{"id":"https://openalex.org/W7214464417","doi":"https://doi.org/10.1038/s41467-026-78058-y","title":"PARP10 condensation inhibits viral replication via targeting NAD+ homeostasis","display_name":"PARP10 condensation inhibits viral replication via targeting NAD+ homeostasis","publication_year":2026,"publication_date":"2026-09-26","ids":{"openalex":"https://openalex.org/W7214464417","doi":"https://doi.org/10.1038/s41467-026-78058-y","pmid":"https://pubmed.ncbi.nlm.nih.gov/42934229","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13710856"},"language":"en","primary_location":{"id":"doi:10.1038/s41467-026-78058-y","doi":"https://doi.org/10.1038/s41467-026-78058-y","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-026-78058-y","pdf_url":"https://www.nature.com/articles/s41467-026-78058-y_reference.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41467-026-78058-y_reference.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5121286518","display_name":"Xiaoxin Chen","orcid":"https://orcid.org/0009-0007-3237-1606","observed_orcids":["https://orcid.org/0009-0007-3237-1606"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I3133055985","display_name":"Westlake University","ror":"https://ror.org/05hfa4n20","country_code":"CN","type":"education","lineage":["https://openalex.org/I3133055985"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoxin Chen","raw_affiliation_strings":["Fudan University, Shanghai, China","State Key Laboratory of Gene Expression & Zhejiang Key Laboratory of Structural Biology, School of Life Sciences, Westlake University, Hangzhou, China","Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China"],"raw_orcid":"https://orcid.org/0009-0007-3237-1606","affiliations":[{"raw_affiliation_string":"Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I24943067"]},{"raw_affiliation_string":"State Key Laboratory of Gene Expression & Zhejiang Key Laboratory of Structural Biology, School of Life Sciences, Westlake University, Hangzhou, China","institution_ids":["https://openalex.org/I3133055985"]},{"raw_affiliation_string":"Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China","institution_ids":["https://openalex.org/I3133055985"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101429557","display_name":"Qi Keng Xu","orcid":"https://orcid.org/0000-0002-9480-4776","observed_orcids":["https://orcid.org/0000-0002-9480-4776"]},"institutions":[{"id":"https://openalex.org/I3133055985","display_name":"Westlake University","ror":"https://ror.org/05hfa4n20","country_code":"CN","type":"education","lineage":["https://openalex.org/I3133055985"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qi Xu","raw_affiliation_strings":["State Key Laboratory of Gene Expression & Zhejiang Key Laboratory of Structural Biology, School of Life Sciences, Westlake University, Hangzhou, China","Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China"],"raw_orcid":"https://orcid.org/0000-0002-9480-4776","affiliations":[{"raw_affiliation_string":"State Key Laboratory of Gene Expression & Zhejiang Key Laboratory of Structural Biology, School of Life Sciences, Westlake University, Hangzhou, China","institution_ids":["https://openalex.org/I3133055985"]},{"raw_affiliation_string":"Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China","institution_ids":["https://openalex.org/I3133055985"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5153003268","display_name":"Yi Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3133055985","display_name":"Westlake University","ror":"https://ror.org/05hfa4n20","country_code":"CN","type":"education","lineage":["https://openalex.org/I3133055985"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yi Liu","raw_affiliation_strings":["State Key Laboratory of Gene Expression & Zhejiang Key Laboratory of Structural Biology, School of Life Sciences, Westlake University, Hangzhou, China","Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Gene Expression & Zhejiang Key Laboratory of Structural Biology, School of Life Sciences, Westlake University, Hangzhou, China","institution_ids":["https://openalex.org/I3133055985"]},{"raw_affiliation_string":"Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China","institution_ids":["https://openalex.org/I3133055985"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5153009128","display_name":"Zhenshuo Zhu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3133055985","display_name":"Westlake University","ror":"https://ror.org/05hfa4n20","country_code":"CN","type":"education","lineage":["https://openalex.org/I3133055985"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhenshuo Zhu","raw_affiliation_strings":["State Key Laboratory of Gene Expression & Zhejiang Key Laboratory of Structural Biology, School of Life Sciences, Westlake University, Hangzhou, China","Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Gene Expression & Zhejiang Key Laboratory of Structural Biology, School of Life Sciences, Westlake University, Hangzhou, China","institution_ids":["https://openalex.org/I3133055985"]},{"raw_affiliation_string":"Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China","institution_ids":["https://openalex.org/I3133055985"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017576191","display_name":"Ziqiu Wang","orcid":"https://orcid.org/0009-0002-5992-258X","observed_orcids":["https://orcid.org/0009-0002-5992-258X"]},"institutions":[{"id":"https://openalex.org/I3133055985","display_name":"Westlake University","ror":"https://ror.org/05hfa4n20","country_code":"CN","type":"education","lineage":["https://openalex.org/I3133055985"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ziqiu Wang","raw_affiliation_strings":["State Key Laboratory of Gene Expression & Zhejiang Key Laboratory of Structural Biology, School of Life Sciences, Westlake University, Hangzhou, China","Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Gene Expression & Zhejiang Key Laboratory of Structural Biology, School of Life Sciences, Westlake University, Hangzhou, China","institution_ids":["https://openalex.org/I3133055985"]},{"raw_affiliation_string":"Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China","institution_ids":["https://openalex.org/I3133055985"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5152982211","display_name":"Yun Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3133055985","display_name":"Westlake University","ror":"https://ror.org/05hfa4n20","country_code":"CN","type":"education","lineage":["https://openalex.org/I3133055985"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yun Zhang","raw_affiliation_strings":["State Key Laboratory of Gene Expression & Zhejiang Key Laboratory of Structural Biology, School of Life Sciences, Westlake University, Hangzhou, China","Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Gene Expression & Zhejiang Key Laboratory of Structural Biology, School of Life Sciences, Westlake University, Hangzhou, China","institution_ids":["https://openalex.org/I3133055985"]},{"raw_affiliation_string":"Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China","institution_ids":["https://openalex.org/I3133055985"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5152956725","display_name":"Ziru Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3133055985","display_name":"Westlake University","ror":"https://ror.org/05hfa4n20","country_code":"CN","type":"education","lineage":["https://openalex.org/I3133055985"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ziru Li","raw_affiliation_strings":["State Key Laboratory of Gene Expression & Zhejiang Key Laboratory of Structural Biology, School of Life Sciences, Westlake University, Hangzhou, China","Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Gene Expression & Zhejiang Key Laboratory of Structural Biology, School of Life Sciences, Westlake University, Hangzhou, China","institution_ids":["https://openalex.org/I3133055985"]},{"raw_affiliation_string":"Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China","institution_ids":["https://openalex.org/I3133055985"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5153000286","display_name":"Yunan Mao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3133055985","display_name":"Westlake University","ror":"https://ror.org/05hfa4n20","country_code":"CN","type":"education","lineage":["https://openalex.org/I3133055985"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yunan Mao","raw_affiliation_strings":["School of Future Biomedicine, Westlake University, Hangzhou, China","State Key Laboratory of Gene Expression & Zhejiang Key Laboratory of Structural Biology, School of Life Sciences, Westlake University, Hangzhou, China","Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Future Biomedicine, Westlake University, Hangzhou, China","institution_ids":["https://openalex.org/I3133055985"]},{"raw_affiliation_string":"State Key Laboratory of Gene Expression & Zhejiang Key Laboratory of Structural Biology, School of Life Sciences, Westlake University, Hangzhou, China","institution_ids":["https://openalex.org/I3133055985"]},{"raw_affiliation_string":"Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China","institution_ids":["https://openalex.org/I3133055985"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5152983358","display_name":"Chenmiao Ai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3133055985","display_name":"Westlake University","ror":"https://ror.org/05hfa4n20","country_code":"CN","type":"education","lineage":["https://openalex.org/I3133055985"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chenmiao Ai","raw_affiliation_strings":["State Key Laboratory of Gene Expression & Zhejiang Key Laboratory of Structural Biology, School of Life Sciences, Westlake University, Hangzhou, China","Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Gene Expression & Zhejiang Key Laboratory of Structural Biology, School of Life Sciences, Westlake University, Hangzhou, China","institution_ids":["https://openalex.org/I3133055985"]},{"raw_affiliation_string":"Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China","institution_ids":["https://openalex.org/I3133055985"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5152984766","display_name":"Qi Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3133055985","display_name":"Westlake University","ror":"https://ror.org/05hfa4n20","country_code":"CN","type":"education","lineage":["https://openalex.org/I3133055985"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qi Chen","raw_affiliation_strings":["State Key Laboratory of Gene Expression & Zhejiang Key Laboratory of Structural Biology, School of Life Sciences, Westlake University, Hangzhou, China","Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Gene Expression & Zhejiang Key Laboratory of Structural Biology, School of Life Sciences, Westlake University, Hangzhou, China","institution_ids":["https://openalex.org/I3133055985"]},{"raw_affiliation_string":"Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China","institution_ids":["https://openalex.org/I3133055985"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5121296824","display_name":"Le Tian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3133055985","display_name":"Westlake University","ror":"https://ror.org/05hfa4n20","country_code":"CN","type":"education","lineage":["https://openalex.org/I3133055985"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Le Tian","raw_affiliation_strings":["State Key Laboratory of Gene Expression & Zhejiang Key Laboratory of Structural Biology, School of Life Sciences, Westlake University, Hangzhou, China","Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Gene Expression & Zhejiang Key Laboratory of Structural Biology, School of Life Sciences, Westlake University, Hangzhou, China","institution_ids":["https://openalex.org/I3133055985"]},{"raw_affiliation_string":"Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China","institution_ids":["https://openalex.org/I3133055985"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030201391","display_name":"Zhiying Yao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3133055985","display_name":"Westlake University","ror":"https://ror.org/05hfa4n20","country_code":"CN","type":"education","lineage":["https://openalex.org/I3133055985"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhiying Yao","raw_affiliation_strings":["State Key Laboratory of Gene Expression & Zhejiang Key Laboratory of Structural Biology, School of Life Sciences, Westlake University, Hangzhou, China","Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Gene Expression & Zhejiang Key Laboratory of Structural Biology, School of Life Sciences, Westlake University, Hangzhou, China","institution_ids":["https://openalex.org/I3133055985"]},{"raw_affiliation_string":"Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China","institution_ids":["https://openalex.org/I3133055985"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073505589","display_name":"Youngdae Gwon","orcid":"https://orcid.org/0000-0002-5618-9370","observed_orcids":["https://orcid.org/0000-0002-5618-9370"]},"institutions":[{"id":"https://openalex.org/I848706","display_name":"Sungkyunkwan University","ror":"https://ror.org/04q78tk20","country_code":"KR","type":"education","lineage":["https://openalex.org/I848706"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Youngdae Gwon","raw_affiliation_strings":["Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine, Suwon, Republic of Korea"],"raw_orcid":"https://orcid.org/0000-0002-5618-9370","affiliations":[{"raw_affiliation_string":"Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine, Suwon, Republic of Korea","institution_ids":["https://openalex.org/I848706"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060110465","display_name":"Zhubing Shi","orcid":"https://orcid.org/0000-0002-9624-4960","observed_orcids":["https://orcid.org/0000-0002-9624-4960"]},"institutions":[{"id":"https://openalex.org/I3133055985","display_name":"Westlake University","ror":"https://ror.org/05hfa4n20","country_code":"CN","type":"education","lineage":["https://openalex.org/I3133055985"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhubing Shi","raw_affiliation_strings":["State Key Laboratory of Gene Expression & Zhejiang Key Laboratory of Structural Biology, School of Life Sciences, Westlake University, Hangzhou, China. shizhubing@westlake.edu.cn","Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China. shizhubing@westlake.edu.cn"],"raw_orcid":"https://orcid.org/0000-0002-9624-4960","affiliations":[{"raw_affiliation_string":"State Key Laboratory of Gene Expression & Zhejiang Key Laboratory of Structural Biology, School of Life Sciences, Westlake University, Hangzhou, China. shizhubing@westlake.edu.cn","institution_ids":["https://openalex.org/I3133055985"]},{"raw_affiliation_string":"Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China. shizhubing@westlake.edu.cn","institution_ids":["https://openalex.org/I3133055985"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016729762","display_name":"Peiguo Yang","orcid":"https://orcid.org/0000-0002-2334-5664","observed_orcids":["https://orcid.org/0000-0002-2334-5664"]},"institutions":[{"id":"https://openalex.org/I3133055985","display_name":"Westlake University","ror":"https://ror.org/05hfa4n20","country_code":"CN","type":"education","lineage":["https://openalex.org/I3133055985"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Peiguo Yang","raw_affiliation_strings":["School of Future Biomedicine, Westlake University, Hangzhou, China. yangpeiguo@westlake.edu.cn","State Key Laboratory of Gene Expression & Zhejiang Key Laboratory of Structural Biology, School of Life Sciences, Westlake University, Hangzhou, China. yangpeiguo@westlake.edu.cn","Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China. yangpeiguo@westlake.edu.cn"],"raw_orcid":"https://orcid.org/0000-0002-2334-5664","affiliations":[{"raw_affiliation_string":"School of Future Biomedicine, Westlake University, Hangzhou, China. yangpeiguo@westlake.edu.cn","institution_ids":["https://openalex.org/I3133055985"]},{"raw_affiliation_string":"State Key Laboratory of Gene Expression & Zhejiang Key Laboratory of Structural Biology, School of Life Sciences, Westlake University, Hangzhou, China. yangpeiguo@westlake.edu.cn","institution_ids":["https://openalex.org/I3133055985"]},{"raw_affiliation_string":"Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China. yangpeiguo@westlake.edu.cn","institution_ids":["https://openalex.org/I3133055985"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5016729762","https://openalex.org/A5060110465"],"corresponding_institution_ids":["https://openalex.org/I3133055985"],"apc_list":{"value":6990,"currency":"USD","value_usd":6990},"apc_paid":{"value":6990,"currency":"USD","value_usd":6990},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.63326322,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.27709999680519104,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.27709999680519104,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":0.24379999935626984,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.10790000110864639,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/parp10","display_name":"PARP10","score":1.0},{"id":"https://openalex.org/keywords/biomolecular-condensates","display_name":"biomolecular condensates","score":0.953000009059906},{"id":"https://openalex.org/keywords/nad-homeostasis","display_name":"NAD+ homeostasis","score":0.8790000081062317},{"id":"https://openalex.org/keywords/mono-adp-ribosylation","display_name":"mono-ADP-ribosylation","score":0.9309999942779541},{"id":"https://openalex.org/keywords/adp-ribosyltransferase","display_name":"ADP-ribosyltransferase","score":0.9710000157356262},{"id":"https://openalex.org/keywords/antiviral-defense","display_name":"antiviral defense","score":0.7200000286102295},{"id":"https://openalex.org/keywords/viral-replication-inhibition","display_name":"viral replication inhibition","score":0.8899999856948853},{"id":"https://openalex.org/keywords/innate-immunity","display_name":"innate immunity","score":0.6119999885559082},{"id":"https://openalex.org/keywords/protein-stability","display_name":"protein stability","score":0.503000020980835},{"id":"https://openalex.org/keywords/enzyme-compartmentalization","display_name":"enzyme compartmentalization","score":0.7649999856948853},{"id":"https://openalex.org/keywords/homotypic-interactions","display_name":"homotypic interactions","score":0.734000027179718}],"concepts":[{"id":"https://openalex.org/C2779057330","wikidata":"https://www.wikidata.org/wiki/Q162762","display_name":"Vesicular stomatitis virus","level":3,"score":0.6644999980926514},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.6191999912261963},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5957000255584717},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5950999855995178},{"id":"https://openalex.org/C110455231","wikidata":"https://www.wikidata.org/wiki/Q897788","display_name":"Compartmentalization (fire protection)","level":3,"score":0.5533000230789185},{"id":"https://openalex.org/C58475186","wikidata":"https://www.wikidata.org/wiki/Q4118894","display_name":"Viral entry","level":4,"score":0.4699999988079071},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.4334000051021576},{"id":"https://openalex.org/C2777210771","wikidata":"https://www.wikidata.org/wiki/Q4927124","display_name":"Block (permutation group theory)","level":2,"score":0.39239999651908875},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.3630000054836273},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.34529998898506165},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.31869998574256897},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.3100000023841858},{"id":"https://openalex.org/C12590798","wikidata":"https://www.wikidata.org/wiki/Q3933199","display_name":"Replication (statistics)","level":2,"score":0.30149999260902405},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2881999909877777},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.2782999873161316},{"id":"https://openalex.org/C166342909","wikidata":"https://www.wikidata.org/wiki/Q845326","display_name":"Allosteric regulation","level":3,"score":0.27649998664855957},{"id":"https://openalex.org/C200093464","wikidata":"https://www.wikidata.org/wiki/Q166583","display_name":"Condensation","level":2,"score":0.2639000117778778},{"id":"https://openalex.org/C140933497","wikidata":"https://www.wikidata.org/wiki/Q7933606","display_name":"Viral pathogenesis","level":4,"score":0.26339998841285706},{"id":"https://openalex.org/C126831891","wikidata":"https://www.wikidata.org/wiki/Q221673","display_name":"Host (biology)","level":2,"score":0.25119999051094055}],"mesh":[{"descriptor_ui":"D000074744","descriptor_name":"ADP-Ribosylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009243","descriptor_name":"NAD","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011065","descriptor_name":"Poly(ADP-ribose) Polymerases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011065","descriptor_name":"Poly(ADP-ribose) Polymerases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011065","descriptor_name":"Poly(ADP-ribose) Polymerases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D036002","descriptor_name":"ADP Ribose Transferases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D036002","descriptor_name":"ADP Ribose Transferases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D054884","descriptor_name":"Host-Pathogen Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1038/s41467-026-78058-y","doi":"https://doi.org/10.1038/s41467-026-78058-y","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-026-78058-y","pdf_url":"https://www.nature.com/articles/s41467-026-78058-y_reference.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},{"id":"doi:10.64898/2025.12.22.696120","doi":"https://doi.org/10.64898/2025.12.22.696120","is_oa":false,"landing_page_url":"https://doi.org/10.64898/2025.12.22.696120","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:13710856","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13710856/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13710856/pdf/41467_2026_Article_78058.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nat Commun","raw_type":"Text"},{"id":"pmid:42934229","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42934229","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature communications","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:e2eda41e91644aceb5386dc541245422","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/e2eda41e91644aceb5386dc541245422","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Communications, Vol 17, Iss 1 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41467-026-78058-y","doi":"https://doi.org/10.1038/s41467-026-78058-y","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-026-78058-y","pdf_url":"https://www.nature.com/articles/s41467-026-78058-y_reference.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2312039477","display_name":null,"funder_award_id":"2024SSYS0030","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4135297550","display_name":null,"funder_award_id":"32470733","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4494845038","display_name":null,"funder_award_id":"2024SSYS0030","funder_id":"https://openalex.org/F4320318567","funder_display_name":"Westlake University"},{"id":"https://openalex.org/G5176728900","display_name":null,"funder_award_id":"32271264","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7220214129","display_name":null,"funder_award_id":"32170696","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320318567","display_name":"Westlake University","ror":null},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320322392","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549"},{"id":"https://openalex.org/F4320326863","display_name":"State Key Laboratory of Genetic Engineering","ror":"https://ror.org/01n3rg866"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7214464417.pdf","grobid_xml":"https://content.openalex.org/works/W7214464417.grobid-xml"},"referenced_works_count":71,"referenced_works":["https://openalex.org/W1484451637","https://openalex.org/W1504661786","https://openalex.org/W1528852596","https://openalex.org/W1975272351","https://openalex.org/W2046338307","https://openalex.org/W2062200458","https://openalex.org/W2074118849","https://openalex.org/W2132629607","https://openalex.org/W2150379282","https://openalex.org/W2166617377","https://openalex.org/W2169274959","https://openalex.org/W2169456326","https://openalex.org/W2257942016","https://openalex.org/W2461977200","https://openalex.org/W2466484812","https://openalex.org/W2521785925","https://openalex.org/W2587280520","https://openalex.org/W2590568317","https://openalex.org/W2734356283","https://openalex.org/W2765249630","https://openalex.org/W2793402357","https://openalex.org/W2800314655","https://openalex.org/W2947902196","https://openalex.org/W2949222247","https://openalex.org/W2969268623","https://openalex.org/W3004448724","https://openalex.org/W3004480256","https://openalex.org/W3005146799","https://openalex.org/W3005241740","https://openalex.org/W3005287521","https://openalex.org/W3005496161","https://openalex.org/W3016489853","https://openalex.org/W3081212540","https://openalex.org/W3093017508","https://openalex.org/W3099323319","https://openalex.org/W3104775068","https://openalex.org/W3115773653","https://openalex.org/W3120123622","https://openalex.org/W3120852312","https://openalex.org/W3132284869","https://openalex.org/W3164397064","https://openalex.org/W3173459698","https://openalex.org/W3176820067","https://openalex.org/W3199031620","https://openalex.org/W3202985671","https://openalex.org/W3213943866","https://openalex.org/W4211221655","https://openalex.org/W4220933565","https://openalex.org/W4225117517","https://openalex.org/W4246774303","https://openalex.org/W4284679237","https://openalex.org/W4302011994","https://openalex.org/W4306888754","https://openalex.org/W4309873855","https://openalex.org/W4313325039","https://openalex.org/W4321996704","https://openalex.org/W4380870307","https://openalex.org/W4382752735","https://openalex.org/W4382813536","https://openalex.org/W4387566852","https://openalex.org/W4394933452","https://openalex.org/W4396721167","https://openalex.org/W4398234472","https://openalex.org/W4401377313","https://openalex.org/W4402827205","https://openalex.org/W4403680383","https://openalex.org/W4406313508","https://openalex.org/W4407011005","https://openalex.org/W4407911537","https://openalex.org/W4410876454","https://openalex.org/W4411206153"],"related_works":["https://openalex.org/W7117270272","https://openalex.org/W2303885862","https://openalex.org/W4407011005","https://openalex.org/W4295094744","https://openalex.org/W4407265273","https://openalex.org/W4320493578","https://openalex.org/W3122892082","https://openalex.org/W3149142423","https://openalex.org/W4386591874","https://openalex.org/W2156904418"],"abstract_inverted_index":{"Abstract":[0],"ADP-ribosylation":[1],"is":[2],"a":[3,59,81,120],"critical":[4],"post-translational":[5],"modification":[6],"mediated":[7],"by":[8,62],"diphtheria":[9],"toxin-like":[10],"ADP-ribosyltransferases":[11],"(ARTDs).":[12],"The":[13],"human":[14],"ARTD":[15,34,124],"family":[16],"comprises":[17],"17":[18],"members":[19],"that":[20,72,85],"catalyze":[21],"either":[22],"poly-":[23],"or":[24],"mono-ADP-ribosylation.":[25],"However,":[26],"the":[27,67],"functions":[28],"and":[29,89,104,133],"regulatory":[30],"mechanisms":[31],"of":[32,74,106],"many":[33],"proteins":[35],"remain":[36],"poorly":[37],"understood.":[38],"Here,":[39],"we":[40],"uncover":[41],"an":[42],"antiviral":[43],"role":[44],"for":[45,123,130],"PARP10":[46,57,75,92,117],"through":[47],"its":[48,77],"ability":[49],"to":[50,99],"form":[51],"biomolecular":[52],"condensates.":[53],"Viral":[54],"infection":[55],"triggers":[56],"condensation,":[58,78],"process":[60],"driven":[61],"multivalent":[63],"homotypic":[64],"interactions":[65],"among":[66],"structured":[68],"domains.":[69],"We":[70],"show":[71],"mono-ADP-ribosylation":[73],"suppresses":[76],"serving":[79],"as":[80,119],"negative":[82],"feedback":[83],"mechanism":[84,122],"regulates":[86],"condensate":[87],"dynamics":[88],"protein":[90],"stability.":[91],"condensates":[93],"exhibit":[94],"enhanced":[95],"enzymatic":[96],"activity,":[97],"leading":[98],"decreased":[100],"NAD":[101,107],"+":[102,108],"levels":[103],"disruption":[105],"homeostasis,":[109],"ultimately":[110],"inhibiting":[111],"viral":[112],"replication.":[113],"Our":[114],"findings":[115],"establish":[116],"condensation":[118],"novel":[121],"enzyme":[125],"compartmentalization,":[126],"with":[127],"significant":[128],"implications":[129],"innate":[131],"immunity":[132],"host":[134],"defense.":[135]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-09-27T00:00:00"}