{"id":"https://openalex.org/W7214477113","doi":"https://doi.org/10.3390/ijms27188321","title":"Polyol-Functionalized Manganese-Based Nanoparticles: From Insulin Amyloid Inhibition to Nanozyme-Mediated Antioxidant Activity","display_name":"Polyol-Functionalized Manganese-Based Nanoparticles: From Insulin Amyloid Inhibition to Nanozyme-Mediated Antioxidant Activity","publication_year":2026,"publication_date":"2026-09-18","ids":{"openalex":"https://openalex.org/W7214477113","doi":"https://doi.org/10.3390/ijms27188321","pmid":"https://pubmed.ncbi.nlm.nih.gov/42794748","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13607232"},"language":"en","primary_location":{"id":"doi:10.3390/ijms27188321","doi":"https://doi.org/10.3390/ijms27188321","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms27188321","pdf_url":null,"source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/ijms27188321","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078799162","display_name":"Kleoniki Giannousi","orcid":"https://orcid.org/0000-0002-6574-7813","observed_orcids":["https://orcid.org/0000-0002-6574-7813"]},"institutions":[{"id":"https://openalex.org/I21370196","display_name":"Aristotle University of Thessaloniki","ror":"https://ror.org/02j61yw88","country_code":"GR","type":"education","lineage":["https://openalex.org/I21370196"]}],"countries":["GR"],"is_corresponding":true,"raw_author_name":"Kleoniki Giannousi","raw_affiliation_strings":["Laboratory of Inorganic Chemistry, School of Chemistry, Aristotle University of Thessaloniki, 541 24 Thessaloniki, Greece"],"raw_orcid":"https://orcid.org/0000-0002-6574-7813","affiliations":[{"raw_affiliation_string":"Laboratory of Inorganic Chemistry, School of Chemistry, Aristotle University of Thessaloniki, 541 24 Thessaloniki, Greece","institution_ids":["https://openalex.org/I21370196"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5127767457","display_name":"Zoi Kourpouanidou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I21370196","display_name":"Aristotle University of Thessaloniki","ror":"https://ror.org/02j61yw88","country_code":"GR","type":"education","lineage":["https://openalex.org/I21370196"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Zoi Kourpouanidou","raw_affiliation_strings":["Laboratory of Inorganic Chemistry, School of Chemistry, Aristotle University of Thessaloniki, 541 24 Thessaloniki, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Inorganic Chemistry, School of Chemistry, Aristotle University of Thessaloniki, 541 24 Thessaloniki, Greece","institution_ids":["https://openalex.org/I21370196"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5116303875","display_name":"Elpida Pantelidou","orcid":"https://orcid.org/0009-0005-8780-5470","observed_orcids":["https://orcid.org/0009-0005-8780-5470"]},"institutions":[{"id":"https://openalex.org/I21370196","display_name":"Aristotle University of Thessaloniki","ror":"https://ror.org/02j61yw88","country_code":"GR","type":"education","lineage":["https://openalex.org/I21370196"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Elpida Pantelidou","raw_affiliation_strings":["Laboratory of Inorganic Chemistry, School of Chemistry, Aristotle University of Thessaloniki, 541 24 Thessaloniki, Greece"],"raw_orcid":"https://orcid.org/0009-0005-8780-5470","affiliations":[{"raw_affiliation_string":"Laboratory of Inorganic Chemistry, School of Chemistry, Aristotle University of Thessaloniki, 541 24 Thessaloniki, Greece","institution_ids":["https://openalex.org/I21370196"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007203822","display_name":"C. Dendrinou-Samara","orcid":"https://orcid.org/0000-0001-9395-8717","observed_orcids":["https://orcid.org/0000-0001-9395-8717"]},"institutions":[{"id":"https://openalex.org/I21370196","display_name":"Aristotle University of Thessaloniki","ror":"https://ror.org/02j61yw88","country_code":"GR","type":"education","lineage":["https://openalex.org/I21370196"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Catherine Dendrinou-Samara","raw_affiliation_strings":["Laboratory of Inorganic Chemistry, School of Chemistry, Aristotle University of Thessaloniki, 541 24 Thessaloniki, Greece"],"raw_orcid":"https://orcid.org/0000-0001-9395-8717","affiliations":[{"raw_affiliation_string":"Laboratory of Inorganic Chemistry, School of Chemistry, Aristotle University of Thessaloniki, 541 24 Thessaloniki, Greece","institution_ids":["https://openalex.org/I21370196"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5078799162"],"corresponding_institution_ids":["https://openalex.org/I21370196"],"apc_list":{"value":2900,"currency":"CHF","value_usd":3499},"apc_paid":{"value":2900,"currency":"CHF","value_usd":3499},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.54004777,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"27","issue":"18","first_page":"8321","last_page":"8321"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12302","display_name":"Advanced Nanomaterials in Catalysis","score":0.8246999979019165,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T12302","display_name":"Advanced Nanomaterials in Catalysis","score":0.8246999979019165,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.009999999776482582,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10212","display_name":"Electrochemical sensors and biosensors","score":0.006899999920278788,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/manganese-oxide-nanoparticles","display_name":"manganese oxide nanoparticles","score":0.7739999890327454},{"id":"https://openalex.org/keywords/insulin-aspart","display_name":"insulin aspart","score":0.7300000190734863},{"id":"https://openalex.org/keywords/insulin-glargine","display_name":"insulin glargine","score":0.9950000047683716},{"id":"https://openalex.org/keywords/amyloid-fibril-formation","display_name":"amyloid fibril formation","score":0.7689999938011169},{"id":"https://openalex.org/keywords/catalase-like-activity","display_name":"catalase-like activity","score":0.7799999713897705},{"id":"https://openalex.org/keywords/hydrogen-peroxide-scavenging","display_name":"hydrogen peroxide scavenging","score":0.9290000200271606},{"id":"https://openalex.org/keywords/nanozymes","display_name":"nanozymes","score":0.8709999918937683},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.7649999856948853},{"id":"https://openalex.org/keywords/solvothermal-synthesis","display_name":"solvothermal synthesis","score":0.6809999942779541},{"id":"https://openalex.org/keywords/nanoparticle-size-and-surface-charge","display_name":"nanoparticle size and surface charge","score":0.6800000071525574},{"id":"https://openalex.org/keywords/tht-fluorescence","display_name":"ThT fluorescence","score":0.5429999828338623}],"concepts":[{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.7017999887466431},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.6129999756813049},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6032999753952026},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.5976999998092651},{"id":"https://openalex.org/C2777633098","wikidata":"https://www.wikidata.org/wiki/Q2736051","display_name":"Amyloid (mycology)","level":2,"score":0.5873000025749207},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4422999918460846},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.44200000166893005},{"id":"https://openalex.org/C2779951007","wikidata":"https://www.wikidata.org/wiki/Q816798","display_name":"Amyloidosis","level":2,"score":0.4377000033855438},{"id":"https://openalex.org/C2994168385","wikidata":"https://www.wikidata.org/wiki/Q6740853","display_name":"Amyloid fibril","level":4,"score":0.4239000082015991},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.39959999918937683},{"id":"https://openalex.org/C27523624","wikidata":"https://www.wikidata.org/wiki/Q14860849","display_name":"Fibril","level":2,"score":0.3564000129699707},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.35420000553131104},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.33640000224113464},{"id":"https://openalex.org/C3020296196","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative damage","level":3,"score":0.3352000117301941},{"id":"https://openalex.org/C116073593","wikidata":"https://www.wikidata.org/wiki/Q864491","display_name":"Biological activity","level":3,"score":0.33489999175071716},{"id":"https://openalex.org/C136238340","wikidata":"https://www.wikidata.org/wiki/Q7251455","display_name":"Protein aggregation","level":2,"score":0.33480000495910645},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.33250001072883606},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.3224000036716461},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.32190001010894775},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.31769999861717224},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.30250000953674316},{"id":"https://openalex.org/C57600042","wikidata":"https://www.wikidata.org/wiki/Q227564","display_name":"Oxidative phosphorylation","level":2,"score":0.2761000096797943},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2517000138759613}],"mesh":[{"descriptor_ui":"D000682","descriptor_name":"Amyloid","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D000682","descriptor_name":"Amyloid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000682","descriptor_name":"Amyloid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008345","descriptor_name":"Manganese","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011108","descriptor_name":"Polymers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.3390/ijms27188321","doi":"https://doi.org/10.3390/ijms27188321","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms27188321","pdf_url":null,"source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},{"id":"pmid:42794748","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42794748","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular sciences","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13607232","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13607232/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Mol Sci","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3390/ijms27188321","doi":"https://doi.org/10.3390/ijms27188321","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms27188321","pdf_url":null,"source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":52,"referenced_works":["https://openalex.org/W1482232821","https://openalex.org/W1832400535","https://openalex.org/W1987665052","https://openalex.org/W2000483769","https://openalex.org/W2008547187","https://openalex.org/W2021876818","https://openalex.org/W2025607001","https://openalex.org/W2040009394","https://openalex.org/W2041908678","https://openalex.org/W2063595745","https://openalex.org/W2086478297","https://openalex.org/W2093491751","https://openalex.org/W2126699352","https://openalex.org/W2151790917","https://openalex.org/W2258409964","https://openalex.org/W2322019973","https://openalex.org/W2551584141","https://openalex.org/W2614053601","https://openalex.org/W2616212523","https://openalex.org/W2664009300","https://openalex.org/W2756282825","https://openalex.org/W2786474781","https://openalex.org/W2791880767","https://openalex.org/W2808586993","https://openalex.org/W2890980244","https://openalex.org/W2961730214","https://openalex.org/W2999053679","https://openalex.org/W3001462071","https://openalex.org/W3015124741","https://openalex.org/W3015769349","https://openalex.org/W3035889001","https://openalex.org/W3110654034","https://openalex.org/W3178870085","https://openalex.org/W3179304260","https://openalex.org/W3210332949","https://openalex.org/W4200402466","https://openalex.org/W4309192821","https://openalex.org/W4317434639","https://openalex.org/W4388289636","https://openalex.org/W4394857640","https://openalex.org/W4399705444","https://openalex.org/W4404790654","https://openalex.org/W4405150308","https://openalex.org/W4407252326","https://openalex.org/W4407677865","https://openalex.org/W4408762437","https://openalex.org/W4410108579","https://openalex.org/W4410640737","https://openalex.org/W4411952148","https://openalex.org/W4413439614","https://openalex.org/W7133132461","https://openalex.org/W7159796734"],"related_works":["https://openalex.org/W2890679449","https://openalex.org/W4413439614","https://openalex.org/W2535858071","https://openalex.org/W7167416457","https://openalex.org/W940770792","https://openalex.org/W2948016102","https://openalex.org/W4407303063","https://openalex.org/W4408762437","https://openalex.org/W3197807589","https://openalex.org/W3024467522"],"abstract_inverted_index":{"Insulin":[0],"amyloidosis":[1,191],"poses":[2],"challenges":[3],"in":[4,27,121],"diabetes":[5],"therapy":[6],"and":[7,18,25,36,45,57,105,154,179,192,206],"biopharmaceuticals":[8],"handling.":[9],"Here,":[10],"functionalized":[11],"manganese-based":[12],"nanoparticles":[13,68,97],"(MnCO3@TEG,":[14],"MnCO3@OAm,":[15],"MnOHCO3@TEG,":[16],"MnO2/Mn2O3@TEG,":[17],"Mn3O4@PG)":[19,99],"were":[20],"synthesized":[21],"via":[22],"solvothermal":[23],"routes":[24],"evaluated":[26],"vitro":[28],"using":[29],"a":[30,37,101,137,184],"fresh":[31,63],"insulin":[32,40,64,87,190],"aspart":[33,65],"formulation":[34,42],"(NovoRapid)":[35],"separately":[38],"aged":[39,86],"glargine":[41,88],"(Lantus).":[43],"Structural":[44],"colloidal":[46,156],"characterization":[47,205],"(ATR-FTIR,":[48],"XRD,":[49],"TGA,":[50],"DLS,":[51],"zeta":[52],"potential)":[53],"confirmed":[54],"phase":[55,104],"purity":[56],"distinct":[58,102],"surface":[59,177],"profiles.":[60],"In":[61,84,109],"the":[62,70,85,110,118,127],"system,":[66],"all":[67],"extended":[69],"nucleation":[71],"lag":[72,103],"phase,":[73],"with":[74],"MnCO3@TEG":[75],"delaying":[76],"fibrillogenesis":[77],"from":[78,143],"21.16":[79],"h":[80],"to":[81,124,162,212],"105.41":[82],"h.":[83],"system":[89],"containing":[90],"pre-existing":[91],"ThT-positive":[92],"aggregates,":[93],"small,":[94],"negatively":[95],"charged":[96],"(MnOHCO3@TEG,":[98],"re-established":[100],"suppressed":[106],"further":[107,203],"aggregation.":[108],"ThT":[111],"decay":[112],"assays,":[113],"highly":[114],"dispersed":[115],"Mn3O4@PG":[116],"produced":[117,136],"largest":[119],"decrease":[120],"amyloid-associated":[122],"fluorescence,":[123],"~40%":[125],"of":[126,199],"initial":[128],"signal,":[129],"whereas":[130],"large":[131],"clusters":[132],"(MnO2/Mn2O3@TEG,":[133],"624":[134],"nm)":[135],"smaller":[138],"decrease;":[139],"limited":[140],"access":[141],"arising":[142],"steric":[144],"effects":[145],"is":[146],"one":[147],"possible":[148],"explanation.":[149],"Additionally,":[150],"structural":[151,204],"hydroxyl":[152],"groups":[153],"high":[155],"stability":[157],"enabled":[158],"MnOHCO3@TEG":[159],"(\u221238.7":[160],"mV)":[161],"exhibit":[163],"superior":[164],"catalase-like":[165],"H2O2":[166],"scavenging":[167],"(42.27%":[168],"inhibition":[169],"at":[170],"250":[171],"\u03bcg/mL).":[172],"Overall,":[173],"fine-tuning":[174],"nanoparticle":[175],"size,":[176],"charge,":[178],"core":[180],"composition":[181],"may":[182],"offer":[183],"promising":[185],"dual-action":[186],"strategy":[187],"for":[188],"targeting":[189],"associated":[193],"oxidative":[194],"stress":[195],"across":[196],"different":[197],"stages":[198],"fibril":[200],"formation,":[201],"while":[202],"biological":[207],"safety":[208],"studies":[209],"are":[210],"needed":[211],"establish":[213],"its":[214],"therapeutic":[215],"relevance.":[216]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-09-27T00:00:00"}