{"id":"https://openalex.org/W7214548853","doi":"https://doi.org/10.64898/2026.09.24.754042","title":"Targeted CRISPRi screening reveals unexpected resilience across the RNA polymerase III transcriptome","display_name":"Targeted CRISPRi screening reveals unexpected resilience across the RNA polymerase III transcriptome","publication_year":2026,"publication_date":"2026-09-27","ids":{"openalex":"https://openalex.org/W7214548853","doi":"https://doi.org/10.64898/2026.09.24.754042"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.24.754042","doi":"https://doi.org/10.64898/2026.09.24.754042","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.24.754042","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/27/2026.09.24.754042.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/27/2026.09.24.754042.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5106649718","display_name":"Boris Simeonov","orcid":"https://orcid.org/0009-0000-4771-1019","observed_orcids":["https://orcid.org/0009-0000-4771-1019"]},"institutions":[{"id":"https://openalex.org/I4210151833","display_name":"Amsterdam University Medical Centers","ror":"https://ror.org/05grdyy37","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833"]},{"id":"https://openalex.org/I4387152927","display_name":"Cancer Center Amsterdam","ror":"https://ror.org/0286p1c86","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4387152927"]},{"id":"https://openalex.org/I865915315","display_name":"Vrije Universiteit Amsterdam","ror":"https://ror.org/008xxew50","country_code":"NL","type":"education","lineage":["https://openalex.org/I865915315"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Boris Simeonov","raw_affiliation_strings":["Cancer Center Amsterdam, Cancer Biology and Immunology, Amsterdam UMC, Amsterdam, The Netherlands","Department of Neurosurgery, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands"],"raw_orcid":"https://orcid.org/0009-0000-4771-1019","affiliations":[{"raw_affiliation_string":"Cancer Center Amsterdam, Cancer Biology and Immunology, Amsterdam UMC, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I4210151833","https://openalex.org/I4387152927"]},{"raw_affiliation_string":"Department of Neurosurgery, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I4210151833","https://openalex.org/I865915315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5153133641","display_name":"Zeynep Veryeri","orcid":"https://orcid.org/0009-0004-7804-6647","observed_orcids":["https://orcid.org/0009-0004-7804-6647"]},"institutions":[{"id":"https://openalex.org/I4210151833","display_name":"Amsterdam University Medical Centers","ror":"https://ror.org/05grdyy37","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833"]},{"id":"https://openalex.org/I4387152927","display_name":"Cancer Center Amsterdam","ror":"https://ror.org/0286p1c86","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4387152927"]},{"id":"https://openalex.org/I865915315","display_name":"Vrije Universiteit Amsterdam","ror":"https://ror.org/008xxew50","country_code":"NL","type":"education","lineage":["https://openalex.org/I865915315"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Zeynep Veryeri","raw_affiliation_strings":["Cancer Center Amsterdam, Cancer Biology and Immunology, Amsterdam UMC, Amsterdam, The Netherlands","Department of Neurosurgery, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands"],"raw_orcid":"https://orcid.org/0009-0004-7804-6647","affiliations":[{"raw_affiliation_string":"Cancer Center Amsterdam, Cancer Biology and Immunology, Amsterdam UMC, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I4210151833","https://openalex.org/I4387152927"]},{"raw_affiliation_string":"Department of Neurosurgery, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I4210151833","https://openalex.org/I865915315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5153085079","display_name":"Yvette Faas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210151833","display_name":"Amsterdam University Medical Centers","ror":"https://ror.org/05grdyy37","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833"]},{"id":"https://openalex.org/I4387152927","display_name":"Cancer Center Amsterdam","ror":"https://ror.org/0286p1c86","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4387152927"]},{"id":"https://openalex.org/I865915315","display_name":"Vrije Universiteit Amsterdam","ror":"https://ror.org/008xxew50","country_code":"NL","type":"education","lineage":["https://openalex.org/I865915315"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Yvette Faas","raw_affiliation_strings":["Cancer Center Amsterdam, Cancer Biology and Immunology, Amsterdam UMC, Amsterdam, The Netherlands","Department of Neurosurgery, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Center Amsterdam, Cancer Biology and Immunology, Amsterdam UMC, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I4210151833","https://openalex.org/I4387152927"]},{"raw_affiliation_string":"Department of Neurosurgery, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I4210151833","https://openalex.org/I865915315"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039514008","display_name":"Alan Gerber","orcid":"https://orcid.org/0000-0003-3909-3606","observed_orcids":["https://orcid.org/0000-0003-3909-3606"]},"institutions":[{"id":"https://openalex.org/I4210151833","display_name":"Amsterdam University Medical Centers","ror":"https://ror.org/05grdyy37","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833"]},{"id":"https://openalex.org/I4387152927","display_name":"Cancer Center Amsterdam","ror":"https://ror.org/0286p1c86","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4387152927"]},{"id":"https://openalex.org/I865915315","display_name":"Vrije Universiteit Amsterdam","ror":"https://ror.org/008xxew50","country_code":"NL","type":"education","lineage":["https://openalex.org/I865915315"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Alan Gerber","raw_affiliation_strings":["Cancer Center Amsterdam, Cancer Biology and Immunology, Amsterdam UMC, Amsterdam, The Netherlands","Department of Neurosurgery, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands"],"raw_orcid":"https://orcid.org/0000-0003-3909-3606","affiliations":[{"raw_affiliation_string":"Cancer Center Amsterdam, Cancer Biology and Immunology, Amsterdam UMC, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I4210151833","https://openalex.org/I4387152927"]},{"raw_affiliation_string":"Department of Neurosurgery, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I4210151833","https://openalex.org/I865915315"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5039514008"],"corresponding_institution_ids":["https://openalex.org/I4210151833","https://openalex.org/I4387152927","https://openalex.org/I865915315"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.4702000021934509,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.4702000021934509,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10878","display_name":"CRISPR and Genetic Engineering","score":0.23399999737739563,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.13510000705718994,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rna-polymerase-iii","display_name":"RNA polymerase III","score":0.9980000257492065},{"id":"https://openalex.org/keywords/trna-genes","display_name":"tRNA genes","score":0.7200000286102295},{"id":"https://openalex.org/keywords/crispr-interference","display_name":"CRISPR interference","score":0.8659999966621399},{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.6990000009536743},{"id":"https://openalex.org/keywords/trna-pool","display_name":"tRNA pool","score":0.5040000081062317},{"id":"https://openalex.org/keywords/cellular-fitness","display_name":"cell fitness","score":0.6520000100135803},{"id":"https://openalex.org/keywords/hek293t-cells","display_name":"HEK293T cells","score":0.8040000200271606},{"id":"https://openalex.org/keywords/diploid-fibroblasts","display_name":"diploid fibroblasts","score":0.9419999718666077}],"concepts":[{"id":"https://openalex.org/C70916841","wikidata":"https://www.wikidata.org/wiki/Q3501658","display_name":"RNA polymerase III","level":5,"score":0.8690000176429749},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7174000144004822},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.640500009059906},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.6205000281333923},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5703999996185303},{"id":"https://openalex.org/C166703698","wikidata":"https://www.wikidata.org/wiki/Q201993","display_name":"RNA interference","level":4,"score":0.5077999830245972},{"id":"https://openalex.org/C64350747","wikidata":"https://www.wikidata.org/wiki/Q15334993","display_name":"RNA polymerase II","level":5,"score":0.46209999918937683},{"id":"https://openalex.org/C186310378","wikidata":"https://www.wikidata.org/wiki/Q941796","display_name":"Psychological repression","level":4,"score":0.4571000039577484},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.43619999289512634},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.41499999165534973},{"id":"https://openalex.org/C153957851","wikidata":"https://www.wikidata.org/wiki/Q201448","display_name":"Transfer RNA","level":4,"score":0.39809998869895935},{"id":"https://openalex.org/C2776449523","wikidata":"https://www.wikidata.org/wiki/Q272631","display_name":"RNA polymerase","level":4,"score":0.3871000111103058},{"id":"https://openalex.org/C82381507","wikidata":"https://www.wikidata.org/wiki/Q416878","display_name":"Polymerase","level":3,"score":0.37380000948905945},{"id":"https://openalex.org/C98108389","wikidata":"https://www.wikidata.org/wiki/Q412563","display_name":"CRISPR","level":3,"score":0.34119999408721924},{"id":"https://openalex.org/C190232843","wikidata":"https://www.wikidata.org/wiki/Q1950808","display_name":"Small hairpin RNA","level":4,"score":0.328000009059906},{"id":"https://openalex.org/C2191507","wikidata":"https://www.wikidata.org/wiki/Q7277185","display_name":"RNA silencing","level":5,"score":0.326200008392334},{"id":"https://openalex.org/C25281209","wikidata":"https://www.wikidata.org/wiki/Q3502188","display_name":"RNA polymerase I","level":5,"score":0.31850001215934753},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.3107999861240387},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.30869999527931213},{"id":"https://openalex.org/C174510640","wikidata":"https://www.wikidata.org/wiki/Q489618","display_name":"HEK 293 cells","level":3,"score":0.2838999927043915},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.27799999713897705},{"id":"https://openalex.org/C67585878","wikidata":"https://www.wikidata.org/wiki/Q7243183","display_name":"Primary transcript","level":5,"score":0.2754000127315521},{"id":"https://openalex.org/C199216141","wikidata":"https://www.wikidata.org/wiki/Q4995178","display_name":"Conserved sequence","level":4,"score":0.2736999988555908},{"id":"https://openalex.org/C131140672","wikidata":"https://www.wikidata.org/wiki/Q2031164","display_name":"Processivity","level":4,"score":0.26409998536109924},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.25999999046325684},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.2513999938964844}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.09.24.754042","doi":"https://doi.org/10.64898/2026.09.24.754042","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.24.754042","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/27/2026.09.24.754042.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.09.24.754042","doi":"https://doi.org/10.64898/2026.09.24.754042","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.24.754042","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/27/2026.09.24.754042.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.5683000087738037,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320319101","display_name":"Amsterdam University Medical Centers","ror":"https://ror.org/05grdyy37"},{"id":"https://openalex.org/F4320321800","display_name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","ror":"https://ror.org/04jsz6e67"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7214548853.pdf","grobid_xml":"https://content.openalex.org/works/W7214548853.grobid-xml"},"referenced_works_count":61,"referenced_works":["https://openalex.org/W1932665887","https://openalex.org/W1973260880","https://openalex.org/W1984783168","https://openalex.org/W2001222172","https://openalex.org/W2013690770","https://openalex.org/W2049579102","https://openalex.org/W2087936477","https://openalex.org/W2094355872","https://openalex.org/W2095236772","https://openalex.org/W2100122648","https://openalex.org/W2104088469","https://openalex.org/W2131105865","https://openalex.org/W2131395804","https://openalex.org/W2145957078","https://openalex.org/W2154608547","https://openalex.org/W2154759788","https://openalex.org/W2161340657","https://openalex.org/W2167279371","https://openalex.org/W2223836536","https://openalex.org/W2252568502","https://openalex.org/W2378488822","https://openalex.org/W2399978169","https://openalex.org/W2405180732","https://openalex.org/W2418276263","https://openalex.org/W2523099503","https://openalex.org/W2544093984","https://openalex.org/W2596547449","https://openalex.org/W2614103706","https://openalex.org/W2792897553","https://openalex.org/W2803479625","https://openalex.org/W2878721160","https://openalex.org/W2904226822","https://openalex.org/W2908130330","https://openalex.org/W2911986456","https://openalex.org/W3010125916","https://openalex.org/W3012588995","https://openalex.org/W3017295488","https://openalex.org/W3042910263","https://openalex.org/W3081414515","https://openalex.org/W3114693742","https://openalex.org/W3119263865","https://openalex.org/W3164721363","https://openalex.org/W3176747215","https://openalex.org/W3179871140","https://openalex.org/W3195010157","https://openalex.org/W3198905519","https://openalex.org/W4220777942","https://openalex.org/W4281696950","https://openalex.org/W4282914538","https://openalex.org/W4293574566","https://openalex.org/W4315796829","https://openalex.org/W4321445749","https://openalex.org/W4366271416","https://openalex.org/W4387450879","https://openalex.org/W4390663488","https://openalex.org/W4393086358","https://openalex.org/W4406380891","https://openalex.org/W4412993424","https://openalex.org/W4416983933","https://openalex.org/W7118173082","https://openalex.org/W7155082806"],"related_works":["https://openalex.org/W4413902210","https://openalex.org/W2134320468","https://openalex.org/W4391664855","https://openalex.org/W3010125916","https://openalex.org/W4282048623","https://openalex.org/W2031136260","https://openalex.org/W2049915175","https://openalex.org/W4417303063","https://openalex.org/W4319656340","https://openalex.org/W1967385251"],"abstract_inverted_index":{"Summary":[0],"Increased":[1],"RNA":[2,58],"polymerase":[3],"III":[4,25,70,77,108,113,131,143,158,190],"(Pol":[5],"III)":[6],"activity":[7],"and":[8,27,54,68,82,110,133,145,177,192],"tRNA":[9,89,164,172],"abundance":[10],"are":[11],"widely":[12],"linked":[13],"to":[14,35,102,161],"cancer":[15],"cell":[16],"growth,":[17],"yet":[18],"the":[19,36,92,162],"functional":[20,153,169],"requirement":[21],"for":[22,125],"individual":[23,106,156],"Pol":[24,65,69,76,107,112,130,142,157,189],"genes":[26,67,90,109,132,144,173,191],"core":[28,111],"components":[29],"remains":[30],"unclear,":[31],"in":[32,79],"part":[33],"due":[34],"difficulty":[37],"of":[38,42,64,104,128,141,155,188],"achieving":[39],"gene-specific":[40,62,126],"perturbation":[41,140,187],"highly":[43],"conserved":[44,129],"loci.":[45],"Here,":[46],"we":[47],"developed":[48],"an":[49],"inducible":[50],"CRISPR":[51],"interference":[52],"platform":[53],"a":[55,122],"custom":[56],"single-guide":[57],"(sgRNA)":[59],"library":[60,151],"enabling":[61],"targeting":[63],"III-transcribed":[66],"machinery.":[71,146,193],"Genome-wide":[72],"screening":[73],"identified":[74],"several":[75],"dependencies":[78],"diploid":[80],"fibroblasts":[81],"HEK293T":[83],"cells,":[84],"including":[85],"multiple":[86],"initiator":[87],"methionine":[88],"among":[91],"strongest":[93],"fitness":[94],"dependencies.":[95],"Unexpectedly,":[96],"glioblastoma":[97,136],"models":[98,137,184],"remained":[99],"largely":[100],"insensitive":[101],"repression":[103],"both":[105],"components,":[114],"despite":[115],"efficient":[116],"target":[117],"repression.":[118],"These":[119],"findings":[120],"establish":[121],"general":[123],"strategy":[124],"interrogation":[127,154],"indicate":[134],"that":[135],"tolerate":[138,185],"extensive":[139,186],"Highlights":[147],"A":[148],"genome-wide":[149],"CRISPRi":[150],"enables":[152],"genes.":[159],"Contribution":[160],"mature":[163],"pool":[165],"does":[166],"not":[167],"predict":[168],"requirement.":[170],"Individual":[171],"exhibit":[174],"context-dependent":[175],"effects":[176,179],"opposing":[178],"on":[180],"cellular":[181],"fitness.":[182],"Glioblastoma":[183]},"counts_by_year":[],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2026-09-28T00:00:00"}
