{"id":"https://openalex.org/W7214483067","doi":"https://doi.org/10.3390/ijms27188323","title":"Lessons from In Utero and Postnatal Exposure to Pesticide DDT: Mechanisms of Chromaffin Cell Vulnerability and Altered Catecholamine Homeostasis","display_name":"Lessons from In Utero and Postnatal Exposure to Pesticide DDT: Mechanisms of Chromaffin Cell Vulnerability and Altered Catecholamine Homeostasis","publication_year":2026,"publication_date":"2026-09-18","ids":{"openalex":"https://openalex.org/W7214483067","doi":"https://doi.org/10.3390/ijms27188323","pmid":"https://pubmed.ncbi.nlm.nih.gov/42794750","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13607560"},"language":"en","primary_location":{"id":"doi:10.3390/ijms27188323","doi":"https://doi.org/10.3390/ijms27188323","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms27188323","pdf_url":null,"source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/ijms27188323","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000309293","display_name":"Nataliya Valentinovna Yaglova","orcid":"https://orcid.org/0000-0002-8239-5039","observed_orcids":["https://orcid.org/0000-0002-8239-5039"]},"institutions":[{"id":"https://openalex.org/I3129448551","display_name":"Federal Research Centre of Nutrition and Biotechnology","ror":"https://ror.org/05ssfag15","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I3129448551","https://openalex.org/I4210110862"]}],"countries":["RU"],"is_corresponding":true,"raw_author_name":"Nataliya V. Yaglova","raw_affiliation_strings":["Federal Research Centre of Nutrition, Biotechnology and Food Safety, Ustinsky Passage 2/14, Moscow 109240, Russia"],"raw_orcid":"https://orcid.org/0000-0002-8239-5039","affiliations":[{"raw_affiliation_string":"Federal Research Centre of Nutrition, Biotechnology and Food Safety, Ustinsky Passage 2/14, Moscow 109240, Russia","institution_ids":["https://openalex.org/I3129448551"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061778093","display_name":"Victor A. Tutelyan","orcid":"https://orcid.org/0000-0002-4164-8992","observed_orcids":["https://orcid.org/0000-0002-4164-8992"]},"institutions":[{"id":"https://openalex.org/I3129448551","display_name":"Federal Research Centre of Nutrition and Biotechnology","ror":"https://ror.org/05ssfag15","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I3129448551","https://openalex.org/I4210110862"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Victor A. Tutelyan","raw_affiliation_strings":["Federal Research Centre of Nutrition, Biotechnology and Food Safety, Ustinsky Passage 2/14, Moscow 109240, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Federal Research Centre of Nutrition, Biotechnology and Food Safety, Ustinsky Passage 2/14, Moscow 109240, Russia","institution_ids":["https://openalex.org/I3129448551"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082318791","display_name":"Inna Yu. Tarmaeva","orcid":"https://orcid.org/0000-0001-7791-1222","observed_orcids":["https://orcid.org/0000-0001-7791-1222","https://orcid.org/0000-0002-5129-8367"]},"institutions":[{"id":"https://openalex.org/I3129448551","display_name":"Federal Research Centre of Nutrition and Biotechnology","ror":"https://ror.org/05ssfag15","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I3129448551","https://openalex.org/I4210110862"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Inna Yu. Tarmaeva","raw_affiliation_strings":["Federal Research Centre of Nutrition, Biotechnology and Food Safety, Ustinsky Passage 2/14, Moscow 109240, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Federal Research Centre of Nutrition, Biotechnology and Food Safety, Ustinsky Passage 2/14, Moscow 109240, Russia","institution_ids":["https://openalex.org/I3129448551"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018396512","display_name":"Sergey Stanislavovich Obernikhin","orcid":"https://orcid.org/0000-0003-0997-6766","observed_orcids":["https://orcid.org/0000-0003-0997-6766"]},"institutions":[{"id":"https://openalex.org/I3129448551","display_name":"Federal Research Centre of Nutrition and Biotechnology","ror":"https://ror.org/05ssfag15","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I3129448551","https://openalex.org/I4210110862"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Sergey S. Obernikhin","raw_affiliation_strings":["Federal Research Centre of Nutrition, Biotechnology and Food Safety, Ustinsky Passage 2/14, Moscow 109240, Russia"],"raw_orcid":"https://orcid.org/0000-0003-0997-6766","affiliations":[{"raw_affiliation_string":"Federal Research Centre of Nutrition, Biotechnology and Food Safety, Ustinsky Passage 2/14, Moscow 109240, Russia","institution_ids":["https://openalex.org/I3129448551"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113353683","display_name":"Dmitriy B. Nikityuk","orcid":"https://orcid.org/0000-0002-2259-1222","observed_orcids":["https://orcid.org/0000-0002-2259-1222"]},"institutions":[{"id":"https://openalex.org/I17877952","display_name":"Sechenov University","ror":"https://ror.org/02yqqv993","country_code":"RU","type":"education","lineage":["https://openalex.org/I17877952"]},{"id":"https://openalex.org/I3129448551","display_name":"Federal Research Centre of Nutrition and Biotechnology","ror":"https://ror.org/05ssfag15","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I3129448551","https://openalex.org/I4210110862"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Dmitriy B. Nikityuk","raw_affiliation_strings":["Federal Research Centre of Nutrition, Biotechnology and Food Safety, Ustinsky Passage 2/14, Moscow 109240, Russia","Institute of Clinical Medicine Named After N.V. Sklifosovsky, I.M. Sechenov First Moscow State Medical University (Sechenov University), 8-2 Trubetskaya Str., Moscow 119991, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Federal Research Centre of Nutrition, Biotechnology and Food Safety, Ustinsky Passage 2/14, Moscow 109240, Russia","institution_ids":["https://openalex.org/I3129448551"]},{"raw_affiliation_string":"Institute of Clinical Medicine Named After N.V. Sklifosovsky, I.M. Sechenov First Moscow State Medical University (Sechenov University), 8-2 Trubetskaya Str., Moscow 119991, Russia","institution_ids":["https://openalex.org/I17877952"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5000309293"],"corresponding_institution_ids":["https://openalex.org/I3129448551"],"apc_list":{"value":2900,"currency":"CHF","value_usd":3499},"apc_paid":{"value":2900,"currency":"CHF","value_usd":3499},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.44466801,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"27","issue":"18","first_page":"8323","last_page":"8323"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10875","display_name":"Pesticide Exposure and Toxicity","score":0.548799991607666,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10875","display_name":"Pesticide Exposure and Toxicity","score":0.548799991607666,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10686","display_name":"Effects and risks of endocrine disrupting chemicals","score":0.43380001187324524,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10122","display_name":"Toxic Organic Pollutants Impact","score":0.014700000174343586,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ddt","display_name":"DDT","score":0.9980000257492065},{"id":"https://openalex.org/keywords/persistent-organic-pollutants","display_name":"persistent organic pollutants","score":0.9089999794960022},{"id":"https://openalex.org/keywords/endocrine-disruption","display_name":"endocrine disruption","score":0.921999990940094},{"id":"https://openalex.org/keywords/chromaffin-cells","display_name":"chromaffin cells","score":0.9570000171661377},{"id":"https://openalex.org/keywords/adrenal-medulla","display_name":"adrenal medulla","score":0.9369999766349792},{"id":"https://openalex.org/keywords/catecholamine-biosynthesis","display_name":"catecholamine synthesis","score":0.8600000143051147},{"id":"https://openalex.org/keywords/catecholamine-release","display_name":"catecholamine release","score":0.921999990940094},{"id":"https://openalex.org/keywords/embryonic-development","display_name":"embryonic development","score":0.6499999761581421},{"id":"https://openalex.org/keywords/postnatal-development","display_name":"postnatal development","score":0.9789999723434448},{"id":"https://openalex.org/keywords/cell-renewal","display_name":"cell renewal","score":0.718999981880188},{"id":"https://openalex.org/keywords/low-dose-exposure","display_name":"low-dose exposure","score":0.7139999866485596},{"id":"https://openalex.org/keywords/indoor-residual-spraying","display_name":"indoor residual spraying","score":0.6890000104904175},{"id":"https://openalex.org/keywords/neurotoxicity","display_name":"neurotoxicity","score":0.5690000057220459}],"concepts":[{"id":"https://openalex.org/C46699223","wikidata":"https://www.wikidata.org/wiki/Q11078","display_name":"Endocrine system","level":3,"score":0.7407000064849854},{"id":"https://openalex.org/C2780862370","wikidata":"https://www.wikidata.org/wiki/Q1138899","display_name":"Endocrine disruptor","level":4,"score":0.5691999793052673},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.551800012588501},{"id":"https://openalex.org/C109051061","wikidata":"https://www.wikidata.org/wiki/Q864610","display_name":"Biomonitoring","level":2,"score":0.5256999731063843},{"id":"https://openalex.org/C2775894120","wikidata":"https://www.wikidata.org/wiki/Q271663","display_name":"Catecholamine","level":2,"score":0.4828999936580658},{"id":"https://openalex.org/C2777597313","wikidata":"https://www.wikidata.org/wiki/Q934888","display_name":"Adrenal medulla","level":3,"score":0.4794999957084656},{"id":"https://openalex.org/C201614185","wikidata":"https://www.wikidata.org/wiki/Q396833","display_name":"In utero","level":4,"score":0.4433000087738037},{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.4106000065803528},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3849000036716461},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.35899999737739563},{"id":"https://openalex.org/C182203180","wikidata":"https://www.wikidata.org/wiki/Q324663","display_name":"Endocrine gland","level":3,"score":0.3515999913215637},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3463999927043915},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.3409000039100647},{"id":"https://openalex.org/C2777693530","wikidata":"https://www.wikidata.org/wiki/Q6594689","display_name":"Benzhydryl compounds","level":4,"score":0.32839998602867126},{"id":"https://openalex.org/C161176658","wikidata":"https://www.wikidata.org/wiki/Q131656","display_name":"Pesticide","level":2,"score":0.3206000030040741},{"id":"https://openalex.org/C2780910648","wikidata":"https://www.wikidata.org/wiki/Q919689","display_name":"Chromaffin cell","level":4,"score":0.29760000109672546},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.287200003862381},{"id":"https://openalex.org/C137858568","wikidata":"https://www.wikidata.org/wiki/Q7239","display_name":"Organism","level":2,"score":0.28380000591278076},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.2809000015258789},{"id":"https://openalex.org/C2987857752","wikidata":"https://www.wikidata.org/wiki/Q12147","display_name":"Human health","level":2,"score":0.2808000147342682},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.2759999930858612},{"id":"https://openalex.org/C95713431","wikidata":"https://www.wikidata.org/wiki/Q631425","display_name":"Vulnerability (computing)","level":2,"score":0.26840001344680786},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.2587999999523163},{"id":"https://openalex.org/C2780155452","wikidata":"https://www.wikidata.org/wiki/Q416769","display_name":"Nonylphenol","level":2,"score":0.2515999972820282}],"mesh":[{"descriptor_ui":"D000313","descriptor_name":"Adrenal Medulla","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000313","descriptor_name":"Adrenal Medulla","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002395","descriptor_name":"Catecholamines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003634","descriptor_name":"DDT","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D003634","descriptor_name":"DDT","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010575","descriptor_name":"Pesticides","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011297","descriptor_name":"Prenatal Exposure Delayed Effects","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019439","descriptor_name":"Chromaffin Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D019439","descriptor_name":"Chromaffin Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019439","descriptor_name":"Chromaffin Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D052244","descriptor_name":"Endocrine Disruptors","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.3390/ijms27188323","doi":"https://doi.org/10.3390/ijms27188323","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms27188323","pdf_url":null,"source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13607560","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13607560/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13607560/pdf/ijms-27-08323.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Mol Sci","raw_type":"Text"},{"id":"pmid:42794750","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42794750","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular sciences","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3390/ijms27188323","doi":"https://doi.org/10.3390/ijms27188323","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms27188323","pdf_url":null,"source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8979765303","display_name":null,"funder_award_id":"-2025-0001","funder_id":"https://openalex.org/F4320327494","funder_display_name":"Ministry of Science and Higher Education of the Russian Federation"}],"funders":[{"id":"https://openalex.org/F4320327494","display_name":"Ministry of Science and Higher Education of the Russian Federation","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7214483067.pdf","grobid_xml":"https://content.openalex.org/works/W7214483067.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4391217755","https://openalex.org/W4225143923","https://openalex.org/W3022639073","https://openalex.org/W3203554067","https://openalex.org/W3005366001","https://openalex.org/W4402212744","https://openalex.org/W2062461135","https://openalex.org/W215287385","https://openalex.org/W3165272250","https://openalex.org/W2752001743"],"abstract_inverted_index":{"Dichlorodiphenyltrichloroethane":[0],"(DDT)":[1],"remains":[2],"one":[3,164,194],"of":[4,13,32,71,94,105,118,131,141,158,170,176,187,201,208,218],"the":[5,14,27,30,42,69,92,108,111,119,139,142,154,188,192,213],"most":[6,23],"emblematic":[7],"and":[8,36,114,134,174,184,191,199,220,225],"enduring":[9],"persistent":[10],"organic":[11],"pollutants":[12],"20th":[15],"century.":[16],"Although":[17],"prohibited":[18],"for":[19,48,227],"agricultural":[20],"use":[21],"in":[22,46,74,223],"industrialized":[24],"nations":[25],"during":[26],"1970s-1980s":[28],"on":[29,107,138,153],"grounds":[31],"its":[33,56],"persistence,":[34],"bioaccumulation,":[35],"carcinogenicity,":[37],"DDT":[38,72,81,95,106],"was":[39],"reintroduced":[40],"by":[41,145],"World":[43],"Health":[44],"Organization":[45],"2006":[47],"indoor":[49],"residual":[50],"spraying":[51],"against":[52],"vector-borne":[53],"diseases.":[54],"Consequently,":[55],"environmental":[57],"burden":[58],"continues":[59],"to":[60,80,96,148],"be":[61],"replenished":[62],"rather":[63],"than":[64],"diminished.":[65],"Biomonitoring":[66],"surveys":[67],"confirm":[68],"near-ubiquity":[70],"residues":[73],"human":[75,78],"populations.":[76],"Low-dose":[77],"exposure":[79,147],"occurs":[82],"predominantly":[83],"through":[84],"contaminated":[85],"food.":[86],"Its":[87],"main":[88,156],"health":[89],"risk":[90],"is":[91,122,165,182,195],"ability":[93],"disrupt":[97],"endocrine":[98,132,166,209],"function.":[99],"Numerous":[100],"reports":[101],"show":[102],"negative":[103],"effects":[104],"reproductive":[109],"system,":[110],"thyroid":[112],"gland,":[113],"immune":[115],"defense.":[116],"Affection":[117],"nervous":[120],"system":[121],"sufficiently":[123],"less":[124],"studied.":[125],"This":[126],"article":[127],"presents":[128],"known":[129],"mechanisms":[130,217],"disruption":[133,140,219],"summarizes":[135],"current":[136],"data":[137],"adrenal":[143,189],"medulla":[144],"low-dose":[146],"DDT.":[149],"The":[150,162,180],"review":[151],"focuses":[152],"three":[155],"aspects":[157],"chromaffin":[159],"cell":[160,197,202],"biology.":[161],"first":[163],"function,":[167],"including":[168],"synthesis":[169],"catecholamines,":[171],"secretory":[172],"machinery":[173],"release":[175],"catecholamines":[177],"into":[178],"circulation.":[179],"second":[181],"embryonic":[183],"postnatal":[185],"development":[186],"medulla,":[190],"third":[193],"physiological":[196],"renewal":[198],"maintenance":[200],"population,":[203],"a":[204],"novel":[205],"enigmatic":[206],"aspect":[207],"disruption.":[210],"In":[211],"conclusion,":[212],"authors":[214],"present":[215],"integrated":[216],"indicate":[221],"gaps":[222],"knowledge":[224],"directions":[226],"further":[228],"investigations.":[229]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-09-27T00:00:00"}