{"id":"https://openalex.org/W7214477204","doi":"https://doi.org/10.64898/2026.09.21.26363546","title":"New-Onset Heart Failure in Patients with Obesity using Tirzepatide or Semaglutide","display_name":"New-Onset Heart Failure in Patients with Obesity using Tirzepatide or Semaglutide","publication_year":2026,"publication_date":"2026-09-26","ids":{"openalex":"https://openalex.org/W7214477204","doi":"https://doi.org/10.64898/2026.09.21.26363546"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.21.26363546","doi":"https://doi.org/10.64898/2026.09.21.26363546","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.21.26363546","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2026/09/26/2026.09.21.26363546.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.medrxiv.org/content/medrxiv/early/2026/09/26/2026.09.21.26363546.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087017808","display_name":"Mohammed Al-Nusair","orcid":"https://orcid.org/0000-0003-0572-780X","observed_orcids":["https://orcid.org/0000-0003-0572-780X"]},"institutions":[{"id":"https://openalex.org/I1285739803","display_name":"MedStar Washington Hospital Center","ror":"https://ror.org/05ry42w04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285739803","https://openalex.org/I86755215"]},{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mohammed Al-Nusair","raw_affiliation_strings":["Department of Internal Medicine, Georgetown University- MedStar Washington Hospital Center, 110 Irving St NW, Washington, DC 20010, USA"],"raw_orcid":"https://orcid.org/0000-0003-0572-780X","affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Georgetown University- MedStar Washington Hospital Center, 110 Irving St NW, Washington, DC 20010, USA","institution_ids":["https://openalex.org/I1285739803","https://openalex.org/I184565670"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027329538","display_name":"Tala A. Haddad","orcid":"https://orcid.org/0000-0003-4366-9620","observed_orcids":["https://orcid.org/0000-0003-4366-9620"]},"institutions":[{"id":"https://openalex.org/I1285739803","display_name":"MedStar Washington Hospital Center","ror":"https://ror.org/05ry42w04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285739803","https://openalex.org/I86755215"]},{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tala A. Haddad","raw_affiliation_strings":["Department of Internal Medicine, Georgetown University- MedStar Washington Hospital Center, 110 Irving St NW, Washington, DC 20010, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Georgetown University- MedStar Washington Hospital Center, 110 Irving St NW, Washington, DC 20010, USA","institution_ids":["https://openalex.org/I1285739803","https://openalex.org/I184565670"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061921199","display_name":"Shriya Khurana","orcid":"https://orcid.org/0000-0002-8525-8881","observed_orcids":["https://orcid.org/0000-0002-8525-8881"]},"institutions":[{"id":"https://openalex.org/I1285739803","display_name":"MedStar Washington Hospital Center","ror":"https://ror.org/05ry42w04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285739803","https://openalex.org/I86755215"]},{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shriya Khurana","raw_affiliation_strings":["Department of Internal Medicine, Georgetown University- MedStar Washington Hospital Center, 110 Irving St NW, Washington, DC 20010, USA"],"raw_orcid":"https://orcid.org/0000-0002-8525-8881","affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Georgetown University- MedStar Washington Hospital Center, 110 Irving St NW, Washington, DC 20010, USA","institution_ids":["https://openalex.org/I1285739803","https://openalex.org/I184565670"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064804080","display_name":"Jowan Al\u2010Nusair","orcid":"https://orcid.org/0000-0002-7183-5940","observed_orcids":["https://orcid.org/0000-0002-7183-5940"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jowan Al-Nusair","raw_affiliation_strings":["H. Lee Moffitt Cancer Center, 12902 USF Magnolia Drive, Tampa, FL 33612, USA"],"raw_orcid":"https://orcid.org/0000-0002-7183-5940","affiliations":[{"raw_affiliation_string":"H. Lee Moffitt Cancer Center, 12902 USF Magnolia Drive, Tampa, FL 33612, USA","institution_ids":["https://openalex.org/I3019308854"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5087017808"],"corresponding_institution_ids":["https://openalex.org/I1285739803","https://openalex.org/I184565670"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10198","display_name":"Heart Failure Treatment and Management","score":0.8687000274658203,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10198","display_name":"Heart Failure Treatment and Management","score":0.8687000274658203,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.10279999673366547,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.010400000028312206,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tirzepatide","display_name":"tirzepatide","score":0.9300000071525574},{"id":"https://openalex.org/keywords/semaglutide","display_name":"semaglutide","score":1.0},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.7400000095367432},{"id":"https://openalex.org/keywords/heart-failure","display_name":"heart failure","score":0.8939999938011169},{"id":"https://openalex.org/keywords/new-onset-heart-failure","display_name":"new-onset heart failure","score":0.9089999794960022},{"id":"https://openalex.org/keywords/heart-failure-with-preserved-ejection-fraction","display_name":"heart failure with preserved ejection fraction","score":0.984000027179718},{"id":"https://openalex.org/keywords/heart-failure-with-reduced-ejection-fraction","display_name":"heart failure with reduced ejection fraction","score":0.9160000085830688},{"id":"https://openalex.org/keywords/atrial-fibrillation","display_name":"atrial fibrillation","score":0.9490000009536743},{"id":"https://openalex.org/keywords/all-cause-mortality","display_name":"all-cause mortality","score":0.984000027179718},{"id":"https://openalex.org/keywords/glp-1-receptor-agonists","display_name":"GLP-1 receptor agonists","score":0.9369999766349792},{"id":"https://openalex.org/keywords/sglt2-inhibitors","display_name":"SGLT2 inhibitors","score":0.7149999737739563},{"id":"https://openalex.org/keywords/cardiometabolic-risk","display_name":"cardiometabolic risk","score":0.7009999752044678}],"concepts":[{"id":"https://openalex.org/C2909862629","wikidata":"https://www.wikidata.org/wiki/Q27261089","display_name":"Semaglutide","level":5,"score":0.9549999833106995},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9144999980926514},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.7591999769210815},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.7059999704360962},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.696399986743927},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.6298999786376953},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.5723000168800354},{"id":"https://openalex.org/C2779161974","wikidata":"https://www.wikidata.org/wiki/Q815819","display_name":"Atrial fibrillation","level":2,"score":0.5476999878883362},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.5095000267028809},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.5015000104904175},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.4659999907016754},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.39719998836517334},{"id":"https://openalex.org/C2779668873","wikidata":"https://www.wikidata.org/wiki/Q6693756","display_name":"Lower risk","level":3,"score":0.3928999900817871},{"id":"https://openalex.org/C78085059","wikidata":"https://www.wikidata.org/wiki/Q641303","display_name":"Ejection fraction","level":3,"score":0.3822999894618988},{"id":"https://openalex.org/C88879693","wikidata":"https://www.wikidata.org/wiki/Q217690","display_name":"Cumulative incidence","level":3,"score":0.37229999899864197},{"id":"https://openalex.org/C57900726","wikidata":"https://www.wikidata.org/wiki/Q492905","display_name":"Diastole","level":3,"score":0.353300005197525},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.33629998564720154},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.3353999853134155},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.3328000009059906},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.32010000944137573},{"id":"https://openalex.org/C82789193","wikidata":"https://www.wikidata.org/wiki/Q2142611","display_name":"Relative risk","level":3,"score":0.2623000144958496}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.09.21.26363546","doi":"https://doi.org/10.64898/2026.09.21.26363546","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.21.26363546","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2026/09/26/2026.09.21.26363546.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.09.21.26363546","doi":"https://doi.org/10.64898/2026.09.21.26363546","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.21.26363546","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2026/09/26/2026.09.21.26363546.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7214477204.pdf","grobid_xml":"https://content.openalex.org/works/W7214477204.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W1957007052","https://openalex.org/W2017221955","https://openalex.org/W2525024965","https://openalex.org/W2556053991","https://openalex.org/W2581264645","https://openalex.org/W2592392911","https://openalex.org/W2604584410","https://openalex.org/W2886277721","https://openalex.org/W2969925328","https://openalex.org/W3011482816","https://openalex.org/W3011957437","https://openalex.org/W3177122952","https://openalex.org/W3208960067","https://openalex.org/W3217337816","https://openalex.org/W4224930854","https://openalex.org/W4377990762","https://openalex.org/W4386154055","https://openalex.org/W4392371232","https://openalex.org/W4393255879","https://openalex.org/W4394785699","https://openalex.org/W4399671023","https://openalex.org/W4400415068","https://openalex.org/W4401167578","https://openalex.org/W4404437149","https://openalex.org/W4409162613","https://openalex.org/W4410277932","https://openalex.org/W4410806707","https://openalex.org/W4411277743","https://openalex.org/W4414445746","https://openalex.org/W4416055414","https://openalex.org/W4417497606","https://openalex.org/W7142148474","https://openalex.org/W7172300665"],"related_works":["https://openalex.org/W4415408673","https://openalex.org/W7166475896","https://openalex.org/W7125926726","https://openalex.org/W7211962832","https://openalex.org/W7141072679","https://openalex.org/W4415789333","https://openalex.org/W7139118007","https://openalex.org/W4415793840","https://openalex.org/W7166464557","https://openalex.org/W7131836680"],"abstract_inverted_index":{"ABSTRACT":[0],"Background":[1],"Tirzepatide":[2,23],"and":[3,8,17,95,112,135,208],"semaglutide":[4,52,82,243],"improve":[5],"functional":[6],"status":[7],"heart":[9,126],"failure":[10],"(HF)":[11],"events":[12],"in":[13,34,53,160,171,222],"patients":[14,35,54,228],"with":[15,19,27,36,45,55,74,79,150,229,235],"obesity":[16,37,56,75],"HF":[18,50,109,168,211,240],"preserved":[20],"ejection":[21],"fraction.":[22],"has":[24],"been":[25],"associated":[26,44,234],"greater":[28],"control":[29],"of":[30,48,107,166,200,238],"cardiometabolic":[31],"risk":[32,47,179,199,237],"factors":[33],"compared":[38,113,241],"to":[39,89,99,144,185,242],"semaglutide.":[40],"Whether":[41],"tirzepatide":[42,80,173,193,231],"is":[43,57],"lower":[46,170,198,236],"new-onset":[49,108,121,124,128,167,209,239],"than":[51],"underexplored.":[58],"Methods":[59],"A":[60],"retrospective":[61],"cohort":[62],"study":[63,102,224],"was":[64,110,169,233],"conducted":[65],"using":[66],"data":[67],"pooled":[68],"from":[69],"the":[70,84,115,172,245],"TriNetX":[71],"platform.":[72],"Patients":[73],"who":[76],"initiated":[77],"therapy":[78,232],"or":[81,131],"during":[83],"period":[85],"Jun":[86],"4,":[87],"2021":[88],"Aug":[90],"13,":[91],"2026":[92],"were":[93,142,162,195,248],"identified":[94],"1:1":[96],"propensity-score":[97],"matched":[98],"produce":[100],"two":[101,116],"cohorts.":[103,117],"The":[104,164,192],"one-year":[105],"incidence":[106,165],"calculated":[111],"between":[114],"Secondary":[118],"outcomes":[119,217],"included":[120],"systolic":[122,210],"HF,":[123],"diastolic":[125],"failure,":[127],"atrial":[129],"fibrillation":[130],"flutter,":[132],"all-cause":[133,201],"mortality,":[134],"hospital":[136],"encounters.":[137],"Cox":[138],"proportional":[139],"hazards":[140],"models":[141],"fitted":[143],"calculate":[145],"hazard":[146],"ratios":[147],"(HR)":[148],"along":[149],"95%":[151,182,189,204],"confidence":[152],"intervals":[153],"(CI).":[154],"Results":[155],"Two":[156],"well-matched":[157],"cohorts":[158],"(N=424,269":[159],"each)":[161],"formed.":[163],"group":[174,194],"(1.0%":[175],"vs.":[176],"1.3%;":[177],"absolute":[178],"difference":[180],"\u22120.3%,":[181],"CI":[183,190],"\u22120.35":[184],"\u22120.26;":[186],"HR":[187],"0.9,":[188],"0.86\u25000.93).":[191],"also":[196],"at":[197,219],"mortality":[202],"(HR,":[203],"CI:":[205],"0.8,":[206],"0.77\u25000.91)":[207],"(0.8,":[212],"0.79\u25000.92).":[213],"All":[214],"other":[215],"secondary":[216],"occurred":[218],"similar":[220],"rates":[221],"both":[223],"groups.":[225],"Conclusion":[226],"Among":[227],"obesity,":[230],"although":[244],"effect":[246],"sizes":[247],"modest.":[249]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-09-27T00:00:00"}
