{"id":"https://openalex.org/W7214536850","doi":"https://doi.org/10.64898/2026.09.25.754282","title":"Gasdermin E couples mitochondrial stress to STING-driven neuronal pyroptosis during Chandipura virus encephalitis","display_name":"Gasdermin E couples mitochondrial stress to STING-driven neuronal pyroptosis during Chandipura virus encephalitis","publication_year":2026,"publication_date":"2026-09-27","ids":{"openalex":"https://openalex.org/W7214536850","doi":"https://doi.org/10.64898/2026.09.25.754282"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.25.754282","doi":"https://doi.org/10.64898/2026.09.25.754282","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.25.754282","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/27/2026.09.25.754282.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/27/2026.09.25.754282.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043445246","display_name":"Nripa Kumari","orcid":"https://orcid.org/0009-0006-4502-8877","observed_orcids":["https://orcid.org/0009-0006-4502-8877"]},"institutions":[{"id":"https://openalex.org/I157674215","display_name":"Presidency University","ror":"https://ror.org/04xgbph11","country_code":"IN","type":"education","lineage":["https://openalex.org/I157674215"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Nripa Kumari","raw_affiliation_strings":["Institute of Health Sciences, Presidency University, Canal Bank Rd, DG Block, New Town, Kolkata-700156, West Bengal, India"],"raw_orcid":"https://orcid.org/0009-0006-4502-8877","affiliations":[{"raw_affiliation_string":"Institute of Health Sciences, Presidency University, Canal Bank Rd, DG Block, New Town, Kolkata-700156, West Bengal, India","institution_ids":["https://openalex.org/I157674215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104087259","display_name":"Sourav Dutta","orcid":"https://orcid.org/0000-0002-4409-047X","observed_orcids":["https://orcid.org/0000-0002-4409-047X"]},"institutions":[{"id":"https://openalex.org/I157674215","display_name":"Presidency University","ror":"https://ror.org/04xgbph11","country_code":"IN","type":"education","lineage":["https://openalex.org/I157674215"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sourav Dutta","raw_affiliation_strings":["Institute of Health Sciences, Presidency University, Canal Bank Rd, DG Block, New Town, Kolkata-700156, West Bengal, India"],"raw_orcid":"https://orcid.org/0000-0002-4409-047X","affiliations":[{"raw_affiliation_string":"Institute of Health Sciences, Presidency University, Canal Bank Rd, DG Block, New Town, Kolkata-700156, West Bengal, India","institution_ids":["https://openalex.org/I157674215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5134744662","display_name":"Akasmika Priyadarsani","orcid":"https://orcid.org/0009-0004-6382-3538","observed_orcids":["https://orcid.org/0009-0004-6382-3538"]},"institutions":[{"id":"https://openalex.org/I85332549","display_name":"National Brain Research Centre","ror":"https://ror.org/022swbj46","country_code":"IN","type":"government","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I85332549"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Akasmika Priyadarsini","raw_affiliation_strings":["National Brain Research Centre, Manesar, Haryana-122052, India"],"raw_orcid":"https://orcid.org/0009-0004-6382-3538","affiliations":[{"raw_affiliation_string":"National Brain Research Centre, Manesar, Haryana-122052, India","institution_ids":["https://openalex.org/I85332549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046490901","display_name":"Joyanta Biswas","orcid":"https://orcid.org/0009-0000-5888-7474","observed_orcids":["https://orcid.org/0009-0000-5888-7474","https://orcid.org/0000-0003-3725-2212"]},"institutions":[{"id":"https://openalex.org/I157674215","display_name":"Presidency University","ror":"https://ror.org/04xgbph11","country_code":"IN","type":"education","lineage":["https://openalex.org/I157674215"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Joyanta Biswas","raw_affiliation_strings":["Institute of Health Sciences, Presidency University, Canal Bank Rd, DG Block, New Town, Kolkata-700156, West Bengal, India"],"raw_orcid":"https://orcid.org/0009-0000-5888-7474","affiliations":[{"raw_affiliation_string":"Institute of Health Sciences, Presidency University, Canal Bank Rd, DG Block, New Town, Kolkata-700156, West Bengal, India","institution_ids":["https://openalex.org/I157674215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5153053595","display_name":"Shubhangi Roy","orcid":"https://orcid.org/0009-0008-7300-3022","observed_orcids":["https://orcid.org/0009-0008-7300-3022"]},"institutions":[{"id":"https://openalex.org/I157674215","display_name":"Presidency University","ror":"https://ror.org/04xgbph11","country_code":"IN","type":"education","lineage":["https://openalex.org/I157674215"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Shubhangi Roy","raw_affiliation_strings":["Institute of Health Sciences, Presidency University, Canal Bank Rd, DG Block, New Town, Kolkata-700156, West Bengal, India"],"raw_orcid":"https://orcid.org/0009-0008-7300-3022","affiliations":[{"raw_affiliation_string":"Institute of Health Sciences, Presidency University, Canal Bank Rd, DG Block, New Town, Kolkata-700156, West Bengal, India","institution_ids":["https://openalex.org/I157674215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101746120","display_name":"Suman Samanta","orcid":"https://orcid.org/0009-0002-4741-7842","observed_orcids":["https://orcid.org/0009-0002-4741-7842"]},"institutions":[{"id":"https://openalex.org/I127439422","display_name":"Indian Institute of Science Education and Research Kolkata","ror":"https://ror.org/00djv2c17","country_code":"IN","type":"education","lineage":["https://openalex.org/I127439422"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Suman Samanta","raw_affiliation_strings":["Department of Biological Sciences, Indian Institute of Science Education and Research (IISER) Kolkata, Mohanpur, West Bengal, India"],"raw_orcid":"https://orcid.org/0009-0002-4741-7842","affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Indian Institute of Science Education and Research (IISER) Kolkata, Mohanpur, West Bengal, India","institution_ids":["https://openalex.org/I127439422"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000083049","display_name":"Semanti Chakraborty","orcid":"https://orcid.org/0000-0001-9288-8032","observed_orcids":["https://orcid.org/0000-0001-9288-8032"]},"institutions":[{"id":"https://openalex.org/I157674215","display_name":"Presidency University","ror":"https://ror.org/04xgbph11","country_code":"IN","type":"education","lineage":["https://openalex.org/I157674215"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Semanti Chakraborty","raw_affiliation_strings":["Institute of Health Sciences, Presidency University, Canal Bank Rd, DG Block, New Town, Kolkata-700156, West Bengal, India"],"raw_orcid":"https://orcid.org/0000-0001-9288-8032","affiliations":[{"raw_affiliation_string":"Institute of Health Sciences, Presidency University, Canal Bank Rd, DG Block, New Town, Kolkata-700156, West Bengal, India","institution_ids":["https://openalex.org/I157674215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5146819258","display_name":"Jyotirmoyee Roy","orcid":"https://orcid.org/0009-0004-6964-475X","observed_orcids":["https://orcid.org/0009-0004-6964-475X"]},"institutions":[{"id":"https://openalex.org/I157674215","display_name":"Presidency University","ror":"https://ror.org/04xgbph11","country_code":"IN","type":"education","lineage":["https://openalex.org/I157674215"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Jyotirmoyee Roy","raw_affiliation_strings":["Institute of Health Sciences, Presidency University, Canal Bank Rd, DG Block, New Town, Kolkata-700156, West Bengal, India"],"raw_orcid":"https://orcid.org/0009-0004-6964-475X","affiliations":[{"raw_affiliation_string":"Institute of Health Sciences, Presidency University, Canal Bank Rd, DG Block, New Town, Kolkata-700156, West Bengal, India","institution_ids":["https://openalex.org/I157674215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075526464","display_name":"Anirban Basu","orcid":"https://orcid.org/0000-0002-5200-2054","observed_orcids":["https://orcid.org/0000-0002-5200-2054"]},"institutions":[{"id":"https://openalex.org/I85332549","display_name":"National Brain Research Centre","ror":"https://ror.org/022swbj46","country_code":"IN","type":"government","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I85332549"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Anirban Basu","raw_affiliation_strings":["National Brain Research Centre, Manesar, Haryana-122052, India"],"raw_orcid":"https://orcid.org/0000-0002-5200-2054","affiliations":[{"raw_affiliation_string":"National Brain Research Centre, Manesar, Haryana-122052, India","institution_ids":["https://openalex.org/I85332549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058753331","display_name":"Debanjan Mukhopadhyay","orcid":"https://orcid.org/0000-0002-8921-4106","observed_orcids":["https://orcid.org/0000-0002-8921-4106"]},"institutions":[{"id":"https://openalex.org/I157674215","display_name":"Presidency University","ror":"https://ror.org/04xgbph11","country_code":"IN","type":"education","lineage":["https://openalex.org/I157674215"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Debanjan Mukhopadhyay","raw_affiliation_strings":["Institute of Health Sciences, Presidency University, Canal Bank Rd, DG Block, New Town, Kolkata-700156, West Bengal, India"],"raw_orcid":"https://orcid.org/0000-0002-8921-4106","affiliations":[{"raw_affiliation_string":"Institute of Health Sciences, Presidency University, Canal Bank Rd, DG Block, New Town, Kolkata-700156, West Bengal, India","institution_ids":["https://openalex.org/I157674215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082768696","display_name":"Abhik Saha","orcid":"https://orcid.org/0000-0001-7390-4578","observed_orcids":["https://orcid.org/0000-0001-7390-4578"]},"institutions":[{"id":"https://openalex.org/I157674215","display_name":"Presidency University","ror":"https://ror.org/04xgbph11","country_code":"IN","type":"education","lineage":["https://openalex.org/I157674215"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Abhik Saha","raw_affiliation_strings":["Institute of Health Sciences, Presidency University, Canal Bank Rd, DG Block, New Town, Kolkata-700156, West Bengal, India"],"raw_orcid":"https://orcid.org/0000-0001-7390-4578","affiliations":[{"raw_affiliation_string":"Institute of Health Sciences, Presidency University, Canal Bank Rd, DG Block, New Town, Kolkata-700156, West Bengal, India","institution_ids":["https://openalex.org/I157674215"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017618710","display_name":"Piyali Mukherjee","orcid":"https://orcid.org/0000-0002-0140-7414","observed_orcids":["https://orcid.org/0000-0002-0140-7414"]},"institutions":[{"id":"https://openalex.org/I157674215","display_name":"Presidency University","ror":"https://ror.org/04xgbph11","country_code":"IN","type":"education","lineage":["https://openalex.org/I157674215"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Piyali Mukherjee","raw_affiliation_strings":["Institute of Health Sciences, Presidency University, Canal Bank Rd, DG Block, New Town, Kolkata-700156, West Bengal, India"],"raw_orcid":"https://orcid.org/0000-0002-0140-7414","affiliations":[{"raw_affiliation_string":"Institute of Health Sciences, Presidency University, Canal Bank Rd, DG Block, New Town, Kolkata-700156, West Bengal, India","institution_ids":["https://openalex.org/I157674215"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5017618710"],"corresponding_institution_ids":["https://openalex.org/I157674215"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.8711000084877014,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.8711000084877014,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11078","display_name":"Inflammasome and immune disorders","score":0.11490000039339066,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11135","display_name":"Virology and Viral Diseases","score":0.004000000189989805,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chandipura-virus","display_name":"Chandipura virus","score":0.9879999756813049},{"id":"https://openalex.org/keywords/neuronal-pyroptosis","display_name":"neuronal pyroptosis","score":0.8550000190734863},{"id":"https://openalex.org/keywords/gasdermin-e","display_name":"gasdermin E","score":0.8970000147819519},{"id":"https://openalex.org/keywords/sting","display_name":"STING","score":0.8629999756813049},{"id":"https://openalex.org/keywords/mitochondrial-stress","display_name":"mitochondrial stress","score":0.8330000042915344},{"id":"https://openalex.org/keywords/mavs","display_name":"MAVS","score":0.8600000143051147},{"id":"https://openalex.org/keywords/mitochondrial-antiviral-signaling","display_name":"mitochondrial antiviral signaling","score":0.7350000143051147},{"id":"https://openalex.org/keywords/mitochondrial-ros","display_name":"mitochondrial reactive oxygen species","score":0.6579999923706055},{"id":"https://openalex.org/keywords/mtdna-release","display_name":"mtDNA release","score":0.8880000114440918},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.9020000100135803},{"id":"https://openalex.org/keywords/interferon-inhibition","display_name":"interferon inhibition","score":0.5889999866485596},{"id":"https://openalex.org/keywords/viral-immune-evasion","display_name":"viral immune evasion","score":0.7149999737739563},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.5260000228881836}],"concepts":[{"id":"https://openalex.org/C17172800","wikidata":"https://www.wikidata.org/wiki/Q7263707","display_name":"Pyroptosis","level":4,"score":0.8302000164985657},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7271999716758728},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5873000025749207},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.5504000186920166},{"id":"https://openalex.org/C87753298","wikidata":"https://www.wikidata.org/wiki/Q17157137","display_name":"Neuroinflammation","level":3,"score":0.5457000136375427},{"id":"https://openalex.org/C2776178377","wikidata":"https://www.wikidata.org/wiki/Q188269","display_name":"Interferon","level":2,"score":0.5392000079154968},{"id":"https://openalex.org/C2779734145","wikidata":"https://www.wikidata.org/wiki/Q3053951","display_name":"Viral encephalitis","level":4,"score":0.5005999803543091},{"id":"https://openalex.org/C2778529815","wikidata":"https://www.wikidata.org/wiki/Q3560951","display_name":"Neurotropic virus","level":3,"score":0.49779999256134033},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.46070000529289246},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.4569000005722046},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.44609999656677246},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.44429999589920044},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.41359999775886536},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.3935999870300293},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.38670000433921814},{"id":"https://openalex.org/C83455156","wikidata":"https://www.wikidata.org/wiki/Q199615","display_name":"Encephalitis","level":3,"score":0.3707999885082245},{"id":"https://openalex.org/C2778278966","wikidata":"https://www.wikidata.org/wiki/Q6046488","display_name":"Interferon type I","level":3,"score":0.3398999869823456},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.3294000029563904},{"id":"https://openalex.org/C2777209026","wikidata":"https://www.wikidata.org/wiki/Q412405","display_name":"Inflammasome","level":3,"score":0.31279999017715454},{"id":"https://openalex.org/C2779300339","wikidata":"https://www.wikidata.org/wiki/Q7617409","display_name":"Sting","level":2,"score":0.3093000054359436},{"id":"https://openalex.org/C2779324830","wikidata":"https://www.wikidata.org/wiki/Q1806192","display_name":"Mitophagy","level":4,"score":0.29440000653266907},{"id":"https://openalex.org/C187831198","wikidata":"https://www.wikidata.org/wiki/Q18034187","display_name":"AIM2","level":4,"score":0.2930000126361847},{"id":"https://openalex.org/C166703698","wikidata":"https://www.wikidata.org/wiki/Q201993","display_name":"RNA interference","level":4,"score":0.28949999809265137},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.2847000062465668},{"id":"https://openalex.org/C2779830541","wikidata":"https://www.wikidata.org/wiki/Q1622829","display_name":"Microglia","level":3,"score":0.2728999853134155},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.2703999876976013},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.260699987411499},{"id":"https://openalex.org/C2779174946","wikidata":"https://www.wikidata.org/wiki/Q751911","display_name":"RNA virus","level":4,"score":0.2500999867916107}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.09.25.754282","doi":"https://doi.org/10.64898/2026.09.25.754282","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.25.754282","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/27/2026.09.25.754282.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.09.25.754282","doi":"https://doi.org/10.64898/2026.09.25.754282","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.25.754282","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/27/2026.09.25.754282.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306227","display_name":"Arthritis National Research Foundation","ror":"https://ror.org/03abbex33"},{"id":"https://openalex.org/F4320320671","display_name":"National Research Foundation","ror":"https://ror.org/05s0g1g46"},{"id":"https://openalex.org/F4320326593","display_name":"Indian Institute of Science Education and Research Bhopal","ror":"https://ror.org/02rb21j89"},{"id":"https://openalex.org/F4320327686","display_name":"Presidency University","ror":"https://ror.org/04xgbph11"},{"id":"https://openalex.org/F4320327976","display_name":"Indian Institute of Science Education and Research Kolkata","ror":"https://ror.org/00djv2c17"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7214536850.pdf","grobid_xml":"https://content.openalex.org/works/W7214536850.grobid-xml"},"referenced_works_count":76,"referenced_works":["https://openalex.org/W343513958","https://openalex.org/W1534477124","https://openalex.org/W1776390480","https://openalex.org/W1985970823","https://openalex.org/W2004826140","https://openalex.org/W2014960200","https://openalex.org/W2034387476","https://openalex.org/W2049263535","https://openalex.org/W2081983232","https://openalex.org/W2086050354","https://openalex.org/W2098345971","https://openalex.org/W2098464555","https://openalex.org/W2099003198","https://openalex.org/W2111907482","https://openalex.org/W2148985310","https://openalex.org/W2175794645","https://openalex.org/W2216324555","https://openalex.org/W2300023009","https://openalex.org/W2314710072","https://openalex.org/W2578052194","https://openalex.org/W2608687752","https://openalex.org/W2767451245","https://openalex.org/W2793707549","https://openalex.org/W2805118976","https://openalex.org/W2810037075","https://openalex.org/W2893140873","https://openalex.org/W2936083981","https://openalex.org/W2941734675","https://openalex.org/W2943789579","https://openalex.org/W2967505920","https://openalex.org/W2972296982","https://openalex.org/W3003227744","https://openalex.org/W3023251337","https://openalex.org/W3034693034","https://openalex.org/W3036231704","https://openalex.org/W3094197186","https://openalex.org/W3095202855","https://openalex.org/W3122083218","https://openalex.org/W3153860035","https://openalex.org/W3181250621","https://openalex.org/W3201025765","https://openalex.org/W3202570798","https://openalex.org/W3211506940","https://openalex.org/W4241325400","https://openalex.org/W4286230128","https://openalex.org/W4295488765","https://openalex.org/W4321790660","https://openalex.org/W4324045999","https://openalex.org/W4327953232","https://openalex.org/W4328047910","https://openalex.org/W4362459424","https://openalex.org/W4362585200","https://openalex.org/W4363674796","https://openalex.org/W4386272384","https://openalex.org/W4388304484","https://openalex.org/W4390610922","https://openalex.org/W4392872108","https://openalex.org/W4396545890","https://openalex.org/W4401326889","https://openalex.org/W4404144272","https://openalex.org/W4404411240","https://openalex.org/W4408343864","https://openalex.org/W4408845517","https://openalex.org/W4411254352","https://openalex.org/W4412389800","https://openalex.org/W4412393115","https://openalex.org/W4414222369","https://openalex.org/W4414620193","https://openalex.org/W7117999416","https://openalex.org/W7131652462","https://openalex.org/W7140830353","https://openalex.org/W7156231666","https://openalex.org/W7162933940","https://openalex.org/W7163883881","https://openalex.org/W7172297444","https://openalex.org/W7203713181"],"related_works":["https://openalex.org/W2748049509","https://openalex.org/W2098464555","https://openalex.org/W1534477124","https://openalex.org/W2828195625","https://openalex.org/W1979537768","https://openalex.org/W4411254352","https://openalex.org/W4414222369","https://openalex.org/W2946145398","https://openalex.org/W2569191487","https://openalex.org/W4281705454"],"abstract_inverted_index":{"Abstract":[0],"Neurotropic":[1],"RNA":[2,61],"viruses":[3],"are":[4],"major":[5],"causes":[6,34],"of":[7,82,92,101,115,119,143,220,243,312,335,393],"fatal":[8],"encephalitis":[9,38,226,255,269],"worldwide,":[10],"yet":[11],"how":[12],"infected":[13,387],"neurons":[14,155],"transition":[15,327],"from":[16,156],"antiviral":[17,95,304,314],"defense":[18],"to":[19,68,210,283,291,408],"inflammatory":[20,77,147,221,306,371],"cell":[21,78,136,157,372],"death":[22,158,223,373],"is":[23,328,374],"not":[24,362,375],"well":[25],"characterized.":[26],"Chandipura":[27],"virus":[28,62,249],"(CHPV),":[29],"an":[30],"emerging":[31],"neurotropic":[32],"rhabdovirus,":[33],"acute,":[35],"rapidly":[36],"progressive":[37],"with":[39,85,131,256,330],"high":[40,257],"case":[41],"fatality":[42],"in":[43,76,224,235,275,385],"children,":[44,279],"but":[45,65],"the":[46,93,244,281,286,379,386,391,400],"mechanisms":[47],"underlying":[48],"its":[49],"neuropathogenesis":[50],"remain":[51,270],"poorly":[52],"defined.":[53],"Here,":[54,294],"we":[55,295,360],"demonstrate":[56],"that":[57,74,289,297,368],"CHPV":[58,86,213,273,298,416],"suppresses":[59],"canonical":[60,380],"sensing":[63],"early":[64,207,310],"subsequently":[66],"switches":[67],"a":[69,203,216,231,301,350,404],"mitochondria-driven":[70],"innate":[71],"immune":[72,208],"program":[73],"culminates":[75],"death.":[79,137,174],"Early":[80],"infection":[81,109,299],"neuronal":[83,173,197,222,370,413],"cells":[84],"was":[87,358],"marked":[88],"by":[89,309,317,378],"reduced":[90,168,186,339,346],"levels":[91],"mitochondrial":[94,111,117,313,318,331],"adaptor":[96],"protein,":[97],"MAVS":[98],"and":[99,104,122,134,153,172,227,250,305,322,333,412],"attenuation":[100],"type":[102],"I":[103],"III":[105],"interferon":[106],"responses.":[107],"As":[108],"progressed,":[110],"dysfunction":[112],"promoted":[113],"accumulation":[114,118,332],"mtROS,":[116],"cleaved":[120],"GSDME":[121,166,176,187,337,347],"cytosolic":[123],"mtDNA":[124,320],"release,":[125,321],"triggering":[126],"STING":[127,144,180,183,229,324,340,343],"activation,":[128,188,341],"which":[129],"coincided":[130],"robust":[132,323],"neuroinflammation":[133,211,411],"pyroptotic":[135,150],"Pharmacological":[138],"inhibition":[139],"or":[140],"genetic":[141],"silencing":[142],"markedly":[145,178],"attenuated":[146,179],"signaling,":[148],"prevented":[149],"membrane":[151],"rupture":[152],"protected":[154],"without":[159],"significantly":[160],"affecting":[161],"viral":[162,170,225,238],"replication.":[163],"In":[164],"contrast,":[165],"depletion":[167,177,184,338,344],"both":[169],"replication":[171],"Notably,":[175],"phosphorylation,":[181],"while":[182,342],"also":[185],"revealing":[189,215,349],"functional":[190,351],"coupling":[191],"between":[192,353],"these":[193,354,397],"pathways":[194],"during":[195,212,415],"CHPV-induced":[196,369],"injury.":[198],"Collectively,":[199],"our":[200],"findings":[201,398],"identify":[202,399],"mitochondria-GSDME-STING":[204],"axis":[205,402],"linking":[206],"evasion":[209],"infection,":[214],"previously":[217],"unrecognized":[218],"mechanism":[219],"highlighting":[228],"as":[230,403],"potential":[232,405],"therapeutic":[233,265,406],"target":[234,407],"certain":[236],"CNS":[237],"infections.":[239],"Author":[240],"summary":[241],"Members":[242],"Rhabdoviridae":[245],"family,":[246],"including":[247],"Rabies":[248],"CHPV,":[251],"can":[252],"cause":[253],"acute":[254],"case-fatality":[258],"rates.":[259],"Despite":[260],"their":[261],"clinical":[262],"burden,":[263],"effective":[264],"options":[266],"for":[267],"CHPV-associated":[268,394],"limited.":[271],"Recent":[272],"outbreaks":[274],"India,":[276],"particularly":[277],"among":[278],"highlight":[280,390],"need":[282],"better":[284],"understand":[285],"host":[287],"responses":[288,384],"contribute":[290],"disease":[292],"progression.":[293],"show":[296],"induces":[300],"temporally":[302],"distinct":[303],"response,":[307],"characterized":[308],"suppression":[311],"signaling":[315],"followed":[316],"dysfunction,":[319],"activation.":[325],"This":[326],"associated":[329],"cleavage":[334],"GSDME.":[336],"reciprocally":[345],"cleavage,":[348,366],"interplay":[352],"pathways.":[355],"Although":[356],"caspase-1":[357],"activated,":[359],"did":[361],"detect":[363],"convincing":[364],"GSDMD":[365],"suggesting":[367],"fully":[376],"explained":[377],"inflammasome":[381],"pathway.":[382],"Cell-type-specific":[383],"brain":[388],"further":[389],"complexity":[392],"neuroinflammation.":[395],"Together,":[396],"GSDME-STING":[401],"limit":[409],"pathological":[410],"injury":[414],"encephalitis.":[417]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-09-28T00:00:00"}