{"id":"https://openalex.org/W7214577486","doi":"https://doi.org/10.1002/slct.202600070","title":"Quercetin From Ocimum Basilicum L. Differentially Affects PC\u201012 Survival in 2D and 3D Culture","display_name":"Quercetin From Ocimum Basilicum L. Differentially Affects PC\u201012 Survival in 2D and 3D Culture","publication_year":2026,"publication_date":"2026-09-28","ids":{"openalex":"https://openalex.org/W7214577486","doi":"https://doi.org/10.1002/slct.202600070"},"language":"en","primary_location":{"id":"doi:10.1002/slct.202600070","doi":"https://doi.org/10.1002/slct.202600070","is_oa":false,"landing_page_url":"https://doi.org/10.1002/slct.202600070","pdf_url":null,"source":{"id":"https://openalex.org/S4210221416","display_name":"ChemistrySelect","issn_l":"2365-6549","issn":["2365-6549"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ChemistrySelect","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011962384","display_name":"Tu\u011fba Bal","orcid":"https://orcid.org/0000-0003-2100-285X","observed_orcids":["https://orcid.org/0000-0003-2100-285X"]},"institutions":[{"id":"https://openalex.org/I1281256770","display_name":"\u00dcsk\u00fcdar University","ror":"https://ror.org/02dzjmc73","country_code":"TR","type":"education","lineage":["https://openalex.org/I1281256770"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Tugba Bal","raw_affiliation_strings":["Department of Bioengineering \u00dcsk\u00fcdar University, Faculty of Engineering and Natural Sciences  Istanbul Turkiye","Department of Bioengineering \u00dcsk\u00fcdar University, Graduate School of Sciences  Istanbul Turkiye"],"raw_orcid":"https://orcid.org/0000-0003-2100-285X","affiliations":[{"raw_affiliation_string":"Department of Bioengineering \u00dcsk\u00fcdar University, Faculty of Engineering and Natural Sciences  Istanbul Turkiye","institution_ids":["https://openalex.org/I1281256770"]},{"raw_affiliation_string":"Department of Bioengineering \u00dcsk\u00fcdar University, Graduate School of Sciences  Istanbul Turkiye","institution_ids":["https://openalex.org/I1281256770"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041445313","display_name":"Nihan Bay\u0131nd\u0131r","orcid":"https://orcid.org/0000-0001-6181-5957","observed_orcids":["https://orcid.org/0000-0001-6181-5957"]},"institutions":[{"id":"https://openalex.org/I1281256770","display_name":"\u00dcsk\u00fcdar University","ror":"https://ror.org/02dzjmc73","country_code":"TR","type":"education","lineage":["https://openalex.org/I1281256770"]},{"id":"https://openalex.org/I3132756774","display_name":"Fenerbah\u00e7e University","ror":"https://ror.org/00xf89h18","country_code":"TR","type":"education","lineage":["https://openalex.org/I3132756774"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Nihan Bay\u0131nd\u0131r","raw_affiliation_strings":["Department of Bioengineering \u00dcsk\u00fcdar University, Graduate School of Sciences  Istanbul Turkiye","Department of Pathology Laboratory Techniques Fenerbah\u00e7e University, Vocational School of Health Services  Istanbul Turkiye"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering \u00dcsk\u00fcdar University, Graduate School of Sciences  Istanbul Turkiye","institution_ids":["https://openalex.org/I1281256770"]},{"raw_affiliation_string":"Department of Pathology Laboratory Techniques Fenerbah\u00e7e University, Vocational School of Health Services  Istanbul Turkiye","institution_ids":["https://openalex.org/I3132756774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076699365","display_name":"Salih Tuncay","orcid":"https://orcid.org/0000-0003-3838-5228","observed_orcids":["https://orcid.org/0000-0003-3838-5228"]},"institutions":[{"id":"https://openalex.org/I1281256770","display_name":"\u00dcsk\u00fcdar University","ror":"https://ror.org/02dzjmc73","country_code":"TR","type":"education","lineage":["https://openalex.org/I1281256770"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Salih Tuncay","raw_affiliation_strings":["Atabay Pharmaceuticals and Fine Chemicals Inc. Ac\u0131badem R&D Center Istanbul Turkiye","Department of Food Technology \u00dcsk\u00fcdar University, Vocational School of Health Sciences  Istanbul Turkiye"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Atabay Pharmaceuticals and Fine Chemicals Inc. Ac\u0131badem R&D Center Istanbul Turkiye","institution_ids":[]},{"raw_affiliation_string":"Department of Food Technology \u00dcsk\u00fcdar University, Vocational School of Health Sciences  Istanbul Turkiye","institution_ids":["https://openalex.org/I1281256770"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114662496","display_name":"Meryem Zeroual","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1281256770","display_name":"\u00dcsk\u00fcdar University","ror":"https://ror.org/02dzjmc73","country_code":"TR","type":"education","lineage":["https://openalex.org/I1281256770"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Meryem Zeroual","raw_affiliation_strings":["Department of Bioengineering \u00dcsk\u00fcdar University, Graduate School of Sciences  Istanbul Turkiye"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering \u00dcsk\u00fcdar University, Graduate School of Sciences  Istanbul Turkiye","institution_ids":["https://openalex.org/I1281256770"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037405893","display_name":"Shirin Tarbiat","orcid":"https://orcid.org/0000-0001-7931-1546","observed_orcids":["https://orcid.org/0000-0001-7931-1546"]},"institutions":[{"id":"https://openalex.org/I1281256770","display_name":"\u00dcsk\u00fcdar University","ror":"https://ror.org/02dzjmc73","country_code":"TR","type":"education","lineage":["https://openalex.org/I1281256770"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Shirin Tarbiat","raw_affiliation_strings":["Department of Molecular Biology and Genetics \u00dcsk\u00fcdar University, Faculty of Engineering and Natural Sciences  Istanbul Turkiye"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Genetics \u00dcsk\u00fcdar University, Faculty of Engineering and Natural Sciences  Istanbul Turkiye","institution_ids":["https://openalex.org/I1281256770"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5093671167","display_name":"Yunus Emre Toprak","orcid":"https://orcid.org/0000-0002-7090-8909","observed_orcids":["https://orcid.org/0000-0002-7090-8909"]},"institutions":[{"id":"https://openalex.org/I74897591","display_name":"Marmara University","ror":"https://ror.org/02kswqa67","country_code":"TR","type":"education","lineage":["https://openalex.org/I74897591"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Yunus Emre Toprak","raw_affiliation_strings":["Department of Chemistry Marmara University, Faculty of Sciences  Istanbul Turkiye"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry Marmara University, Faculty of Sciences  Istanbul Turkiye","institution_ids":["https://openalex.org/I74897591"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3880,"currency":"USD","value_usd":3880},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"11","issue":"37","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10035","display_name":"Phytochemicals and Antioxidant Activities","score":0.5551999807357788,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10035","display_name":"Phytochemicals and Antioxidant Activities","score":0.5551999807357788,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12582","display_name":"Flavonoids in Medical Research","score":0.2320999950170517,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12298","display_name":"Phytochemicals and Medicinal Plants","score":0.039900001138448715,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/quercetin","display_name":"quercetin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/ocimum-basilicum","display_name":"Ocimum basilicum","score":0.9750000238418579},{"id":"https://openalex.org/keywords/purple-basil","display_name":"purple basil","score":0.9240000247955322},{"id":"https://openalex.org/keywords/flavonoids","display_name":"flavonoids","score":0.8059999942779541},{"id":"https://openalex.org/keywords/pc12-cells","display_name":"PC12 cells","score":0.9240000247955322},{"id":"https://openalex.org/keywords/extracellular-matrix-mimicry","display_name":"extracellular matrix mimicry","score":0.8289999961853027},{"id":"https://openalex.org/keywords/cell-survival","display_name":"cell survival","score":0.7210000157356262},{"id":"https://openalex.org/keywords/2d-vs-3d-culture","display_name":"2D vs 3D culture","score":0.796999990940094},{"id":"https://openalex.org/keywords/nutraceuticals","display_name":"nutraceuticals","score":0.7360000014305115},{"id":"https://openalex.org/keywords/flavonoid-toxicity","display_name":"flavonoid toxicity","score":0.5839999914169312}],"concepts":[{"id":"https://openalex.org/C2777612184","wikidata":"https://www.wikidata.org/wiki/Q3206267","display_name":"Basilicum","level":3,"score":0.9706000089645386},{"id":"https://openalex.org/C2779342943","wikidata":"https://www.wikidata.org/wiki/Q148818","display_name":"Ocimum","level":2,"score":0.9563999772071838},{"id":"https://openalex.org/C2781263971","wikidata":"https://www.wikidata.org/wiki/Q409478","display_name":"Quercetin","level":3,"score":0.8981000185012817},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.5001999735832214},{"id":"https://openalex.org/C2779054382","wikidata":"https://www.wikidata.org/wiki/Q72185287","display_name":"Flavonoid","level":3,"score":0.47850000858306885},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.46140000224113464},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.43959999084472656},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4345000088214874},{"id":"https://openalex.org/C2775941552","wikidata":"https://www.wikidata.org/wiki/Q25212305","display_name":"Isolation (microbiology)","level":2,"score":0.4106000065803528},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.3700000047683716},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36320000886917114},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.35199999809265137},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.34459999203681946},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.2996000051498413},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.27230000495910645},{"id":"https://openalex.org/C2992092908","wikidata":"https://www.wikidata.org/wiki/Q45959","display_name":"Drug toxicity","level":3,"score":0.26089999079704285},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2556000053882599},{"id":"https://openalex.org/C33070731","wikidata":"https://www.wikidata.org/wiki/Q7218","display_name":"Toxicology","level":1,"score":0.2506999969482422}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1002/slct.202600070","doi":"https://doi.org/10.1002/slct.202600070","is_oa":false,"landing_page_url":"https://doi.org/10.1002/slct.202600070","pdf_url":null,"source":{"id":"https://openalex.org/S4210221416","display_name":"ChemistrySelect","issn_l":"2365-6549","issn":["2365-6549"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ChemistrySelect","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8230999708175659,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":69,"referenced_works":["https://openalex.org/W1971963552","https://openalex.org/W2116952515","https://openalex.org/W2139014218","https://openalex.org/W2171747062","https://openalex.org/W2174948209","https://openalex.org/W2331628193","https://openalex.org/W2339667234","https://openalex.org/W2479858070","https://openalex.org/W2539107597","https://openalex.org/W2557267498","https://openalex.org/W2587788572","https://openalex.org/W2624265672","https://openalex.org/W2626725994","https://openalex.org/W2730517114","https://openalex.org/W2736741939","https://openalex.org/W2788759532","https://openalex.org/W2906267672","https://openalex.org/W2909132458","https://openalex.org/W2934802914","https://openalex.org/W2937820813","https://openalex.org/W2963987509","https://openalex.org/W2965002476","https://openalex.org/W2969464129","https://openalex.org/W2969924684","https://openalex.org/W2970748584","https://openalex.org/W2980581402","https://openalex.org/W2996537070","https://openalex.org/W3009670898","https://openalex.org/W3017206975","https://openalex.org/W3018155904","https://openalex.org/W3024750580","https://openalex.org/W3025860373","https://openalex.org/W3029096680","https://openalex.org/W3085469110","https://openalex.org/W3087728783","https://openalex.org/W3087860542","https://openalex.org/W3092861146","https://openalex.org/W3119804059","https://openalex.org/W3128687569","https://openalex.org/W3132259578","https://openalex.org/W3159112056","https://openalex.org/W3165427824","https://openalex.org/W3197275773","https://openalex.org/W3205716724","https://openalex.org/W3216647719","https://openalex.org/W3216713526","https://openalex.org/W3217070948","https://openalex.org/W4200064246","https://openalex.org/W4210566459","https://openalex.org/W4220745751","https://openalex.org/W4224118676","https://openalex.org/W4285261944","https://openalex.org/W4309455172","https://openalex.org/W4313588653","https://openalex.org/W4317733587","https://openalex.org/W4323653463","https://openalex.org/W4327679279","https://openalex.org/W4381461233","https://openalex.org/W4382814351","https://openalex.org/W4386032288","https://openalex.org/W4391252362","https://openalex.org/W4400192417","https://openalex.org/W4400591719","https://openalex.org/W4401564937","https://openalex.org/W4402126619","https://openalex.org/W4402740300","https://openalex.org/W4406963870","https://openalex.org/W4408462645","https://openalex.org/W7125974523"],"related_works":["https://openalex.org/W1977356977","https://openalex.org/W2394302814","https://openalex.org/W3007428736","https://openalex.org/W6977202407","https://openalex.org/W2573232958","https://openalex.org/W4315621601","https://openalex.org/W130908341","https://openalex.org/W7204218089","https://openalex.org/W1775629547","https://openalex.org/W7071246835"],"abstract_inverted_index":{"ABSTRACT":[0],"Alteration":[1],"of":[2,15,24,158],"cellular":[3],"environment":[4,91],"from":[5,115],"3D":[6,149],"body":[7],"conditions":[8],"to":[9,19,86,156,165],"traditional":[10],"2D":[11,72,159],"culture":[12,73],"is":[13,33,47,128],"one":[14],"the":[16,22,83,96,105,148],"main":[17],"contributors":[18],"failure":[20],"in":[21,88,104],"transition":[23],"many":[25],"drug":[26,75],"candidates":[27],"into":[28],"clinical":[29,171],"success":[30],"as":[31,56,61,135,137],"it":[32,46],"associated":[34],"with":[35,58,122,161],"bioavailability,":[36],"activity,":[37],"and":[38,64,79,95,125,172],"toxicity.":[39],"As":[40],"a":[41,49],"well\u2010known":[42],"challenge":[43],"for":[44,52,113,170],"drugs,":[45],"also":[48],"significant":[50],"obstacle":[51],"secondary":[53],"metabolites":[54],"such":[55],"flavonoids,":[57],"current":[59],"interest":[60],"dietary":[62],"supplements":[63],"nutraceuticals.":[65],"Previous":[66],"research":[67],"on":[68,71,130,138,142],"quercetin":[69,87,103,114],"focused":[70],"tests,":[74],"carrier":[76],"platforms,":[77],"spheroids,":[78],"animal":[80],"models,":[81],"yet":[82],"survival":[84],"response":[85],"an":[89,110],"ECM\u2010mimicking":[90],"was":[92],"not":[93],"explored,":[94],"investigated":[97],"quercetins":[98],"were":[99],"mainly":[100],"commercially":[101],"available":[102],"literature.":[106],"Here,":[107],"we":[108],"described":[109],"isolation":[111],"strategy":[112],"purple":[116],"basil":[117],"(":[118],"Ocimum":[119],"basilicum":[120],"L.)":[121],"93%":[123],"purity,":[124],"its":[126],"effect":[127],"examined":[129],"collagen\u2010hydrogel":[131],"encapsulated":[132],"PC\u201012":[133,139],"cells":[134,140],"well":[136],"cultured":[141],"collagen\u2010treated":[143],"surfaces.":[144],"Results":[145],"indicate":[146],"that":[147],"system":[150],"had":[151],"greater":[152],"IC50":[153],"values":[154],"(up":[155],"2.33\u2010fold":[157],"culture)":[160],"similar":[162],"toxicity":[163],"compared":[164],"commercial":[166],"quercetin,":[167],"showing":[168],"promise":[169],"food":[173],"applications.":[174]},"counts_by_year":[],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2026-09-29T00:00:00"}
