{"id":"https://openalex.org/W7214574100","doi":"https://doi.org/10.64898/2026.09.22.747582","title":"CTR1-mediated copper uptake orchestrates metabolic-epigenetic regulation of pathogenic T H 17 cells in autoimmune disease","display_name":"CTR1-mediated copper uptake orchestrates metabolic-epigenetic regulation of pathogenic T H 17 cells in autoimmune disease","publication_year":2026,"publication_date":"2026-09-28","ids":{"openalex":"https://openalex.org/W7214574100","doi":"https://doi.org/10.64898/2026.09.22.747582","pmid":"https://pubmed.ncbi.nlm.nih.gov/42856209","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13648362"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.22.747582","doi":"https://doi.org/10.64898/2026.09.22.747582","is_oa":false,"landing_page_url":"https://doi.org/10.64898/2026.09.22.747582","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13648362/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043172175","display_name":"Lucile Noyer","orcid":"https://orcid.org/0000-0002-1369-684X","observed_orcids":["https://orcid.org/0000-0002-1369-684X"]},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lucile Noyer","raw_affiliation_strings":["Department of Pathology, New York University Grossman School of Medicine, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, New York University Grossman School of Medicine, New York, NY, USA","institution_ids":["https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5132919331","display_name":"Liwei Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Liwei Wang","raw_affiliation_strings":["Department of Pathology, New York University Grossman School of Medicine, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, New York University Grossman School of Medicine, New York, NY, USA","institution_ids":["https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035850116","display_name":"Miki Jishage","orcid":"https://orcid.org/0000-0002-2835-2564","observed_orcids":["https://orcid.org/0000-0002-2835-2564"]},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Miki Jishage","raw_affiliation_strings":["Department of Pathology, New York University Grossman School of Medicine, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, New York University Grossman School of Medicine, New York, NY, USA","institution_ids":["https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5153402281","display_name":"Maxwell McDermott","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maxwell McDermott","raw_affiliation_strings":["Department of Pathology, New York University Grossman School of Medicine, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, New York University Grossman School of Medicine, New York, NY, USA","institution_ids":["https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004744860","display_name":"Aidan T. Pezacki","orcid":"https://orcid.org/0000-0002-7321-462X","observed_orcids":["https://orcid.org/0000-0002-7321-462X"]},"institutions":[{"id":"https://openalex.org/I20089843","display_name":"Princeton University","ror":"https://ror.org/00hx57361","country_code":"US","type":"education","lineage":["https://openalex.org/I20089843"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aidan T Pezacki","raw_affiliation_strings":["Department of Chemistry, Princeton University, NJ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Princeton University, NJ, USA","institution_ids":["https://openalex.org/I20089843"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056967422","display_name":"Anthony Y. Tao","orcid":"https://orcid.org/0000-0003-0978-2769","observed_orcids":["https://orcid.org/0000-0003-0978-2769"]},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anthony Y Tao","raw_affiliation_strings":["Department of Pathology, New York University Grossman School of Medicine, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, New York University Grossman School of Medicine, New York, NY, USA","institution_ids":["https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051573119","display_name":"Ravichandran Ramasamy","orcid":"https://orcid.org/0000-0001-9502-8265","observed_orcids":["https://orcid.org/0000-0001-9502-8265","https://orcid.org/0000-0002-3666-3346"]},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ravichandran Ramasamy","raw_affiliation_strings":["Diabetes Research Program, Department of Medicine, NYU Grossman School of Medicine, New York, NY 10016, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Diabetes Research Program, Department of Medicine, NYU Grossman School of Medicine, New York, NY 10016, USA","institution_ids":["https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046792632","display_name":"Matthias Stadtfeld","orcid":"https://orcid.org/0000-0002-5852-9906","observed_orcids":["https://orcid.org/0000-0002-5852-9906"]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]},{"id":"https://openalex.org/I4405272987","display_name":"Weill Cornell Medical Center","ror":"https://ror.org/052v90092","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466","https://openalex.org/I4405272987"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthias Stadtfeld","raw_affiliation_strings":["Sanford I. Weill Department of Medicine, Sandra and Edward Cancer Center, Weill Cornell Medicine, New York, NY 10065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sanford I. Weill Department of Medicine, Sandra and Edward Cancer Center, Weill Cornell Medicine, New York, NY 10065, USA","institution_ids":["https://openalex.org/I4387153466","https://openalex.org/I4405272987"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072113162","display_name":"Christopher J. Chang","orcid":"https://orcid.org/0000-0001-5732-9497","observed_orcids":["https://orcid.org/0000-0001-5732-9497"]},"institutions":[{"id":"https://openalex.org/I20089843","display_name":"Princeton University","ror":"https://ror.org/00hx57361","country_code":"US","type":"education","lineage":["https://openalex.org/I20089843"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher J Chang","raw_affiliation_strings":["Department of Chemistry, Princeton University, NJ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Princeton University, NJ, USA","institution_ids":["https://openalex.org/I20089843"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091404565","display_name":"Stefan Feske","orcid":"https://orcid.org/0000-0001-5431-8178","observed_orcids":["https://orcid.org/0000-0001-5431-8178"]},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Stefan Feske","raw_affiliation_strings":["Department of Pathology, New York University Grossman School of Medicine, New York, NY, USA"],"raw_orcid":"https://orcid.org/0000-0001-5431-8178","affiliations":[{"raw_affiliation_string":"Department of Pathology, New York University Grossman School of Medicine, New York, NY, USA","institution_ids":["https://openalex.org/I57206974"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5091404565"],"corresponding_institution_ids":["https://openalex.org/I57206974"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.7612000107765198,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.7612000107765198,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.17159999907016754,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10915","display_name":"Trace Elements in Health","score":0.022600000724196434,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ctr1","display_name":"CTR1","score":0.7919999957084656},{"id":"https://openalex.org/keywords/slc31a1","display_name":"SLC31A1","score":0.9229999780654907},{"id":"https://openalex.org/keywords/copper-uptake","display_name":"copper uptake","score":0.9440000057220459},{"id":"https://openalex.org/keywords/copper-homeostasis","display_name":"copper homeostasis","score":0.9079999923706055},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.7839999794960022},{"id":"https://openalex.org/keywords/multiple-sclerosis","display_name":"multiple sclerosis","score":0.859000027179718},{"id":"https://openalex.org/keywords/experimental-autoimmune-encephalomyelitis","display_name":"experimental autoimmune encephalomyelitis","score":0.9800000190734863},{"id":"https://openalex.org/keywords/oxidative-phosphorylation","display_name":"oxidative phosphorylation","score":0.8349999785423279},{"id":"https://openalex.org/keywords/mitochondrial-respiration","display_name":"mitochondrial respiration","score":0.8870000243186951},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.746999979019165},{"id":"https://openalex.org/keywords/chromatin-accessibility","display_name":"chromatin accessibility","score":0.9599999785423279},{"id":"https://openalex.org/keywords/ap-1-transcription-factor","display_name":"AP-1 transcription factor","score":0.9340000152587891},{"id":"https://openalex.org/keywords/il-17a","display_name":"IL-17A","score":0.9649999737739563},{"id":"https://openalex.org/keywords/t-cell-metabolism","display_name":"T cell metabolism","score":0.7300000190734863},{"id":"https://openalex.org/keywords/autoimmunity","display_name":"autoimmunity","score":0.6620000004768372},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.7139999866485596}],"concepts":[{"id":"https://openalex.org/C2778486448","wikidata":"https://www.wikidata.org/wiki/Q494066","display_name":"Experimental autoimmune encephalomyelitis","level":3,"score":0.7626000046730042},{"id":"https://openalex.org/C2779075594","wikidata":"https://www.wikidata.org/wiki/Q8084905","display_name":"Autoimmune disease","level":3,"score":0.5285999774932861},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.504800021648407},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.4896000027656555},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.47600001096725464},{"id":"https://openalex.org/C2780640218","wikidata":"https://www.wikidata.org/wiki/Q8277","display_name":"Multiple sclerosis","level":2,"score":0.45660001039505005},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4528000056743622},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.4124999940395355},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4097999930381775},{"id":"https://openalex.org/C47348012","wikidata":"https://www.wikidata.org/wiki/Q99486570","display_name":"Interleukin 17","level":3,"score":0.4000000059604645},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.39340001344680786},{"id":"https://openalex.org/C95862172","wikidata":"https://www.wikidata.org/wiki/Q9032597","display_name":"Myelopoiesis","level":4,"score":0.3864000141620636},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.3864000141620636},{"id":"https://openalex.org/C2779727006","wikidata":"https://www.wikidata.org/wiki/Q426188","display_name":"FOXP3","level":3,"score":0.382999986410141},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.37549999356269836},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.36820000410079956},{"id":"https://openalex.org/C2776985911","wikidata":"https://www.wikidata.org/wiki/Q916698","display_name":"Oligodendrocyte","level":4,"score":0.3598000109195709},{"id":"https://openalex.org/C2779357208","wikidata":"https://www.wikidata.org/wiki/Q6947292","display_name":"Myelin oligodendrocyte glycoprotein","level":4,"score":0.35690000653266907},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.34940001368522644},{"id":"https://openalex.org/C129374314","wikidata":"https://www.wikidata.org/wiki/Q909381","display_name":"Interleukin 21","level":4,"score":0.34439998865127563},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.33719998598098755},{"id":"https://openalex.org/C2780130043","wikidata":"https://www.wikidata.org/wiki/Q192360","display_name":"Autoimmunity","level":3,"score":0.30660000443458557},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.30480000376701355},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.3010999858379364},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.2994000017642975},{"id":"https://openalex.org/C120642132","wikidata":"https://www.wikidata.org/wiki/Q14907110","display_name":"ZAP70","level":5,"score":0.2955000102519989},{"id":"https://openalex.org/C24586158","wikidata":"https://www.wikidata.org/wiki/Q27075","display_name":"Mitochondrial DNA","level":3,"score":0.2906999886035919},{"id":"https://openalex.org/C67662055","wikidata":"https://www.wikidata.org/wiki/Q1047791","display_name":"Antigen-presenting cell","level":4,"score":0.29030001163482666},{"id":"https://openalex.org/C79484868","wikidata":"https://www.wikidata.org/wiki/Q5971673","display_name":"IL-2 receptor","level":4,"score":0.28029999136924744},{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.27790001034736633},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.2770000100135803},{"id":"https://openalex.org/C2777106986","wikidata":"https://www.wikidata.org/wiki/Q1495005","display_name":"Copper deficiency","level":3,"score":0.26919999718666077},{"id":"https://openalex.org/C2777899865","wikidata":"https://www.wikidata.org/wiki/Q1634879","display_name":"Encephalomyelitis","level":3,"score":0.2687000036239624},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.2635999917984009},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.25999999046325684},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.2554999887943268},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.2549999952316284},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.2529999911785126}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.64898/2026.09.22.747582","doi":"https://doi.org/10.64898/2026.09.22.747582","is_oa":false,"landing_page_url":"https://doi.org/10.64898/2026.09.22.747582","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:42856209","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42856209","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13648362","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13648362/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:13648362","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13648362/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":72,"referenced_works":["https://openalex.org/W1862295486","https://openalex.org/W1892007280","https://openalex.org/W1982947106","https://openalex.org/W1999768705","https://openalex.org/W2006138834","https://openalex.org/W2010355719","https://openalex.org/W2014912105","https://openalex.org/W2015412201","https://openalex.org/W2019870906","https://openalex.org/W2021340905","https://openalex.org/W2035618305","https://openalex.org/W2036012609","https://openalex.org/W2040151622","https://openalex.org/W2047604395","https://openalex.org/W2061662711","https://openalex.org/W2079248963","https://openalex.org/W2089597510","https://openalex.org/W2112237268","https://openalex.org/W2118310701","https://openalex.org/W2123879187","https://openalex.org/W2131271579","https://openalex.org/W2131860315","https://openalex.org/W2133300386","https://openalex.org/W2136648876","https://openalex.org/W2140198501","https://openalex.org/W2147846966","https://openalex.org/W2148904280","https://openalex.org/W2150264392","https://openalex.org/W2164819852","https://openalex.org/W2170551349","https://openalex.org/W2170830174","https://openalex.org/W2171808845","https://openalex.org/W2179438025","https://openalex.org/W2214074259","https://openalex.org/W2343452853","https://openalex.org/W2411886515","https://openalex.org/W2513778339","https://openalex.org/W2607349616","https://openalex.org/W2623907055","https://openalex.org/W2761049646","https://openalex.org/W2896329144","https://openalex.org/W2909014200","https://openalex.org/W2914840597","https://openalex.org/W2921400210","https://openalex.org/W2923540984","https://openalex.org/W2951924500","https://openalex.org/W2982684621","https://openalex.org/W3004655368","https://openalex.org/W3006552983","https://openalex.org/W3011699272","https://openalex.org/W3016501710","https://openalex.org/W3045677734","https://openalex.org/W3045910546","https://openalex.org/W3092457640","https://openalex.org/W3174978055","https://openalex.org/W3191173883","https://openalex.org/W3194040044","https://openalex.org/W4220656004","https://openalex.org/W4220784483","https://openalex.org/W4283395007","https://openalex.org/W4297497349","https://openalex.org/W4306641898","https://openalex.org/W4313528847","https://openalex.org/W4367049738","https://openalex.org/W4400455611","https://openalex.org/W4404654268","https://openalex.org/W4411472705","https://openalex.org/W4413865457","https://openalex.org/W4414085900","https://openalex.org/W4417321333","https://openalex.org/W7118715453","https://openalex.org/W7148679307"],"related_works":["https://openalex.org/W7171550444","https://openalex.org/W4416448948","https://openalex.org/W3204104915","https://openalex.org/W2019535767","https://openalex.org/W2976117258","https://openalex.org/W2273198103","https://openalex.org/W2109737182","https://openalex.org/W2169701358","https://openalex.org/W6908502631","https://openalex.org/W7148679307"],"abstract_inverted_index":{"ABSTRACT":[0],"Pathogenic":[1],"T":[2,15,27,33,72,120,138,192,210,222,229,259],"helper":[3],"17":[4,29,38,78,159,186,200,212,272],"(pT":[5],"H":[6,28,34,37,77,158,185,199,211,271,291],"17)":[7],"cells":[8,16,30,139,160,193],"are":[9,86,127],"a":[10,189,266,277],"subset":[11],"of":[12,95,113,117,133,156,205,209,218,232,249,255,269],"CD4":[13,70,136,220,257],"+":[14,71,137,221,258],"driving":[17],"autoimmune":[18,245],"diseases":[19],"including":[20],"multiple":[21],"sclerosis":[22],"(MS).":[23],"Compared":[24],"to":[25,88,100,107,167],"homeostatic":[26],"and":[31,43,51,75,81,103,123,147,170,207,274,286],"other":[32,219],"subsets,":[35],"pT":[36,76,157,184,198,270,290],"have":[39],"enhanced":[40],"mitochondrial":[41,145],"function":[42,122],"oxidative":[44],"phosphorylation":[45],"(OXPHOS)":[46],"that":[47,131],"supports":[48],"their":[49],"differentiation":[50,80,196,217,273],"pathogenic":[52],"function.":[53,82],"Here":[54],"we":[55],"identify":[56],"Copper":[57],"Transporter":[58],"1":[59],"(CTR1),":[60],"encoded":[61],"by":[62,161,251],"Slc31a1,":[63],"as":[64,265],"essential":[65,182],"for":[66,178,183],"copper":[67,84,105,118,142,264,283],"uptake":[68],"in":[69,91,110,125,135,242],"cells,":[73,201],"OXPHOS":[74],"cell":[79,121,223],"While":[83],"levels":[85],"known":[87],"be":[89],"higher":[90],"the":[92,115,153,216,243],"cerebrospinal":[93],"fluid":[94],"patients":[96],"with":[97,202],"MS":[98,126,250],"compared":[99],"healthy":[101],"individuals,":[102],"excess":[104],"contributes":[106],"oligodendrocyte":[108],"loss":[109],"murine":[111],"models":[112],"MS,":[114],"effect":[116],"on":[119],"pathogenicity":[124],"unclear.":[128],"We":[129],"demonstrate":[130],"deletion":[132,231],"Slc31a1":[134,233],"decreased":[140,203],"intracellular":[141],"levels,":[143],"disrupting":[144],"respiration":[146],"rewiring":[148],"metabolism.":[149],"These":[150,261],"changes":[151],"altered":[152,171],"epigenetic":[154,287],"landscape":[155],"impairing":[162],"DNA":[163,169],"demethylation":[164],"capacity,":[165],"leading":[166],"hypermethylated":[168],"chromatin":[172],"accessibility":[173],"at":[174],"key":[175],"binding":[176],"sites":[177],"AP-1":[179],"transcription":[180],"factors":[181],"differentiation.":[187],"As":[188],"result,":[190],"CTR1-deficient":[191],"showed":[194],"defective":[195],"into":[197],"production":[204],"IL-17A":[206],"expression":[208],"signature":[213],"genes,":[214],"while":[215],"subsets":[224],"remained":[225],"largely":[226],"unaffected.":[227],"Moreover,":[228],"cell-specific":[230],"protected":[234],"mice":[235],"from":[236],"central":[237],"nervous":[238],"system":[239],"(CNS)":[240],"inflammation":[241],"experimental":[244],"encephalomyelitis":[246],"(EAE)":[247],"model":[248],"suppressing":[252],"clonal":[253],"expansion":[254],"autoreactive":[256],"cells.":[260],"findings":[262],"establish":[263],"critical":[267],"regulator":[268],"function,":[275],"revealing":[276],"previously":[278],"unknown":[279],"molecular":[280],"link":[281],"between":[282],"homeostasis,":[284],"metabolism":[285],"regulation":[288],"governing":[289],"17-mediated":[292],"autoimmunity.":[293]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2026-09-29T00:00:00"}