{"id":"https://openalex.org/W7214458355","doi":"https://doi.org/10.1002/hon.70257","title":"Venetoclax\u2010Based Regimens in Newly Diagnosed FLT3\u2010Mutated Older or Unfit Acute Myeloid Leukemia: A Systematic Review and Meta\u2010Analysis of Comparative and Single\u2010Arm Outcomes","display_name":"Venetoclax\u2010Based Regimens in Newly Diagnosed FLT3\u2010Mutated Older or Unfit Acute Myeloid Leukemia: A Systematic Review and Meta\u2010Analysis of Comparative and Single\u2010Arm Outcomes","publication_year":2026,"publication_date":"2026-09-01","ids":{"openalex":"https://openalex.org/W7214458355","doi":"https://doi.org/10.1002/hon.70257","pmid":"https://pubmed.ncbi.nlm.nih.gov/42800061"},"language":"en","primary_location":{"id":"doi:10.1002/hon.70257","doi":"https://doi.org/10.1002/hon.70257","is_oa":true,"landing_page_url":"https://doi.org/10.1002/hon.70257","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/hon.70257","source":{"id":"https://openalex.org/S23714410","display_name":"Hematological Oncology","issn_l":"0278-0232","issn":["0278-0232","1099-1069"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hematological Oncology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/hon.70257","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068204824","display_name":"Mahboob Younus Shaik","orcid":"https://orcid.org/0009-0000-9438-6589","observed_orcids":["https://orcid.org/0009-0000-9438-6589"]},"institutions":[{"id":"https://openalex.org/I2802797007","display_name":"Catholic Health Initiatives","ror":"https://ror.org/011kd6273","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802797007"]},{"id":"https://openalex.org/I4210124418","display_name":"CHI St. Vincent","ror":"https://ror.org/02tr0ps12","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210124418"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mahboob Younus Shaik","raw_affiliation_strings":["Department of Internal Medicine CHI St. Vincent Hospital  Hot Springs Arkansas USA"],"raw_orcid":"https://orcid.org/0009-0000-9438-6589","affiliations":[{"raw_affiliation_string":"Department of Internal Medicine CHI St. Vincent Hospital  Hot Springs Arkansas USA","institution_ids":["https://openalex.org/I2802797007","https://openalex.org/I4210124418"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5153243631","display_name":"Jay Patel","orcid":"https://orcid.org/0009-0001-9602-0561","observed_orcids":["https://orcid.org/0009-0001-9602-0561"]},"institutions":[{"id":"https://openalex.org/I4210161575","display_name":"Kaweah Delta Health Care District","ror":"https://ror.org/0596qfc35","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210161575"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jay Patel","raw_affiliation_strings":["Department of Internal Medicine Kaweah Health Medical Center  Visalia California USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine Kaweah Health Medical Center  Visalia California USA","institution_ids":["https://openalex.org/I4210161575"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5152989074","display_name":"Vaishali Aggarwal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I155284866","display_name":"Maharishi Markandeshwar University, Mullana","ror":"https://ror.org/013qfkw58","country_code":"IN","type":"education","lineage":["https://openalex.org/I155284866"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Vaishali Aggarwal","raw_affiliation_strings":["Department of Internal Medicine Maharishi Markandeshwar Medical College and Hospital  Kumarhatti India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine Maharishi Markandeshwar Medical College and Hospital  Kumarhatti India","institution_ids":["https://openalex.org/I155284866"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090286841","display_name":"Sunilkumar Kakadia","orcid":"https://orcid.org/0000-0002-3312-1605","observed_orcids":["https://orcid.org/0000-0002-3312-1605"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sunil Kakadia","raw_affiliation_strings":["Genesis Cancer and Blood Institute  Hot Springs Arkansas USA"],"raw_orcid":"https://orcid.org/0000-0002-3312-1605","affiliations":[{"raw_affiliation_string":"Genesis Cancer and Blood Institute  Hot Springs Arkansas USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5123645709","display_name":"Stephen Divers","orcid":"https://orcid.org/0000-0002-9499-6843","observed_orcids":["https://orcid.org/0000-0002-9499-6843"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stephen Divers","raw_affiliation_strings":["Genesis Cancer and Blood Institute  Hot Springs Arkansas USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genesis Cancer and Blood Institute  Hot Springs Arkansas USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5068204824"],"corresponding_institution_ids":["https://openalex.org/I2802797007","https://openalex.org/I4210124418"],"apc_list":{"value":4650,"currency":"USD","value_usd":4650},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"44","issue":"5","first_page":"e70257","last_page":"e70257"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12582","display_name":"Flavonoids in Medical Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/venetoclax","display_name":"venetoclax","score":0.9620000123977661},{"id":"https://openalex.org/keywords/flt3-mutated-acute-myeloid-leukemia","display_name":"FLT3-mutated acute myeloid leukemia","score":0.9639999866485596},{"id":"https://openalex.org/keywords/elderly-patients","display_name":"elderly patients","score":0.6700000166893005},{"id":"https://openalex.org/keywords/unfit-patients","display_name":"unfit patients","score":0.8840000033378601},{"id":"https://openalex.org/keywords/hypomethylating-agents","display_name":"hypomethylating agents","score":0.8809999823570251},{"id":"https://openalex.org/keywords/azacitidine","display_name":"azacitidine","score":0.9350000023841858},{"id":"https://openalex.org/keywords/gilteritinib","display_name":"gilteritinib","score":0.7689999938011169},{"id":"https://openalex.org/keywords/flt3-inhibitors","display_name":"FLT3 inhibitors","score":0.7630000114440918},{"id":"https://openalex.org/keywords/complete-remission","display_name":"complete remission","score":0.6899999976158142},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.8270000219345093},{"id":"https://openalex.org/keywords/measurable-residual-disease","display_name":"minimal residual disease","score":0.7689999938011169}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9067000150680542},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6449000239372253},{"id":"https://openalex.org/C2779675984","wikidata":"https://www.wikidata.org/wiki/Q23671272","display_name":"Venetoclax","level":4,"score":0.6212999820709229},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.5748999714851379},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.536300003528595},{"id":"https://openalex.org/C2776012956","wikidata":"https://www.wikidata.org/wiki/Q17125294","display_name":"Hypomethylating agent","level":5,"score":0.47440001368522644},{"id":"https://openalex.org/C187960798","wikidata":"https://www.wikidata.org/wiki/Q7631152","display_name":"Subgroup analysis","level":3,"score":0.40869998931884766},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.4072999954223633},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.391400009393692},{"id":"https://openalex.org/C3019894029","wikidata":"https://www.wikidata.org/wiki/Q332823","display_name":"Overall survival","level":2,"score":0.38920000195503235},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.37560001015663147},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.3571999967098236},{"id":"https://openalex.org/C9583187","wikidata":"https://www.wikidata.org/wiki/Q7919510","display_name":"Ven","level":2,"score":0.3303000032901764},{"id":"https://openalex.org/C2779282312","wikidata":"https://www.wikidata.org/wiki/Q1956561","display_name":"Myeloid","level":2,"score":0.321399986743927},{"id":"https://openalex.org/C2780235182","wikidata":"https://www.wikidata.org/wiki/Q1181878","display_name":"Decitabine","level":5,"score":0.3140000104904175},{"id":"https://openalex.org/C2778111679","wikidata":"https://www.wikidata.org/wiki/Q5155639","display_name":"Comparative effectiveness research","level":3,"score":0.3125999867916107},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.3061000108718872},{"id":"https://openalex.org/C2776239401","wikidata":"https://www.wikidata.org/wiki/Q416451","display_name":"Azacitidine","level":5,"score":0.30000001192092896},{"id":"https://openalex.org/C3019203764","wikidata":"https://www.wikidata.org/wiki/Q1105202","display_name":"Cochrane collaboration","level":4,"score":0.295199990272522},{"id":"https://openalex.org/C189708586","wikidata":"https://www.wikidata.org/wiki/Q1504425","display_name":"Systematic review","level":3,"score":0.2809000015258789},{"id":"https://openalex.org/C10515644","wikidata":"https://www.wikidata.org/wiki/Q543310","display_name":"Survival analysis","level":2,"score":0.27239999175071716},{"id":"https://openalex.org/C2776863199","wikidata":"https://www.wikidata.org/wiki/Q976388","display_name":"Acute leukemia","level":3,"score":0.2705000042915344},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.26820001006126404},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.26669999957084656},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.26249998807907104},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.26190000772476196},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.25690001249313354},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.25619998574256897},{"id":"https://openalex.org/C2776283816","wikidata":"https://www.wikidata.org/wiki/Q332823","display_name":"Survival rate","level":2,"score":0.2556999921798706},{"id":"https://openalex.org/C2780439572","wikidata":"https://www.wikidata.org/wiki/Q919364","display_name":"Publication bias","level":3,"score":0.2515000104904175}],"mesh":[{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013449","descriptor_name":"Sulfonamides","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D013449","descriptor_name":"Sulfonamides","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D019086","descriptor_name":"Bridged Bicyclo Compounds, Heterocyclic","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D019086","descriptor_name":"Bridged Bicyclo Compounds, Heterocyclic","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D051941","descriptor_name":"fms-Like Tyrosine Kinase 3","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/hon.70257","doi":"https://doi.org/10.1002/hon.70257","is_oa":true,"landing_page_url":"https://doi.org/10.1002/hon.70257","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/hon.70257","source":{"id":"https://openalex.org/S23714410","display_name":"Hematological Oncology","issn_l":"0278-0232","issn":["0278-0232","1099-1069"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hematological Oncology","raw_type":"journal-article"},{"id":"pmid:42800061","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42800061","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hematological oncology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1002/hon.70257","doi":"https://doi.org/10.1002/hon.70257","is_oa":true,"landing_page_url":"https://doi.org/10.1002/hon.70257","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/hon.70257","source":{"id":"https://openalex.org/S23714410","display_name":"Hematological Oncology","issn_l":"0278-0232","issn":["0278-0232","1099-1069"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hematological Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Systematic Review","id":"https://openalex.org/study-designs/systematic-review"},{"display_name":"Meta-Analysis","id":"https://openalex.org/study-designs/meta-analysis"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7214458355.pdf","grobid_xml":"https://content.openalex.org/works/W7214458355.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W1600365609","https://openalex.org/W1979423827","https://openalex.org/W2080059445","https://openalex.org/W2106084333","https://openalex.org/W2531269403","https://openalex.org/W2883443104","https://openalex.org/W2898284215","https://openalex.org/W2909346948","https://openalex.org/W2970684805","https://openalex.org/W3000515035","https://openalex.org/W3048827006","https://openalex.org/W3118615836","https://openalex.org/W3128822483","https://openalex.org/W3153501712","https://openalex.org/W4207058592","https://openalex.org/W4225262626","https://openalex.org/W4289522686","https://openalex.org/W4321352678","https://openalex.org/W4376223818","https://openalex.org/W4391247392","https://openalex.org/W4391696648","https://openalex.org/W4401649213","https://openalex.org/W4402795017","https://openalex.org/W4404535718","https://openalex.org/W4407410660","https://openalex.org/W4408582016","https://openalex.org/W4409420899","https://openalex.org/W4413270789","https://openalex.org/W4413846750","https://openalex.org/W4414745023","https://openalex.org/W4416848478","https://openalex.org/W7152475204","https://openalex.org/W7162485472"],"related_works":["https://openalex.org/W4225262626","https://openalex.org/W3040121048","https://openalex.org/W4405034844","https://openalex.org/W4310108996","https://openalex.org/W3128822483","https://openalex.org/W3211430792","https://openalex.org/W7203787138","https://openalex.org/W4417015718","https://openalex.org/W4385667383","https://openalex.org/W4414745023"],"abstract_inverted_index":{"Older":[0],"or":[1,107],"medically":[2],"unfit":[3],"patients":[4],"with":[5,16,76,96,179,222,273],"newly":[6,89],"diagnosed":[7,90],"FLT3-mutated":[8,30,146,277],"acute":[9],"myeloid":[10],"leukemia":[11],"(AML)":[12],"have":[13],"poor":[14],"outcomes":[15,87],"hypomethylating":[17],"agent":[18],"(HMA)":[19],"monotherapy.":[20],"Venetoclax":[21],"plus":[22,104,109,111],"HMA":[23,99],"is":[24,283],"a":[25,42,306,315],"modern":[26],"lower-intensity":[27,98],"standard,":[28],"but":[29,279,298],"AML":[31,94],"remains":[32],"biologically":[33,317],"heterogeneous,":[34],"and":[35,41,61,79,118,126,164,231,244,258,264,295],"triplet":[36,207,233],"regimens":[37],"combining":[38],"HMA,":[39],"venetoclax,":[40],"FLT3":[43,105,112],"inhibitor":[44,113],"are":[45,314],"increasingly":[46],"used":[47],"despite":[48],"limited":[49],"randomized":[50,172,307,322],"comparative":[51,206],"evidence.":[52],"PubMed/MEDLINE,":[53],"Embase,":[54],"Cochrane":[55],"CENTRAL,":[56],"Web":[57],"of":[58,238],"Science,":[59],"Scopus,":[60],"major":[62],"hematology/oncology":[63],"conference":[64],"proceedings":[65],"were":[66,121,129,134],"searched":[67],"from":[68,144,254],"inception":[69],"to":[70,248],"12":[71],"June":[72],"2026":[73],"in":[74,275,305],"accordance":[75],"PRISMA":[77],"2020":[78],"MOOSE":[80],"guidance.":[81],"Eligible":[82],"studies":[83],"reported":[84],"primary":[85],"clinical":[86,125],"for":[88,189,285],"FLT3-ITD":[91,241],"and/or":[92],"FLT3-TKD":[93],"treated":[95],"frontline":[97,308],"alone,":[100],"VEN-HMA":[101,304,327],"doublet,":[102],"HMA/LIC":[103,108],"inhibitor,":[106],"VEN":[110,137,267],"therapy.":[114],"Comparative":[115],"effect":[116],"estimates":[117],"single-arm":[119],"proportions":[120],"synthesized":[122],"only":[123],"when":[124],"statistical":[127],"assumptions":[128],"defensible.":[130],"Thirteen":[131],"eligible":[132],"records":[133],"retained.":[135],"Direct":[136],"+":[138,181,268],"AZA":[139,141,182,184,269,274],"versus":[140,157,168,215,227],"evidence":[142,208,281],"came":[143],"one":[145,210],"pooled":[147],"subgroup":[148],"comparison":[149],"(42":[150],"vs.":[151,186],"22":[152],"patients),":[153],"showing":[154],"CRc":[155,178],"67%":[156],"36%,":[158],"RR":[159,217],"1.83":[160],"(95%":[161,219],"CI":[162,220],"1.01-3.32),":[163],"median":[165,223,245],"OS":[166,190,224,246],"12.5":[167],"8.6":[169],"months.":[170,229],"The":[171,204],"non-venetoclax":[173],"LACEWING":[174],"trial":[175],"showed":[176],"higher":[177],"gilteritinib":[180],"than":[183],"(58.1%":[185],"26.5%;":[187],"HR":[188],"0.916;":[191],"p":[192],"=":[193],"0.753),":[194],"illustrating":[195],"that":[196],"improved":[197],"remission":[198,271],"does":[199],"not":[200,225,300],"guarantee":[201],"survival":[202,287],"benefit.":[203],"principal":[205],"was":[209],"retrospective":[211],"study:":[212],"CR/CRi":[213,236],"93%":[214],"70%,":[216],"1.32":[218],"1.09-1.61),":[221],"reached":[226],"9.5":[228],"Prospective":[230],"long-term":[232],"reports":[234,252],"described":[235],"rates":[237],"93%-96%,":[239],"deep":[240],"MRD":[242,296],"negativity,":[243],"up":[247],"38.5":[249],"months;":[250],"several":[251],"derive":[253],"overlapping":[255],"institutional":[256],"series":[257],"non-randomized":[259],"designs,":[260],"limiting":[261],"independent":[262],"corroboration":[263],"causal":[265],"inference.":[266],"improves":[270],"compared":[272],"the":[276,280,292,325],"subgroup,":[278],"base":[282],"underpowered":[284],"FLT3-specific":[286],"conclusions.":[288],"Triplet":[289],"therapy":[290],"produces":[291],"strongest":[293],"remission-depth":[294],"signals":[297],"has":[299],"shown":[301],"superiority":[302],"over":[303],"comparison.":[309],"On":[310],"current":[311],"evidence,":[312],"triplets":[313],"promising":[316],"rational":[318],"strategy":[319],"requiring":[320],"direct":[321],"validation":[323],"against":[324],"contemporary":[326],"standard.":[328]},"counts_by_year":[],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2026-09-27T00:00:00"}