{"id":"https://openalex.org/W7214460503","doi":"https://doi.org/10.3390/ijms27188360","title":"CRISPR Technologies in Type 2 Diabetes: From Mechanistic Insights to Therapeutic Discovery","display_name":"CRISPR Technologies in Type 2 Diabetes: From Mechanistic Insights to Therapeutic Discovery","publication_year":2026,"publication_date":"2026-09-19","ids":{"openalex":"https://openalex.org/W7214460503","doi":"https://doi.org/10.3390/ijms27188360","pmid":"https://pubmed.ncbi.nlm.nih.gov/42794786","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13607165"},"language":"en","primary_location":{"id":"doi:10.3390/ijms27188360","doi":"https://doi.org/10.3390/ijms27188360","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms27188360","pdf_url":null,"source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/ijms27188360","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101344616","display_name":"Shuangshuang Fan","orcid":"https://orcid.org/0009-0000-0290-0027","observed_orcids":["https://orcid.org/0009-0000-0290-0027"]},"institutions":[{"id":"https://openalex.org/I9224756","display_name":"Northeastern University","ror":"https://ror.org/03awzbc87","country_code":"CN","type":"education","lineage":["https://openalex.org/I9224756"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shuangshuang Fan","raw_affiliation_strings":["Interdisciplinary Research Center for Brain-Computer Interface, Key Laboratory of Research and Development of Liaoning Province, College of Life and Health Sciences, Northeastern University, Shenyang 110819, China","Key Laboratory of Data Analytics and Optimization for Smart Industry, Northeastern University, Ministry of Education, Shenyang 110819, China","National Frontiers Science Center for Industrial Intelligence and Systems Optimization, Northeastern University, Shenyang 110819, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Interdisciplinary Research Center for Brain-Computer Interface, Key Laboratory of Research and Development of Liaoning Province, College of Life and Health Sciences, Northeastern University, Shenyang 110819, China","institution_ids":["https://openalex.org/I9224756"]},{"raw_affiliation_string":"Key Laboratory of Data Analytics and Optimization for Smart Industry, Northeastern University, Ministry of Education, Shenyang 110819, China","institution_ids":["https://openalex.org/I9224756"]},{"raw_affiliation_string":"National Frontiers Science Center for Industrial Intelligence and Systems Optimization, Northeastern University, Shenyang 110819, China","institution_ids":["https://openalex.org/I9224756"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5120843178","display_name":"Ruipu Liang","orcid":"https://orcid.org/0009-0009-6813-9977","observed_orcids":["https://orcid.org/0009-0009-6813-9977"]},"institutions":[{"id":"https://openalex.org/I9224756","display_name":"Northeastern University","ror":"https://ror.org/03awzbc87","country_code":"CN","type":"education","lineage":["https://openalex.org/I9224756"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ruipu Liang","raw_affiliation_strings":["Interdisciplinary Research Center for Brain-Computer Interface, Key Laboratory of Research and Development of Liaoning Province, College of Life and Health Sciences, Northeastern University, Shenyang 110819, China","Key Laboratory of Data Analytics and Optimization for Smart Industry, Northeastern University, Ministry of Education, Shenyang 110819, China","National Frontiers Science Center for Industrial Intelligence and Systems Optimization, Northeastern University, Shenyang 110819, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Interdisciplinary Research Center for Brain-Computer Interface, Key Laboratory of Research and Development of Liaoning Province, College of Life and Health Sciences, Northeastern University, Shenyang 110819, China","institution_ids":["https://openalex.org/I9224756"]},{"raw_affiliation_string":"Key Laboratory of Data Analytics and Optimization for Smart Industry, Northeastern University, Ministry of Education, Shenyang 110819, China","institution_ids":["https://openalex.org/I9224756"]},{"raw_affiliation_string":"National Frontiers Science Center for Industrial Intelligence and Systems Optimization, Northeastern University, Shenyang 110819, China","institution_ids":["https://openalex.org/I9224756"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5128024408","display_name":"Teng Fei","orcid":"https://orcid.org/0000-0001-9620-0450","observed_orcids":["https://orcid.org/0000-0001-9620-0450"]},"institutions":[{"id":"https://openalex.org/I9224756","display_name":"Northeastern University","ror":"https://ror.org/03awzbc87","country_code":"CN","type":"education","lineage":["https://openalex.org/I9224756"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Teng Fei","raw_affiliation_strings":["Interdisciplinary Research Center for Brain-Computer Interface, Key Laboratory of Research and Development of Liaoning Province, College of Life and Health Sciences, Northeastern University, Shenyang 110819, China","Key Laboratory of Data Analytics and Optimization for Smart Industry, Northeastern University, Ministry of Education, Shenyang 110819, China","National Frontiers Science Center for Industrial Intelligence and Systems Optimization, Northeastern University, Shenyang 110819, China"],"raw_orcid":"https://orcid.org/0000-0001-9620-0450","affiliations":[{"raw_affiliation_string":"Interdisciplinary Research Center for Brain-Computer Interface, Key Laboratory of Research and Development of Liaoning Province, College of Life and Health Sciences, Northeastern University, Shenyang 110819, China","institution_ids":["https://openalex.org/I9224756"]},{"raw_affiliation_string":"Key Laboratory of Data Analytics and Optimization for Smart Industry, Northeastern University, Ministry of Education, Shenyang 110819, China","institution_ids":["https://openalex.org/I9224756"]},{"raw_affiliation_string":"National Frontiers Science Center for Industrial Intelligence and Systems Optimization, Northeastern University, Shenyang 110819, China","institution_ids":["https://openalex.org/I9224756"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5128024408"],"corresponding_institution_ids":["https://openalex.org/I9224756"],"apc_list":{"value":2900,"currency":"CHF","value_usd":3499},"apc_paid":{"value":2900,"currency":"CHF","value_usd":3499},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.39963644,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"27","issue":"18","first_page":"8360","last_page":"8360"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10878","display_name":"CRISPR and Genetic Engineering","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10878","display_name":"CRISPR and Genetic Engineering","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.005499999970197678,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9800000190734863},{"id":"https://openalex.org/keywords/crispr","display_name":"CRISPR","score":0.7990000247955322},{"id":"https://openalex.org/keywords/beta-cell-dysfunction","display_name":"beta-cell dysfunction","score":0.7070000171661377},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.9890000224113464},{"id":"https://openalex.org/keywords/glucose-metabolism","display_name":"glucose metabolism","score":0.7680000066757202},{"id":"https://openalex.org/keywords/lipid-metabolism","display_name":"lipid metabolism","score":1.0},{"id":"https://openalex.org/keywords/pancreatic-beta-cells","display_name":"pancreatic beta cells","score":0.8370000123977661},{"id":"https://openalex.org/keywords/gene-correction","display_name":"gene correction","score":0.6629999876022339},{"id":"https://openalex.org/keywords/epigenetic-reprogramming","display_name":"epigenetic reprogramming","score":0.9210000038146973},{"id":"https://openalex.org/keywords/high-throughput-phenotypic-screening","display_name":"high-throughput phenotypic screening","score":0.8429999947547913},{"id":"https://openalex.org/keywords/off-target-effects","display_name":"off-target effects","score":0.7390000224113464},{"id":"https://openalex.org/keywords/gene-delivery","display_name":"gene delivery","score":0.7020000219345093},{"id":"https://openalex.org/keywords/crispr-therapeutics","display_name":"CRISPR therapeutics","score":0.7110000252723694}],"concepts":[{"id":"https://openalex.org/C98108389","wikidata":"https://www.wikidata.org/wiki/Q412563","display_name":"CRISPR","level":3,"score":0.8770999908447266},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5188000202178955},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.46860000491142273},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.41019999980926514},{"id":"https://openalex.org/C144501496","wikidata":"https://www.wikidata.org/wiki/Q5533489","display_name":"Genome editing","level":4,"score":0.37959998846054077},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3686000108718872},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3303000032901764},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.30469998717308044},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.28439998626708984},{"id":"https://openalex.org/C78604142","wikidata":"https://www.wikidata.org/wiki/Q1640582","display_name":"Fight-or-flight response","level":3,"score":0.2827000021934509},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.26179999113082886}],"mesh":[{"descriptor_ui":"D000072669","descriptor_name":"Gene Editing","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015316","descriptor_name":"Genetic Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050356","descriptor_name":"Lipid Metabolism","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050417","descriptor_name":"Insulin-Secreting Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064112","descriptor_name":"Clustered Regularly Interspaced Short Palindromic Repeats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D064113","descriptor_name":"CRISPR-Cas Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.3390/ijms27188360","doi":"https://doi.org/10.3390/ijms27188360","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms27188360","pdf_url":null,"source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},{"id":"pmid:42794786","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42794786","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular sciences","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13607165","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13607165/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Mol Sci","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3390/ijms27188360","doi":"https://doi.org/10.3390/ijms27188360","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms27188360","pdf_url":null,"source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8560000061988831,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4117710315","display_name":null,"funder_award_id":"2025YFA0921900","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"}],"funders":[{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":144,"referenced_works":["https://openalex.org/W1594078235","https://openalex.org/W1965141016","https://openalex.org/W1973260880","https://openalex.org/W1975621550","https://openalex.org/W2003171404","https://openalex.org/W2009480581","https://openalex.org/W2045017910","https://openalex.org/W2045435533","https://openalex.org/W2047309981","https://openalex.org/W2049680243","https://openalex.org/W2050480410","https://openalex.org/W2061574308","https://openalex.org/W2063148079","https://openalex.org/W2096261947","https://openalex.org/W2109728760","https://openalex.org/W2126776706","https://openalex.org/W2137345995","https://openalex.org/W2144472637","https://openalex.org/W2160051211","https://openalex.org/W2336828812","https://openalex.org/W2342536142","https://openalex.org/W2465180814","https://openalex.org/W2507528796","https://openalex.org/W2523099503","https://openalex.org/W2572481665","https://openalex.org/W2581307619","https://openalex.org/W2611446801","https://openalex.org/W2755239475","https://openalex.org/W2765809583","https://openalex.org/W2766599608","https://openalex.org/W2770848007","https://openalex.org/W2772524563","https://openalex.org/W2891818439","https://openalex.org/W2904226822","https://openalex.org/W2907381384","https://openalex.org/W2918441162","https://openalex.org/W2921153415","https://openalex.org/W2921398065","https://openalex.org/W2922473881","https://openalex.org/W2944727022","https://openalex.org/W2948557045","https://openalex.org/W2979921213","https://openalex.org/W2981137429","https://openalex.org/W2982558411","https://openalex.org/W3006116138","https://openalex.org/W3009825875","https://openalex.org/W3018853840","https://openalex.org/W3031641356","https://openalex.org/W3042599313","https://openalex.org/W3043143974","https://openalex.org/W3045045289","https://openalex.org/W3141751158","https://openalex.org/W3153594903","https://openalex.org/W3173311813","https://openalex.org/W3174970081","https://openalex.org/W3197669205","https://openalex.org/W3198659496","https://openalex.org/W3203405076","https://openalex.org/W3216964707","https://openalex.org/W4211123163","https://openalex.org/W4211161436","https://openalex.org/W4224223443","https://openalex.org/W4224232645","https://openalex.org/W4237715440","https://openalex.org/W4284701626","https://openalex.org/W4285009429","https://openalex.org/W4294190626","https://openalex.org/W4297102731","https://openalex.org/W4312094292","https://openalex.org/W4316810847","https://openalex.org/W4317437864","https://openalex.org/W4323667134","https://openalex.org/W4365148592","https://openalex.org/W4377094292","https://openalex.org/W4379203118","https://openalex.org/W4380786202","https://openalex.org/W4385406340","https://openalex.org/W4386996314","https://openalex.org/W4387058983","https://openalex.org/W4387604779","https://openalex.org/W4387874003","https://openalex.org/W4389140056","https://openalex.org/W4389304734","https://openalex.org/W4389484646","https://openalex.org/W4390742093","https://openalex.org/W4391026674","https://openalex.org/W4391037323","https://openalex.org/W4391925503","https://openalex.org/W4392923527","https://openalex.org/W4398781119","https://openalex.org/W4399913919","https://openalex.org/W4400194605","https://openalex.org/W4400887083","https://openalex.org/W4401232815","https://openalex.org/W4401728734","https://openalex.org/W4402070846","https://openalex.org/W4402276312","https://openalex.org/W4402423858","https://openalex.org/W4403984400","https://openalex.org/W4405236241","https://openalex.org/W4405467931","https://openalex.org/W4405659635","https://openalex.org/W4406716602","https://openalex.org/W4407357752","https://openalex.org/W4407697397","https://openalex.org/W4408530563","https://openalex.org/W4408589737","https://openalex.org/W4410741240","https://openalex.org/W4412447431","https://openalex.org/W4412630410","https://openalex.org/W4412777707","https://openalex.org/W4413043449","https://openalex.org/W4413940020","https://openalex.org/W4413961805","https://openalex.org/W4414030085","https://openalex.org/W4414139556","https://openalex.org/W4414229438","https://openalex.org/W4414969377","https://openalex.org/W4415205596","https://openalex.org/W4415346019","https://openalex.org/W4415411985","https://openalex.org/W4415447582","https://openalex.org/W4416411704","https://openalex.org/W4416534418","https://openalex.org/W4417017052","https://openalex.org/W7118001492","https://openalex.org/W7124439347","https://openalex.org/W7124751251","https://openalex.org/W7125799229","https://openalex.org/W7128740060","https://openalex.org/W7130588039","https://openalex.org/W7130593192","https://openalex.org/W7131381198","https://openalex.org/W7131427926","https://openalex.org/W7139061505","https://openalex.org/W7140526097","https://openalex.org/W7143932002","https://openalex.org/W7148317234","https://openalex.org/W7154023638","https://openalex.org/W7154992147","https://openalex.org/W7155175642","https://openalex.org/W7155506825","https://openalex.org/W7163711913","https://openalex.org/W7206176167"],"related_works":["https://openalex.org/W4406035363","https://openalex.org/W4239314815","https://openalex.org/W4402070846","https://openalex.org/W4405659635","https://openalex.org/W4387865955","https://openalex.org/W4390943275","https://openalex.org/W7220053497","https://openalex.org/W4406401804","https://openalex.org/W4316035838","https://openalex.org/W7078385358"],"abstract_inverted_index":{"Type":[0],"2":[1],"diabetes":[2],"(T2D)":[3],"is":[4],"a":[5,104],"complex":[6],"metabolic":[7],"disorder":[8],"driven":[9],"by":[10],"the":[11,75,89,120,142,147],"interplay":[12],"of":[13,46,66,77,91,122,149],"genetic":[14,34,70,96],"susceptibility,":[15],"\u03b2-cell":[16],"dysfunction,":[17],"and":[18,39,63,69,80,99,114,135,159],"insulin":[19],"resistance.":[20],"Although":[21],"genome-wide":[22],"association":[23],"studies":[24],"(GWAS)":[25],"have":[26],"identified":[27],"numerous":[28],"T2D":[29,85,95],"risk":[30],"loci,":[31],"translating":[32],"these":[33],"findings":[35],"into":[36],"biological":[37],"mechanisms":[38],"therapeutic":[40],"strategies":[41],"remains":[42],"challenging.":[43],"The":[44],"emergence":[45],"CRISPR":[47,78,92,123,150],"(Clustered":[48],"Regularly":[49],"Interspaced":[50],"Short":[51],"Palindromic":[52],"Repeats)-based":[53],"technologies":[54,79,93],"has":[55],"provided":[56],"powerful":[57],"tools":[58],"for":[59],"precise":[60],"genome":[61],"manipulation":[62],"functional":[64],"interrogation":[65],"disease-associated":[67],"genes":[68],"variations.":[71],"This":[72],"review":[73,88],"summarizes":[74],"development":[76],"highlights":[81],"their":[82],"applications":[83,148],"in":[84,94,124,146],"research.":[86],"We":[87,117],"application":[90],"factor":[97],"analysis":[98],"high-throughput":[100],"phenotypic":[101],"screening,":[102],"with":[103],"focus":[105],"on":[106],"three":[107],"key":[108],"areas:":[109],"glucose":[110],"metabolism,":[111,113],"lipid":[112],"pancreatic":[115,128],"functionality.":[116],"further":[118],"examine":[119],"role":[121],"therapeutics":[125],"that":[126],"target":[127],"\u03b2-cells":[129],"via":[130],"gene":[131],"correction,":[132],"stress":[133],"protection,":[134],"epigenetic":[136],"reprogramming.":[137],"Finally,":[138],"we":[139],"briefly":[140],"discuss":[141],"major":[143],"challenges":[144],"encountered":[145],"technology,":[151],"including":[152],"delivery":[153],"efficiency,":[154],"off-target":[155],"effects,":[156],"safety":[157],"concerns":[158],"ethical":[160],"considerations.":[161]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-09-27T00:00:00"}
