{"id":"https://openalex.org/W7214617773","doi":"https://doi.org/10.7150/ijbs.138620","title":"Young plasma-derived exosomes deliver YOD1 to induce M2 polarization and ameliorate osteoporosis via mTOR signaling pathways","display_name":"Young plasma-derived exosomes deliver YOD1 to induce M2 polarization and ameliorate osteoporosis via mTOR signaling pathways","publication_year":2026,"publication_date":"2026-09-18","ids":{"openalex":"https://openalex.org/W7214617773","doi":"https://doi.org/10.7150/ijbs.138620","pmid":"https://pubmed.ncbi.nlm.nih.gov/42910259","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13685755"},"language":"en","primary_location":{"id":"doi:10.7150/ijbs.138620","doi":"https://doi.org/10.7150/ijbs.138620","is_oa":true,"landing_page_url":"https://doi.org/10.7150/ijbs.138620","pdf_url":null,"source":{"id":"https://openalex.org/S26312460","display_name":"International Journal of Biological Sciences","issn_l":"1449-2288","issn":["1449-2288"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310317973","host_organization_name":"Ivyspring International Publisher","host_organization_lineage":["https://openalex.org/P4310317973"],"host_organization_lineage_names":["Ivyspring International Publisher"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Biological Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.7150/ijbs.138620","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5153319310","display_name":"Jiahao Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1327237609","display_name":"Ministry of Education of the People's Republic of China","ror":"https://ror.org/01mv9t934","country_code":"CN","type":"government","lineage":["https://openalex.org/I1327237609","https://openalex.org/I4210127390"]},{"id":"https://openalex.org/I205237279","display_name":"Nankai University","ror":"https://ror.org/01y1kjr75","country_code":"CN","type":"education","lineage":["https://openalex.org/I205237279"]},{"id":"https://openalex.org/I4210088328","display_name":"Third Hospital of Hebei Medical University","ror":"https://ror.org/004eknx63","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210088328"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jiahao Wang","raw_affiliation_strings":["Department of Orthopedic Research Center, the Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, P.R. China","Engineering Research Center of Orthopedic Minimally Invasive Intelligent Equipment, China Ministry of Education","Key Laboratory of Biomechanics of Hebei Province, Shijiazhuang, Hebei, China","Key Laboratory of Precise Assessment, Diagnosis, and Treatment of Soft Tissue Injury of Hebei Province","NHC Key Laboratory of Intelligent Orthopaedic Equipment, Shijiazhuang, Hebei, China","Nankai University School of Medicine, Tianjin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedic Research Center, the Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, P.R. China","institution_ids":["https://openalex.org/I4210088328"]},{"raw_affiliation_string":"Engineering Research Center of Orthopedic Minimally Invasive Intelligent Equipment, China Ministry of Education","institution_ids":["https://openalex.org/I1327237609"]},{"raw_affiliation_string":"Key Laboratory of Biomechanics of Hebei Province, Shijiazhuang, Hebei, China","institution_ids":[]},{"raw_affiliation_string":"Key Laboratory of Precise Assessment, Diagnosis, and Treatment of Soft Tissue Injury of Hebei Province","institution_ids":[]},{"raw_affiliation_string":"NHC Key Laboratory of Intelligent Orthopaedic Equipment, Shijiazhuang, Hebei, China","institution_ids":[]},{"raw_affiliation_string":"Nankai University School of Medicine, Tianjin, China","institution_ids":["https://openalex.org/I205237279"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124010753","display_name":"Xiaokang Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1327237609","display_name":"Ministry of Education of the People's Republic of China","ror":"https://ror.org/01mv9t934","country_code":"CN","type":"government","lineage":["https://openalex.org/I1327237609","https://openalex.org/I4210127390"]},{"id":"https://openalex.org/I4210088328","display_name":"Third Hospital of Hebei Medical University","ror":"https://ror.org/004eknx63","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210088328"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiaokang Zhang","raw_affiliation_strings":["Department of Orthopedic Research Center, the Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, P.R. China","Engineering Research Center of Orthopedic Minimally Invasive Intelligent Equipment, China Ministry of Education","Key Laboratory of Biomechanics of Hebei Province, Shijiazhuang, Hebei, China","Key Laboratory of Precise Assessment, Diagnosis, and Treatment of Soft Tissue Injury of Hebei Province","NHC Key Laboratory of Intelligent Orthopaedic Equipment, Shijiazhuang, Hebei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedic Research Center, the Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, P.R. China","institution_ids":["https://openalex.org/I4210088328"]},{"raw_affiliation_string":"Engineering Research Center of Orthopedic Minimally Invasive Intelligent Equipment, China Ministry of Education","institution_ids":["https://openalex.org/I1327237609"]},{"raw_affiliation_string":"Key Laboratory of Biomechanics of Hebei Province, Shijiazhuang, Hebei, China","institution_ids":[]},{"raw_affiliation_string":"Key Laboratory of Precise Assessment, Diagnosis, and Treatment of Soft Tissue Injury of Hebei Province","institution_ids":[]},{"raw_affiliation_string":"NHC Key Laboratory of Intelligent Orthopaedic Equipment, Shijiazhuang, Hebei, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5144101904","display_name":"Siteng Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1327237609","display_name":"Ministry of Education of the People's Republic of China","ror":"https://ror.org/01mv9t934","country_code":"CN","type":"government","lineage":["https://openalex.org/I1327237609","https://openalex.org/I4210127390"]},{"id":"https://openalex.org/I205237279","display_name":"Nankai University","ror":"https://ror.org/01y1kjr75","country_code":"CN","type":"education","lineage":["https://openalex.org/I205237279"]},{"id":"https://openalex.org/I4210088328","display_name":"Third Hospital of Hebei Medical University","ror":"https://ror.org/004eknx63","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210088328"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Siteng Li","raw_affiliation_strings":["Department of Orthopedic Research Center, the Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, P.R. China","Engineering Research Center of Orthopedic Minimally Invasive Intelligent Equipment, China Ministry of Education","Key Laboratory of Biomechanics of Hebei Province, Shijiazhuang, Hebei, China","Key Laboratory of Precise Assessment, Diagnosis, and Treatment of Soft Tissue Injury of Hebei Province","NHC Key Laboratory of Intelligent Orthopaedic Equipment, Shijiazhuang, Hebei, China","Nankai University School of Medicine, Tianjin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedic Research Center, the Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, P.R. China","institution_ids":["https://openalex.org/I4210088328"]},{"raw_affiliation_string":"Engineering Research Center of Orthopedic Minimally Invasive Intelligent Equipment, China Ministry of Education","institution_ids":["https://openalex.org/I1327237609"]},{"raw_affiliation_string":"Key Laboratory of Biomechanics of Hebei Province, Shijiazhuang, Hebei, China","institution_ids":[]},{"raw_affiliation_string":"Key Laboratory of Precise Assessment, Diagnosis, and Treatment of Soft Tissue Injury of Hebei Province","institution_ids":[]},{"raw_affiliation_string":"NHC Key Laboratory of Intelligent Orthopaedic Equipment, Shijiazhuang, Hebei, China","institution_ids":[]},{"raw_affiliation_string":"Nankai University School of Medicine, Tianjin, China","institution_ids":["https://openalex.org/I205237279"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5153204952","display_name":"Qi Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1327237609","display_name":"Ministry of Education of the People's Republic of China","ror":"https://ror.org/01mv9t934","country_code":"CN","type":"government","lineage":["https://openalex.org/I1327237609","https://openalex.org/I4210127390"]},{"id":"https://openalex.org/I4210088328","display_name":"Third Hospital of Hebei Medical University","ror":"https://ror.org/004eknx63","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210088328"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qi Zhang","raw_affiliation_strings":["Department of Orthopedic Research Center, the Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, P.R. China","Engineering Research Center of Orthopedic Minimally Invasive Intelligent Equipment, China Ministry of Education","Key Laboratory of Biomechanics of Hebei Province, Shijiazhuang, Hebei, China","Key Laboratory of Precise Assessment, Diagnosis, and Treatment of Soft Tissue Injury of Hebei Province","NHC Key Laboratory of Intelligent Orthopaedic Equipment, Shijiazhuang, Hebei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedic Research Center, the Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, P.R. China","institution_ids":["https://openalex.org/I4210088328"]},{"raw_affiliation_string":"Engineering Research Center of Orthopedic Minimally Invasive Intelligent Equipment, China Ministry of Education","institution_ids":["https://openalex.org/I1327237609"]},{"raw_affiliation_string":"Key Laboratory of Biomechanics of Hebei Province, Shijiazhuang, Hebei, China","institution_ids":[]},{"raw_affiliation_string":"Key Laboratory of Precise Assessment, Diagnosis, and Treatment of Soft Tissue Injury of Hebei Province","institution_ids":[]},{"raw_affiliation_string":"NHC Key Laboratory of Intelligent Orthopaedic Equipment, Shijiazhuang, Hebei, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024304264","display_name":"Jiheng Xiao","orcid":"https://orcid.org/0000-0003-1133-4703","observed_orcids":["https://orcid.org/0000-0003-1133-4703"]},"institutions":[{"id":"https://openalex.org/I1327237609","display_name":"Ministry of Education of the People's Republic of China","ror":"https://ror.org/01mv9t934","country_code":"CN","type":"government","lineage":["https://openalex.org/I1327237609","https://openalex.org/I4210127390"]},{"id":"https://openalex.org/I4210088328","display_name":"Third Hospital of Hebei Medical University","ror":"https://ror.org/004eknx63","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210088328"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiheng Xiao","raw_affiliation_strings":["Department of Orthopedic Research Center, the Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, P.R. China","Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China","Engineering Research Center of Orthopedic Minimally Invasive Intelligent Equipment, China Ministry of Education","Key Laboratory of Biomechanics of Hebei Province, Shijiazhuang, Hebei, China","Key Laboratory of Precise Assessment, Diagnosis, and Treatment of Soft Tissue Injury of Hebei Province","NHC Key Laboratory of Intelligent Orthopaedic Equipment, Shijiazhuang, Hebei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedic Research Center, the Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, P.R. China","institution_ids":["https://openalex.org/I4210088328"]},{"raw_affiliation_string":"Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China","institution_ids":["https://openalex.org/I47720641"]},{"raw_affiliation_string":"Engineering Research Center of Orthopedic Minimally Invasive Intelligent Equipment, China Ministry of Education","institution_ids":["https://openalex.org/I1327237609"]},{"raw_affiliation_string":"Key Laboratory of Biomechanics of Hebei Province, Shijiazhuang, Hebei, China","institution_ids":[]},{"raw_affiliation_string":"Key Laboratory of Precise Assessment, Diagnosis, and Treatment of Soft Tissue Injury of Hebei Province","institution_ids":[]},{"raw_affiliation_string":"NHC Key Laboratory of Intelligent Orthopaedic Equipment, Shijiazhuang, Hebei, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5153394890","display_name":"Chengbin Huang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1327237609","display_name":"Ministry of Education of the People's Republic of China","ror":"https://ror.org/01mv9t934","country_code":"CN","type":"government","lineage":["https://openalex.org/I1327237609","https://openalex.org/I4210127390"]},{"id":"https://openalex.org/I4210088328","display_name":"Third Hospital of Hebei Medical University","ror":"https://ror.org/004eknx63","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210088328"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chengbin Huang","raw_affiliation_strings":["Department of Orthopedic Research Center, the Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, P.R. China","Engineering Research Center of Orthopedic Minimally Invasive Intelligent Equipment, China Ministry of Education","Key Laboratory of Biomechanics of Hebei Province, Shijiazhuang, Hebei, China","Key Laboratory of Precise Assessment, Diagnosis, and Treatment of Soft Tissue Injury of Hebei Province","NHC Key Laboratory of Intelligent Orthopaedic Equipment, Shijiazhuang, Hebei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedic Research Center, the Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, P.R. China","institution_ids":["https://openalex.org/I4210088328"]},{"raw_affiliation_string":"Engineering Research Center of Orthopedic Minimally Invasive Intelligent Equipment, China Ministry of Education","institution_ids":["https://openalex.org/I1327237609"]},{"raw_affiliation_string":"Key Laboratory of Biomechanics of Hebei Province, Shijiazhuang, Hebei, China","institution_ids":[]},{"raw_affiliation_string":"Key Laboratory of Precise Assessment, Diagnosis, and Treatment of Soft Tissue Injury of Hebei Province","institution_ids":[]},{"raw_affiliation_string":"NHC Key Laboratory of Intelligent Orthopaedic Equipment, Shijiazhuang, Hebei, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5153362073","display_name":"Jianpeng Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1327237609","display_name":"Ministry of Education of the People's Republic of China","ror":"https://ror.org/01mv9t934","country_code":"CN","type":"government","lineage":["https://openalex.org/I1327237609","https://openalex.org/I4210127390"]},{"id":"https://openalex.org/I205237279","display_name":"Nankai University","ror":"https://ror.org/01y1kjr75","country_code":"CN","type":"education","lineage":["https://openalex.org/I205237279"]},{"id":"https://openalex.org/I4210088328","display_name":"Third Hospital of Hebei Medical University","ror":"https://ror.org/004eknx63","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210088328"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jianpeng Chen","raw_affiliation_strings":["Department of Orthopedic Research Center, the Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, P.R. China","Engineering Research Center of Orthopedic Minimally Invasive Intelligent Equipment, China Ministry of Education","Key Laboratory of Biomechanics of Hebei Province, Shijiazhuang, Hebei, China","Key Laboratory of Precise Assessment, Diagnosis, and Treatment of Soft Tissue Injury of Hebei Province","NHC Key Laboratory of Intelligent Orthopaedic Equipment, Shijiazhuang, Hebei, China","Nankai University School of Medicine, Tianjin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedic Research Center, the Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, P.R. China","institution_ids":["https://openalex.org/I4210088328"]},{"raw_affiliation_string":"Engineering Research Center of Orthopedic Minimally Invasive Intelligent Equipment, China Ministry of Education","institution_ids":["https://openalex.org/I1327237609"]},{"raw_affiliation_string":"Key Laboratory of Biomechanics of Hebei Province, Shijiazhuang, Hebei, China","institution_ids":[]},{"raw_affiliation_string":"Key Laboratory of Precise Assessment, Diagnosis, and Treatment of Soft Tissue Injury of Hebei Province","institution_ids":[]},{"raw_affiliation_string":"NHC Key Laboratory of Intelligent Orthopaedic Equipment, Shijiazhuang, Hebei, China","institution_ids":[]},{"raw_affiliation_string":"Nankai University School of Medicine, Tianjin, China","institution_ids":["https://openalex.org/I205237279"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5121779387","display_name":"Yang Luo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1327237609","display_name":"Ministry of Education of the People's Republic of China","ror":"https://ror.org/01mv9t934","country_code":"CN","type":"government","lineage":["https://openalex.org/I1327237609","https://openalex.org/I4210127390"]},{"id":"https://openalex.org/I4210088328","display_name":"Third Hospital of Hebei Medical University","ror":"https://ror.org/004eknx63","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210088328"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yang Luo","raw_affiliation_strings":["Department of Orthopedic Research Center, the Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, P.R. China","Engineering Research Center of Orthopedic Minimally Invasive Intelligent Equipment, China Ministry of Education","Key Laboratory of Biomechanics of Hebei Province, Shijiazhuang, Hebei, China","Key Laboratory of Precise Assessment, Diagnosis, and Treatment of Soft Tissue Injury of Hebei Province","NHC Key Laboratory of Intelligent Orthopaedic Equipment, Shijiazhuang, Hebei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedic Research Center, the Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, P.R. China","institution_ids":["https://openalex.org/I4210088328"]},{"raw_affiliation_string":"Engineering Research Center of Orthopedic Minimally Invasive Intelligent Equipment, China Ministry of Education","institution_ids":["https://openalex.org/I1327237609"]},{"raw_affiliation_string":"Key Laboratory of Biomechanics of Hebei Province, Shijiazhuang, Hebei, China","institution_ids":[]},{"raw_affiliation_string":"Key Laboratory of Precise Assessment, Diagnosis, and Treatment of Soft Tissue Injury of Hebei Province","institution_ids":[]},{"raw_affiliation_string":"NHC Key Laboratory of Intelligent Orthopaedic Equipment, Shijiazhuang, Hebei, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5144150684","display_name":"Zeming Shan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1327237609","display_name":"Ministry of Education of the People's Republic of China","ror":"https://ror.org/01mv9t934","country_code":"CN","type":"government","lineage":["https://openalex.org/I1327237609","https://openalex.org/I4210127390"]},{"id":"https://openalex.org/I4210088328","display_name":"Third Hospital of Hebei Medical University","ror":"https://ror.org/004eknx63","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210088328"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zeming Shan","raw_affiliation_strings":["Department of Orthopedic Research Center, the Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, P.R. China","Engineering Research Center of Orthopedic Minimally Invasive Intelligent Equipment, China Ministry of Education","Key Laboratory of Biomechanics of Hebei Province, Shijiazhuang, Hebei, China","Key Laboratory of Precise Assessment, Diagnosis, and Treatment of Soft Tissue Injury of Hebei Province","NHC Key Laboratory of Intelligent Orthopaedic Equipment, Shijiazhuang, Hebei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedic Research Center, the Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, P.R. China","institution_ids":["https://openalex.org/I4210088328"]},{"raw_affiliation_string":"Engineering Research Center of Orthopedic Minimally Invasive Intelligent Equipment, China Ministry of Education","institution_ids":["https://openalex.org/I1327237609"]},{"raw_affiliation_string":"Key Laboratory of Biomechanics of Hebei Province, Shijiazhuang, Hebei, China","institution_ids":[]},{"raw_affiliation_string":"Key Laboratory of Precise Assessment, Diagnosis, and Treatment of Soft Tissue Injury of Hebei Province","institution_ids":[]},{"raw_affiliation_string":"NHC Key Laboratory of Intelligent Orthopaedic Equipment, Shijiazhuang, Hebei, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5144097723","display_name":"Ziping Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1327237609","display_name":"Ministry of Education of the People's Republic of China","ror":"https://ror.org/01mv9t934","country_code":"CN","type":"government","lineage":["https://openalex.org/I1327237609","https://openalex.org/I4210127390"]},{"id":"https://openalex.org/I4210088328","display_name":"Third Hospital of Hebei Medical University","ror":"https://ror.org/004eknx63","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210088328"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ziping Chen","raw_affiliation_strings":["Department of Orthopedic Research Center, the Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, P.R. China","Engineering Research Center of Orthopedic Minimally Invasive Intelligent Equipment, China Ministry of Education","Key Laboratory of Biomechanics of Hebei Province, Shijiazhuang, Hebei, China","Key Laboratory of Precise Assessment, Diagnosis, and Treatment of Soft Tissue Injury of Hebei Province","NHC Key Laboratory of Intelligent Orthopaedic Equipment, Shijiazhuang, Hebei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedic Research Center, the Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, P.R. China","institution_ids":["https://openalex.org/I4210088328"]},{"raw_affiliation_string":"Engineering Research Center of Orthopedic Minimally Invasive Intelligent Equipment, China Ministry of Education","institution_ids":["https://openalex.org/I1327237609"]},{"raw_affiliation_string":"Key Laboratory of Biomechanics of Hebei Province, Shijiazhuang, Hebei, China","institution_ids":[]},{"raw_affiliation_string":"Key Laboratory of Precise Assessment, Diagnosis, and Treatment of Soft Tissue Injury of Hebei Province","institution_ids":[]},{"raw_affiliation_string":"NHC Key Laboratory of Intelligent Orthopaedic Equipment, Shijiazhuang, Hebei, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5153325519","display_name":"Ling Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1327237609","display_name":"Ministry of Education of the People's Republic of China","ror":"https://ror.org/01mv9t934","country_code":"CN","type":"government","lineage":["https://openalex.org/I1327237609","https://openalex.org/I4210127390"]},{"id":"https://openalex.org/I4210088328","display_name":"Third Hospital of Hebei Medical University","ror":"https://ror.org/004eknx63","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210088328"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ling Wang","raw_affiliation_strings":["Department of Orthopedic Oncology, The Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, P.R. China","Department of Orthopedic Research Center, the Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, P.R. China","Engineering Research Center of Orthopedic Minimally Invasive Intelligent Equipment, China Ministry of Education","Key Laboratory of Biomechanics of Hebei Province, Shijiazhuang, Hebei, China","Key Laboratory of Precise Assessment, Diagnosis, and Treatment of Soft Tissue Injury of Hebei Province","NHC Key Laboratory of Intelligent Orthopaedic Equipment, Shijiazhuang, Hebei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedic Oncology, The Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, P.R. China","institution_ids":["https://openalex.org/I4210088328"]},{"raw_affiliation_string":"Department of Orthopedic Research Center, the Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, P.R. China","institution_ids":["https://openalex.org/I4210088328"]},{"raw_affiliation_string":"Engineering Research Center of Orthopedic Minimally Invasive Intelligent Equipment, China Ministry of Education","institution_ids":["https://openalex.org/I1327237609"]},{"raw_affiliation_string":"Key Laboratory of Biomechanics of Hebei Province, Shijiazhuang, Hebei, China","institution_ids":[]},{"raw_affiliation_string":"Key Laboratory of Precise Assessment, Diagnosis, and Treatment of Soft Tissue Injury of Hebei Province","institution_ids":[]},{"raw_affiliation_string":"NHC Key Laboratory of Intelligent Orthopaedic Equipment, Shijiazhuang, Hebei, China","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5153323583","display_name":"Yingze Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1327237609","display_name":"Ministry of Education of the People's Republic of China","ror":"https://ror.org/01mv9t934","country_code":"CN","type":"government","lineage":["https://openalex.org/I1327237609","https://openalex.org/I4210127390"]},{"id":"https://openalex.org/I205237279","display_name":"Nankai University","ror":"https://ror.org/01y1kjr75","country_code":"CN","type":"education","lineage":["https://openalex.org/I205237279"]},{"id":"https://openalex.org/I4210088328","display_name":"Third Hospital of Hebei Medical University","ror":"https://ror.org/004eknx63","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210088328"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yingze Zhang","raw_affiliation_strings":["Department of Orthopedic Research Center, the Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, P.R. China","Engineering Research Center of Orthopedic Minimally Invasive Intelligent Equipment, China Ministry of Education","Key Laboratory of Biomechanics of Hebei Province, Shijiazhuang, Hebei, China","Key Laboratory of Precise Assessment, Diagnosis, and Treatment of Soft Tissue Injury of Hebei Province","NHC Key Laboratory of Intelligent Orthopaedic Equipment, Shijiazhuang, Hebei, China","Nankai University School of Medicine, Tianjin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedic Research Center, the Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, P.R. China","institution_ids":["https://openalex.org/I4210088328"]},{"raw_affiliation_string":"Engineering Research Center of Orthopedic Minimally Invasive Intelligent Equipment, China Ministry of Education","institution_ids":["https://openalex.org/I1327237609"]},{"raw_affiliation_string":"Key Laboratory of Biomechanics of Hebei Province, Shijiazhuang, Hebei, China","institution_ids":[]},{"raw_affiliation_string":"Key Laboratory of Precise Assessment, Diagnosis, and Treatment of Soft Tissue Injury of Hebei Province","institution_ids":[]},{"raw_affiliation_string":"NHC Key Laboratory of Intelligent Orthopaedic Equipment, Shijiazhuang, Hebei, China","institution_ids":[]},{"raw_affiliation_string":"Nankai University School of Medicine, Tianjin, China","institution_ids":["https://openalex.org/I205237279"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5124010753","https://openalex.org/A5153319310"],"corresponding_institution_ids":["https://openalex.org/I1327237609","https://openalex.org/I205237279","https://openalex.org/I4210088328"],"apc_list":{"value":2000,"currency":"AUD","value_usd":1337},"apc_paid":{"value":2000,"currency":"AUD","value_usd":1337},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.59034885,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"22","issue":"15","first_page":"8364","last_page":"8389"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.003800000064074993,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/plasma-exosomes","display_name":"plasma exosomes","score":0.8569999933242798},{"id":"https://openalex.org/keywords/yod1","display_name":"YOD1","score":0.8309999704360962},{"id":"https://openalex.org/keywords/osteoporosis","display_name":"osteoporosis","score":0.9700000286102295},{"id":"https://openalex.org/keywords/m2-macrophage-polarization","display_name":"M2 macrophage polarization","score":0.9810000061988831},{"id":"https://openalex.org/keywords/mtor-signaling","display_name":"mTOR signaling","score":0.9810000061988831},{"id":"https://openalex.org/keywords/hippo-signaling-pathway","display_name":"Hippo signaling pathway","score":0.9850000143051147},{"id":"https://openalex.org/keywords/bone-formation","display_name":"bone formation","score":0.8690000176429749},{"id":"https://openalex.org/keywords/bone-marrow-mesenchymal-stem-cells","display_name":"bone marrow mesenchymal stem cells","score":0.8849999904632568},{"id":"https://openalex.org/keywords/exosome-therapy","display_name":"exosome therapy","score":0.7129999995231628},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.6940000057220459}],"concepts":[{"id":"https://openalex.org/C20518536","wikidata":"https://www.wikidata.org/wiki/Q6840469","display_name":"Microvesicles","level":4,"score":0.8194000124931335},{"id":"https://openalex.org/C2776541429","wikidata":"https://www.wikidata.org/wiki/Q165328","display_name":"Osteoporosis","level":2,"score":0.6610000133514404},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.6238999962806702},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5647000074386597},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.5584999918937683},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5504999756813049},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5102999806404114},{"id":"https://openalex.org/C2781261824","wikidata":"https://www.wikidata.org/wiki/Q903634","display_name":"Exosome","level":5,"score":0.45010000467300415},{"id":"https://openalex.org/C150555746","wikidata":"https://www.wikidata.org/wiki/Q210973","display_name":"Cell signaling","level":3,"score":0.36500000953674316},{"id":"https://openalex.org/C205049153","wikidata":"https://www.wikidata.org/wiki/Q2698605","display_name":"Polarization (electrochemistry)","level":2,"score":0.32179999351501465},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.3077999949455261},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2757999897003174},{"id":"https://openalex.org/C2779230013","wikidata":"https://www.wikidata.org/wiki/Q25303877","display_name":"Pathway analysis","level":4,"score":0.2678999900817871},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.2621999979019165}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010010","descriptor_name":"Osteoclasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010012","descriptor_name":"Osteogenesis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010024","descriptor_name":"Osteoporosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010024","descriptor_name":"Osteoporosis","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D010052","descriptor_name":"Ovariectomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055354","descriptor_name":"Exosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D058570","descriptor_name":"TOR Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D059630","descriptor_name":"Mesenchymal Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.7150/ijbs.138620","doi":"https://doi.org/10.7150/ijbs.138620","is_oa":true,"landing_page_url":"https://doi.org/10.7150/ijbs.138620","pdf_url":null,"source":{"id":"https://openalex.org/S26312460","display_name":"International Journal of Biological Sciences","issn_l":"1449-2288","issn":["1449-2288"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310317973","host_organization_name":"Ivyspring International Publisher","host_organization_lineage":["https://openalex.org/P4310317973"],"host_organization_lineage_names":["Ivyspring International Publisher"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Biological Sciences","raw_type":"journal-article"},{"id":"pmid:42910259","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42910259","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of biological sciences","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13685755","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13685755/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Biol Sci","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.7150/ijbs.138620","doi":"https://doi.org/10.7150/ijbs.138620","is_oa":true,"landing_page_url":"https://doi.org/10.7150/ijbs.138620","pdf_url":null,"source":{"id":"https://openalex.org/S26312460","display_name":"International Journal of Biological Sciences","issn_l":"1449-2288","issn":["1449-2288"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310317973","host_organization_name":"Ivyspring International Publisher","host_organization_lineage":["https://openalex.org/P4310317973"],"host_organization_lineage_names":["Ivyspring International Publisher"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Biological Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4392381430","https://openalex.org/W7166032228","https://openalex.org/W7170198262","https://openalex.org/W2973298276","https://openalex.org/W7204438012","https://openalex.org/W4408680662","https://openalex.org/W3194255578","https://openalex.org/W7129378394","https://openalex.org/W4408267898","https://openalex.org/W4404512986"],"abstract_inverted_index":{"(LSK)":[0],"cell":[1],"population.":[2],"YOD1":[3,20,41],"was":[4,13],"identified":[5],"as":[6],"a":[7,69],"key":[8],"effector":[9],"in":[10,24,81],"Y-Exos":[11,18,39],"and":[12,29,50,62,73],"downregulated":[14],"with":[15],"aging.":[16],"Mechanistically,":[17],"delivered":[19],"to":[21,30,42],"activate":[22],"mTOR":[23,48],"BMMs,":[25],"driving":[26],"M2":[27,44],"polarization,":[28],"BMSCs,":[31],"promoting":[32],"osteogenesis":[33,52],"via":[34,53],"Hippo":[35,54],"signaling.":[36],"In":[37],"conclusion,":[38],"deliver":[40],"induce":[43],"macrophage":[45],"polarization":[46],"through":[47],"activation":[49],"enhance":[51],"signaling,":[55],"thereby":[56],"improving":[57],"the":[58],"bone":[59],"immune":[60],"microenvironment":[61],"effectively":[63],"ameliorating":[64],"osteoporosis.":[65,82],"These":[66],"findings":[67],"reveal":[68],"new":[70],"immunomodulatory":[71],"mechanism":[72],"provide":[74],"an":[75],"experimental":[76],"basis":[77],"for":[78],"Y-Exos-based":[79],"therapy":[80]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-09-29T00:00:00"}