{"id":"https://openalex.org/W7214534346","doi":"https://doi.org/10.7759/cureus.116997","title":"Comparative Performance of Oxygenation Indices for Mortality Prediction in Patients With Acute Respiratory Distress Syndrome at a Tertiary Care Intensive Care Unit in Bangladesh","display_name":"Comparative Performance of Oxygenation Indices for Mortality Prediction in Patients With Acute Respiratory Distress Syndrome at a Tertiary Care Intensive Care Unit in Bangladesh","publication_year":2026,"publication_date":"2026-09-27","ids":{"openalex":"https://openalex.org/W7214534346","doi":"https://doi.org/10.7759/cureus.116997","pmid":"https://pubmed.ncbi.nlm.nih.gov/42948266","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13711625"},"language":"en","primary_location":{"id":"doi:10.7759/cureus.116997","doi":"https://doi.org/10.7759/cureus.116997","is_oa":true,"landing_page_url":"https://doi.org/10.7759/cureus.116997","pdf_url":"https://www.cureus.com/articles/528623-comparative-performance-of-oxygenation-indices-for-mortality-prediction-in-patients-with-acute-respiratory-distress-syndrome-at-a-tertiary-care-intensive-care-unit-in-bangladesh.pdf","source":{"id":"https://openalex.org/S2738950867","display_name":"Cureus","issn_l":"2168-8184","issn":["2168-8184"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310316779","host_organization_name":"Cureus, Inc.","host_organization_lineage":["https://openalex.org/P4310316779"],"host_organization_lineage_names":["Cureus, Inc."],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.cureus.com/articles/528623-comparative-performance-of-oxygenation-indices-for-mortality-prediction-in-patients-with-acute-respiratory-distress-syndrome-at-a-tertiary-care-intensive-care-unit-in-bangladesh.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5094143192","display_name":"Jannatun Naim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I5476602","display_name":"Ministry of Health and Family Welfare","ror":"https://ror.org/05256fm24","country_code":"BD","type":"government","lineage":["https://openalex.org/I5476602"]}],"countries":["BD"],"is_corresponding":true,"raw_author_name":"Jannatun Naim","raw_affiliation_strings":["Department of Critical Care Medicine, Ministry of Health and Family Welfare, Dhaka, BGD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Critical Care Medicine, Ministry of Health and Family Welfare, Dhaka, BGD","institution_ids":["https://openalex.org/I5476602"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045433700","display_name":"Nafiza Afroz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nafiza Afroz","raw_affiliation_strings":["Department of Anesthesia, Intensive Care, and Pain Medicine, National Institute of Burn and Plastic Surgery, Dhaka, BGD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesia, Intensive Care, and Pain Medicine, National Institute of Burn and Plastic Surgery, Dhaka, BGD","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111414051","display_name":"Mst. Adia Sultana","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I14870802","display_name":"Rajshahi Medical College","ror":"https://ror.org/02k4h0b10","country_code":"BD","type":"education","lineage":["https://openalex.org/I14870802"]}],"countries":["BD"],"is_corresponding":false,"raw_author_name":"Most. Nasrin Sultana","raw_affiliation_strings":["Department of Critical Care Medicine, Rajshahi Medical College Hospital, Rajshahi, BGD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Critical Care Medicine, Rajshahi Medical College Hospital, Rajshahi, BGD","institution_ids":["https://openalex.org/I14870802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5149105124","display_name":"Sabiha Binte Hossain","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405254697","display_name":"Central Police Hospital","ror":"https://ror.org/024d4px27","country_code":"BD","type":"healthcare","lineage":["https://openalex.org/I4405254697"]}],"countries":["BD"],"is_corresponding":false,"raw_author_name":"Sabiha Binte Hossain","raw_affiliation_strings":["Department of Critical Care Medicine, Central Police Hospital, Dhaka, BGD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Critical Care Medicine, Central Police Hospital, Dhaka, BGD","institution_ids":["https://openalex.org/I4405254697"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5153033297","display_name":"A. B. M. Borhan Uddin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201969901","display_name":"Bangladesh Medical University","ror":"https://ror.org/042mrsz23","country_code":"BD","type":"education","lineage":["https://openalex.org/I201969901"]}],"countries":["BD"],"is_corresponding":false,"raw_author_name":"A. B. M. Borhan Uddin","raw_affiliation_strings":["Department of Critical Care Medicine, Bangladesh Medical University, Dhaka, BGD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Critical Care Medicine, Bangladesh Medical University, Dhaka, BGD","institution_ids":["https://openalex.org/I201969901"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5094143192"],"corresponding_institution_ids":["https://openalex.org/I5476602"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.71431475,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"18","issue":"9","first_page":"e116997","last_page":"e116997"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10549","display_name":"Neonatal Respiratory Health Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-respiratory-distress-syndrome","display_name":"acute respiratory distress syndrome","score":0.996999979019165},{"id":"https://openalex.org/keywords/mortality-prediction","display_name":"mortality prediction","score":0.8240000009536743},{"id":"https://openalex.org/keywords/oxygenation-index","display_name":"oxygenation index","score":0.9539999961853027},{"id":"https://openalex.org/keywords/oxygen-saturation-index","display_name":"oxygen saturation index","score":0.9800000190734863},{"id":"https://openalex.org/keywords/pao2-fio2-ratio","display_name":"PaO2/FiO2 ratio","score":0.9570000171661377},{"id":"https://openalex.org/keywords/icu-mortality","display_name":"ICU mortality","score":0.7329999804496765},{"id":"https://openalex.org/keywords/mechanical-ventilation","display_name":"mechanical ventilation","score":0.7200000286102295},{"id":"https://openalex.org/keywords/prognostic-discrimination","display_name":"prognostic discrimination","score":0.7559999823570251},{"id":"https://openalex.org/keywords/bangladesh","display_name":"Bangladesh","score":0.4410000145435333},{"id":"https://openalex.org/keywords/south-asia","display_name":"South Asia","score":0.40799999237060547}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9817000031471252},{"id":"https://openalex.org/C2909621147","wikidata":"https://www.wikidata.org/wiki/Q344873","display_name":"Acute respiratory distress","level":3,"score":0.6639999747276306},{"id":"https://openalex.org/C2776376669","wikidata":"https://www.wikidata.org/wiki/Q5094647","display_name":"Intensive care unit","level":2,"score":0.6273999810218811},{"id":"https://openalex.org/C2991842025","wikidata":"https://www.wikidata.org/wiki/Q31207","display_name":"Tertiary care","level":2,"score":0.5752000212669373},{"id":"https://openalex.org/C194828623","wikidata":"https://www.wikidata.org/wiki/Q2861470","display_name":"Emergency medicine","level":1,"score":0.5676000118255615},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.5562000274658203},{"id":"https://openalex.org/C70289976","wikidata":"https://www.wikidata.org/wiki/Q17143603","display_name":"Oxygenation","level":2,"score":0.4278999865055084},{"id":"https://openalex.org/C141983124","wikidata":"https://www.wikidata.org/wiki/Q188008","display_name":"Respiratory distress","level":2,"score":0.3799000084400177},{"id":"https://openalex.org/C122637931","wikidata":"https://www.wikidata.org/wiki/Q118084","display_name":"Unit (ring theory)","level":2,"score":0.31349998712539673},{"id":"https://openalex.org/C2987404301","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care","level":2,"score":0.3073999881744385},{"id":"https://openalex.org/C30036603","wikidata":"https://www.wikidata.org/wiki/Q17125150","display_name":"Severity of illness","level":2,"score":0.2953000068664551},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.2750999927520752},{"id":"https://openalex.org/C2777080012","wikidata":"https://www.wikidata.org/wiki/Q3766250","display_name":"Mechanical ventilation","level":2,"score":0.27309998869895935},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.2667999863624573},{"id":"https://openalex.org/C545542383","wikidata":"https://www.wikidata.org/wiki/Q2751242","display_name":"Medical emergency","level":1,"score":0.258899986743927}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.7759/cureus.116997","doi":"https://doi.org/10.7759/cureus.116997","is_oa":true,"landing_page_url":"https://doi.org/10.7759/cureus.116997","pdf_url":"https://www.cureus.com/articles/528623-comparative-performance-of-oxygenation-indices-for-mortality-prediction-in-patients-with-acute-respiratory-distress-syndrome-at-a-tertiary-care-intensive-care-unit-in-bangladesh.pdf","source":{"id":"https://openalex.org/S2738950867","display_name":"Cureus","issn_l":"2168-8184","issn":["2168-8184"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310316779","host_organization_name":"Cureus, Inc.","host_organization_lineage":["https://openalex.org/P4310316779"],"host_organization_lineage_names":["Cureus, Inc."],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13711625","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13711625/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13711625/pdf/cureus-0018-00000116997.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"Text"},{"id":"pmid:42948266","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42948266","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.7759/cureus.116997","doi":"https://doi.org/10.7759/cureus.116997","is_oa":true,"landing_page_url":"https://doi.org/10.7759/cureus.116997","pdf_url":"https://www.cureus.com/articles/528623-comparative-performance-of-oxygenation-indices-for-mortality-prediction-in-patients-with-acute-respiratory-distress-syndrome-at-a-tertiary-care-intensive-care-unit-in-bangladesh.pdf","source":{"id":"https://openalex.org/S2738950867","display_name":"Cureus","issn_l":"2168-8184","issn":["2168-8184"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310316779","host_organization_name":"Cureus, Inc.","host_organization_lineage":["https://openalex.org/P4310316779"],"host_organization_lineage_names":["Cureus, Inc."],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7214534346.pdf","grobid_xml":"https://content.openalex.org/works/W7214534346.grobid-xml"},"referenced_works_count":25,"referenced_works":["https://openalex.org/W1803784511","https://openalex.org/W1825782668","https://openalex.org/W1994004631","https://openalex.org/W2140066904","https://openalex.org/W2206411056","https://openalex.org/W2286228001","https://openalex.org/W2331298217","https://openalex.org/W2554976664","https://openalex.org/W2607378823","https://openalex.org/W2747613448","https://openalex.org/W2800406518","https://openalex.org/W2885971195","https://openalex.org/W3096319014","https://openalex.org/W3190692202","https://openalex.org/W4200059895","https://openalex.org/W4220851038","https://openalex.org/W4237939525","https://openalex.org/W4293509722","https://openalex.org/W4387992839","https://openalex.org/W4389669349","https://openalex.org/W4390174602","https://openalex.org/W4390614298","https://openalex.org/W4402990251","https://openalex.org/W4407627411","https://openalex.org/W4416324205"],"related_works":["https://openalex.org/W2885971195","https://openalex.org/W2747613448","https://openalex.org/W4417497546","https://openalex.org/W2622847847","https://openalex.org/W2545357671","https://openalex.org/W1902506647","https://openalex.org/W7151766665","https://openalex.org/W7196925616","https://openalex.org/W3031165546","https://openalex.org/W3094891414"],"abstract_inverted_index":{"Background":[0],"Acute":[1],"respiratory":[2,199],"distress":[3],"syndrome":[4,8],"(ARDS)":[5],"is":[6,257],"a":[7,66],"of":[9,30,34,38,56,85,179,345],"acute":[10],"inflammatory":[11],"lung":[12],"injury":[13],"and":[14,21,47,87,99,122,129,138,149,171,187,198,201,207,211,237,249,266,268,272,290,296,317,326,333,350],"impaired":[15],"gas":[16],"exchange,":[17],"not":[18,168,285],"hypoxemia":[19],"alone,":[20],"carries":[22],"high":[23],"mortality.":[24],"This":[25,71],"study":[26,75],"compared":[27,134],"the":[28,31,54,81,107,109,164,185,212,238,246,277,305,313,334],"discrimination":[29,150,300,325],"partial":[32],"pressure":[33],"arterial":[35],"oxygen":[36,40,48],"(PaO\u2082)/fraction":[37],"inspired":[39],"(FiO\u2082)":[41],"(PF)":[42],"ratio,":[43,307],"oxygenation":[44],"index":[45,50],"(OI),":[46],"saturation":[49],"(OSI),":[51],"measured":[52],"on":[53,118],"day":[55,108],"ARDS":[57,86],"diagnosis,":[58],"for":[59,224,263,276,301],"intensive":[60],"care":[61],"unit":[62],"(ICU)":[63],"mortality":[64,303],"in":[65,146,184],"Bangladeshi":[67],"tertiary":[68],"ICU.":[69],"Methods":[70],"single-center":[72],"prospective":[73],"observational":[74],"enrolled":[76],"80":[77,180],"consecutive":[78],"adults":[79],"meeting":[80],"2012":[82],"Berlin":[83,110],"definition":[84],"requiring":[88],"invasive":[89],"mechanical":[90],"ventilation":[91],"at":[92],"Bangladesh":[93],"Medical":[94],"University":[95],"between":[96],"June":[97],"2024":[98],"May":[100],"2025.":[101],"Time":[102],"zero":[103],"(day":[104],"1)":[105],"was":[106,175,215,221,253,261,270,284,315],"criteria":[111],"were":[112,116,133,167,209,292,319],"first":[113],"met.":[114],"Indices":[115],"calculated":[117],"days":[119],"1,":[120],"3,":[121],"7":[123],"from":[124],"simultaneous":[125],"blood":[126,194],"gas,":[127],"oximetry,":[128],"ventilator":[130],"data.":[131],"Groups":[132],"by":[135,143,151,231],"independent":[136,330,351],"t-":[137],"chi-square":[139],"tests,":[140],"serial":[141],"change":[142],"paired":[144,251,343],"t-tests":[145],"survivors":[147,283],"only,":[148],"receiver":[152],"operating":[153],"characteristic":[154],"(ROC)":[155],"curve":[156,165],"analysis":[157,314],"with":[158,308,341],"Youden":[159],"cutoffs.":[160],"Correlated":[161],"areas":[162],"under":[163],"(AUCs)":[166],"formally":[169],"compared,":[170],"no":[172,250],"multivariable":[173,348],"model":[174],"fitted.":[176],"Results":[177],"Forty-five":[178],"patients":[181],"(56.3%)":[182],"died":[183],"ICU,":[186],"35":[188],"(43.8%)":[189],"survived.":[190],"Non-survivors":[191],"had":[192],"lower":[193,216],"pressure,":[195],"higher":[196,210,293,299],"heart":[197],"rates,":[200],"greater":[202],"ventilatory":[203],"requirements":[204],"(p<0.05).":[205,219],"OI":[206,232,289],"OSI":[208,225,265,291,309],"PF":[213,239,278,306],"ratio":[214,240],"among":[217,282,294],"non-survivors":[218,295],"Discrimination":[220],"numerically":[222,298],"highest":[223],"(AUC=0.879;":[226],"95%":[227,234,242],"CI:":[228,235,243],"0.786-0.977),":[229],"followed":[230],"(AUC=0.867;":[233],"0.788-0.963)":[236],"(AUC=0.731;":[241],"0.612-0.881);":[244],"as":[245],"intervals":[247],"overlapped":[248],"test":[252],"applied,":[254],"this":[255],"ordering":[256],"descriptive":[258],"only.":[259],"Specificity":[260],"91.4%":[262],"both":[264],"OI,":[267],"accuracy":[269],"86.3%":[271],"83.8%":[273],"versus":[274],"70%":[275],"ratio.":[279],"Serial":[280],"improvement":[281],"statistically":[286],"significant.":[287],"Conclusions":[288],"showed":[297],"ICU":[302],"than":[304,329],"performing":[310],"best.":[311],"As":[312],"univariable":[316],"cutoffs":[318],"internally":[320],"derived,":[321],"these":[322],"findings":[323],"indicate":[324],"association":[327],"rather":[328],"prognostic":[331],"value,":[332],"thresholds":[335],"are":[336,353],"exploratory.":[337],"Larger":[338],"multicenter":[339],"studies":[340],"formal":[342],"comparison":[344],"ROC":[346],"curves,":[347],"adjustment,":[349],"validation":[352],"warranted.":[354]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-09-28T00:00:00"}