{"id":"https://openalex.org/W7214599301","doi":"https://doi.org/10.1093/nar/gkag922","title":"A type VI secretion ADP-ribosyltransferase Rhs toxin selectively modifies charged tRNAThr(GGU) anticodon loops to block ACC codon decoding","display_name":"A type VI secretion ADP-ribosyltransferase Rhs toxin selectively modifies charged tRNAThr(GGU) anticodon loops to block ACC codon decoding","publication_year":2026,"publication_date":"2026-09-12","ids":{"openalex":"https://openalex.org/W7214599301","doi":"https://doi.org/10.1093/nar/gkag922","pmid":"https://pubmed.ncbi.nlm.nih.gov/42803188","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13617354"},"language":"en","primary_location":{"id":"doi:10.1093/nar/gkag922","doi":"https://doi.org/10.1093/nar/gkag922","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkag922","pdf_url":null,"source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1093/nar/gkag922","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5107933186","display_name":"Ma\u00efal\u00e8ne Chabalier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I21491767","display_name":"Aix-Marseille Universit\u00e9","ror":"https://ror.org/035xkbk20","country_code":"FR","type":"education","lineage":["https://openalex.org/I21491767"]},{"id":"https://openalex.org/I4387156207","display_name":"Laboratoire d'Ing\u00e9nierie des Syst\u00e8mes Macromol\u00e9culaires","ror":"https://ror.org/02hwc1z56","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I21491767","https://openalex.org/I4387156207"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Ma\u00efal\u00e8ne Chabalier","raw_affiliation_strings":["Laboratoire d\u2019Ing\u00e9nierie des Syst\u00e8mes Macromol\u00e9culaires (LISM, UMR7255), Aix-Marseille Universit\u00e9, CNRS , 31 Chemin Joseph Aiguier CS7071, Marseille Cedex 20 13402 ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire d\u2019Ing\u00e9nierie des Syst\u00e8mes Macromol\u00e9culaires (LISM, UMR7255), Aix-Marseille Universit\u00e9, CNRS , 31 Chemin Joseph Aiguier CS7071, Marseille Cedex 20 13402 ,","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I21491767","https://openalex.org/I4387156207"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025794687","display_name":"Jonas B. Desjardins","orcid":"https://orcid.org/0009-0004-4652-1626","observed_orcids":["https://orcid.org/0009-0004-4652-1626"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I21491767","display_name":"Aix-Marseille Universit\u00e9","ror":"https://ror.org/035xkbk20","country_code":"FR","type":"education","lineage":["https://openalex.org/I21491767"]},{"id":"https://openalex.org/I4387156207","display_name":"Laboratoire d'Ing\u00e9nierie des Syst\u00e8mes Macromol\u00e9culaires","ror":"https://ror.org/02hwc1z56","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I21491767","https://openalex.org/I4387156207"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jonas B Desjardins","raw_affiliation_strings":["Laboratoire d\u2019Ing\u00e9nierie des Syst\u00e8mes Macromol\u00e9culaires (LISM, UMR7255), Aix-Marseille Universit\u00e9, CNRS , 31 Chemin Joseph Aiguier CS7071, Marseille Cedex 20 13402 ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire d\u2019Ing\u00e9nierie des Syst\u00e8mes Macromol\u00e9culaires (LISM, UMR7255), Aix-Marseille Universit\u00e9, CNRS , 31 Chemin Joseph Aiguier CS7071, Marseille Cedex 20 13402 ,","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I21491767","https://openalex.org/I4387156207"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019821991","display_name":"Julius Martinkus","orcid":"https://orcid.org/0000-0002-7109-6156","observed_orcids":["https://orcid.org/0000-0002-7109-6156"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I21491767","display_name":"Aix-Marseille Universit\u00e9","ror":"https://ror.org/035xkbk20","country_code":"FR","type":"education","lineage":["https://openalex.org/I21491767"]},{"id":"https://openalex.org/I4387156207","display_name":"Laboratoire d'Ing\u00e9nierie des Syst\u00e8mes Macromol\u00e9culaires","ror":"https://ror.org/02hwc1z56","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I21491767","https://openalex.org/I4387156207"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Julius Martinkus","raw_affiliation_strings":["Laboratoire d\u2019Ing\u00e9nierie des Syst\u00e8mes Macromol\u00e9culaires (LISM, UMR7255), Aix-Marseille Universit\u00e9, CNRS , 31 Chemin Joseph Aiguier CS7071, Marseille Cedex 20 13402 ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire d\u2019Ing\u00e9nierie des Syst\u00e8mes Macromol\u00e9culaires (LISM, UMR7255), Aix-Marseille Universit\u00e9, CNRS , 31 Chemin Joseph Aiguier CS7071, Marseille Cedex 20 13402 ,","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I21491767","https://openalex.org/I4387156207"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018842385","display_name":"Eric Cascal\u00e8s","orcid":"https://orcid.org/0000-0003-0611-9179","observed_orcids":["https://orcid.org/0000-0003-0611-9179"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I21491767","display_name":"Aix-Marseille Universit\u00e9","ror":"https://ror.org/035xkbk20","country_code":"FR","type":"education","lineage":["https://openalex.org/I21491767"]},{"id":"https://openalex.org/I4387156207","display_name":"Laboratoire d'Ing\u00e9nierie des Syst\u00e8mes Macromol\u00e9culaires","ror":"https://ror.org/02hwc1z56","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I21491767","https://openalex.org/I4387156207"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Eric Cascales","raw_affiliation_strings":["Laboratoire d\u2019Ing\u00e9nierie des Syst\u00e8mes Macromol\u00e9culaires (LISM, UMR7255), Aix-Marseille Universit\u00e9, CNRS , 31 Chemin Joseph Aiguier CS7071, Marseille Cedex 20 13402 ,"],"raw_orcid":"https://orcid.org/0000-0003-0611-9179","affiliations":[{"raw_affiliation_string":"Laboratoire d\u2019Ing\u00e9nierie des Syst\u00e8mes Macromol\u00e9culaires (LISM, UMR7255), Aix-Marseille Universit\u00e9, CNRS , 31 Chemin Joseph Aiguier CS7071, Marseille Cedex 20 13402 ,","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I21491767","https://openalex.org/I4387156207"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5018842385"],"corresponding_institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I21491767","https://openalex.org/I4387156207"],"apc_list":{"value":3992,"currency":"USD","value_usd":3992},"apc_paid":{"value":3992,"currency":"USD","value_usd":3992},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.58973206,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"54","issue":"18","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.6240000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.6240000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12477","display_name":"Toxin Mechanisms and Immunotoxins","score":0.2741999924182892,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.052000001072883606,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/type-vi-secretion-system","display_name":"type VI secretion system","score":0.9760000109672546},{"id":"https://openalex.org/keywords/adp-ribosyltransferase","display_name":"ADP-ribosyltransferase","score":0.9509999752044678},{"id":"https://openalex.org/keywords/chromobacterium-violaceum","display_name":"Chromobacterium violaceum","score":0.9599999785423279},{"id":"https://openalex.org/keywords/trna-isoacceptors","display_name":"tRNA isoacceptors","score":0.7369999885559082},{"id":"https://openalex.org/keywords/protein-synthesis-inhibition","display_name":"protein synthesis inhibition","score":0.6759999990463257},{"id":"https://openalex.org/keywords/immunity-proteins","display_name":"immunity proteins","score":0.8130000233650208},{"id":"https://openalex.org/keywords/trna-modification","display_name":"tRNA modification","score":0.3050000071525574}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8519999980926514},{"id":"https://openalex.org/C153957851","wikidata":"https://www.wikidata.org/wiki/Q201448","display_name":"Transfer RNA","level":4,"score":0.6273999810218811},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5508999824523926},{"id":"https://openalex.org/C2777367657","wikidata":"https://www.wikidata.org/wiki/Q184651","display_name":"Toxin","level":2,"score":0.5353000164031982},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.5123000144958496},{"id":"https://openalex.org/C16318435","wikidata":"https://www.wikidata.org/wiki/Q149299","display_name":"Mutagenesis","level":4,"score":0.48579999804496765},{"id":"https://openalex.org/C103244968","wikidata":"https://www.wikidata.org/wiki/Q273193","display_name":"Bacterial conjugation","level":4,"score":0.37599998712539673},{"id":"https://openalex.org/C2776901170","wikidata":"https://www.wikidata.org/wiki/Q12499775","display_name":"Nicotinamide adenine dinucleotide","level":4,"score":0.328000009059906},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.32120001316070557},{"id":"https://openalex.org/C2775880066","wikidata":"https://www.wikidata.org/wiki/Q186521","display_name":"Threonine","level":4,"score":0.28790000081062317},{"id":"https://openalex.org/C2778827730","wikidata":"https://www.wikidata.org/wiki/Q24944355","display_name":"Type VI secretion system","level":4,"score":0.2669000029563904},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.26109999418258667},{"id":"https://openalex.org/C103408237","wikidata":"https://www.wikidata.org/wiki/Q2642668","display_name":"Site-directed mutagenesis","level":4,"score":0.26089999079704285},{"id":"https://openalex.org/C129312508","wikidata":"https://www.wikidata.org/wiki/Q133686","display_name":"Oligonucleotide","level":3,"score":0.25290000438690186}],"mesh":[{"descriptor_ui":"D000069376","descriptor_name":"Type VI Secretion Systems","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000069376","descriptor_name":"Type VI Secretion Systems","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000069376","descriptor_name":"Type VI Secretion Systems","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000074744","descriptor_name":"ADP-Ribosylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000926","descriptor_name":"Anticodon","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000926","descriptor_name":"Anticodon","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000926","descriptor_name":"Anticodon","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D001427","descriptor_name":"Bacterial Toxins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001427","descriptor_name":"Bacterial Toxins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001427","descriptor_name":"Bacterial Toxins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D003062","descriptor_name":"Codon","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009243","descriptor_name":"NAD","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012343","descriptor_name":"RNA, Transfer","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012343","descriptor_name":"RNA, Transfer","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012343","descriptor_name":"RNA, Transfer","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D013912","descriptor_name":"Threonine","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014176","descriptor_name":"Protein Biosynthesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D036002","descriptor_name":"ADP Ribose Transferases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D036002","descriptor_name":"ADP Ribose Transferases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D036002","descriptor_name":"ADP Ribose Transferases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1093/nar/gkag922","doi":"https://doi.org/10.1093/nar/gkag922","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkag922","pdf_url":null,"source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},{"id":"pmid:42803188","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42803188","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic acids research","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13617354","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13617354/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Res","raw_type":"Text"},{"id":"pmh:oai:HAL:hal-05777163v1","doi":null,"is_oa":true,"landing_page_url":"https://hal.science/hal-05777163","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nucleic Acids Research, 2026, 54 (18), &#x27E8;10.1093/nar/gkag922&#x27E9;","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1093/nar/gkag922","doi":"https://doi.org/10.1093/nar/gkag922","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkag922","pdf_url":null,"source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1910735563","display_name":"Solving the Type VI secretion puzzle: understanding subcomplexes organization and dynamics by a multidisciplinary approach","funder_award_id":"ANR-20-CE11-0017","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G3393027343","display_name":null,"funder_award_id":"ECO202206015565","funder_id":"https://openalex.org/F4320321589","funder_display_name":"Fondation pour la Recherche M\u00e9dicale"},{"id":"https://openalex.org/G3681899431","display_name":null,"funder_award_id":"FDT202504020886","funder_id":"https://openalex.org/F4320321589","funder_display_name":"Fondation pour la Recherche M\u00e9dicale"}],"funders":[{"id":"https://openalex.org/F4320320883","display_name":"Agence Nationale de la Recherche","ror":"https://ror.org/00rbzpz17"},{"id":"https://openalex.org/F4320321589","display_name":"Fondation pour la Recherche M\u00e9dicale","ror":"https://ror.org/04w6kn183"},{"id":"https://openalex.org/F4320322892","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73"},{"id":"https://openalex.org/F4320324477","display_name":"Fondation Bettencourt Schueller","ror":"https://ror.org/02p3abx23"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":70,"referenced_works":["https://openalex.org/W172203261","https://openalex.org/W805066248","https://openalex.org/W1899329792","https://openalex.org/W1919814215","https://openalex.org/W1976615657","https://openalex.org/W1978352011","https://openalex.org/W1996881985","https://openalex.org/W2000230362","https://openalex.org/W2002677631","https://openalex.org/W2010222055","https://openalex.org/W2018448695","https://openalex.org/W2021470992","https://openalex.org/W2040539560","https://openalex.org/W2042700625","https://openalex.org/W2066490004","https://openalex.org/W2075198363","https://openalex.org/W2089553534","https://openalex.org/W2090486365","https://openalex.org/W2090535305","https://openalex.org/W2095104880","https://openalex.org/W2121914232","https://openalex.org/W2126452774","https://openalex.org/W2131599797","https://openalex.org/W2157732438","https://openalex.org/W2160084442","https://openalex.org/W2163884196","https://openalex.org/W2217161021","https://openalex.org/W2417855243","https://openalex.org/W2604136844","https://openalex.org/W2604858366","https://openalex.org/W2624112134","https://openalex.org/W2760377560","https://openalex.org/W2785504019","https://openalex.org/W2809369434","https://openalex.org/W2890545350","https://openalex.org/W2891160423","https://openalex.org/W2896023929","https://openalex.org/W2925022214","https://openalex.org/W2948849558","https://openalex.org/W2960925540","https://openalex.org/W2968548142","https://openalex.org/W3016337782","https://openalex.org/W3037477253","https://openalex.org/W3043584664","https://openalex.org/W3105893579","https://openalex.org/W3106059749","https://openalex.org/W3183090963","https://openalex.org/W3216515447","https://openalex.org/W4224436105","https://openalex.org/W4226195134","https://openalex.org/W4233814629","https://openalex.org/W4282922306","https://openalex.org/W4287377372","https://openalex.org/W4294782877","https://openalex.org/W4310947226","https://openalex.org/W4379094917","https://openalex.org/W4387164156","https://openalex.org/W4387566852","https://openalex.org/W4396721167","https://openalex.org/W4403204445","https://openalex.org/W4403959664","https://openalex.org/W4404106686","https://openalex.org/W4404837144","https://openalex.org/W4405066714","https://openalex.org/W4413995683","https://openalex.org/W4414687078","https://openalex.org/W4416222678","https://openalex.org/W7143845244","https://openalex.org/W7162135309","https://openalex.org/W7163006424"],"related_works":["https://openalex.org/W4310947226","https://openalex.org/W7222241756","https://openalex.org/W7036201413","https://openalex.org/W4403204445","https://openalex.org/W4388802710","https://openalex.org/W7125712277","https://openalex.org/W4294782877","https://openalex.org/W7162135309","https://openalex.org/W2550227253","https://openalex.org/W4226195134"],"abstract_inverted_index":{"The":[0],"type":[1],"VI":[2],"secretion":[3],"system":[4],"(T6SS)":[5],"is":[6,51,57],"a":[7,12,52,78,96],"sophisticated":[8],"machine":[9],"that":[10,45,69,90,116],"uses":[11],"contractile":[13],"mechanism":[14],"to":[15,24,72],"deliver":[16],"antibacterial":[17,54],"toxins":[18],"into":[19],"neighboring":[20],"cells,":[21],"hence":[22],"participating":[23],"interbacterial":[25],"competition":[26],"and":[27,66,112,125,129],"pathogenesis.":[28],"Here,":[29],"we":[30,88],"characterize":[31],"the":[32,46,60,73,119],"T6SS-associated":[33],"rearrangement":[34],"hotspot":[35],"RhsF":[36,47],"polymorphic":[37],"toxin":[38],"from":[39],"Chromobacterium":[40],"violaceum.":[41],"Toxicity":[42],"assays":[43],"showed":[44],"C-terminal":[48],"extension,":[49],"TreThr,":[50],"cytoplasmic-acting":[53],"toxin,":[55],"which":[56],"neutralized":[58],"by":[59],"downstream":[61],"immunity":[62],"protein.":[63],"Structural":[64],"modeling":[65],"mutagenesis":[67],"demonstrated":[68],"TreThr":[70,91,117],"belongs":[71],"ADP-ribosyltransferase":[74],"(ART)":[75],"family,":[76],"adopting":[77],"canonical":[79],"ART":[80],"fold.":[81],"Using":[82],"coupled":[83],"in":[84,95],"vitro":[85],"transcription-translation":[86],"assays,":[87],"found":[89],"inhibits":[92],"protein":[93],"synthesis":[94],"Nicotinamide":[97],"Adenine":[98],"Dinucleotide":[99],"(NAD)-dependent":[100],"manner,":[101],"through":[102],"isoacceptor-specific":[103],"ADP-ribosylation":[104],"of":[105,122,132],"transfer":[106],"RNAs":[107],"(tRNAs).":[108],"Biotin-NAD":[109],"labeling":[110],"experiments":[111],"mapping":[113],"further":[114],"revealed":[115],"modifies":[118],"GGU":[120],"anticodon":[121],"charged":[123],"thrT":[124],"thrV":[126],"tRNA":[127],"isoacceptors":[128],"prevents":[130],"decoding":[131],"threonine":[133],"ACC":[134],"codons.":[135]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2026-09-29T00:00:00"}
