{"id":"https://openalex.org/W7214523407","doi":"https://doi.org/10.64898/2026.09.26.754479","title":"Axons organize into micro-tracts around the cortical vasculature","display_name":"Axons organize into micro-tracts around the cortical vasculature","publication_year":2026,"publication_date":"2026-09-26","ids":{"openalex":"https://openalex.org/W7214523407","doi":"https://doi.org/10.64898/2026.09.26.754479"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.26.754479","doi":"https://doi.org/10.64898/2026.09.26.754479","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.26.754479","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.64898/2026.09.26.754479","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007310492","display_name":"Javier J. How","orcid":"https://orcid.org/0000-0002-9952-9304","observed_orcids":["https://orcid.org/0000-0002-9952-9304"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I195573530","display_name":"Janelia Research Campus","ror":"https://ror.org/013sk6x84","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410","https://openalex.org/I195573530"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Javier J How","raw_affiliation_strings":["Janelia Research Campus"],"raw_orcid":"https://orcid.org/0000-0002-9952-9304","affiliations":[{"raw_affiliation_string":"Janelia Research Campus","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I195573530"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064278531","display_name":"Bethanny P. Danskin","orcid":"https://orcid.org/0000-0002-4832-1220","observed_orcids":["https://orcid.org/0000-0002-4832-1220"]},"institutions":[{"id":"https://openalex.org/I1314596251","display_name":"Allen Institute for Brain Science","ror":"https://ror.org/00dcv1019","country_code":"US","type":"facility","lineage":["https://openalex.org/I1314596251","https://openalex.org/I4210140341"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bethanny Danskin","raw_affiliation_strings":["Allen Institute for Brain Science"],"raw_orcid":"https://orcid.org/0000-0002-4832-1220","affiliations":[{"raw_affiliation_string":"Allen Institute for Brain Science","institution_ids":["https://openalex.org/I1314596251"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078489506","display_name":"Benjamin D. Pedigo","orcid":"https://orcid.org/0000-0002-9519-1190","observed_orcids":["https://orcid.org/0000-0002-9519-1190"]},"institutions":[{"id":"https://openalex.org/I1314596251","display_name":"Allen Institute for Brain Science","ror":"https://ror.org/00dcv1019","country_code":"US","type":"facility","lineage":["https://openalex.org/I1314596251","https://openalex.org/I4210140341"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Benjamin D Pedigo","raw_affiliation_strings":["Allen Institute for Brain Science"],"raw_orcid":"https://orcid.org/0000-0002-9519-1190","affiliations":[{"raw_affiliation_string":"Allen Institute for Brain Science","institution_ids":["https://openalex.org/I1314596251"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5153180143","display_name":"Elana Marie Memke","orcid":"https://orcid.org/0009-0001-8815-1588","observed_orcids":["https://orcid.org/0009-0001-8815-1588"]},"institutions":[{"id":"https://openalex.org/I4405262941","display_name":"Seattle Children's Research Institute","ror":"https://ror.org/00cz0md82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295499534","https://openalex.org/I4405262941"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elana M Memke","raw_affiliation_strings":["Seattle Children\u2019s Research Institute"],"raw_orcid":"https://orcid.org/0009-0001-8815-1588","affiliations":[{"raw_affiliation_string":"Seattle Children\u2019s Research Institute","institution_ids":["https://openalex.org/I4405262941"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009444251","display_name":"Stefan Stamenkovi\u0107","orcid":"https://orcid.org/0000-0002-3443-9156","observed_orcids":["https://orcid.org/0000-0002-3443-9156"]},"institutions":[{"id":"https://openalex.org/I4405262941","display_name":"Seattle Children's Research Institute","ror":"https://ror.org/00cz0md82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295499534","https://openalex.org/I4405262941"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stefan Stamenkovic","raw_affiliation_strings":["Seattle Children\u2019s Research Institute"],"raw_orcid":"https://orcid.org/0000-0002-3443-9156","affiliations":[{"raw_affiliation_string":"Seattle Children\u2019s Research Institute","institution_ids":["https://openalex.org/I4405262941"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020283755","display_name":"David Kleinfeld","orcid":"https://orcid.org/0000-0001-9797-4722","observed_orcids":["https://orcid.org/0000-0001-9797-4722","https://orcid.org/0000-0001-9072-5088"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Kleinfeld","raw_affiliation_strings":["University of California San Diego"],"raw_orcid":"https://orcid.org/0000-0001-9797-4722","affiliations":[{"raw_affiliation_string":"University of California San Diego","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088648796","display_name":"Andy Y. Shih","orcid":"https://orcid.org/0000-0002-7839-392X","observed_orcids":["https://orcid.org/0000-0002-7839-392X"]},"institutions":[{"id":"https://openalex.org/I4405262941","display_name":"Seattle Children's Research Institute","ror":"https://ror.org/00cz0md82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295499534","https://openalex.org/I4405262941"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andy Y Shih","raw_affiliation_strings":["Seattle Children\u2019s Research Institute"],"raw_orcid":"https://orcid.org/0000-0002-7839-392X","affiliations":[{"raw_affiliation_string":"Seattle Children\u2019s Research Institute","institution_ids":["https://openalex.org/I4405262941"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5007310492"],"corresponding_institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I195573530"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.7720000147819519,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.7720000147819519,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.04149999842047691,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14144","display_name":"Neurological Disease Mechanisms and Treatments","score":0.039900001138448715,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neurovascular-coupling","display_name":"neurovascular coupling","score":0.9480000138282776},{"id":"https://openalex.org/keywords/neurovascular-interface","display_name":"neurovascular interface","score":0.7649999856948853},{"id":"https://openalex.org/keywords/cerebral-blood-flow","display_name":"cerebral blood flow","score":0.7300000190734863},{"id":"https://openalex.org/keywords/capillaries","display_name":"capillaries","score":0.8949999809265137},{"id":"https://openalex.org/keywords/basket-cells","display_name":"basket cells","score":0.859000027179718},{"id":"https://openalex.org/keywords/visual-cortex","display_name":"visual cortex","score":0.8050000071525574},{"id":"https://openalex.org/keywords/vascular-wall","display_name":"vascular wall","score":0.42399999499320984},{"id":"https://openalex.org/keywords/axon-bundling","display_name":"axon bundling","score":0.49900001287460327},{"id":"https://openalex.org/keywords/serial-electron-microscopy","display_name":"serial electron microscopy","score":0.4959999918937683}],"concepts":[{"id":"https://openalex.org/C2779530196","wikidata":"https://www.wikidata.org/wiki/Q178999","display_name":"Axon","level":2,"score":0.6488000154495239},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.5759000182151794},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5526999831199646},{"id":"https://openalex.org/C105572291","wikidata":"https://www.wikidata.org/wiki/Q7002775","display_name":"Neurovascular bundle","level":2,"score":0.49900001287460327},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.49380001425743103},{"id":"https://openalex.org/C98045186","wikidata":"https://www.wikidata.org/wiki/Q205663","display_name":"Process (computing)","level":2,"score":0.3774999976158142},{"id":"https://openalex.org/C2777663904","wikidata":"https://www.wikidata.org/wiki/Q988343","display_name":"Blood vessel","level":2,"score":0.3662000000476837},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.3330000042915344},{"id":"https://openalex.org/C2777348757","wikidata":"https://www.wikidata.org/wiki/Q2346577","display_name":"Cortex (anatomy)","level":2,"score":0.33169999718666077},{"id":"https://openalex.org/C2781041448","wikidata":"https://www.wikidata.org/wiki/Q75839","display_name":"Cerebral cortex","level":2,"score":0.30309998989105225},{"id":"https://openalex.org/C2777670902","wikidata":"https://www.wikidata.org/wiki/Q492038","display_name":"Human brain","level":2,"score":0.3003999888896942},{"id":"https://openalex.org/C2778794669","wikidata":"https://www.wikidata.org/wiki/Q43054","display_name":"Neuron","level":2,"score":0.29429998993873596},{"id":"https://openalex.org/C2776992346","wikidata":"https://www.wikidata.org/wiki/Q111140","display_name":"Endothelium","level":2,"score":0.2786000072956085},{"id":"https://openalex.org/C2779345533","wikidata":"https://www.wikidata.org/wiki/Q75785","display_name":"Visual cortex","level":2,"score":0.27720001339912415},{"id":"https://openalex.org/C2777918570","wikidata":"https://www.wikidata.org/wiki/Q2423067","display_name":"Axon terminal","level":3,"score":0.275299996137619},{"id":"https://openalex.org/C119671327","wikidata":"https://www.wikidata.org/wiki/Q886843","display_name":"Cerebral circulation","level":2,"score":0.27239999175071716},{"id":"https://openalex.org/C2779097085","wikidata":"https://www.wikidata.org/wiki/Q1348853","display_name":"Mechanoreceptor","level":3,"score":0.27129998803138733},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2660999894142151},{"id":"https://openalex.org/C103378370","wikidata":"https://www.wikidata.org/wiki/Q948647","display_name":"Neuroanatomy","level":2,"score":0.2619999945163727},{"id":"https://openalex.org/C69125201","wikidata":"https://www.wikidata.org/wiki/Q2034716","display_name":"Axon guidance","level":3,"score":0.2547000050544739},{"id":"https://openalex.org/C189014844","wikidata":"https://www.wikidata.org/wiki/Q189118","display_name":"Cell type","level":3,"score":0.2506999969482422}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.09.26.754479","doi":"https://doi.org/10.64898/2026.09.26.754479","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.26.754479","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.09.26.754479","doi":"https://doi.org/10.64898/2026.09.26.754479","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.26.754479","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W151377110","https://openalex.org/W1843983222","https://openalex.org/W1900636106","https://openalex.org/W1993671632","https://openalex.org/W2001552996","https://openalex.org/W2042422091","https://openalex.org/W2048733914","https://openalex.org/W2056532130","https://openalex.org/W2083252150","https://openalex.org/W2096956704","https://openalex.org/W2103065509","https://openalex.org/W2129433521","https://openalex.org/W2139123746","https://openalex.org/W2169118010","https://openalex.org/W2536050198","https://openalex.org/W2602561729","https://openalex.org/W2607283788","https://openalex.org/W2759050422","https://openalex.org/W2763985063","https://openalex.org/W3134409008","https://openalex.org/W3206871822","https://openalex.org/W4226058222","https://openalex.org/W4322604190","https://openalex.org/W4327750150","https://openalex.org/W4385830351","https://openalex.org/W4387450464","https://openalex.org/W4388834501","https://openalex.org/W4390501292","https://openalex.org/W4409283533","https://openalex.org/W4409283696","https://openalex.org/W4411143022","https://openalex.org/W4412692211","https://openalex.org/W4413112549","https://openalex.org/W4415954460","https://openalex.org/W7147061573"],"related_works":["https://openalex.org/W4402233510","https://openalex.org/W7096926155","https://openalex.org/W7099260152","https://openalex.org/W2099656082","https://openalex.org/W7049113546","https://openalex.org/W4398165525","https://openalex.org/W7099191203","https://openalex.org/W4390675278","https://openalex.org/W3080275473","https://openalex.org/W2169118010"],"abstract_inverted_index":{"Abstract":[0],"Neural":[1],"activity":[2,20],"is":[3,35],"metabolically":[4],"costly":[5],"and":[6,86,103],"supported":[7],"by":[8,17,108],"local":[9,46],"increases":[10],"in":[11,129],"cerebral":[12],"blood":[13,22],"flow.":[14],"The":[15],"process":[16],"which":[18],"neural":[19],"drives":[21],"flow":[23],"increase,":[24],"neurovascular":[25,55],"coupling":[26],"(NVC),":[27],"remains":[28],"poorly":[29],"understood.":[30],"One":[31],"persistent":[32],"knowledge":[33],"gap":[34],"how":[36],"subcellular":[37],"compartments":[38],"are":[39,106,166],"arranged":[40],"at":[41,57,196],"the":[42,54,58,88,126,139,158],"vascular":[43,84,151],"wall,":[44],"where":[45,122],"signaling":[47,195],"occurs.":[48],"This":[49],"requires":[50],"a":[51,66,130],"survey":[52],"of":[53,71,93,132,138,141,148,169],"interface":[56],"nanometer":[59],"scale.":[60],"To":[61],"this":[62],"end,":[63],"we":[64,155],"analyzed":[65],"\u223c1":[67],"mm":[68],"3":[69],"volume":[70,111],"mouse":[72],"visual":[73],"cortex":[74],"imaged":[75],"with":[76,161],"serial":[77],"electron":[78],"microscopy.":[79],"We":[80,99],"manually":[81],"labeled":[82],"different":[83],"zones":[85],"classified":[87],"EM":[89],"segments":[90,95],"surrounding":[91],"hundreds":[92],"vessel":[94,127],"across":[96],"these":[97],"zones.":[98],"found":[100],"that":[101,157],"capillaries":[102,178],"venous":[104],"vessels":[105],"surrounded":[107],"more":[109,177],"axonal":[110,164,185],"than":[112,179],"arteriolar":[113],"vessels.":[114],"Perivascular":[115],"axons":[116,123,174],"tended":[117],"to":[118],"bundle":[119],"into":[120],"micro-tracts,":[121],"coursed":[124],"near":[125],"wall":[128],"variety":[131],"geometric":[133],"orientations.":[134],"Micro-tracts":[135],"covered":[136],"\u223c60%":[137],"surface":[140],"capillaries,":[142],"but":[143],"only":[144],"24":[145],"\u2013":[146],"40%":[147],"every":[149],"other":[150,180],"zone\u2019s":[152],"surface.":[153],"Finally,":[154],"show":[156],"basket":[159],"cells,":[160],"their":[162,173],"extensive":[163],"arbors,":[165],"candidate":[167],"members":[168],"micro-tracts:":[170],"on":[171],"average,":[172],"approach":[175],"2-to-3-fold":[176],"neuronal":[181],"subtypes.":[182],"Altogether,":[183],"perivascular":[184],"micro-tracts":[186],"may":[187],"be":[188],"an":[189],"important":[190],"physical":[191],"substrate":[192],"for":[193],"NVC":[194],"capillaries.":[197]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-09-28T00:00:00"}
