{"id":"https://openalex.org/W7214466812","doi":"https://doi.org/10.64898/2026.09.25.754415","title":"Novel Synthetic Polymyxin Variants Inspired by Newly Uncovered Natural Sequences Explored as Potential Antibiotics","display_name":"Novel Synthetic Polymyxin Variants Inspired by Newly Uncovered Natural Sequences Explored as Potential Antibiotics","publication_year":2026,"publication_date":"2026-09-26","ids":{"openalex":"https://openalex.org/W7214466812","doi":"https://doi.org/10.64898/2026.09.25.754415"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.25.754415","doi":"https://doi.org/10.64898/2026.09.25.754415","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.25.754415","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/26/2026.09.25.754415.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/26/2026.09.25.754415.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070394815","display_name":"Walliyulahi Ajibola","orcid":"https://orcid.org/0000-0001-8081-4693","observed_orcids":["https://orcid.org/0000-0001-8081-4693"]},"institutions":[{"id":"https://openalex.org/I227486990","display_name":"University of Szeged","ror":"https://ror.org/01pnej532","country_code":"HU","type":"education","lineage":["https://openalex.org/I227486990"]},{"id":"https://openalex.org/I2800351701","display_name":"HUN-REN Szegedi Biol\u00f3giai Kutat\u00f3k\u00f6zpont","ror":"https://ror.org/016gb1631","country_code":"HU","type":"facility","lineage":["https://openalex.org/I2800351701","https://openalex.org/I7597260"]},{"id":"https://openalex.org/I4210103004","display_name":"Institute of Biochemistry","ror":"https://ror.org/022dvs210","country_code":"HU","type":"facility","lineage":["https://openalex.org/I2800351701","https://openalex.org/I4210103004","https://openalex.org/I7597260"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Walliyulahi Ajibola","raw_affiliation_strings":["Doctoral School in Biology, Faculty of Science and Informatics, University of Szeged, Szeged, Hungary","Synthetic and Systems Biology Unit, Institute of Biochemistry, Hun-Ren Biological Research Centre, Szeged, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Doctoral School in Biology, Faculty of Science and Informatics, University of Szeged, Szeged, Hungary","institution_ids":["https://openalex.org/I227486990"]},{"raw_affiliation_string":"Synthetic and Systems Biology Unit, Institute of Biochemistry, Hun-Ren Biological Research Centre, Szeged, Hungary","institution_ids":["https://openalex.org/I2800351701","https://openalex.org/I4210103004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060831245","display_name":"Roland Teng\u00f6lics","orcid":"https://orcid.org/0000-0002-1338-431X","observed_orcids":["https://orcid.org/0000-0002-1338-431X"]},"institutions":[{"id":"https://openalex.org/I2800351701","display_name":"HUN-REN Szegedi Biol\u00f3giai Kutat\u00f3k\u00f6zpont","ror":"https://ror.org/016gb1631","country_code":"HU","type":"facility","lineage":["https://openalex.org/I2800351701","https://openalex.org/I7597260"]},{"id":"https://openalex.org/I4210103004","display_name":"Institute of Biochemistry","ror":"https://ror.org/022dvs210","country_code":"HU","type":"facility","lineage":["https://openalex.org/I2800351701","https://openalex.org/I4210103004","https://openalex.org/I7597260"]},{"id":"https://openalex.org/I4387152226","display_name":"Hungarian Research Network","ror":"https://ror.org/04w6pnc49","country_code":"HU","type":"other","lineage":["https://openalex.org/I4387152226"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Roland Teng\u00f6lics","raw_affiliation_strings":["Laboratory of Metabolomics, Complex Molecular and Cell Biology Service Centre, HUN-REN Biological Research Centre, Szeged, Hungary","Synthetic and Systems Biology Unit, Institute of Biochemistry, Hun-Ren Biological Research Centre, Szeged, Hungary"],"raw_orcid":"https://orcid.org/0000-0002-1338-431X","affiliations":[{"raw_affiliation_string":"Laboratory of Metabolomics, Complex Molecular and Cell Biology Service Centre, HUN-REN Biological Research Centre, Szeged, Hungary","institution_ids":["https://openalex.org/I2800351701","https://openalex.org/I4387152226"]},{"raw_affiliation_string":"Synthetic and Systems Biology Unit, Institute of Biochemistry, Hun-Ren Biological Research Centre, Szeged, Hungary","institution_ids":["https://openalex.org/I2800351701","https://openalex.org/I4210103004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033988381","display_name":"Bakhtiyar Mahmood","orcid":"https://orcid.org/0009-0008-7627-3554","observed_orcids":["https://orcid.org/0009-0008-7627-3554"]},"institutions":[{"id":"https://openalex.org/I227486990","display_name":"University of Szeged","ror":"https://ror.org/01pnej532","country_code":"HU","type":"education","lineage":["https://openalex.org/I227486990"]},{"id":"https://openalex.org/I4387153056","display_name":"University of Garmian","ror":"https://ror.org/04rc8af74","country_code":"IQ","type":"education","lineage":["https://openalex.org/I4387153056"]}],"countries":["HU","IQ"],"is_corresponding":false,"raw_author_name":"Bakhtiyar Mahmood","raw_affiliation_strings":["Department of Nutrition and Dietetics, College of Science, University of Garmian, Kalar, Kurdistan Region, Iraq","Institute of Medical Microbiology, Albert Szent-Gy\u00f6rgyi Medical School, University of Szeged, Szeged, Hungary"],"raw_orcid":"https://orcid.org/0009-0008-7627-3554","affiliations":[{"raw_affiliation_string":"Department of Nutrition and Dietetics, College of Science, University of Garmian, Kalar, Kurdistan Region, Iraq","institution_ids":["https://openalex.org/I4387153056"]},{"raw_affiliation_string":"Institute of Medical Microbiology, Albert Szent-Gy\u00f6rgyi Medical School, University of Szeged, Szeged, Hungary","institution_ids":["https://openalex.org/I227486990"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076472778","display_name":"Annam\u00e1ria Marton","orcid":"https://orcid.org/0009-0005-0490-3359","observed_orcids":["https://orcid.org/0009-0005-0490-3359"]},"institutions":[{"id":"https://openalex.org/I2800351701","display_name":"HUN-REN Szegedi Biol\u00f3giai Kutat\u00f3k\u00f6zpont","ror":"https://ror.org/016gb1631","country_code":"HU","type":"facility","lineage":["https://openalex.org/I2800351701","https://openalex.org/I7597260"]},{"id":"https://openalex.org/I4210103004","display_name":"Institute of Biochemistry","ror":"https://ror.org/022dvs210","country_code":"HU","type":"facility","lineage":["https://openalex.org/I2800351701","https://openalex.org/I4210103004","https://openalex.org/I7597260"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Annam\u00e1ria Marton","raw_affiliation_strings":["Synthetic and Systems Biology Unit, Institute of Biochemistry, Hun-Ren Biological Research Centre, Szeged, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Synthetic and Systems Biology Unit, Institute of Biochemistry, Hun-Ren Biological Research Centre, Szeged, Hungary","institution_ids":["https://openalex.org/I2800351701","https://openalex.org/I4210103004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022498386","display_name":"\u00c9va Hunyadi\u2010Guly\u00e1s","orcid":"https://orcid.org/0000-0003-2089-1499","observed_orcids":["https://orcid.org/0000-0003-2089-1499"]},"institutions":[{"id":"https://openalex.org/I2800351701","display_name":"HUN-REN Szegedi Biol\u00f3giai Kutat\u00f3k\u00f6zpont","ror":"https://ror.org/016gb1631","country_code":"HU","type":"facility","lineage":["https://openalex.org/I2800351701","https://openalex.org/I7597260"]},{"id":"https://openalex.org/I4387152226","display_name":"Hungarian Research Network","ror":"https://ror.org/04w6pnc49","country_code":"HU","type":"other","lineage":["https://openalex.org/I4387152226"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"\u00c9va Hunyadi-Guly\u00e1s","raw_affiliation_strings":["Laboratory of Proteomics Research, Complex Molecular and Cell Biology Service Centre, HUN-REN Biological Research Centre, Szeged, Hungary"],"raw_orcid":"https://orcid.org/0000-0003-2089-1499","affiliations":[{"raw_affiliation_string":"Laboratory of Proteomics Research, Complex Molecular and Cell Biology Service Centre, HUN-REN Biological Research Centre, Szeged, Hungary","institution_ids":["https://openalex.org/I2800351701","https://openalex.org/I4387152226"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016916565","display_name":"Csaba V\u00edzler","orcid":"https://orcid.org/0009-0005-2750-8845","observed_orcids":["https://orcid.org/0009-0005-2750-8845"]},"institutions":[{"id":"https://openalex.org/I2800351701","display_name":"HUN-REN Szegedi Biol\u00f3giai Kutat\u00f3k\u00f6zpont","ror":"https://ror.org/016gb1631","country_code":"HU","type":"facility","lineage":["https://openalex.org/I2800351701","https://openalex.org/I7597260"]},{"id":"https://openalex.org/I4210103004","display_name":"Institute of Biochemistry","ror":"https://ror.org/022dvs210","country_code":"HU","type":"facility","lineage":["https://openalex.org/I2800351701","https://openalex.org/I4210103004","https://openalex.org/I7597260"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Csaba Vizler","raw_affiliation_strings":["Synthetic and Systems Biology Unit, Institute of Biochemistry, Hun-Ren Biological Research Centre, Szeged, Hungary"],"raw_orcid":"https://orcid.org/0009-0005-2750-8845","affiliations":[{"raw_affiliation_string":"Synthetic and Systems Biology Unit, Institute of Biochemistry, Hun-Ren Biological Research Centre, Szeged, Hungary","institution_ids":["https://openalex.org/I2800351701","https://openalex.org/I4210103004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056370710","display_name":"J\u00f3zsef S\u00f3ki","orcid":"https://orcid.org/0000-0001-9230-8907","observed_orcids":["https://orcid.org/0000-0001-9230-8907"]},"institutions":[{"id":"https://openalex.org/I227486990","display_name":"University of Szeged","ror":"https://ror.org/01pnej532","country_code":"HU","type":"education","lineage":["https://openalex.org/I227486990"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"J\u00f3zsef S\u00f3ki","raw_affiliation_strings":["Institute of Medical Microbiology, Albert Szent-Gy\u00f6rgyi Medical School, University of Szeged, Szeged, Hungary"],"raw_orcid":"https://orcid.org/0000-0001-9230-8907","affiliations":[{"raw_affiliation_string":"Institute of Medical Microbiology, Albert Szent-Gy\u00f6rgyi Medical School, University of Szeged, Szeged, Hungary","institution_ids":["https://openalex.org/I227486990"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062271042","display_name":"Zsuzsanna Darula","orcid":"https://orcid.org/0000-0003-1692-7591","observed_orcids":["https://orcid.org/0000-0003-1692-7591"]},"institutions":[{"id":"https://openalex.org/I2800351701","display_name":"HUN-REN Szegedi Biol\u00f3giai Kutat\u00f3k\u00f6zpont","ror":"https://ror.org/016gb1631","country_code":"HU","type":"facility","lineage":["https://openalex.org/I2800351701","https://openalex.org/I7597260"]},{"id":"https://openalex.org/I4387152226","display_name":"Hungarian Research Network","ror":"https://ror.org/04w6pnc49","country_code":"HU","type":"other","lineage":["https://openalex.org/I4387152226"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Zsuzsanna Darula","raw_affiliation_strings":["Laboratory of Proteomics Research, Complex Molecular and Cell Biology Service Centre, HUN-REN Biological Research Centre, Szeged, Hungary","Single Cell Omics Advanced Core Facility, Hungarian Centre of Excellence for Molecular Medicine, Szeged, Hungary"],"raw_orcid":"https://orcid.org/0000-0003-1692-7591","affiliations":[{"raw_affiliation_string":"Laboratory of Proteomics Research, Complex Molecular and Cell Biology Service Centre, HUN-REN Biological Research Centre, Szeged, Hungary","institution_ids":["https://openalex.org/I2800351701","https://openalex.org/I4387152226"]},{"raw_affiliation_string":"Single Cell Omics Advanced Core Facility, Hungarian Centre of Excellence for Molecular Medicine, Szeged, Hungary","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066113346","display_name":"Tam\u00e1s Feh\u00e9r","orcid":"https://orcid.org/0000-0001-9318-3640","observed_orcids":["https://orcid.org/0000-0001-9318-3640"]},"institutions":[{"id":"https://openalex.org/I2800351701","display_name":"HUN-REN Szegedi Biol\u00f3giai Kutat\u00f3k\u00f6zpont","ror":"https://ror.org/016gb1631","country_code":"HU","type":"facility","lineage":["https://openalex.org/I2800351701","https://openalex.org/I7597260"]},{"id":"https://openalex.org/I4210103004","display_name":"Institute of Biochemistry","ror":"https://ror.org/022dvs210","country_code":"HU","type":"facility","lineage":["https://openalex.org/I2800351701","https://openalex.org/I4210103004","https://openalex.org/I7597260"]}],"countries":["HU"],"is_corresponding":true,"raw_author_name":"Tam\u00e1s Feh\u00e9r","raw_affiliation_strings":["Synthetic and Systems Biology Unit, Institute of Biochemistry, Hun-Ren Biological Research Centre, Szeged, Hungary"],"raw_orcid":"https://orcid.org/0000-0001-9318-3640","affiliations":[{"raw_affiliation_string":"Synthetic and Systems Biology Unit, Institute of Biochemistry, Hun-Ren Biological Research Centre, Szeged, Hungary","institution_ids":["https://openalex.org/I2800351701","https://openalex.org/I4210103004"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5066113346"],"corresponding_institution_ids":["https://openalex.org/I2800351701","https://openalex.org/I4210103004"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12526","display_name":"Antimicrobial agents and applications","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/polymyxins","display_name":"polymyxins","score":0.9459999799728394},{"id":"https://openalex.org/keywords/antimicrobial-peptides","display_name":"antimicrobial peptides","score":0.8759999871253967},{"id":"https://openalex.org/keywords/paenibacillus","display_name":"Paenibacillus","score":0.871999979019165},{"id":"https://openalex.org/keywords/multidrug-resistant-bacteria","display_name":"multidrug-resistant bacteria","score":0.7070000171661377},{"id":"https://openalex.org/keywords/antibiotic-resistance","display_name":"antibiotic resistance","score":0.5109999775886536},{"id":"https://openalex.org/keywords/peptide-synthesis","display_name":"peptide synthesis","score":0.640999972820282},{"id":"https://openalex.org/keywords/natural-product-screening","display_name":"natural product screening","score":0.5609999895095825},{"id":"https://openalex.org/keywords/colistin","display_name":"colistin","score":0.6600000262260437},{"id":"https://openalex.org/keywords/cyclic-peptides","display_name":"cyclic peptides","score":0.46799999475479126},{"id":"https://openalex.org/keywords/human-pathogenic-bacteria","display_name":"human pathogenic bacteria","score":0.7110000252723694},{"id":"https://openalex.org/keywords/antibacterial-activity","display_name":"antibacterial activity","score":0.753000020980835}],"concepts":[{"id":"https://openalex.org/C2780675486","wikidata":"https://www.wikidata.org/wiki/Q423765","display_name":"Polymyxin","level":3,"score":0.8349000215530396},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6603999733924866},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.5949000120162964},{"id":"https://openalex.org/C540938839","wikidata":"https://www.wikidata.org/wiki/Q1201508","display_name":"Antimicrobial peptides","level":3,"score":0.5893999934196472},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.5716999769210815},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.5374000072479248},{"id":"https://openalex.org/C2779259085","wikidata":"https://www.wikidata.org/wiki/Q418946","display_name":"Colistin","level":3,"score":0.5271999835968018},{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.525600016117096},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.48559999465942383},{"id":"https://openalex.org/C2780026444","wikidata":"https://www.wikidata.org/wiki/Q1088175","display_name":"Polymyxin B","level":3,"score":0.36070001125335693},{"id":"https://openalex.org/C2778883795","wikidata":"https://www.wikidata.org/wiki/Q804517","display_name":"Pathogenic bacteria","level":3,"score":0.34540000557899475},{"id":"https://openalex.org/C2779396153","wikidata":"https://www.wikidata.org/wiki/Q901227","display_name":"Natural product","level":2,"score":0.33079999685287476},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.3255999982357025},{"id":"https://openalex.org/C132141352","wikidata":"https://www.wikidata.org/wiki/Q1724806","display_name":"Lantibiotics","level":4,"score":0.2971000075340271},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.2955000102519989},{"id":"https://openalex.org/C146587185","wikidata":"https://www.wikidata.org/wiki/Q258248","display_name":"Bacterial outer membrane","level":4,"score":0.2872999906539917},{"id":"https://openalex.org/C2776051709","wikidata":"https://www.wikidata.org/wiki/Q632006","display_name":"Gram-negative bacteria","level":4,"score":0.263700008392334},{"id":"https://openalex.org/C180223184","wikidata":"https://www.wikidata.org/wiki/Q4839986","display_name":"Bacterial genetics","level":4,"score":0.2632000148296356},{"id":"https://openalex.org/C3019249092","wikidata":"https://www.wikidata.org/wiki/Q274493","display_name":"Antibacterial agent","level":3,"score":0.2630000114440918}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.09.25.754415","doi":"https://doi.org/10.64898/2026.09.25.754415","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.25.754415","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/26/2026.09.25.754415.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.09.25.754415","doi":"https://doi.org/10.64898/2026.09.25.754415","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.25.754415","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/26/2026.09.25.754415.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.504800021648407}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1666635675","display_name":null,"funder_award_id":"No. 739593","funder_id":"https://openalex.org/F4320332999","funder_display_name":"Horizon 2020 Framework Programme"},{"id":"https://openalex.org/G2642974238","display_name":null,"funder_award_id":"739593","funder_id":"https://openalex.org/F4320332999","funder_display_name":"Horizon 2020 Framework Programme"},{"id":"https://openalex.org/G3370310483","display_name":null,"funder_award_id":"2022\u20132.1.1-NL","funder_id":"https://openalex.org/F4320335908","funder_display_name":"Nemzeti Kutat\u00e1si, Fejleszt\u00e9si \u00e9s Innovaci\u00f3s Alap"},{"id":"https://openalex.org/G3948699883","display_name":null,"funder_award_id":"2022-2.1.1-NL-2022-00005","funder_id":"https://openalex.org/F4320335908","funder_display_name":"Nemzeti Kutat\u00e1si, Fejleszt\u00e9si \u00e9s Innovaci\u00f3s Alap"},{"id":"https://openalex.org/G4133045208","display_name":null,"funder_award_id":"739593","funder_id":"https://openalex.org/F4320335908","funder_display_name":"Nemzeti Kutat\u00e1si, Fejleszt\u00e9si \u00e9s Innovaci\u00f3s Alap"},{"id":"https://openalex.org/G4201371158","display_name":null,"funder_award_id":"TKP-2021-EGA-05","funder_id":"https://openalex.org/F4320335908","funder_display_name":"Nemzeti Kutat\u00e1si, Fejleszt\u00e9si \u00e9s Innovaci\u00f3s Alap"},{"id":"https://openalex.org/G4771075709","display_name":null,"funder_award_id":"TKP-2021-EGA-05","funder_id":"https://openalex.org/F4320332999","funder_display_name":"Horizon 2020 Framework Programme"},{"id":"https://openalex.org/G495187929","display_name":null,"funder_award_id":"EU\u2010H2020","funder_id":"https://openalex.org/F4320332999","funder_display_name":"Horizon 2020 Framework Programme"},{"id":"https://openalex.org/G7519623380","display_name":null,"funder_award_id":"KIM NKFIA 2022-2.1.1-NL-2022-00005","funder_id":"https://openalex.org/F4320335908","funder_display_name":"Nemzeti Kutat\u00e1si, Fejleszt\u00e9si \u00e9s Innovaci\u00f3s Alap"}],"funders":[{"id":"https://openalex.org/F4320332999","display_name":"Horizon 2020 Framework Programme","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320335908","display_name":"Nemzeti Kutat\u00e1si, Fejleszt\u00e9si \u00e9s Innovaci\u00f3s Alap","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7214466812.pdf","grobid_xml":"https://content.openalex.org/works/W7214466812.grobid-xml"},"referenced_works_count":53,"referenced_works":["https://openalex.org/W1485657158","https://openalex.org/W1781531090","https://openalex.org/W1888612477","https://openalex.org/W1944648180","https://openalex.org/W1953835897","https://openalex.org/W2016052066","https://openalex.org/W2024220820","https://openalex.org/W2031240692","https://openalex.org/W2039160511","https://openalex.org/W2055043387","https://openalex.org/W2063419767","https://openalex.org/W2076915648","https://openalex.org/W2097706568","https://openalex.org/W2100882223","https://openalex.org/W2123749084","https://openalex.org/W2137992445","https://openalex.org/W2142157770","https://openalex.org/W2144775551","https://openalex.org/W2159916488","https://openalex.org/W2162745520","https://openalex.org/W2167026084","https://openalex.org/W2171632431","https://openalex.org/W2175068438","https://openalex.org/W2336358258","https://openalex.org/W2433634675","https://openalex.org/W2472136907","https://openalex.org/W2518579334","https://openalex.org/W2593444269","https://openalex.org/W2611907400","https://openalex.org/W2734956387","https://openalex.org/W2786157344","https://openalex.org/W3011335140","https://openalex.org/W3088761283","https://openalex.org/W3134022672","https://openalex.org/W3157364600","https://openalex.org/W3201802222","https://openalex.org/W4211053798","https://openalex.org/W4220893990","https://openalex.org/W4253924407","https://openalex.org/W4309005198","https://openalex.org/W4368358469","https://openalex.org/W4392162030","https://openalex.org/W4395009167","https://openalex.org/W4401078981","https://openalex.org/W4402557213","https://openalex.org/W4403140326","https://openalex.org/W4406239844","https://openalex.org/W4407895503","https://openalex.org/W4410308364","https://openalex.org/W4411455183","https://openalex.org/W4412933410","https://openalex.org/W7125501761","https://openalex.org/W7165747032"],"related_works":["https://openalex.org/W7202307680","https://openalex.org/W7140959126","https://openalex.org/W2911739254","https://openalex.org/W3004736506","https://openalex.org/W2335023577","https://openalex.org/W7034230812","https://openalex.org/W7157323935","https://openalex.org/W2300926630","https://openalex.org/W6987639263","https://openalex.org/W7071603114"],"abstract_inverted_index":{"Abstract":[0],"The":[1],"incidence":[2],"of":[3,20,41,58,76,82,91,145,170,179,188],"infections":[4],"caused":[5],"by":[6],"multidrug-resistant":[7],"bacterial":[8,59,157,172],"agents":[9],"has":[10],"increased":[11],"at":[12,111],"an":[13,139],"alarming":[14],"rate":[15],"worldwide.":[16],"With":[17],"the":[18,38,74,101,118,125,148,177,185],"aim":[19],"identifying":[21],"novel":[22,180],"antimicrobial":[23,181],"peptides":[24],"(AMPs),":[25],"we":[26],"screened":[27],"bacteria":[28],"isolated":[29,78],"from":[30,51,79,143],"various":[31],"environmental":[32],"samples.":[33],"Our":[34],"hypothesis":[35],"was":[36,84,93],"that":[37,144,167],"sequence":[39],"space":[40],"natural":[42,126,171],"AMPs":[43,68,77],"belonging":[44],"to":[45,66,124],"known":[46],"AMP":[47],"classes":[48],"is":[49],"far":[50],"saturation.":[52],"We":[53],"used":[54],"a":[55,80,88],"classical":[56],"pipeline":[57],"culturing,":[60],"overlay":[61],"assays,":[62],"extraction":[63],"and":[64,87,104,130],"fractionation":[65],"purify":[67],"for":[69],"identification.":[70],"Using":[71],"LC/MS":[72],"analysis,":[73],"structure":[75],"strain":[81],"Paenibacillus":[83],"narrowed":[85],"down":[86],"new":[89,119],"subclass":[90],"polymyxins":[92,116,127],"uncovered.":[94],"These":[95,164],"harbor":[96],"three":[97,162],"aliphatic":[98],"residues":[99],"within":[100],"cyclic":[102],"C-terminal,":[103],"in":[105,153],"certain":[106],"cases":[107],"Ser":[108],"replaces":[109],"Thr":[110],"position":[112],"A2.":[113],"Four":[114],"discrete":[115],"fitting":[117],"class,":[120],"but":[121,159],"not":[122],"identical":[123],"were":[128],"synthesized":[129],"tested":[131],"against":[132,155,161],"29":[133],"human":[134],"pathogenic":[135],"bacteria.":[136],"Each":[137],"displayed":[138],"antibacterial":[140],"spectrum":[141],"different":[142],"colistin,":[146],"with":[147],"best":[149],"candidate":[150],"surpassing":[151],"it":[152],"potency":[154],"ten":[156],"strains,":[158],"underperforming":[160],"others.":[163],"results":[165],"demonstrate":[166],"current":[168],"screening":[169],"isolates":[173],"can":[174],"still":[175],"permit":[176],"design":[178],"peptide":[182],"variants":[183],"without":[184],"substantial":[186],"threat":[187],"diminishing":[189],"returns.":[190]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-09-27T00:00:00"}