics, University of California, Irvine, School of Medicine, Irvine, CA 92697, USA","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"Sam and Ann Barshop Institute for Longevity and Aging Studies, Department of Pharmacology, UT Health San Antonio, San Antonio, TX 78229, USA","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006989054","display_name":"Xi Fang","orcid":"https://orcid.org/0000-0001-7816-8821","observed_orcids":["https://orcid.org/0000-0001-7816-8821"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xi Fang","raw_affiliation_strings":["Department of Medicine, University of California San Diego, La Jolla, CA 92093, USA"],"raw_orcid":"https://orcid.org/0000-0001-7816-8821","affiliations":[{"raw_affiliation_string":"Department of Medicine, University of California San Diego, La Jolla, CA 92093, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110285065","display_name":"Wendong Huang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]},{"id":"https://openalex.org/I4387156432","display_name":"Beckman Research Institute","ror":"https://ror.org/05fazth07","country_code":"US","type":"facility","lineage":["https://openalex.org/I1301076528","https://openalex.org/I4387156432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wendong Huang","raw_affiliation_strings":["Department of Diabetes Complications & Metabolism, Arthur Riggs Diabetes & Metabolism Research Institute, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA 91010, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Diabetes Complications & Metabolism, Arthur Riggs Diabetes & Metabolism Research Institute, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA 91010, USA","institution_ids":["https://openalex.org/I1301076528","https://openalex.org/I4387156432"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017441842","display_name":"Yuguang Shi","orcid":"https://orcid.org/0000-0002-9979-5661","observed_orcids":["https://orcid.org/0000-0002-9979-5661"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]},{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yuguang Shi","raw_affiliation_strings":["Department of Medicine, Physiology and Biophysics, University of California, Irvine, School of Medicine, Irvine, CA 92697, USA","Sam and Ann Barshop Institute for Longevity and Aging Studies, Department of Pharmacology, UT Health San Antonio, San Antonio, TX 78229, USA"],"raw_orcid":"https://orcid.org/0000-0002-9979-5661","affiliations":[{"raw_affiliation_string":"Department of Medicine, Physiology and Biophysics, University of California, Irvine, School of Medicine, Irvine, CA 92697, USA","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"Sam and Ann Barshop Institute for Longevity and Aging Studies, Department of Pharmacology, UT Health San Antonio, San Antonio, TX 78229, USA","institution_ids":["https://openalex.org/I165951966"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5017441842"],"corresponding_institution_ids":["https://openalex.org/I165951966","https://openalex.org/I204250578"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.92330002784729,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.92330002784729,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11027","display_name":"Metabolism and Genetic Disorders","score":0.03799999877810478,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.008899999782443047,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/barth-syndrome","display_name":"Barth syndrome","score":0.996999979019165},{"id":"https://openalex.org/keywords/taz","display_name":"TAZ","score":0.6019999980926514},{"id":"https://openalex.org/keywords/cardiolipin-remodeling","display_name":"cardiolipin remodeling","score":0.8140000104904175},{"id":"https://openalex.org/keywords/cardiomyopathy","display_name":"cardiomyopathy","score":0.972000002861023},{"id":"https://openalex.org/keywords/mitochondrial-quality-control","display_name":"mitochondrial quality control","score":0.8100000023841858},{"id":"https://openalex.org/keywords/phosphoinositide-signaling","display_name":"phosphoinositide signaling","score":0.9739999771118164},{"id":"https://openalex.org/keywords/lysosomal-dysfunction","display_name":"lysosomal dysfunction","score":0.9649999737739563},{"id":"https://openalex.org/keywords/mitophagy","display_name":"mitophagy","score":0.9990000128746033},{"id":"https://openalex.org/keywords/mitochondrial-oxidative-stress","display_name":"mitochondrial oxidative stress","score":0.7900000214576721},{"id":"https://openalex.org/keywords/disease-modifying-therapy","display_name":"disease-modifying therapy","score":0.8230000138282776}],"concepts":[{"id":"https://openalex.org/C2781302388","wikidata":"https://www.wikidata.org/wiki/Q183453","display_name":"Cardiolipin","level":4,"score":0.8113999962806702},{"id":"https://openalex.org/C2779324830","wikidata":"https://www.wikidata.org/wiki/Q1806192","display_name":"Mitophagy","level":4,"score":0.7038999795913696},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.6295999884605408},{"id":"https://openalex.org/C2778797674","wikidata":"https://www.wikidata.org/wiki/Q847583","display_name":"Cardiomyopathy","level":3,"score":0.6029999852180481},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.5976999998092651},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.4885999858379364},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.46000000834465027},{"id":"https://openalex.org/C2776804853","wikidata":"https://www.wikidata.org/wiki/Q18045837","display_name":"PINK1","level":5,"score":0.4390000104904175},{"id":"https://openalex.org/C24586158","wikidata":"https://www.wikidata.org/wiki/Q27075","display_name":"Mitochondrial DNA","level":3,"score":0.41749998927116394},{"id":"https://openalex.org/C75385678","wikidata":"https://www.wikidata.org/wiki/Q4896390","display_name":"Inner mitochondrial membrane","level":3,"score":0.38920000195503235},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.3880999982357025},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.373199999332428},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.37279999256134033},{"id":"https://openalex.org/C111566952","wikidata":"https://www.wikidata.org/wiki/Q1303462","display_name":"Cardiac function curve","level":3,"score":0.367900013923645},{"id":"https://openalex.org/C163950672","wikidata":"https://www.wikidata.org/wiki/Q14905375","display_name":"mitochondrial fusion","level":4,"score":0.34689998626708984},{"id":"https://openalex.org/C2777614518","wikidata":"https://www.wikidata.org/wiki/Q935710","display_name":"Mitochondrial disease","level":4,"score":0.34610000252723694},{"id":"https://openalex.org/C182704531","wikidata":"https://www.wikidata.org/wiki/Q1364740","display_name":"Knockout mouse","level":3,"score":0.3391999900341034},{"id":"https://openalex.org/C57600042","wikidata":"https://www.wikidata.org/wiki/Q227564","display_name":"Oxidative phosphorylation","level":2,"score":0.3280999958515167},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3222000002861023},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.290800005197525},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.27810001373291016},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2777999937534332},{"id":"https://openalex.org/C2992519594","wikidata":"https://www.wikidata.org/wiki/Q870433","display_name":"Genetic model","level":3,"score":0.27410000562667847},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.265500009059906}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.64898/2026.09.24.754267","doi":"https://doi.org/10.64898/2026.09.24.754267","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.24.754267","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/28/2026.09.24.754267.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:42856204","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42856204","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13648465","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13648465/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.64898/2026.09.24.754267","doi":"https://doi.org/10.64898/2026.09.24.754267","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.24.754267","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/28/2026.09.24.754267.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320307186","display_name":"Barth Syndrome Foundation","ror":"https://ror.org/00p5z3m34"},{"id":"https://openalex.org/F4320310145","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7214634428.pdf","grobid_xml":"https://content.openalex.org/works/W7214634428.grobid-xml"},"referenced_works_count":48,"referenced_works":["https://openalex.org/W1618265444","https://openalex.org/W1965280884","https://openalex.org/W1968134726","https://openalex.org/W1970661950","https://openalex.org/W1974045282","https://openalex.org/W1976081400","https://openalex.org/W1999169071","https://openalex.org/W2009970917","https://openalex.org/W2015643261","https://openalex.org/W2017550994","https://openalex.org/W2019692395","https://openalex.org/W2025155867","https://openalex.org/W2027474840","https://openalex.org/W2038049117","https://openalex.org/W2041982853","https://openalex.org/W2091884933","https://openalex.org/W2098188264","https://openalex.org/W2104816318","https://openalex.org/W2139574693","https://openalex.org/W2144207859","https://openalex.org/W2155888791","https://openalex.org/W2283150845","https://openalex.org/W2311826957","https://openalex.org/W2321178866","https://openalex.org/W2568720009","https://openalex.org/W2885702860","https://openalex.org/W2920355054","https://openalex.org/W2921886188","https://openalex.org/W2980198690","https://openalex.org/W2991456852","https://openalex.org/W3001602420","https://openalex.org/W3010479900","https://openalex.org/W3026593394","https://openalex.org/W3093230103","https://openalex.org/W3094432368","https://openalex.org/W3171102171","https://openalex.org/W3171438515","https://openalex.org/W3190293731","https://openalex.org/W3204899978","https://openalex.org/W4205395791","https://openalex.org/W4282546715","https://openalex.org/W4283659192","https://openalex.org/W4380869568","https://openalex.org/W4391788402","https://openalex.org/W4392367321","https://openalex.org/W4394575904","https://openalex.org/W7125513491","https://openalex.org/W7155705816"],"related_works":["https://openalex.org/W4312901426","https://openalex.org/W4205395791","https://openalex.org/W3089941351","https://openalex.org/W4401118272","https://openalex.org/W4396224504","https://openalex.org/W2810745755","https://openalex.org/W1896002657","https://openalex.org/W3175037748","https://openalex.org/W6946039812","https://openalex.org/W4225409654"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Barth":[2],"syndrome":[3],"(BTHS)":[4],"is":[5],"an":[6],"X-linked":[7],"mitochondrial":[8,36,111,164,170,208,241],"disorder":[9],"caused":[10,182],"by":[11,183],"loss-of-function":[12],"mutations":[13],"in":[14,20,65,127,137,146,154,211],"TAFAZZIN":[15],"(":[16,72,80],"TAZ":[17,32,70,73,78,81,128,138,147,155,184,212],"),":[18],"resulting":[19],"defective":[21],"cardiolipin":[22],"(CL)":[23],"remodeling,":[24,114,194],"cardiomyopathy,":[25],"and":[26,42,76,117,150,166,168,198,202,231,235,242],"premature":[27],"death.":[28],"The":[29],"mechanisms":[30],"linking":[31],"deficiency":[33],"to":[34,87,206,218],"impaired":[35,232],"quality":[37,209],"control":[38,210],"remain":[39],"incompletely":[40],"understood,":[41],"there":[43],"are":[44],"no":[45],"disease-modifying":[46,254],"therapies":[47],"available":[48],"for":[49,257],"BTHS.":[50,258],"Here,":[51],"we":[52],"investigated":[53],"the":[54,89,178],"role":[55],"of":[56,91,238],"Acyl-CoA":[57],"Lysocardiolipin":[58],"Acyltransferase-1":[59],"(ALCAT1),":[60],"a":[61,100,222,252],"stress-inducible":[62],"phospholipid-remodeling":[63],"enzyme,":[64],"BTHS":[66,219],"cardiomyopathy.":[67],"Methods":[68],"Inducible":[69],"knockdown":[71],"KD":[74,139,148],")":[75,83],"cardiomyocyte-specific":[77],"knockout":[79],"cKO":[82,156],"mice":[84,149],"were":[85,120],"used":[86],"determine":[88],"effects":[90],"genetic":[92],"ALCAT1":[93,105,123,132,161,187,216,239,250],"deletion":[94,133,188],"or":[95,159,189],"pharmacological":[96,160,236],"inhibition":[97,162,190],"with":[98],"Juvenatin,":[99],"highly":[101],"selective":[102],"small":[103],"molecule":[104],"inhibitor.":[106],"Cardiac":[107],"function,":[108,112,116],"exercise":[109],"capacity,":[110],"lipid":[113],"lysosomal":[115,200,229],"mitophagic":[118,203],"flux":[119],"assessed.":[121],"Results":[122],"was":[124],"markedly":[125],"upregulated":[126],"-deficient":[129,213],"hearts.":[130],"Genetic":[131,158,234],"attenuated":[134],"cardiac":[135,144,243],"dysfunction":[136],"mice.":[140,157],"Juvenatin":[141],"similarly":[142],"improved":[143,163,207],"function":[145,201,244],"reversed":[151],"established":[152],"cardiomyopathy":[153,220],"ultrastructure":[165],"respiration":[167],"reduced":[169],"oxidative":[171],"stress.":[172],"These":[173],"benefits":[174],"occurred":[175],"without":[176],"correcting":[177],"characteristic":[179],"CL":[180,247],"abnormalities":[181],"deficiency.":[185],"Instead,":[186],"corrected":[191],"pathological":[192],"phosphatidylinositol":[193],"normalized":[195],"phosphoinositide":[196],"signaling,":[197,228],"restored":[199],"flux,":[204],"leading":[205],"cells.":[214],"Conclusions":[215],"contributes":[217],"through":[221],"CL-independent":[223],"pathway":[224],"involving":[225],"dysregulated":[226],"phosphatidylinositol/phosphoinositide":[227],"dysfunction,":[230],"mitophagy.":[233],"targeting":[237],"restores":[240],"despite":[245],"persistent":[246],"abnormalities,":[248],"establishing":[249],"as":[251],"promising":[253],"therapeutic":[255],"target":[256]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-09-29T00:00:00"}
