{"id":"https://openalex.org/W7214460812","doi":"https://doi.org/10.3390/ijms27188343","title":"Naturally Occurring Variability in the Regulatory Region of the Drosophila melanogaster Gene shuttle craft Affects Gene Expression and Lifespan","display_name":"Naturally Occurring Variability in the Regulatory Region of the Drosophila melanogaster Gene shuttle craft Affects Gene Expression and Lifespan","publication_year":2026,"publication_date":"2026-09-19","ids":{"openalex":"https://openalex.org/W7214460812","doi":"https://doi.org/10.3390/ijms27188343","pmid":"https://pubmed.ncbi.nlm.nih.gov/42794770","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13607089"},"language":"en","primary_location":{"id":"doi:10.3390/ijms27188343","doi":"https://doi.org/10.3390/ijms27188343","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms27188343","pdf_url":null,"source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/ijms27188343","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090207482","display_name":"Alexander V. Symonenko","orcid":"https://orcid.org/0000-0003-1473-4470","observed_orcids":["https://orcid.org/0000-0003-1473-4470"]},"institutions":[{"id":"https://openalex.org/I2800235667","display_name":"Kurchatov Institute","ror":"https://ror.org/00n1nz186","country_code":"RU","type":"facility","lineage":["https://openalex.org/I2800235667"]}],"countries":["RU"],"is_corresponding":true,"raw_author_name":"Alexander V. Symonenko","raw_affiliation_strings":["National Research Centre \u201cKurchatov Institute\u201d, 2 Kurchatov Sq., 123182 Moscow, Russia"],"raw_orcid":"https://orcid.org/0000-0003-1473-4470","affiliations":[{"raw_affiliation_string":"National Research Centre \u201cKurchatov Institute\u201d, 2 Kurchatov Sq., 123182 Moscow, Russia","institution_ids":["https://openalex.org/I2800235667"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108674650","display_name":"Natalia V. Roshina","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I2800235667","display_name":"Kurchatov Institute","ror":"https://ror.org/00n1nz186","country_code":"RU","type":"facility","lineage":["https://openalex.org/I2800235667"]},{"id":"https://openalex.org/I4210148309","display_name":"Vavilov Institute of General Genetics","ror":"https://ror.org/05ermrg42","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210129690","https://openalex.org/I4210148309"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Natalia V. Roshina","raw_affiliation_strings":["National Research Centre \u201cKurchatov Institute\u201d, 2 Kurchatov Sq., 123182 Moscow, Russia","Vavilov Institute of General Genetics, Russian Academy of Sciences, 3 Gubkin Str., 119991 Moscow, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Research Centre \u201cKurchatov Institute\u201d, 2 Kurchatov Sq., 123182 Moscow, Russia","institution_ids":["https://openalex.org/I2800235667"]},{"raw_affiliation_string":"Vavilov Institute of General Genetics, Russian Academy of Sciences, 3 Gubkin Str., 119991 Moscow, Russia","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210148309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085991867","display_name":"Olga Y. Rybina","orcid":"https://orcid.org/0000-0002-3431-162X","observed_orcids":["https://orcid.org/0000-0002-3431-162X"]},"institutions":[{"id":"https://openalex.org/I2800235667","display_name":"Kurchatov Institute","ror":"https://ror.org/00n1nz186","country_code":"RU","type":"facility","lineage":["https://openalex.org/I2800235667"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Olga Y. Rybina","raw_affiliation_strings":["National Research Centre \u201cKurchatov Institute\u201d, 2 Kurchatov Sq., 123182 Moscow, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Research Centre \u201cKurchatov Institute\u201d, 2 Kurchatov Sq., 123182 Moscow, Russia","institution_ids":["https://openalex.org/I2800235667"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020995809","display_name":"Evgeniya A. Tsybulko","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800235667","display_name":"Kurchatov Institute","ror":"https://ror.org/00n1nz186","country_code":"RU","type":"facility","lineage":["https://openalex.org/I2800235667"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Evgeniya A. Tsybul\u2019ko","raw_affiliation_strings":["National Research Centre \u201cKurchatov Institute\u201d, 2 Kurchatov Sq., 123182 Moscow, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Research Centre \u201cKurchatov Institute\u201d, 2 Kurchatov Sq., 123182 Moscow, Russia","institution_ids":["https://openalex.org/I2800235667"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080881978","display_name":"Anna V. Krementsova","orcid":"https://orcid.org/0000-0003-0416-7222","observed_orcids":["https://orcid.org/0000-0003-0416-7222"]},"institutions":[{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I2800235667","display_name":"Kurchatov Institute","ror":"https://ror.org/00n1nz186","country_code":"RU","type":"facility","lineage":["https://openalex.org/I2800235667"]},{"id":"https://openalex.org/I4210147035","display_name":"Institute of Biochemical Physics NM Emanuel","ror":"https://ror.org/048tnm037","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210145551","https://openalex.org/I4210147035"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Anna V. Krementsova","raw_affiliation_strings":["Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, 4 Kosygin St., 119334 Moscow, Russia","National Research Centre \u201cKurchatov Institute\u201d, 2 Kurchatov Sq., 123182 Moscow, Russia"],"raw_orcid":"https://orcid.org/0000-0003-0416-7222","affiliations":[{"raw_affiliation_string":"Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, 4 Kosygin St., 119334 Moscow, Russia","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210147035"]},{"raw_affiliation_string":"National Research Centre \u201cKurchatov Institute\u201d, 2 Kurchatov Sq., 123182 Moscow, Russia","institution_ids":["https://openalex.org/I2800235667"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020453750","display_name":"Elena A. Mikhaleva","orcid":"https://orcid.org/0000-0002-2665-7137","observed_orcids":["https://orcid.org/0000-0002-2665-7137"]},"institutions":[{"id":"https://openalex.org/I2800235667","display_name":"Kurchatov Institute","ror":"https://ror.org/00n1nz186","country_code":"RU","type":"facility","lineage":["https://openalex.org/I2800235667"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Elena A. Mikhaleva","raw_affiliation_strings":["National Research Centre \u201cKurchatov Institute\u201d, 2 Kurchatov Sq., 123182 Moscow, Russia"],"raw_orcid":"https://orcid.org/0000-0002-2665-7137","affiliations":[{"raw_affiliation_string":"National Research Centre \u201cKurchatov Institute\u201d, 2 Kurchatov Sq., 123182 Moscow, Russia","institution_ids":["https://openalex.org/I2800235667"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066904993","display_name":"Vladimir E. Alatortsev","orcid":"https://orcid.org/0000-0003-4713-6610","observed_orcids":["https://orcid.org/0000-0003-4713-6610"]},"institutions":[{"id":"https://openalex.org/I2800235667","display_name":"Kurchatov Institute","ror":"https://ror.org/00n1nz186","country_code":"RU","type":"facility","lineage":["https://openalex.org/I2800235667"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Vladimir E. Alatortsev","raw_affiliation_strings":["National Research Centre \u201cKurchatov Institute\u201d, 2 Kurchatov Sq., 123182 Moscow, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Research Centre \u201cKurchatov Institute\u201d, 2 Kurchatov Sq., 123182 Moscow, Russia","institution_ids":["https://openalex.org/I2800235667"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011806716","display_name":"Dmitry V. Mukha","orcid":"https://orcid.org/0000-0002-7380-0776","observed_orcids":["https://orcid.org/0000-0002-7380-0776"]},"institutions":[{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I4210148309","display_name":"Vavilov Institute of General Genetics","ror":"https://ror.org/05ermrg42","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210129690","https://openalex.org/I4210148309"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Dmitry V. Mukha","raw_affiliation_strings":["Vavilov Institute of General Genetics, Russian Academy of Sciences, 3 Gubkin Str., 119991 Moscow, Russia"],"raw_orcid":"https://orcid.org/0000-0002-7380-0776","affiliations":[{"raw_affiliation_string":"Vavilov Institute of General Genetics, Russian Academy of Sciences, 3 Gubkin Str., 119991 Moscow, Russia","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210148309"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066599605","display_name":"ELENA G. PASYUKOVA","orcid":"https://orcid.org/0000-0002-6491-8561","observed_orcids":["https://orcid.org/0000-0002-6491-8561"]},"institutions":[{"id":"https://openalex.org/I2800235667","display_name":"Kurchatov Institute","ror":"https://ror.org/00n1nz186","country_code":"RU","type":"facility","lineage":["https://openalex.org/I2800235667"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Elena G. Pasyukova","raw_affiliation_strings":["National Research Centre \u201cKurchatov Institute\u201d, 2 Kurchatov Sq., 123182 Moscow, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Research Centre \u201cKurchatov Institute\u201d, 2 Kurchatov Sq., 123182 Moscow, Russia","institution_ids":["https://openalex.org/I2800235667"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5090207482"],"corresponding_institution_ids":["https://openalex.org/I2800235667"],"apc_list":{"value":2900,"currency":"CHF","value_usd":3499},"apc_paid":{"value":2900,"currency":"CHF","value_usd":3499},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.6066315,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"27","issue":"18","first_page":"8343","last_page":"8343"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.9038000106811523,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.9038000106811523,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.01269999984651804,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10174","display_name":"Animal Behavior and Reproduction","score":0.01269999984651804,"subfield":{"id":"https://openalex.org/subfields/1105","display_name":"Ecology, Evolution, Behavior and Systematics"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/stc","display_name":"STC","score":0.796999990940094},{"id":"https://openalex.org/keywords/drosophila-melanogaster","display_name":"Drosophila melanogaster","score":0.8920000195503235},{"id":"https://openalex.org/keywords/5-regulatory-region","display_name":"5' regulatory region","score":0.8080000281333923},{"id":"https://openalex.org/keywords/structural-variants","display_name":"structural variants","score":0.6639999747276306},{"id":"https://openalex.org/keywords/natural-polymorphisms","display_name":"natural polymorphisms","score":0.6899999976158142},{"id":"https://openalex.org/keywords/lifespan","display_name":"lifespan","score":0.8569999933242798},{"id":"https://openalex.org/keywords/longevity","display_name":"longevity","score":0.9169999957084656},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.8349999785423279},{"id":"https://openalex.org/keywords/inbred-lines","display_name":"inbred lines","score":0.7549999952316284},{"id":"https://openalex.org/keywords/reporter-gene-assay","display_name":"reporter gene assay","score":0.5210000276565552},{"id":"https://openalex.org/keywords/population-genetics","display_name":"population genetics","score":0.5109999775886536},{"id":"https://openalex.org/keywords/latitudinal-adaptation","display_name":"latitudinal adaptation","score":0.8930000066757202}],"concepts":[{"id":"https://openalex.org/C2780104201","wikidata":"https://www.wikidata.org/wiki/Q130888","display_name":"Drosophila melanogaster","level":3,"score":0.7160000205039978},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.70660001039505},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.5421000123023987},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.49570000171661377},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4796999990940094},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.4203000068664551},{"id":"https://openalex.org/C90559484","wikidata":"https://www.wikidata.org/wiki/Q778379","display_name":"Expression (computer science)","level":2,"score":0.37070000171661377},{"id":"https://openalex.org/C2776998849","wikidata":"https://www.wikidata.org/wiki/Q3766082","display_name":"Melanogaster","level":4,"score":0.3617999851703644},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.35370001196861267},{"id":"https://openalex.org/C110121322","wikidata":"https://www.wikidata.org/wiki/Q865811","display_name":"Distribution (mathematics)","level":2,"score":0.33739998936653137},{"id":"https://openalex.org/C33498276","wikidata":"https://www.wikidata.org/wiki/Q2138797","display_name":"Regulator gene","level":4,"score":0.32010000944137573},{"id":"https://openalex.org/C21592294","wikidata":"https://www.wikidata.org/wiki/Q3238407","display_name":"Regulatory sequence","level":4,"score":0.3127000033855438},{"id":"https://openalex.org/C2777379243","wikidata":"https://www.wikidata.org/wiki/Q1054318","display_name":"Drosophilidae","level":4,"score":0.3018999993801117},{"id":"https://openalex.org/C2776041557","wikidata":"https://www.wikidata.org/wiki/Q3715451","display_name":"Drosophila (subgenus)","level":3,"score":0.28839999437332153},{"id":"https://openalex.org/C2779732396","wikidata":"https://www.wikidata.org/wiki/Q2207288","display_name":"Craft","level":2,"score":0.2840000092983246},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.26190000772476196},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.257099986076355},{"id":"https://openalex.org/C68873052","wikidata":"https://www.wikidata.org/wiki/Q349856","display_name":"Genetic variation","level":3,"score":0.25360000133514404}],"mesh":[{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004331","descriptor_name":"Drosophila melanogaster","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008136","descriptor_name":"Longevity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012045","descriptor_name":"Regulatory Sequences, Nucleic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029721","descriptor_name":"Drosophila Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.3390/ijms27188343","doi":"https://doi.org/10.3390/ijms27188343","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms27188343","pdf_url":null,"source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},{"id":"pmid:42794770","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42794770","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular sciences","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13607089","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13607089/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Mol Sci","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3390/ijms27188343","doi":"https://doi.org/10.3390/ijms27188343","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms27188343","pdf_url":null,"source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320327961","display_name":"National Research Center \"Kurchatov Institute\"","ror":"https://ror.org/037styt87"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":94,"referenced_works":["https://openalex.org/W1744230361","https://openalex.org/W1759549944","https://openalex.org/W1971216836","https://openalex.org/W1974956115","https://openalex.org/W1975606520","https://openalex.org/W1980251469","https://openalex.org/W1985699005","https://openalex.org/W1989585567","https://openalex.org/W1995889062","https://openalex.org/W1997172163","https://openalex.org/W2010656240","https://openalex.org/W2014673667","https://openalex.org/W2017153527","https://openalex.org/W2022591158","https://openalex.org/W2036936909","https://openalex.org/W2039309132","https://openalex.org/W2041745051","https://openalex.org/W2049480738","https://openalex.org/W2052014103","https://openalex.org/W2056694786","https://openalex.org/W2058915771","https://openalex.org/W2069978019","https://openalex.org/W2070403076","https://openalex.org/W2071888863","https://openalex.org/W2082967637","https://openalex.org/W2084191969","https://openalex.org/W2097353028","https://openalex.org/W2101833790","https://openalex.org/W2102517327","https://openalex.org/W2103777723","https://openalex.org/W2106436941","https://openalex.org/W2117925179","https://openalex.org/W2126735903","https://openalex.org/W2129211286","https://openalex.org/W2129436708","https://openalex.org/W2130927162","https://openalex.org/W2132393729","https://openalex.org/W2134545213","https://openalex.org/W2134610197","https://openalex.org/W2137075243","https://openalex.org/W2140784970","https://openalex.org/W2140952049","https://openalex.org/W2142160822","https://openalex.org/W2144734823","https://openalex.org/W2159357690","https://openalex.org/W2167954017","https://openalex.org/W2169858839","https://openalex.org/W2253829908","https://openalex.org/W2278514747","https://openalex.org/W2316767634","https://openalex.org/W2327597718","https://openalex.org/W2344274659","https://openalex.org/W2409532517","https://openalex.org/W2515386838","https://openalex.org/W2564377745","https://openalex.org/W2605351129","https://openalex.org/W2668997732","https://openalex.org/W2727180246","https://openalex.org/W2755331695","https://openalex.org/W2783560193","https://openalex.org/W2790210354","https://openalex.org/W2796468132","https://openalex.org/W2809885717","https://openalex.org/W2847591900","https://openalex.org/W2887533004","https://openalex.org/W2898168302","https://openalex.org/W2903245274","https://openalex.org/W2908864763","https://openalex.org/W2912289751","https://openalex.org/W2916105629","https://openalex.org/W2939096293","https://openalex.org/W2950772037","https://openalex.org/W2953162895","https://openalex.org/W2961576630","https://openalex.org/W2971739435","https://openalex.org/W2997889425","https://openalex.org/W2998476202","https://openalex.org/W3009501570","https://openalex.org/W3010261971","https://openalex.org/W3022469880","https://openalex.org/W3026316627","https://openalex.org/W3033256913","https://openalex.org/W3102206080","https://openalex.org/W3132904250","https://openalex.org/W3142887521","https://openalex.org/W3198625378","https://openalex.org/W3210019977","https://openalex.org/W3214909687","https://openalex.org/W3215596355","https://openalex.org/W4213061429","https://openalex.org/W4220975283","https://openalex.org/W4300033245","https://openalex.org/W4312112913","https://openalex.org/W4324129666"],"related_works":["https://openalex.org/W1847670392","https://openalex.org/W1981566904","https://openalex.org/W2167954017","https://openalex.org/W7095490450","https://openalex.org/W2158360553","https://openalex.org/W2847591900","https://openalex.org/W2200765636","https://openalex.org/W6980088208","https://openalex.org/W2103999749","https://openalex.org/W6967712626"],"abstract_inverted_index":{"Revealing":[0],"gene":[1,20,61,126,160],"expression":[2,120,161],"patterns":[3],"is":[4,26,189],"essential":[5],"for":[6],"comprehending":[7],"the":[8,48,52,57,63,80,101,144,157,182],"genetic":[9],"control":[10],"of":[11,51,56,67,82,185],"complex":[12],"traits":[13],"like":[14],"lifespan.":[15],"Analyzing":[16],"structural":[17,49],"variation":[18],"in":[19,30,44,62,93,100,119,129,195],"regulatory":[21,37,54,104,171],"regions":[22],"within":[23],"natural":[24],"populations":[25,179],"a":[27,71,192],"promising":[28],"approach":[29],"functional":[31],"genetics,":[32],"allowing":[33],"us":[34],"to":[35,75],"identify":[36],"sites":[38],"that":[39,181],"influence":[40],"transcription":[41,72],"and":[42,96,112,141,151,162,177],"phenotype":[43],"vivo.":[45],"We":[46,78],"describe":[47],"variability":[50,173],"5\u2032":[53,103,170],"region":[55,105,172],"shuttle":[58],"craft":[59],"(stc)":[60],"Alexandrov":[64],"population":[65],"(Russia)":[66],"Drosophila":[68,131],"melanogaster,":[69],"encoding":[70],"factor":[73],"homologous":[74],"human":[76],"NF-X1.":[77],"evaluated":[79,123],"association":[81],"frequently":[83],"occurring":[84],"polymorphisms":[85,99],"with":[86,109,148,191],"fly":[87],"lifespan":[88,111,163],"from":[89],"inbred":[90],"lines":[91],"sampled":[92],"2010,":[94],"2011,":[95],"2014.":[97],"Two":[98],"stc":[102,114,154,169],"exhibit":[106],"strong":[107],"associations":[108],"both":[110],"embryonic":[113,153],"transcript":[115],"levels.":[116],"Their":[117],"role":[118,194],"regulation":[121],"was":[122],"via":[124],"reporter":[125],"assays":[127],"conducted":[128],"S2":[130],"cell":[132],"culture.":[133],"The":[134],"\u2018C\u2019":[135],"allele":[136],"at":[137,143],"one":[138],"polymorphic":[139],"site":[140],"\u2018T\u2019":[142],"other":[145],"are":[146],"associated":[147],"increased":[149],"longevity":[150],"decreased":[152],"transcription,":[155],"reaffirming":[156],"link":[158],"between":[159],"we":[164],"previously":[165],"established.":[166],"Furthermore,":[167],"comparing":[168],"across":[174],"Alexandrov,":[175],"European":[176],"African":[178],"suggests":[180],"macro-geographic":[183],"distribution":[184],"these":[186],"longevity-associated":[187],"variants":[188],"consistent":[190],"potential":[193],"latitudinal":[196],"or":[197],"climatic":[198],"adaptation.":[199]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-09-27T00:00:00"}