{"id":"https://openalex.org/W7214631409","doi":"https://doi.org/10.64898/2026.09.28.753401","title":"Context and exposure history shape insecticide sensitivity in Drosophila melanogaster","display_name":"Context and exposure history shape insecticide sensitivity in Drosophila melanogaster","publication_year":2026,"publication_date":"2026-09-28","ids":{"openalex":"https://openalex.org/W7214631409","doi":"https://doi.org/10.64898/2026.09.28.753401"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.28.753401","doi":"https://doi.org/10.64898/2026.09.28.753401","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.28.753401","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/28/2026.09.28.753401.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/28/2026.09.28.753401.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5153269406","display_name":"Andjela Plavotic","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I149899117","display_name":"Max Planck Society","ror":"https://ror.org/01hhn8329","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I149899117"]},{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]},{"id":"https://openalex.org/I4210164321","display_name":"Max Planck Institute of Immunobiology and Epigenetics","ror":"https://ror.org/058xzat49","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210164321"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Andjela Plavoti\u0107","raw_affiliation_strings":["CIBSS Centre for Integrative Biological Signalling Studies, University of Freiburg, Freiburg, Germany","Faculty of Biology, University of Freiburg, Freiburg, Germany","International Max Planck Research School for Epigenetics, Biophysics and Metabolism, Freiburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CIBSS Centre for Integrative Biological Signalling Studies, University of Freiburg, Freiburg, Germany","institution_ids":["https://openalex.org/I161046081"]},{"raw_affiliation_string":"Faculty of Biology, University of Freiburg, Freiburg, Germany","institution_ids":["https://openalex.org/I161046081"]},{"raw_affiliation_string":"International Max Planck Research School for Epigenetics, Biophysics and Metabolism, Freiburg, Germany","institution_ids":["https://openalex.org/I149899117","https://openalex.org/I4210164321"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5153216925","display_name":"Bettina Ansorge","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Bettina Ansorge","raw_affiliation_strings":["Faculty of Biology, University of Freiburg, Freiburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Biology, University of Freiburg, Freiburg, Germany","institution_ids":["https://openalex.org/I161046081"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5153349311","display_name":"Emma Sunderbrink","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Emma Sunderbrink","raw_affiliation_strings":["Faculty of Biology, University of Freiburg, Freiburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Biology, University of Freiburg, Freiburg, Germany","institution_ids":["https://openalex.org/I161046081"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013538201","display_name":"Anne-Kathrin Classen","orcid":"https://orcid.org/0000-0001-5157-0749","observed_orcids":["https://orcid.org/0000-0001-5157-0749"]},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Anne-Kathrin Classen","raw_affiliation_strings":["CIBSS Centre for Integrative Biological Signalling Studies, University of Freiburg, Freiburg, Germany","Faculty of Biology, University of Freiburg, Freiburg, Germany"],"raw_orcid":"https://orcid.org/0000-0001-5157-0749","affiliations":[{"raw_affiliation_string":"CIBSS Centre for Integrative Biological Signalling Studies, University of Freiburg, Freiburg, Germany","institution_ids":["https://openalex.org/I161046081"]},{"raw_affiliation_string":"Faculty of Biology, University of Freiburg, Freiburg, Germany","institution_ids":["https://openalex.org/I161046081"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5013538201"],"corresponding_institution_ids":["https://openalex.org/I161046081"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11075","display_name":"Insect Resistance and Genetics","score":0.8378999829292297,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11075","display_name":"Insect Resistance and Genetics","score":0.8378999829292297,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11641","display_name":"Insect and Pesticide Research","score":0.05400000140070915,"subfield":{"id":"https://openalex.org/subfields/1109","display_name":"Insect Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10447","display_name":"Environmental Toxicology and Ecotoxicology","score":0.035100001841783524,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/insecticide-susceptibility","display_name":"insecticide susceptibility","score":0.8999999761581421},{"id":"https://openalex.org/keywords/insecticide-tolerance","display_name":"insecticide tolerance","score":0.8180000185966492},{"id":"https://openalex.org/keywords/drosophila-melanogaster","display_name":"Drosophila melanogaster","score":0.9120000004768372},{"id":"https://openalex.org/keywords/acetamiprid","display_name":"acetamiprid","score":0.9269999861717224},{"id":"https://openalex.org/keywords/chlorantraniliprole","display_name":"chlorantraniliprole","score":0.9990000128746033},{"id":"https://openalex.org/keywords/deltamethrin","display_name":"deltamethrin","score":1.0},{"id":"https://openalex.org/keywords/temperature-effects-on-toxicity","display_name":"temperature effects on toxicity","score":0.8420000076293945},{"id":"https://openalex.org/keywords/developmental-stages","display_name":"developmental stages","score":0.5920000076293945},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.972000002861023},{"id":"https://openalex.org/keywords/age-effects","display_name":"age effects","score":0.6370000243186951},{"id":"https://openalex.org/keywords/thermal-tolerance","display_name":"heat tolerance","score":0.5649999976158142},{"id":"https://openalex.org/keywords/nutrient-starvation","display_name":"nutrient deprivation","score":0.9390000104904175},{"id":"https://openalex.org/keywords/reproductive-performance","display_name":"reproductive performance","score":0.8960000276565552},{"id":"https://openalex.org/keywords/egg-production","display_name":"egg production","score":0.8259999752044678},{"id":"https://openalex.org/keywords/pesticide-risk-assessment","display_name":"pesticide risk assessment","score":0.75},{"id":"https://openalex.org/keywords/insecticide-resistance","display_name":"insecticide resistance","score":0.6140000224113464}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8015999794006348},{"id":"https://openalex.org/C2777553912","wikidata":"https://www.wikidata.org/wiki/Q422257","display_name":"Deltamethrin","level":3,"score":0.7904999852180481},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.7366999983787537},{"id":"https://openalex.org/C20379349","wikidata":"https://www.wikidata.org/wiki/Q1720706","display_name":"Lethality","level":2,"score":0.7293000221252441},{"id":"https://openalex.org/C33070731","wikidata":"https://www.wikidata.org/wiki/Q7218","display_name":"Toxicology","level":1,"score":0.6625999808311462},{"id":"https://openalex.org/C112672928","wikidata":"https://www.wikidata.org/wiki/Q239526","display_name":"Offspring","level":3,"score":0.635200023651123},{"id":"https://openalex.org/C2780104201","wikidata":"https://www.wikidata.org/wiki/Q130888","display_name":"Drosophila melanogaster","level":3,"score":0.4918999969959259},{"id":"https://openalex.org/C2992837615","wikidata":"https://www.wikidata.org/wiki/Q3610615","display_name":"Insecticide resistance","level":2,"score":0.46399998664855957},{"id":"https://openalex.org/C2779990520","wikidata":"https://www.wikidata.org/wiki/Q1561409","display_name":"Multiple exposure","level":2,"score":0.44679999351501465},{"id":"https://openalex.org/C161176658","wikidata":"https://www.wikidata.org/wiki/Q131656","display_name":"Pesticide","level":2,"score":0.4230000078678131},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.4011000096797943},{"id":"https://openalex.org/C946728","wikidata":"https://www.wikidata.org/wiki/Q746408","display_name":"Cross-tolerance","level":3,"score":0.3878999948501587},{"id":"https://openalex.org/C41157215","wikidata":"https://www.wikidata.org/wiki/Q3995923","display_name":"Environmental toxicology","level":3,"score":0.325300008058548},{"id":"https://openalex.org/C3019635159","wikidata":"https://www.wikidata.org/wiki/Q349600","display_name":"Exposure duration","level":2,"score":0.32409998774528503},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.31790000200271606},{"id":"https://openalex.org/C186256576","wikidata":"https://www.wikidata.org/wiki/Q1058294","display_name":"Hormesis","level":3,"score":0.29840001463890076},{"id":"https://openalex.org/C198408306","wikidata":"https://www.wikidata.org/wiki/Q4008388","display_name":"Exposure assessment","level":2,"score":0.2922999858856201},{"id":"https://openalex.org/C90856448","wikidata":"https://www.wikidata.org/wiki/Q431","display_name":"Zoology","level":1,"score":0.26660001277923584},{"id":"https://openalex.org/C2777612826","wikidata":"https://www.wikidata.org/wiki/Q1390","display_name":"Insect","level":2,"score":0.2635999917984009},{"id":"https://openalex.org/C33618052","wikidata":"https://www.wikidata.org/wiki/Q6013136","display_name":"In vitro toxicology","level":3,"score":0.260699987411499},{"id":"https://openalex.org/C12174686","wikidata":"https://www.wikidata.org/wiki/Q1058438","display_name":"Risk assessment","level":2,"score":0.25870001316070557},{"id":"https://openalex.org/C2778693464","wikidata":"https://www.wikidata.org/wiki/Q3610615","display_name":"Pesticide resistance","level":3,"score":0.2529999911785126},{"id":"https://openalex.org/C115346097","wikidata":"https://www.wikidata.org/wiki/Q1412144","display_name":"Ecotoxicology","level":2,"score":0.25119999051094055}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.09.28.753401","doi":"https://doi.org/10.64898/2026.09.28.753401","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.28.753401","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/28/2026.09.28.753401.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.09.28.753401","doi":"https://doi.org/10.64898/2026.09.28.753401","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.28.753401","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/28/2026.09.28.753401.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G259924242","display_name":null,"funder_award_id":"EXC\u20102189","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G4935269520","display_name":"EXC 2189: CIBSS  Centre for Integrative Biological Signalling Studies","funder_award_id":"390939984","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"}],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320325136","display_name":"Boehringer Ingelheim Stiftung","ror":"https://ror.org/03tx8dq56"},{"id":"https://openalex.org/F4320327553","display_name":"International Max Planck Research School for Advanced Methods in Process and Systems Engineering","ror":"https://ror.org/04hazks31"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7214631409.pdf","grobid_xml":"https://content.openalex.org/works/W7214631409.grobid-xml"},"referenced_works_count":66,"referenced_works":["https://openalex.org/W574669807","https://openalex.org/W1973876530","https://openalex.org/W2019403855","https://openalex.org/W2033856456","https://openalex.org/W2040239482","https://openalex.org/W2043356826","https://openalex.org/W2048043678","https://openalex.org/W2076579240","https://openalex.org/W2087467218","https://openalex.org/W2107567567","https://openalex.org/W2133836758","https://openalex.org/W2144808924","https://openalex.org/W2154789444","https://openalex.org/W2161625344","https://openalex.org/W2163288498","https://openalex.org/W2185691657","https://openalex.org/W2320845586","https://openalex.org/W2336362645","https://openalex.org/W2346283449","https://openalex.org/W2413859032","https://openalex.org/W2765655013","https://openalex.org/W2766208183","https://openalex.org/W2772254860","https://openalex.org/W2800476173","https://openalex.org/W2893786660","https://openalex.org/W2900107792","https://openalex.org/W2903796247","https://openalex.org/W2904148646","https://openalex.org/W2955826740","https://openalex.org/W3011007545","https://openalex.org/W3016192641","https://openalex.org/W3019759883","https://openalex.org/W3033765486","https://openalex.org/W3083346274","https://openalex.org/W3114180486","https://openalex.org/W3125352132","https://openalex.org/W3137313384","https://openalex.org/W3154979755","https://openalex.org/W3209563093","https://openalex.org/W4200056931","https://openalex.org/W4200308704","https://openalex.org/W4200462351","https://openalex.org/W4205207649","https://openalex.org/W4205346211","https://openalex.org/W4250236073","https://openalex.org/W4286489707","https://openalex.org/W4322617073","https://openalex.org/W4360820722","https://openalex.org/W4384831370","https://openalex.org/W4386010385","https://openalex.org/W4387779231","https://openalex.org/W4396939497","https://openalex.org/W4401155024","https://openalex.org/W4401171388","https://openalex.org/W4401871373","https://openalex.org/W4401909444","https://openalex.org/W4404885063","https://openalex.org/W4408116699","https://openalex.org/W4408334734","https://openalex.org/W4410980484","https://openalex.org/W4413028155","https://openalex.org/W4415268929","https://openalex.org/W4416602230","https://openalex.org/W7118167883","https://openalex.org/W7154751548","https://openalex.org/W7164853899"],"related_works":["https://openalex.org/W4286489707","https://openalex.org/W2982136563","https://openalex.org/W4404831258","https://openalex.org/W1973876530","https://openalex.org/W7128425792","https://openalex.org/W2296679003","https://openalex.org/W2015480026","https://openalex.org/W1910391055","https://openalex.org/W7154591690","https://openalex.org/W2324276768"],"abstract_inverted_index":{"ABSTRACT":[0],"Insecticide":[1],"toxicity":[2,73],"is":[3],"commonly":[4],"assessed":[5],"under":[6],"standardized":[7],"conditions,":[8,213],"yet":[9],"susceptibility":[10,31,203],"may":[11],"depend":[12],"on":[13],"the":[14,18,33,109,172,177,221,231],"biological":[15,86],"state":[16],"of":[17,54,171,179,197,223,227,234],"organism,":[19],"its":[20,23],"environment,":[21],"and":[22,59,68,87,134,189,200,214],"recent":[24,215],"exposure":[25,120,155,199,216],"history.":[26,217],"How":[27],"these":[28],"factors":[29],"shape":[30],"at":[32],"organismal":[34,207],"level":[35],"remains":[36],"insufficiently":[37],"understood.":[38],"Here,":[39],"using":[40],"Drosophila":[41],"melanogaster":[42],",":[43],"we":[44],"systematically":[45],"compared":[46],"responses":[47],"to":[48,100,131,141,150],"three":[49],"insecticides":[50],"with":[51,64,108,112,128,147,230],"distinct":[52],"modes":[53],"action":[55],"-":[56],"acetamiprid,":[57],"chlorantraniliprole,":[58],"deltamethrin.":[60],"Susceptibility":[61,90],"varied":[62],"substantially":[63],"developmental":[65,169],"stage,":[66],"sex,":[67],"age,":[69],"while":[70],"temperature":[71],"altered":[72],"in":[74],"a":[75,205],"compound-dependent":[76],"manner,":[77],"demonstrating":[78],"that":[79,122,138],"lethal":[80],"effects":[81],"are":[82],"strongly":[83],"conditioned":[84],"by":[85,95,210],"environmental":[88,152,212],"context.":[89],"was":[91],"also":[92,156],"rapidly":[93],"modified":[94],"prior":[96],"exposure:":[97],"sublethal":[98,235],"pre-exposure":[99],"each":[101],"insecticide":[102,124,143,198,202],"reduced":[103,129,148,163],"lethality":[104],"upon":[105],"subsequent":[106],"challenge":[107,144],"same":[110],"compound,":[111],"increased":[113,139,168],"tolerance":[114,125,140,192],"emerging":[115],"within":[116],"24":[117],"h.":[118],"However,":[119],"conditions":[121],"enhanced":[123],"were":[126],"associated":[127],"resistance":[130],"heat":[132],"stress":[133],"nutrient":[135],"starvation,":[136],"indicating":[137],"an":[142,194],"can":[145],"coincide":[146],"resilience":[149],"other":[151],"stresses.":[153],"Sublethal":[154],"affected":[157],"reproductive":[158],"performance:":[159],"increasing":[160],"acetamiprid":[161],"concentrations":[162],"egg":[164],"production":[165],"but":[166],"surprisingly":[167],"success":[170],"resulting":[173],"offspring,":[174],"largely":[175],"maintaining":[176],"number":[178],"offspring":[180],"reaching":[181],"adulthood.":[182],"Together,":[183],"our":[184],"findings":[185,219],"identify":[186],"rapid,":[187],"compound-specific,":[188],"potentially":[190],"costly":[191],"as":[193,204],"underappreciated":[195],"consequence":[196],"establish":[201],"dynamic":[206],"trait":[208],"shaped":[209],"physiology,":[211],"These":[218],"highlight":[220],"importance":[222],"incorporating":[224],"such":[225],"sources":[226],"variation,":[228],"together":[229],"broader":[232],"consequences":[233],"exposure,":[236],"into":[237],"pesticide":[238],"risk":[239],"assessment.":[240]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-09-29T00:00:00"}
