{"id":"https://openalex.org/W7214548366","doi":"https://doi.org/10.1002/sscp.70315","title":"Integrated High\u2010Performance Liquid Chromatography, Gas Chromatography\u2010Mass Spectrometry and Liquid Chromatography\u2010Tandem Mass Spectrometry\u2010Based Metabolomics of Bacopa monnieri : Chemometric Insights Into Bioactive Marker Compounds","display_name":"Integrated High\u2010Performance Liquid Chromatography, Gas Chromatography\u2010Mass Spectrometry and Liquid Chromatography\u2010Tandem Mass Spectrometry\u2010Based Metabolomics of Bacopa monnieri : Chemometric Insights Into Bioactive Marker Compounds","publication_year":2026,"publication_date":"2026-09-01","ids":{"openalex":"https://openalex.org/W7214548366","doi":"https://doi.org/10.1002/sscp.70315"},"language":"en","primary_location":{"id":"doi:10.1002/sscp.70315","doi":"https://doi.org/10.1002/sscp.70315","is_oa":true,"landing_page_url":"https://doi.org/10.1002/sscp.70315","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/sscp.70315","source":{"id":"https://openalex.org/S4210212791","display_name":"Separation Science Plus","issn_l":"2573-1815","issn":["2573-1815"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","norway-1","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SEPARATION SCIENCE PLUS","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/sscp.70315","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049770643","display_name":"Ravi Prakash Jaiswal","orcid":"https://orcid.org/0000-0002-1862-8678","observed_orcids":["https://orcid.org/0000-0002-1862-8678"]},"institutions":[{"id":"https://openalex.org/I4210093971","display_name":"Dabur (India)","ror":"https://ror.org/00pmgap74","country_code":"IN","type":"company","lineage":["https://openalex.org/I4210093971"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Ravi Prakash Jaiswal","raw_affiliation_strings":["Dabur Research and Development Centre Dabur India Limited  Ghaziabad India"],"raw_orcid":"https://orcid.org/0000-0002-1862-8678","affiliations":[{"raw_affiliation_string":"Dabur Research and Development Centre Dabur India Limited  Ghaziabad India","institution_ids":["https://openalex.org/I4210093971"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5153080253","display_name":"Imran Khan","orcid":"https://orcid.org/0009-0000-7217-4841","observed_orcids":["https://orcid.org/0009-0000-7217-4841"]},"institutions":[{"id":"https://openalex.org/I4210093971","display_name":"Dabur (India)","ror":"https://ror.org/00pmgap74","country_code":"IN","type":"company","lineage":["https://openalex.org/I4210093971"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Imran Khan","raw_affiliation_strings":["Dabur Research and Development Centre Dabur India Limited  Ghaziabad India"],"raw_orcid":"https://orcid.org/0009-0000-7217-4841","affiliations":[{"raw_affiliation_string":"Dabur Research and Development Centre Dabur India Limited  Ghaziabad India","institution_ids":["https://openalex.org/I4210093971"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044982898","display_name":"Anubhuti Pasrija","orcid":"https://orcid.org/0000-0003-2740-0664","observed_orcids":["https://orcid.org/0000-0003-2740-0664"]},"institutions":[{"id":"https://openalex.org/I4210093971","display_name":"Dabur (India)","ror":"https://ror.org/00pmgap74","country_code":"IN","type":"company","lineage":["https://openalex.org/I4210093971"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Anubhuti Pasrija","raw_affiliation_strings":["Dabur Research and Development Centre Dabur India Limited  Ghaziabad India"],"raw_orcid":"https://orcid.org/0000-0003-2740-0664","affiliations":[{"raw_affiliation_string":"Dabur Research and Development Centre Dabur India Limited  Ghaziabad India","institution_ids":["https://openalex.org/I4210093971"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086817041","display_name":"Baidyanath Mishra","orcid":"https://orcid.org/0000-0003-4327-5795","observed_orcids":["https://orcid.org/0000-0003-4327-5795","https://orcid.org/0009-0006-5601-8607"]},"institutions":[{"id":"https://openalex.org/I4210093971","display_name":"Dabur (India)","ror":"https://ror.org/00pmgap74","country_code":"IN","type":"company","lineage":["https://openalex.org/I4210093971"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Baidyanath Mishra","raw_affiliation_strings":["Dabur Research and Development Centre Dabur India Limited  Ghaziabad India"],"raw_orcid":"https://orcid.org/0009-0006-5601-8607","affiliations":[{"raw_affiliation_string":"Dabur Research and Development Centre Dabur India Limited  Ghaziabad India","institution_ids":["https://openalex.org/I4210093971"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101878616","display_name":"Pankaj Kumar Gupta","orcid":"https://orcid.org/0009-0002-8829-2935","observed_orcids":["https://orcid.org/0009-0002-8829-2935"]},"institutions":[{"id":"https://openalex.org/I4210093971","display_name":"Dabur (India)","ror":"https://ror.org/00pmgap74","country_code":"IN","type":"company","lineage":["https://openalex.org/I4210093971"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Pankaj Kumar Gupta","raw_affiliation_strings":["Dabur Research and Development Centre Dabur India Limited  Ghaziabad India"],"raw_orcid":"https://orcid.org/0009-0002-8829-2935","affiliations":[{"raw_affiliation_string":"Dabur Research and Development Centre Dabur India Limited  Ghaziabad India","institution_ids":["https://openalex.org/I4210093971"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012867316","display_name":"Ketan Patil","orcid":"https://orcid.org/0000-0002-3815-8685","observed_orcids":["https://orcid.org/0000-0002-3815-8685","https://orcid.org/0009-0009-8487-7232"]},"institutions":[{"id":"https://openalex.org/I4210093971","display_name":"Dabur (India)","ror":"https://ror.org/00pmgap74","country_code":"IN","type":"company","lineage":["https://openalex.org/I4210093971"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Ketan Patil","raw_affiliation_strings":["Dabur Research and Development Centre Dabur India Limited  Ghaziabad India"],"raw_orcid":"https://orcid.org/0009-0009-8487-7232","affiliations":[{"raw_affiliation_string":"Dabur Research and Development Centre Dabur India Limited  Ghaziabad India","institution_ids":["https://openalex.org/I4210093971"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016882417","display_name":"Ranjan Mitra","orcid":"https://orcid.org/0000-0002-9873-0284","observed_orcids":["https://orcid.org/0000-0002-9873-0284"]},"institutions":[{"id":"https://openalex.org/I4210093971","display_name":"Dabur (India)","ror":"https://ror.org/00pmgap74","country_code":"IN","type":"company","lineage":["https://openalex.org/I4210093971"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Ranjan Mitra","raw_affiliation_strings":["Dabur Research and Development Centre Dabur India Limited  Ghaziabad India"],"raw_orcid":"https://orcid.org/0000-0002-9873-0284","affiliations":[{"raw_affiliation_string":"Dabur Research and Development Centre Dabur India Limited  Ghaziabad India","institution_ids":["https://openalex.org/I4210093971"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5016882417","https://openalex.org/A5049770643"],"corresponding_institution_ids":["https://openalex.org/I4210093971"],"apc_list":{"value":3460,"currency":"USD","value_usd":3460},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.72791067,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"9","issue":"9","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12891","display_name":"Medicinal Plants and Neuroprotection","score":0.9437999725341797,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12891","display_name":"Medicinal Plants and Neuroprotection","score":0.9437999725341797,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13128","display_name":"Chromatography in Natural Products","score":0.012500000186264515,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12298","display_name":"Phytochemicals and Medicinal Plants","score":0.010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bacopa-monnieri","display_name":"Bacopa monnieri","score":1.0},{"id":"https://openalex.org/keywords/metabolomics","display_name":"metabolomics","score":0.8059999942779541},{"id":"https://openalex.org/keywords/bacosides","display_name":"bacosides","score":0.8399999737739563},{"id":"https://openalex.org/keywords/apigenin","display_name":"apigenin","score":0.9139999747276306},{"id":"https://openalex.org/keywords/luteolin","display_name":"luteolin","score":1.0},{"id":"https://openalex.org/keywords/triterpenoid-saponins","display_name":"triterpenoid saponins","score":0.9440000057220459},{"id":"https://openalex.org/keywords/flavonoids","display_name":"flavonoids","score":0.8610000014305115},{"id":"https://openalex.org/keywords/phytochemical-variability","display_name":"phytochemical variability","score":0.9309999942779541},{"id":"https://openalex.org/keywords/herbal-medicine-quality-control","display_name":"herbal medicine quality control","score":0.49399998784065247},{"id":"https://openalex.org/keywords/geographical-origin-identification","display_name":"geographical origin discrimination","score":0.6579999923706055},{"id":"https://openalex.org/keywords/phytosterols","display_name":"phytosterols","score":0.675000011920929},{"id":"https://openalex.org/keywords/phenolic-compounds","display_name":"phenolic compounds","score":0.6809999942779541},{"id":"https://openalex.org/keywords/metabolic-profiling","display_name":"metabolite profiling","score":0.4650000035762787}],"concepts":[{"id":"https://openalex.org/C2780433948","wikidata":"https://www.wikidata.org/wiki/Q1366575","display_name":"Bacopa monnieri","level":2,"score":0.9864000082015991},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.698199987411499},{"id":"https://openalex.org/C195475562","wikidata":"https://www.wikidata.org/wiki/Q1639139","display_name":"Phytochemical","level":2,"score":0.6147000193595886},{"id":"https://openalex.org/C21565614","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolomics","level":2,"score":0.5995000004768372},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.5503000020980835},{"id":"https://openalex.org/C2778609962","wikidata":"https://www.wikidata.org/wiki/Q424567","display_name":"Apigenin","level":4,"score":0.5209000110626221},{"id":"https://openalex.org/C2776080593","wikidata":"https://www.wikidata.org/wiki/Q415011","display_name":"Luteolin","level":4,"score":0.47609999775886536},{"id":"https://openalex.org/C151304367","wikidata":"https://www.wikidata.org/wiki/Q910067","display_name":"Chemometrics","level":2,"score":0.444599986076355},{"id":"https://openalex.org/C2778711105","wikidata":"https://www.wikidata.org/wiki/Q1767381","display_name":"Flos","level":4,"score":0.43299999833106995},{"id":"https://openalex.org/C22354355","wikidata":"https://www.wikidata.org/wiki/Q422009","display_name":"Partial least squares regression","level":2,"score":0.336899995803833},{"id":"https://openalex.org/C205345274","wikidata":"https://www.wikidata.org/wiki/Q873009","display_name":"Gas chromatography\u2013mass spectrometry","level":3,"score":0.3310000002384186},{"id":"https://openalex.org/C64489805","wikidata":"https://www.wikidata.org/wiki/Q873864","display_name":"Liquid chromatography\u2013mass spectrometry","level":3,"score":0.31779998540878296},{"id":"https://openalex.org/C162356407","wikidata":"https://www.wikidata.org/wiki/Q180809","display_name":"Mass spectrometry","level":2,"score":0.2980000078678131},{"id":"https://openalex.org/C107585567","wikidata":"https://www.wikidata.org/wiki/Q2915788","display_name":"Triterpenoid","level":2,"score":0.29660001397132874},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.2870999872684479},{"id":"https://openalex.org/C2991655182","wikidata":"https://www.wikidata.org/wiki/Q188840","display_name":"Medicinal herbs","level":2,"score":0.2624000012874603},{"id":"https://openalex.org/C2779158651","wikidata":"https://www.wikidata.org/wiki/Q188840","display_name":"Medicinal plants","level":2,"score":0.2563000023365021},{"id":"https://openalex.org/C27438332","wikidata":"https://www.wikidata.org/wiki/Q2873","display_name":"Principal component analysis","level":2,"score":0.2506999969482422},{"id":"https://openalex.org/C44937612","wikidata":"https://www.wikidata.org/wiki/Q212364","display_name":"Terpene","level":2,"score":0.25029999017715454}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1002/sscp.70315","doi":"https://doi.org/10.1002/sscp.70315","is_oa":true,"landing_page_url":"https://doi.org/10.1002/sscp.70315","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/sscp.70315","source":{"id":"https://openalex.org/S4210212791","display_name":"Separation Science Plus","issn_l":"2573-1815","issn":["2573-1815"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","norway-1","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SEPARATION SCIENCE PLUS","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1002/sscp.70315","doi":"https://doi.org/10.1002/sscp.70315","is_oa":true,"landing_page_url":"https://doi.org/10.1002/sscp.70315","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/sscp.70315","source":{"id":"https://openalex.org/S4210212791","display_name":"Separation Science Plus","issn_l":"2573-1815","issn":["2573-1815"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","norway-1","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SEPARATION SCIENCE PLUS","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7214548366.pdf","grobid_xml":"https://content.openalex.org/works/W7214548366.grobid-xml"},"referenced_works_count":25,"referenced_works":["https://openalex.org/W1963487232","https://openalex.org/W1975091355","https://openalex.org/W1994445359","https://openalex.org/W1997607551","https://openalex.org/W2016381774","https://openalex.org/W2033255130","https://openalex.org/W2045145329","https://openalex.org/W2060288971","https://openalex.org/W2062942406","https://openalex.org/W2076656151","https://openalex.org/W2128728535","https://openalex.org/W2155450897","https://openalex.org/W2158531233","https://openalex.org/W2159710124","https://openalex.org/W2169723002","https://openalex.org/W2184653991","https://openalex.org/W2994617569","https://openalex.org/W3006390374","https://openalex.org/W3189925491","https://openalex.org/W4315853375","https://openalex.org/W4406297455","https://openalex.org/W7134164063","https://openalex.org/W7162189526","https://openalex.org/W7203662186","https://openalex.org/W7203792929"],"related_works":["https://openalex.org/W7223016963","https://openalex.org/W2060960573","https://openalex.org/W4416531465","https://openalex.org/W7204270858","https://openalex.org/W1775775705","https://openalex.org/W7220566441","https://openalex.org/W21137212","https://openalex.org/W1868783833","https://openalex.org/W7169842855","https://openalex.org/W7100647335"],"abstract_inverted_index":{"ABSTRACT":[0],"Bacopa":[1,72,226],"monnieri":[2,73,227],"(Brahmi)":[3],"is":[4],"a":[5,22,37,215],"widely":[6],"used":[7],"Ayurvedic":[8],"medicinal":[9],"herb":[10],"valued":[11],"for":[12,84,91,102,124,218],"its":[13,47,229],"cognitive\u2010enhancing":[14],"and":[15,29,69,96,98,118,160,168,195,207,223,228],"neuroprotective":[16],"properties,":[17],"which":[18],"are":[19],"attributed":[20],"to":[21,60,132,142,204],"complex":[23],"mixture":[24],"of":[25,40,94,166,183,225],"triterpenoid":[26],"saponins,":[27],"flavonoids":[28],"other":[30],"phytochemicals.":[31],"Conventional":[32],"quality\u2010control":[33],"approaches":[34],"based":[35],"on":[36],"limited":[38],"number":[39],"marker":[41],"compounds":[42,179],"may":[43],"not":[44],"adequately":[45],"capture":[46],"phytochemical":[48,63],"complexity.":[49],"In":[50],"this":[51],"study,":[52],"an":[53],"integrated":[54,211],"multimodal":[55],"analytical":[56,212],"platform":[57],"was":[58],"developed":[59],"comprehensively":[61],"evaluate":[62],"variability":[64],"among":[65],"cultivated,":[66],"natural":[67],"habitat":[68],"commercially":[70],"available":[71],"samples.":[74],"Hydroalcoholic":[75],"extracts":[76],"were":[77,122],"analysed":[78],"using":[79],"high\u2010performance":[80],"liquid":[81],"chromatography":[82],"(HPLC)":[83],"total":[85,135],"bacoside":[86,136],"quantification,":[87],"LC\u2010tandem":[88],"MS":[89],"(LC\u2010MS/MS)":[90],"targeted":[92],"determination":[93],"apigenin":[95,167],"luteolin":[97,169],"gas":[99],"chromatography\u2010MS":[100],"(GC\u2010MS)":[101],"untargeted":[103],"metabolomic":[104],"profiling.":[105],"Multivariate":[106],"chemometric":[107],"tools,":[108],"including":[109,190],"principal":[110],"component":[111],"analysis,":[112,115],"hierarchical":[113],"cluster":[114],"correlation":[116],"analysis":[117,121],"Venn":[119],"diagram":[120],"employed":[123],"data":[125],"interpretation.":[126],"Extractive":[127],"yields":[128],"ranged":[129],"from":[130,140],"11.83%":[131],"12.85%,":[133],"whereas":[134],"content":[137],"varied":[138],"markedly":[139],"3.15%":[141],"25.25%,":[143],"indicating":[144],"substantial":[145],"source\u2010dependent":[146],"differences.":[147],"The":[148],"validated":[149],"LC\u2010MS/MS":[150],"method":[151],"demonstrated":[152],"excellent":[153],"linearity":[154],"(":[155],"R":[156],"2":[157],"=":[158],"0.997\u20130.998)":[159],"high":[161],"sensitivity,":[162],"revealing":[163],"higher":[164],"concentrations":[165],"in":[170],"in\u2010house":[171],"extracts,":[172],"while":[173],"several":[174],"commercial":[175,230],"samples":[176,202],"contained":[177],"these":[178],"below":[180],"the":[181],"limit":[182],"quantification.":[184],"GC\u2010MS":[185],"profiling":[186],"identified":[187],"diverse":[188],"metabolites,":[189],"triterpenoids,":[191],"phytosterols,":[192],"fatty":[193],"acids":[194],"phenolic":[196],"compounds.":[197],"Chemometric":[198],"analyses":[199],"effectively":[200],"discriminated":[201],"according":[203],"geographical":[205],"origin":[206],"processing":[208],"history.":[209],"This":[210],"strategy":[213],"provides":[214],"robust":[216],"framework":[217],"authenticity":[219],"assessment,":[220],"quality":[221],"evaluation,":[222],"standardization":[224],"preparations.":[231]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2026-09-28T00:00:00"}
