{"id":"https://openalex.org/W7214610432","doi":"https://doi.org/10.64898/2026.09.22.753597","title":"The p53\u2013p21\u2013Cyclin D2 regulatory axis drives metabolic reprogramming and a distinct senescent macrophage senotype during aging and MASLD","display_name":"The p53\u2013p21\u2013Cyclin D2 regulatory axis drives metabolic reprogramming and a distinct senescent macrophage senotype during aging and MASLD","publication_year":2026,"publication_date":"2026-09-28","ids":{"openalex":"https://openalex.org/W7214610432","doi":"https://doi.org/10.64898/2026.09.22.753597","pmid":"https://pubmed.ncbi.nlm.nih.gov/42856271","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13648435"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.22.753597","doi":"https://doi.org/10.64898/2026.09.22.753597","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.22.753597","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/28/2026.09.22.753597.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/28/2026.09.22.753597.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008312245","display_name":"Grasiela Torres","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Grasiela Torres","raw_affiliation_strings":["Department of Microbiology, Immunology and Molecular Genetics, Los Angeles, CA, USA","Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Immunology and Molecular Genetics, Los Angeles, CA, USA","institution_ids":[]},{"raw_affiliation_string":"Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054890110","display_name":"Ivan Alexander Salladay-Perez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ivan A. Salladay-Perez","raw_affiliation_strings":["Department of Microbiology, Immunology and Molecular Genetics, Los Angeles, CA, USA","Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Immunology and Molecular Genetics, Los Angeles, CA, USA","institution_ids":[]},{"raw_affiliation_string":"Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5133770167","display_name":"Christina Y. Deng","orcid":"https://orcid.org/0009-0000-9141-8899","observed_orcids":["https://orcid.org/0009-0000-9141-8899"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christina Y. Deng","raw_affiliation_strings":["Department of Microbiology, Immunology and Molecular Genetics, Los Angeles, CA, USA","Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Immunology and Molecular Genetics, Los Angeles, CA, USA","institution_ids":[]},{"raw_affiliation_string":"Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054011040","display_name":"Itzetl Avila","orcid":"https://orcid.org/0000-0002-4596-647X","observed_orcids":["https://orcid.org/0000-0002-4596-647X"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Itzetl Avila","raw_affiliation_strings":["Department of Microbiology, Immunology and Molecular Genetics, Los Angeles, CA, USA","Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Immunology and Molecular Genetics, Los Angeles, CA, USA","institution_ids":[]},{"raw_affiliation_string":"Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092566636","display_name":"Yennifer Delgado","orcid":"https://orcid.org/0000-0002-7582-8545","observed_orcids":["https://orcid.org/0000-0002-7582-8545"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yennifer Delgado","raw_affiliation_strings":["Department of Microbiology, Immunology and Molecular Genetics, Los Angeles, CA, USA","Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Immunology and Molecular Genetics, Los Angeles, CA, USA","institution_ids":[]},{"raw_affiliation_string":"Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062668069","display_name":"Gregory Tong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gregory Tong","raw_affiliation_strings":["Department of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005282829","display_name":"Jes\u00fas Mu\u00f1oz\u2010Estrada","orcid":"https://orcid.org/0000-0002-6995-2996","observed_orcids":["https://orcid.org/0000-0002-6995-2996"]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jes\u00fas Mu\u00f1oz-Estrada","raw_affiliation_strings":["Advanced Clinical Biosystems Research Institute, Cedars Sinai Medical Center, Los Angeles, CA, USA","Department of Computational Biomedicine, Cedars Sinai Medical Center, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Advanced Clinical Biosystems Research Institute, Cedars Sinai Medical Center, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I1282927834"]},{"raw_affiliation_string":"Department of Computational Biomedicine, Cedars Sinai Medical Center, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I1282927834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5116577375","display_name":"Lizeth Estrada","orcid":"https://orcid.org/0009-0004-3344-385X","observed_orcids":["https://orcid.org/0009-0004-3344-385X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lizeth Estrada","raw_affiliation_strings":["Department of Microbiology, Immunology and Molecular Genetics, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Immunology and Molecular Genetics, Los Angeles, CA, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113405342","display_name":"Anika Dhingra","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anika Dhingra","raw_affiliation_strings":["Department of Microbiology, Immunology and Molecular Genetics, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Immunology and Molecular Genetics, Los Angeles, CA, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033819749","display_name":"Wesley Robert Armstrong","orcid":"https://orcid.org/0000-0002-9168-8511","observed_orcids":["https://orcid.org/0000-0002-9168-8511"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wesley R. Armstrong","raw_affiliation_strings":["Department of Microbiology, Immunology and Molecular Genetics, Los Angeles, CA, USA","Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Immunology and Molecular Genetics, Los Angeles, CA, USA","institution_ids":[]},{"raw_affiliation_string":"Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5139656593","display_name":"Aishini Singh","orcid":"https://orcid.org/0009-0001-3380-4326","observed_orcids":["https://orcid.org/0009-0001-3380-4326"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Aishini Singh","raw_affiliation_strings":["Department of Microbiology, Immunology and Molecular Genetics, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Immunology and Molecular Genetics, Los Angeles, CA, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5153291589","display_name":"Isabella Cooper","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Isabella Cooper","raw_affiliation_strings":["Department of Microbiology, Immunology and Molecular Genetics, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Immunology and Molecular Genetics, Los Angeles, CA, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5153349274","display_name":"Eduardo Enriquez","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eduardo Enriquez","raw_affiliation_strings":["Department of Microbiology, Immunology and Molecular Genetics, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Immunology and Molecular Genetics, Los Angeles, CA, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033877791","display_name":"Prashant Kaushal","orcid":"https://orcid.org/0009-0001-6630-3309","observed_orcids":["https://orcid.org/0009-0001-6630-3309"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Prashant Kaushal","raw_affiliation_strings":["Department of Microbiology, Immunology and Molecular Genetics, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Immunology and Molecular Genetics, Los Angeles, CA, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5153279730","display_name":"Jocelyn Ni","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jocelyn Ni","raw_affiliation_strings":["Department of Microbiology, Immunology and Molecular Genetics, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Immunology and Molecular Genetics, Los Angeles, CA, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089936760","display_name":"Kushan Chowdhury","orcid":"https://orcid.org/0000-0002-5310-3623","observed_orcids":["https://orcid.org/0000-0002-5310-3623"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kushan Chowdhury","raw_affiliation_strings":["Comprehensive Liver Research Center, University of California, Los Angeles, Los Angeles, CA, USA","Department of Medicine, Vatche and Tamar Manoukian Division of Digestive Diseases, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Comprehensive Liver Research Center, University of California, Los Angeles, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Department of Medicine, Vatche and Tamar Manoukian Division of Digestive Diseases, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5135507179","display_name":"Calvin Pan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Calvin Pan","raw_affiliation_strings":["Comprehensive Liver Research Center, University of California, Los Angeles, Los Angeles, CA, USA","Department of Medicine, Vatche and Tamar Manoukian Division of Digestive Diseases, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Comprehensive Liver Research Center, University of California, Los Angeles, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Department of Medicine, Vatche and Tamar Manoukian Division of Digestive Diseases, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090828402","display_name":"Linsey Stiles","orcid":"https://orcid.org/0000-0002-1514-458X","observed_orcids":["https://orcid.org/0000-0002-1514-458X"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Linsey Stiles","raw_affiliation_strings":["Department of Medicine, Endocrinology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA","Department of Molecular and Medical Pharmacology, University of California, Los Angeles, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Endocrinology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Department of Molecular and Medical Pharmacology, University of California, Los Angeles, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036127638","display_name":"Cristiane Beninc\u00e1","orcid":"https://orcid.org/0000-0001-7933-860X","observed_orcids":["https://orcid.org/0000-0001-7933-860X"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cristiane Beninca","raw_affiliation_strings":["Department of Medicine, Endocrinology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA","Department of Molecular and Medical Pharmacology, University of California, Los Angeles, USA"],"raw_orcid":"https://orcid.org/0000-0001-7933-860X","affiliations":[{"raw_affiliation_string":"Department of Medicine, Endocrinology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Department of Molecular and Medical Pharmacology, University of California, Los Angeles, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017019764","display_name":"Simon T. Y. Hui","orcid":"https://orcid.org/0000-0003-3540-3013","observed_orcids":["https://orcid.org/0000-0003-3540-3013"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Simon T. Hui","raw_affiliation_strings":["Division of Cardiology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069314760","display_name":"Abigail S. Krall","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Abbigail S. Krall","raw_affiliation_strings":["Department of Biological Chemistry, University of California, Los Angeles, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Chemistry, University of California, Los Angeles, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031437834","display_name":"Heather R. Christofk","orcid":"https://orcid.org/0000-0002-8662-4425","observed_orcids":["https://orcid.org/0000-0002-8662-4425"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I4390039293","display_name":"UCLA Jonsson Comprehensive Cancer Center","ror":"https://ror.org/0599cs764","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799798094","https://openalex.org/I4390039293"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Heather R. Christofk","raw_affiliation_strings":["Broad Stem Cell Research Center, University of California, Los Angeles, Los Angeles, CA, USA","Department of Biological Chemistry, University of California, Los Angeles, Los Angeles, CA, USA","Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA, USA","Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA, USA"],"raw_orcid":"https://orcid.org/0000-0002-8662-4425","affiliations":[{"raw_affiliation_string":"Broad Stem Cell Research Center, University of California, Los Angeles, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Department of Biological Chemistry, University of California, Los Angeles, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765","https://openalex.org/I4390039293"]},{"raw_affiliation_string":"Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024741961","display_name":"Aldons Jake Lusis","orcid":"https://orcid.org/0000-0001-9013-0228","observed_orcids":["https://orcid.org/0000-0001-9013-0228"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aldons J. Lusis","raw_affiliation_strings":["Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA","Department of Microbiology, Immunology and Molecular Genetics, Los Angeles, CA, USA","Division of Cardiology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Department of Microbiology, Immunology and Molecular Genetics, Los Angeles, CA, USA","institution_ids":[]},{"raw_affiliation_string":"Division of Cardiology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012538539","display_name":"Timothy Edward O\u2019Sullivan","orcid":"https://orcid.org/0000-0003-1435-8188","observed_orcids":["https://orcid.org/0000-0003-1435-8188"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Timothy E. O\u2019Sullivan","raw_affiliation_strings":["Department of Microbiology, Immunology and Molecular Genetics, Los Angeles, CA, USA","Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Immunology and Molecular Genetics, Los Angeles, CA, USA","institution_ids":[]},{"raw_affiliation_string":"Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067432674","display_name":"Jesse G. Meyer","orcid":"https://orcid.org/0000-0003-2753-3926","observed_orcids":["https://orcid.org/0000-0003-2753-3926"]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jesse G. Meyer","raw_affiliation_strings":["Advanced Clinical Biosystems Research Institute, Cedars Sinai Medical Center, Los Angeles, CA, USA","Department of Computational Biomedicine, Cedars Sinai Medical Center, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Advanced Clinical Biosystems Research Institute, Cedars Sinai Medical Center, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I1282927834"]},{"raw_affiliation_string":"Department of Computational Biomedicine, Cedars Sinai Medical Center, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I1282927834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077962312","display_name":"Rajat Singh","orcid":"https://orcid.org/0000-0001-9389-8574","observed_orcids":["https://orcid.org/0000-0001-9389-8574"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rajat Singh","raw_affiliation_strings":["Comprehensive Liver Research Center, University of California, Los Angeles, Los Angeles, CA, USA","Department of Medicine, Vatche and Tamar Manoukian Division of Digestive Diseases, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Comprehensive Liver Research Center, University of California, Los Angeles, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Department of Medicine, Vatche and Tamar Manoukian Division of Digestive Diseases, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080819092","display_name":"Valerie A. Tornini","orcid":"https://orcid.org/0000-0003-2877-6057","observed_orcids":["https://orcid.org/0000-0003-2877-6057"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I4390039293","display_name":"UCLA Jonsson Comprehensive Cancer Center","ror":"https://ror.org/0599cs764","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799798094","https://openalex.org/I4390039293"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Valerie A. Tornini","raw_affiliation_strings":["Department of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA, USA","Institute for Society and Genetics, University of California, Los Angeles, Los Angeles, CA, USA","Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA, USA","Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA, USA"],"raw_orcid":"https://orcid.org/0000-0003-2877-6057","affiliations":[{"raw_affiliation_string":"Department of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Institute for Society and Genetics, University of California, Los Angeles, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765","https://openalex.org/I4390039293"]},{"raw_affiliation_string":"Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029650508","display_name":"Orian S. Shirihai","orcid":"https://orcid.org/0000-0001-8466-3431","observed_orcids":["https://orcid.org/0000-0001-8466-3431","https://orcid.org/0000-0001-9846-736X","https://orcid.org/0000-0002-9502-2661"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Orian S. Shirihai","raw_affiliation_strings":["Department of Medicine, Endocrinology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA","Department of Molecular and Medical Pharmacology, University of California, Los Angeles, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Endocrinology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Department of Molecular and Medical Pharmacology, University of California, Los Angeles, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051653899","display_name":"Mehdi Bouhaddou","orcid":"https://orcid.org/0000-0002-9526-1427","observed_orcids":["https://orcid.org/0000-0002-9526-1427"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mehdi Bouhaddou","raw_affiliation_strings":["Department of Microbiology, Immunology and Molecular Genetics, Los Angeles, CA, USA","Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Immunology and Molecular Genetics, Los Angeles, CA, USA","institution_ids":[]},{"raw_affiliation_string":"Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054588158","display_name":"Anthony J. Covarrubias","orcid":"https://orcid.org/0000-0002-7884-652X","observed_orcids":["https://orcid.org/0000-0002-7884-652X"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I4390039293","display_name":"UCLA Jonsson Comprehensive Cancer Center","ror":"https://ror.org/0599cs764","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799798094","https://openalex.org/I4390039293"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Anthony J. Covarrubias","raw_affiliation_strings":["Broad Stem Cell Research Center, University of California, Los Angeles, Los Angeles, CA, USA","Comprehensive Liver Research Center, University of California, Los Angeles, Los Angeles, CA, USA","Department of Microbiology, Immunology and Molecular Genetics, Los Angeles, CA, USA","Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA, USA","Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA, USA"],"raw_orcid":"https://orcid.org/0000-0002-7884-652X","affiliations":[{"raw_affiliation_string":"Broad Stem Cell Research Center, University of California, Los Angeles, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Comprehensive Liver Research Center, University of California, Los Angeles, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Department of Microbiology, Immunology and Molecular Genetics, Los Angeles, CA, USA","institution_ids":[]},{"raw_affiliation_string":"Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765","https://openalex.org/I4390039293"]},{"raw_affiliation_string":"Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5054588158"],"corresponding_institution_ids":["https://openalex.org/I161318765","https://openalex.org/I4390039293"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.006300000008195639,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11051","display_name":"Sirtuins and Resveratrol in Medicine","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/macrophage-senescence","display_name":"macrophage senescence","score":0.9309999942779541},{"id":"https://openalex.org/keywords/metabolic-reprogramming","display_name":"metabolic reprogramming","score":0.7329999804496765},{"id":"https://openalex.org/keywords/non-alcoholic-fatty-liver-disease","display_name":"non-alcoholic fatty liver disease","score":0.8939999938011169},{"id":"https://openalex.org/keywords/liver-cirrhosis","display_name":"liver cirrhosis","score":0.7870000004768372},{"id":"https://openalex.org/keywords/senolytics","display_name":"senolytics","score":0.6079999804496765},{"id":"https://openalex.org/keywords/mic60","display_name":"Mic60","score":0.765999972820282},{"id":"https://openalex.org/keywords/senescence-associated-secretory-phenotype","display_name":"senescence-associated secretory phenotype","score":0.8899999856948853},{"id":"https://openalex.org/keywords/lipid-droplets","display_name":"lipid droplets","score":0.8539999723434448},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.6990000009536743}],"concepts":[{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.6797999739646912},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6757000088691711},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6444000005722046},{"id":"https://openalex.org/C77255625","wikidata":"https://www.wikidata.org/wiki/Q402093","display_name":"Reprogramming","level":3,"score":0.5785999894142151},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.5407000184059143},{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.505299985408783},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.48669999837875366},{"id":"https://openalex.org/C522857546","wikidata":"https://www.wikidata.org/wiki/Q2070979","display_name":"Senescence","level":2,"score":0.4368000030517578},{"id":"https://openalex.org/C120089663","wikidata":"https://www.wikidata.org/wiki/Q59250999","display_name":"Cyclin","level":4,"score":0.41530001163482666},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3553999960422516},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3276999890804291},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.31949999928474426},{"id":"https://openalex.org/C2780733254","wikidata":"https://www.wikidata.org/wiki/Q5198271","display_name":"Cyclin D2","level":5,"score":0.3125999867916107},{"id":"https://openalex.org/C4733338","wikidata":"https://www.wikidata.org/wiki/Q2792936","display_name":"Lipid metabolism","level":2,"score":0.3034999966621399},{"id":"https://openalex.org/C53345823","wikidata":"https://www.wikidata.org/wiki/Q5531554","display_name":"Gene isoform","level":3,"score":0.30320000648498535},{"id":"https://openalex.org/C10679952","wikidata":"https://www.wikidata.org/wiki/Q5308937","display_name":"Druggability","level":3,"score":0.3021000027656555},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.2912999987602234},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.290800005197525},{"id":"https://openalex.org/C124320809","wikidata":"https://www.wikidata.org/wiki/Q46292","display_name":"Cyclin-dependent kinase","level":4,"score":0.2777999937534332},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.26330000162124634}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.64898/2026.09.22.753597","doi":"https://doi.org/10.64898/2026.09.22.753597","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.22.753597","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/28/2026.09.22.753597.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:42856271","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42856271","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13648435","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13648435/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.64898/2026.09.22.753597","doi":"https://doi.org/10.64898/2026.09.22.753597","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.22.753597","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/28/2026.09.22.753597.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4679579238","display_name":null,"funder_award_id":"U24DK132746-01","funder_id":"https://openalex.org/F4320337379","funder_display_name":"Office of Behavioral and Social Sciences Research"},{"id":"https://openalex.org/G598865872","display_name":null,"funder_award_id":"P30DK063491","funder_id":"https://openalex.org/F4320332603","funder_display_name":"University of California, San Diego"},{"id":"https://openalex.org/G9000342382","display_name":null,"funder_award_id":"AI007323","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000864848","display_name":"Multidisciplinary Training in Microbial Pathogenesis","funder_award_id":"T32AI007323","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000879444","display_name":"UCLA LIFT-UP (Leveraging Institutional support For Talented, Upcoming Physicians and/or Scientists)","funder_award_id":"U24DK132746","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000884844","display_name":"Diabetes Research Center (DRC)","funder_award_id":"P30DK063491","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000891242","display_name":"Exploring the fundamental cellular mechanisms driving cellular senescence in macrophages","funder_award_id":"1r35gm156893-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000900098","display_name":"Research Training in Cell and Molecular Biology","funder_award_id":"T32GM145388","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320306710","display_name":"Glenn Foundation for Medical Research","ror":"https://ror.org/02ebg5q27"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332603","display_name":"University of California, San Diego","ror":"https://ror.org/0168r3w48"},{"id":"https://openalex.org/F4320337149","display_name":"School of Life Sciences and Biotechnology Division of Life Sciences, Korea University","ror":null},{"id":"https://openalex.org/F4320337345","display_name":"Office of Naval Research","ror":"https://ror.org/00rk2pe57"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337379","display_name":"Office of Behavioral and Social Sciences Research","ror":"https://ror.org/00fj8a872"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7214610432.pdf","grobid_xml":"https://content.openalex.org/works/W7214610432.grobid-xml"},"referenced_works_count":52,"referenced_works":["https://openalex.org/W81266651","https://openalex.org/W1033197108","https://openalex.org/W1595293335","https://openalex.org/W1910950086","https://openalex.org/W1970924670","https://openalex.org/W1981956598","https://openalex.org/W1991510903","https://openalex.org/W2018872127","https://openalex.org/W2035046899","https://openalex.org/W2044057392","https://openalex.org/W2047330128","https://openalex.org/W2084733588","https://openalex.org/W2086528604","https://openalex.org/W2087877138","https://openalex.org/W2088740611","https://openalex.org/W2098027759","https://openalex.org/W2098143955","https://openalex.org/W2098412103","https://openalex.org/W2099786386","https://openalex.org/W2106755467","https://openalex.org/W2137074443","https://openalex.org/W2152701478","https://openalex.org/W2154626333","https://openalex.org/W2178513698","https://openalex.org/W2754438413","https://openalex.org/W2788548733","https://openalex.org/W2808672726","https://openalex.org/W2809177340","https://openalex.org/W3091902158","https://openalex.org/W3138055079","https://openalex.org/W3174072032","https://openalex.org/W3179857518","https://openalex.org/W4200132093","https://openalex.org/W4307357496","https://openalex.org/W4361190599","https://openalex.org/W4362602490","https://openalex.org/W4378212544","https://openalex.org/W4378980781","https://openalex.org/W4379056388","https://openalex.org/W4385619793","https://openalex.org/W4387540644","https://openalex.org/W4391054387","https://openalex.org/W4394893765","https://openalex.org/W4404008485","https://openalex.org/W4405088583","https://openalex.org/W4410703772","https://openalex.org/W7140833454","https://openalex.org/W7154570070","https://openalex.org/W7155212270","https://openalex.org/W7169577117","https://openalex.org/W7171639649","https://openalex.org/W7203834746"],"related_works":["https://openalex.org/W7118067167","https://openalex.org/W7154570070","https://openalex.org/W4403122797","https://openalex.org/W7163657384","https://openalex.org/W2470410803","https://openalex.org/W7131311832","https://openalex.org/W7155202493","https://openalex.org/W4406391087","https://openalex.org/W4391054387","https://openalex.org/W4404615950"],"abstract_inverted_index":{"Summary":[0],"Aging":[1],"drives":[2,41,156],"chronic":[3],"disease":[4,29,46],"in":[5,26,123,126,183,223],"part":[6],"through":[7],"senescent":[8,75],"cells,":[9],"including":[10],"macrophages,":[11],"which":[12],"fuel":[13],"inflammation.":[14],"Senescent":[15],"macrophages":[16,22,117,184,220],"are":[17,221],"functionally":[18],"heterogeneous:":[19],"canonical":[20],"p16-high":[21],"promote":[23],"tumorigenesis":[24],"or,":[25],"other":[27],"contexts,":[28],"tolerance,":[30],"whereas":[31],"we":[32,62],"previously":[33],"identified":[34],"a":[35,65,83,142,189],"distinct":[36],"p21-high,":[37],"p16-low":[38],"senotype":[39,53],"that":[40,64,87,110,147,193],"metabolic":[42,104,215],"dysfunction-associated":[43],"steatotic":[44],"liver":[45,128,228],"(MASLD).":[47],"The":[48],"molecular":[49],"basis":[50],"of":[51],"this":[52],"has":[54],"remained":[55],"undefined.":[56],"Using":[57],"genetic":[58],"and":[59,71,94,106,121,125,130,179,200,209,226,230],"multi-omic":[60],"approaches,":[61],"show":[63],"p53-p21-dependent":[66],"program":[67,155],"actively":[68,160],"represses":[69],"p16":[70,162,164],"is":[72,174,188],"required":[73],"for":[74,176],"macrophage":[76,149,157],"viability.":[77],"We":[78],"identify":[79],"Cyclin":[80,114,186,203,218],"D2":[81,145,187,204],"as":[82],"non-canonical":[84,190],"downstream":[85],"effector":[86,192],"redistributes":[88],"from":[89,195],"the":[90,112,198,206],"nucleus":[91,196],"to":[92,102,197,213],"mitochondria":[93,201],"lipid":[95],"droplets,":[96],"where":[97],"it":[98],"partners":[99],"with":[100,119,211],"MIC60":[101,212],"drive":[103,214],"reprogramming":[105,216],"modulates":[107],"AKT1-mTORC1":[108,207],"signaling":[109],"sustains":[111],"SASP.":[113],"D2-p21":[115],"double-positive":[116],"accumulate":[118],"aging":[120],"MASLD":[122],"mice":[124],"human":[127,227],"cirrhosis,":[129,229],"can":[131,231],"be":[132,232],"selectively":[133],"depleted":[134],"by":[135,234],"senolytic":[136],"treatment.":[137],"Together,":[138],"these":[139],"findings":[140],"define":[141],"druggable":[143],"p53-p21-Cyclin":[144],"axis":[146],"specifies":[148],"senotype.":[150],"Highlights":[151],"\u25cf":[152,163,185,202,217],"A":[153],"p53\u2013p21-dependent":[154],"senescence":[158,181],"while":[159],"repressing":[161],"repression":[165],"promotes":[166],"cell":[167],"survival":[168],"during":[169],"acute":[170],"genotoxic":[171],"stress,":[172],"but":[173],"dispensable":[175],"cell-cycle":[177],"arrest":[178],"core":[180],"features":[182],"p53\u2013p21":[191],"relocalizes":[194],"cytosol":[199],"engages":[205],"pathway":[208],"interacts":[210],"D2+p21+":[219],"abundant":[222],"aging,":[224],"MASLD,":[225],"targeted":[233],"senolytics":[235]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-09-29T00:00:00"}
