{"id":"https://openalex.org/W7214459609","doi":"https://doi.org/10.64898/2026.09.25.754385","title":"L-lactate is a regulator of gametocytogenesis in Plasmodium falciparum","display_name":"L-lactate is a regulator of gametocytogenesis in Plasmodium falciparum","publication_year":2026,"publication_date":"2026-09-26","ids":{"openalex":"https://openalex.org/W7214459609","doi":"https://doi.org/10.64898/2026.09.25.754385"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.25.754385","doi":"https://doi.org/10.64898/2026.09.25.754385","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.25.754385","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/26/2026.09.25.754385.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/26/2026.09.25.754385.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048850286","display_name":"Nana Efua Andoh","orcid":"https://orcid.org/0000-0002-6678-3269","observed_orcids":["https://orcid.org/0000-0002-6678-3269"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Nana Efua Andoh","raw_affiliation_strings":["Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QP, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QP, UK","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087167736","display_name":"Ibtissam Jabre","orcid":"https://orcid.org/0000-0003-3574-597X","observed_orcids":["https://orcid.org/0000-0003-3574-597X"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ibtissam Jabre","raw_affiliation_strings":["Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QP, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QP, UK","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021262946","display_name":"Catherine J. Merrick","orcid":"https://orcid.org/0000-0001-7583-2176","observed_orcids":["https://orcid.org/0000-0001-7583-2176"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Catherine J. Merrick","raw_affiliation_strings":["Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QP, UK"],"raw_orcid":"https://orcid.org/0000-0001-7583-2176","affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QP, UK","institution_ids":["https://openalex.org/I241749"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5021262946"],"corresponding_institution_ids":["https://openalex.org/I241749"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11155","display_name":"Toxoplasma gondii Research Studies","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/plasmodium-falciparum","display_name":"Plasmodium falciparum","score":0.9139999747276306},{"id":"https://openalex.org/keywords/gametocytogenesis","display_name":"gametocytogenesis","score":0.9390000104904175},{"id":"https://openalex.org/keywords/l-lactate","display_name":"L-lactate","score":0.9639999866485596},{"id":"https://openalex.org/keywords/hyperlactatemia","display_name":"hyperlactatemia","score":0.8989999890327454},{"id":"https://openalex.org/keywords/histone-lactylation","display_name":"histone lactylation","score":0.9819999933242798},{"id":"https://openalex.org/keywords/epigenetic-regulation","display_name":"epigenetic regulation","score":0.9570000171661377},{"id":"https://openalex.org/keywords/parasite-virulence","display_name":"parasite virulence","score":0.6600000262260437},{"id":"https://openalex.org/keywords/glycolysis","display_name":"glycolysis","score":0.6370000243186951},{"id":"https://openalex.org/keywords/severe-malaria","display_name":"severe malaria","score":0.503000020980835},{"id":"https://openalex.org/keywords/s-adenosylmethionine","display_name":"S-adenosylmethionine","score":0.777999997138977},{"id":"https://openalex.org/keywords/malaria-transmission","display_name":"malaria transmission","score":0.3449999988079071}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8937000036239624},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.8418999910354614},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.8014000058174133},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.6175000071525574},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5630000233650208},{"id":"https://openalex.org/C2778371730","wikidata":"https://www.wikidata.org/wiki/Q311383","display_name":"Plasmodium falciparum","level":3,"score":0.5540000200271606},{"id":"https://openalex.org/C6929976","wikidata":"https://www.wikidata.org/wiki/Q3771881","display_name":"Regulator","level":3,"score":0.44510000944137573},{"id":"https://openalex.org/C2778675580","wikidata":"https://www.wikidata.org/wiki/Q614956","display_name":"Plasmodium (life cycle)","level":3,"score":0.4171999990940094},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4165000021457672},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.4142000079154968},{"id":"https://openalex.org/C191942190","wikidata":"https://www.wikidata.org/wiki/Q4774739","display_name":"Antigenic variation","level":3,"score":0.38999998569488525},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3790000081062317},{"id":"https://openalex.org/C2778048844","wikidata":"https://www.wikidata.org/wiki/Q12156","display_name":"Malaria","level":2,"score":0.35670000314712524},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.3474999964237213},{"id":"https://openalex.org/C63016187","wikidata":"https://www.wikidata.org/wiki/Q17162664","display_name":"Epigenetic regulation of neurogenesis","level":5,"score":0.3443000018596649},{"id":"https://openalex.org/C167227067","wikidata":"https://www.wikidata.org/wiki/Q5113739","display_name":"Chromatin remodeling","level":4,"score":0.3345000147819519},{"id":"https://openalex.org/C60987743","wikidata":"https://www.wikidata.org/wiki/Q1460232","display_name":"Virulence","level":3,"score":0.33070001006126404},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.31790000200271606},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.30889999866485596},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.29760000109672546},{"id":"https://openalex.org/C27153228","wikidata":"https://www.wikidata.org/wiki/Q3787274","display_name":"Transcriptional regulation","level":4,"score":0.2865999937057495},{"id":"https://openalex.org/C121912465","wikidata":"https://www.wikidata.org/wiki/Q3589153","display_name":"Epigenomics","level":5,"score":0.28459998965263367},{"id":"https://openalex.org/C179463898","wikidata":"https://www.wikidata.org/wiki/Q10273301","display_name":"Epigenesis","level":5,"score":0.2596000134944916},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.25529998540878296},{"id":"https://openalex.org/C2779175743","wikidata":"https://www.wikidata.org/wiki/Q156606","display_name":"Rhesus macaque","level":2,"score":0.2513999938964844}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.09.25.754385","doi":"https://doi.org/10.64898/2026.09.25.754385","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.25.754385","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/26/2026.09.25.754385.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.09.25.754385","doi":"https://doi.org/10.64898/2026.09.25.754385","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.25.754385","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/26/2026.09.25.754385.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7214459609.pdf","grobid_xml":"https://content.openalex.org/works/W7214459609.grobid-xml"},"referenced_works_count":21,"referenced_works":["https://openalex.org/W2013857802","https://openalex.org/W2021868082","https://openalex.org/W2037024376","https://openalex.org/W2094381221","https://openalex.org/W2096937165","https://openalex.org/W2132823138","https://openalex.org/W2790348370","https://openalex.org/W2795504602","https://openalex.org/W2982216374","https://openalex.org/W3091958895","https://openalex.org/W3093092539","https://openalex.org/W4308473443","https://openalex.org/W4310159212","https://openalex.org/W4379390509","https://openalex.org/W4402314310","https://openalex.org/W4410530248","https://openalex.org/W4417173663","https://openalex.org/W4417507885","https://openalex.org/W7124585817","https://openalex.org/W7168150874","https://openalex.org/W7202356235"],"related_works":["https://openalex.org/W4417507885","https://openalex.org/W4308473443","https://openalex.org/W7202356235","https://openalex.org/W7113377184","https://openalex.org/W3091958895","https://openalex.org/W6964831245","https://openalex.org/W2087041435","https://openalex.org/W3093092539","https://openalex.org/W4411865561","https://openalex.org/W7127630357"],"abstract_inverted_index":{"Abstract":[0],"Epigenetic":[1,384],"processes":[2,84],"play":[3],"important":[4,39,430],"roles":[5],"in":[6,113,127,227,234,285,312,412,433],"the":[7,10,53,66,106,140,157,170,173,202,208,289,353,394],"biology":[8],"of":[9,41,76,108,139,148,169,197,201,207,263,274,291,346,359,368],"malaria":[11,46,114,252,310,425,434],"parasite":[12,181,354],"Plasmodium":[13,20],"falciparum":[14,229],".":[15,214,230],"We":[16],"recently":[17],"showed":[18],"that":[19,126,156,211,222,309,370,375,389,420],"histones":[21,182],"are":[22,333,376,386,390,399],"not":[23],"only":[24,272],"acetylated":[25],"and":[26,78,96,123,189,205,254,287,297,316,402],"methylated":[27],"but":[28],"also":[29,206],"lactylated.":[30],"This":[31,245],"new":[32],"epigenetic":[33,89,159,167],"mark":[34],"could":[35,69,349],"form":[36],"a":[37,220,241,340,413,417],"particularly":[38],"axis":[40],"host-parasite":[42],"signalling":[43],"because":[44,301],"severe":[45,296],"is":[47,62,116,270,343,421],"often":[48,236],"characterised":[49],"by":[50,80,192,260,325,365],"hyperlactataemia.":[51,244],"In":[52],"human":[54,255,277,341,414],"host":[55,342],"this":[56,74,269],"can":[57,223,314,426],"cause":[58],"respiratory":[59,304],"distress,":[60],"which":[61,332],"potentially":[63],"fatal.":[64],"For":[65,266],"parasite,":[67],"it":[68,302,348],"be":[70,87,350,379],"advantageous":[71,351],"to":[72,86,98,135,153,258,318,329,337,355,378,409],"sense":[73,315],"state":[75],"pathology":[77],"respond":[79,317],"modulating":[81],"virulence.":[82],"Virulence":[83],"known":[85,377],"under":[88],"control":[90],"include":[91],"antigenic":[92],"variation,":[93],"invasion":[94],"switching":[95],"conversion":[97,328],"sexual":[99,330,372],"gametocytes,":[100],"i.e.":[101],"gametocytogenesis.":[102,111,137],"Here,":[103,306],"we":[104,124,307],"investigated":[105],"influence":[107,428],"lactate":[109,122,320],"on":[110],"Hyperlactataemia":[112,294],"patients":[115],"defined":[117],"as":[118,219],"\u2265":[119],"5mM":[120,131],"blood":[121,239,418],"confirmed":[125],"laboratory":[128],"culture,":[129],"adding":[130],"L-lactate":[132,187,216],"was":[133,163],"sufficient":[134],"boost":[136,356],"Expression":[138],"GDV-1":[141,165,213],"gene":[142,171],"increased":[143],"within":[144],"one":[145],"cell":[146],"cycle":[147],"asexual":[149],"parasites":[150,253,268,311],"being":[151],"exposed":[152],"L-lactate,":[154],"suggesting":[155],"canonical":[158],"switch":[160,363],"for":[161,177,335,352,407],"gametocytogenesis":[162,226],"involved:":[164],"regulates":[166,212],"de-repression":[168],"encoding":[172],"master":[174],"transcription":[175],"factor":[176],"gametocytogenesis,":[178],"AP2-G.":[179],"Indeed,":[180],"became":[183],"rapidly":[184],"lactylated":[185],"after":[186],"exposure":[188],"chromatin":[190,198,387],"profiling":[191],"CUT&Tag":[193],"detected":[194],"inducible":[195],"lactylation":[196],"specifically":[199],"upstream":[200],"AP2-G":[203],"gene,":[204],"antisense":[209],"RNA":[210],"Thus":[215],"joins":[217],"S-adenosylmethionine":[218],"metabolite":[221,419],"epigenetically":[224,427],"regulate":[225],"P.":[228],"Author":[231],"summary":[232],"Malaria":[233],"humans":[235],"causes":[237,303],"elevated":[238,319],"lactate:":[240],"phenomenon":[242],"called":[243],"occurs":[246,364],"because,":[247],"during":[248,424],"malarial":[249,299],"disease,":[250],"both":[251],"tissues":[256,278],"tend":[257],"respire":[259],"glycolysis":[261],"instead":[262],"oxidative":[264],"respiration.":[265],"bloodstream":[267],"their":[271,327],"mode":[273],"respiration,":[275],"while":[276],"become":[279],"hypoxic":[280],"when":[281],"parasitized":[282],"cells":[283],"adhere":[284],"capillaries":[286],"impede":[288],"flow":[290],"oxygenated":[292],"blood.":[293],"predicts":[295],"fatal":[298],"disease":[300],"distress.":[305],"show":[308],"culture":[313],"\u2013":[321,324],"mimicking":[322],"hyperlactataemia":[323],"increasing":[326,366],"cells,":[331],"vital":[334],"transmission":[336,360],"mosquitoes.":[338],"When":[339],"at":[344],"risk":[345],"death,":[347],"its":[357],"chances":[358],"thus.":[361],"The":[362],"expression":[367],"genes":[369,374],"promote":[371],"conversion:":[373],"silenced":[380],"or":[381],"activated":[382],"epigenetically.":[383],"changes":[385],"marks":[388],"made":[391],"without":[392],"changing":[393,410],"underlying":[395],"DNA":[396],"sequence:":[397],"they":[398],"fast,":[400],"flexible":[401],"reversible,":[403],"making":[404],"them":[405],"ideal":[406],"responding":[408],"situations":[411],"host.":[415],"Thus,":[416],"characteristically":[422],"raised":[423],"an":[429],"virulence":[431],"phenotype":[432],"parasites.":[435]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-09-27T00:00:00"}
