{"id":"https://openalex.org/W7214604234","doi":"https://doi.org/10.64898/2026.09.22.753569","title":"A single bout of mistimed eating is sufficient to cause lasting disruptions in the daily rhythms of metabolism and behavior.","display_name":"A single bout of mistimed eating is sufficient to cause lasting disruptions in the daily rhythms of metabolism and behavior.","publication_year":2026,"publication_date":"2026-09-28","ids":{"openalex":"https://openalex.org/W7214604234","doi":"https://doi.org/10.64898/2026.09.22.753569"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.22.753569","doi":"https://doi.org/10.64898/2026.09.22.753569","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.22.753569","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/28/2026.09.22.753569.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/28/2026.09.22.753569.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5115620681","display_name":"Siddhant Dharap","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I193531525","display_name":"George Washington University","ror":"https://ror.org/00y4zzh67","country_code":"US","type":"education","lineage":["https://openalex.org/I193531525"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Siddhant Dharap","raw_affiliation_strings":["George Washington University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"George Washington University","institution_ids":["https://openalex.org/I193531525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5135974376","display_name":"Maya Young","orcid":"https://orcid.org/0009-0009-3293-870X","observed_orcids":["https://orcid.org/0009-0009-3293-870X"]},"institutions":[{"id":"https://openalex.org/I193531525","display_name":"George Washington University","ror":"https://ror.org/00y4zzh67","country_code":"US","type":"education","lineage":["https://openalex.org/I193531525"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maya Young","raw_affiliation_strings":["George Washington University"],"raw_orcid":"https://orcid.org/0009-0009-3293-870X","affiliations":[{"raw_affiliation_string":"George Washington University","institution_ids":["https://openalex.org/I193531525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083568340","display_name":"Erin N. Doherty","orcid":"https://orcid.org/0000-0002-0468-9672","observed_orcids":["https://orcid.org/0000-0002-0468-9672"]},"institutions":[{"id":"https://openalex.org/I193531525","display_name":"George Washington University","ror":"https://ror.org/00y4zzh67","country_code":"US","type":"education","lineage":["https://openalex.org/I193531525"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Erin N Doherty","raw_affiliation_strings":["George Washington University"],"raw_orcid":"https://orcid.org/0000-0002-0468-9672","affiliations":[{"raw_affiliation_string":"George Washington University","institution_ids":["https://openalex.org/I193531525"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063409338","display_name":"Lauren N. Woodie","orcid":"https://orcid.org/0000-0003-2427-4586","observed_orcids":["https://orcid.org/0000-0003-2427-4586"]},"institutions":[{"id":"https://openalex.org/I193531525","display_name":"George Washington University","ror":"https://ror.org/00y4zzh67","country_code":"US","type":"education","lineage":["https://openalex.org/I193531525"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Lauren N Woodie","raw_affiliation_strings":["George Washington University"],"raw_orcid":"https://orcid.org/0000-0003-2427-4586","affiliations":[{"raw_affiliation_string":"George Washington University","institution_ids":["https://openalex.org/I193531525"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5063409338"],"corresponding_institution_ids":["https://openalex.org/I193531525"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12745","display_name":"Dietary Effects on Health","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11373","display_name":"Sleep and Work-Related Fatigue","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/circadian-rhythm","display_name":"circadian rhythm","score":0.8500000238418579},{"id":"https://openalex.org/keywords/circadian-misalignment","display_name":"circadian misalignment","score":0.6079999804496765},{"id":"https://openalex.org/keywords/energy-expenditure","display_name":"energy expenditure","score":0.9359999895095825},{"id":"https://openalex.org/keywords/wheel-running","display_name":"wheel running","score":0.9290000200271606},{"id":"https://openalex.org/keywords/resting-behavior","display_name":"resting behavior","score":0.7960000038146973},{"id":"https://openalex.org/keywords/c57bl-6j-mice","display_name":"C57BL/6J mice","score":0.7789999842643738}],"concepts":[{"id":"https://openalex.org/C3018685816","wikidata":"https://www.wikidata.org/wiki/Q213449","display_name":"Food intake","level":2,"score":0.684499979019165},{"id":"https://openalex.org/C135343436","wikidata":"https://www.wikidata.org/wiki/Q170406","display_name":"Rhythm","level":2,"score":0.5960999727249146},{"id":"https://openalex.org/C2988147884","wikidata":"https://www.wikidata.org/wiki/Q5377024","display_name":"Energy expenditure","level":2,"score":0.5956000089645386},{"id":"https://openalex.org/C3017650416","wikidata":"https://www.wikidata.org/wiki/Q3281331","display_name":"Feeding behavior","level":2,"score":0.5699999928474426},{"id":"https://openalex.org/C121446783","wikidata":"https://www.wikidata.org/wiki/Q208353","display_name":"Circadian rhythm","level":2,"score":0.5651000142097473},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5303000211715698},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4968999922275543},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4593999981880188},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.42669999599456787},{"id":"https://openalex.org/C2986317502","wikidata":"https://www.wikidata.org/wiki/Q570714","display_name":"Energy metabolism","level":2,"score":0.41179999709129333},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.40849998593330383},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.4002000093460083},{"id":"https://openalex.org/C3020172569","wikidata":"https://www.wikidata.org/wiki/Q967168","display_name":"Wheel running","level":2,"score":0.3797000050544739},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.3531000018119812},{"id":"https://openalex.org/C2910500549","wikidata":"https://www.wikidata.org/wiki/Q483921","display_name":"Physiological Adaptations","level":2,"score":0.334199994802475},{"id":"https://openalex.org/C17093226","wikidata":"https://www.wikidata.org/wiki/Q2734081","display_name":"Carbohydrate metabolism","level":2,"score":0.32760000228881836},{"id":"https://openalex.org/C2491326","wikidata":"https://www.wikidata.org/wiki/Q5377024","display_name":"Energy homeostasis","level":3,"score":0.3228999972343445},{"id":"https://openalex.org/C2993436365","wikidata":"https://www.wikidata.org/wiki/Q925958","display_name":"Locomotor activity","level":2,"score":0.3093999922275543},{"id":"https://openalex.org/C2985495968","wikidata":"https://www.wikidata.org/wiki/Q422453","display_name":"Motor activity","level":2,"score":0.3041999936103821},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.266400009393692},{"id":"https://openalex.org/C3018542373","wikidata":"https://www.wikidata.org/wiki/Q14901436","display_name":"Metabolic adaptation","level":3,"score":0.2623000144958496},{"id":"https://openalex.org/C3020271038","wikidata":"https://www.wikidata.org/wiki/Q3281331","display_name":"Eating behavior","level":3,"score":0.259799987077713},{"id":"https://openalex.org/C2993927895","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolic activity","level":2,"score":0.2572000026702881},{"id":"https://openalex.org/C187765855","wikidata":"https://www.wikidata.org/wiki/Q506874","display_name":"Chronobiology","level":3,"score":0.25429999828338623}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.09.22.753569","doi":"https://doi.org/10.64898/2026.09.22.753569","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.22.753569","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/28/2026.09.22.753569.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.09.22.753569","doi":"https://doi.org/10.64898/2026.09.22.753569","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.22.753569","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/28/2026.09.22.753569.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.8048999905586243,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7214604234.pdf","grobid_xml":"https://content.openalex.org/works/W7214604234.grobid-xml"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W1901438300","https://openalex.org/W1965036088","https://openalex.org/W1985337265","https://openalex.org/W2026752638","https://openalex.org/W2054940809","https://openalex.org/W2075957423","https://openalex.org/W2098990166","https://openalex.org/W2161635288","https://openalex.org/W2164628441","https://openalex.org/W2168445785","https://openalex.org/W2171703113","https://openalex.org/W2174790239","https://openalex.org/W2271178259","https://openalex.org/W2339586650","https://openalex.org/W2592814861","https://openalex.org/W2623718881","https://openalex.org/W2799697212","https://openalex.org/W2895896895","https://openalex.org/W2897926834","https://openalex.org/W2911801274","https://openalex.org/W2916479600","https://openalex.org/W2948647741","https://openalex.org/W2969343566","https://openalex.org/W2985009942","https://openalex.org/W2994820011","https://openalex.org/W2999642065","https://openalex.org/W3000776101","https://openalex.org/W3045945845","https://openalex.org/W3108256000","https://openalex.org/W3139923913","https://openalex.org/W3200449343","https://openalex.org/W4206513048","https://openalex.org/W4207068196","https://openalex.org/W4210441686","https://openalex.org/W4285388525","https://openalex.org/W4306160034","https://openalex.org/W4306723863","https://openalex.org/W4319443895","https://openalex.org/W4319829221","https://openalex.org/W4386476020","https://openalex.org/W4392188196","https://openalex.org/W4399419510","https://openalex.org/W4402747611","https://openalex.org/W4404310053","https://openalex.org/W4404469239","https://openalex.org/W4405318625","https://openalex.org/W4409652934","https://openalex.org/W4410473570","https://openalex.org/W4411037209","https://openalex.org/W7130307593","https://openalex.org/W7147220278"],"related_works":["https://openalex.org/W7171400609","https://openalex.org/W7098722001","https://openalex.org/W3036515230","https://openalex.org/W4205938555","https://openalex.org/W4409652934","https://openalex.org/W2104310168","https://openalex.org/W2892220914","https://openalex.org/W4367600589","https://openalex.org/W7166712205","https://openalex.org/W4292745310"],"abstract_inverted_index":{"Synchrony":[0],"between":[1,13],"time-of-day":[2],"and":[3,60,83,97,101,121,129,135,141,196],"food":[4,139],"intake":[5,140],"is":[6,24,32,37,47,197],"critical":[7],"for":[8,39,104,124,146,159,169],"maintaining":[9],"homeostasis":[10],"while":[11],"desynchrony":[12],"these":[14],"cues":[15],"caused":[16],"by":[17],"repeated":[18,65],"bouts":[19],"of":[20,43,73,91,110,119,154,187,201],"mistimed":[21],"eating":[22,95],"(ME)":[23],"profoundly":[25],"disruptive":[26],"to":[27,76,87,114],"organismal":[28],"health.":[29],"However,":[30],"it":[31,46],"unknown":[33],"whether":[34],"the":[35,116,152],"same":[36],"true":[38],"a":[40,88],"single":[41,89,108],"bout":[42,90,109],"ME.":[44],"While":[45],"generally":[48],"accepted":[49],"that":[50,61,184],"mammals":[51],"recover":[52],"quickly":[53],"from":[54],"acute":[55,74],"alterations":[56],"in":[57,138,158],"feeding":[58],"schedule":[59],"chrono-disruption":[62],"requires":[63],"chronic,":[64],"changes,":[66],"there":[67],"have":[68],"been":[69],"no":[70,175],"dedicated":[71],"investigations":[72],"ME":[75,92,111,150,188],"suggest":[77],"otherwise.":[78],"Therefore,":[79],"we":[80],"exposed":[81],"female":[82],"male":[84],"C57Bl6/J":[85],"mice":[86],"or":[93,179],"timed":[94],"(TE)":[96],"continuously":[98],"measured":[99],"metabolic":[100,120],"behavioral":[102,122],"responses":[103],"five":[105],"days.":[106,126,148],"A":[107],"was":[112],"sufficient":[113],"disrupt":[115],"daily":[117,194],"rhythms":[118],"outcomes":[123],"several":[125,147,160],"Energy":[127],"expenditure":[128],"wheel":[130],"running":[131],"activity":[132],"were":[133,144],"disrupted":[134,166],"light:dark":[136],"variation":[137],"macronutrient":[142,167],"utilization":[143,168],"altered":[145],"Finally,":[149],"changed":[151],"amount":[153],"time":[155],"spent":[156],"resting":[157],"days":[161,171],"post-ME.":[162],"The":[163],"TE":[164],"paradigm":[165],"two":[170],"but":[172],"otherwise":[173],"had":[174],"effect":[176],"on":[177,193],"metabolism":[178],"behavior.":[180],"Our":[181],"results":[182],"demonstrate":[183],"one":[185],"instance":[186],"alone":[189],"has":[190],"lasting":[191],"impacts":[192],"rhythmicity":[195],"an":[198],"understudied":[199],"source":[200],"circadian":[202],"disruption.":[203]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-09-29T00:00:00"}