{"id":"https://openalex.org/W7214451622","doi":"https://doi.org/10.3390/ijms27188316","title":"Young Aggressive Prostate Tumors Exhibit Increased Genomic Instability and an Exploratory RNA\u2013CNA-Concordant Transcriptomic Pattern","display_name":"Young Aggressive Prostate Tumors Exhibit Increased Genomic Instability and an Exploratory RNA\u2013CNA-Concordant Transcriptomic Pattern","publication_year":2026,"publication_date":"2026-09-18","ids":{"openalex":"https://openalex.org/W7214451622","doi":"https://doi.org/10.3390/ijms27188316","pmid":"https://pubmed.ncbi.nlm.nih.gov/42794743","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13607054"},"language":"en","primary_location":{"id":"doi:10.3390/ijms27188316","doi":"https://doi.org/10.3390/ijms27188316","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms27188316","pdf_url":null,"source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/ijms27188316","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078246397","display_name":"Fernando Bergez\u2010Hern\u00e1ndez","orcid":"https://orcid.org/0000-0002-8924-5738","observed_orcids":["https://orcid.org/0000-0002-8924-5738"]},"institutions":[{"id":"https://openalex.org/I4210095594","display_name":"Universidad Aut\u00f3noma de Occidente","ror":"https://ror.org/009m7cp22","country_code":"MX","type":"education","lineage":["https://openalex.org/I4210095594"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Fernando Bergez-Hern\u00e1ndez","raw_affiliation_strings":["Unidad Regional Mazatl\u00e1n, Laboratorio de Investigaci\u00f3n Biom\u00e9dica y Biotecnol\u00f3gica, Universidad Aut\u00f3noma de Occidente, Av. del Mar 1200, Col. Teller\u00eda, Mazatl\u00e1n C.P. 82100, Sinaloa, Mexico"],"raw_orcid":"https://orcid.org/0000-0002-8924-5738","affiliations":[{"raw_affiliation_string":"Unidad Regional Mazatl\u00e1n, Laboratorio de Investigaci\u00f3n Biom\u00e9dica y Biotecnol\u00f3gica, Universidad Aut\u00f3noma de Occidente, Av. del Mar 1200, Col. Teller\u00eda, Mazatl\u00e1n C.P. 82100, Sinaloa, Mexico","institution_ids":["https://openalex.org/I4210095594"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090969240","display_name":"Alejandra Mart\u00ednez-Camberos","orcid":"https://orcid.org/0000-0002-3390-7683","observed_orcids":["https://orcid.org/0000-0002-3390-7683"]},"institutions":[{"id":"https://openalex.org/I4210095594","display_name":"Universidad Aut\u00f3noma de Occidente","ror":"https://ror.org/009m7cp22","country_code":"MX","type":"education","lineage":["https://openalex.org/I4210095594"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Alejandra Mart\u00ednez-Camberos","raw_affiliation_strings":["Unidad Regional Mazatl\u00e1n, Laboratorio de Investigaci\u00f3n Biom\u00e9dica y Biotecnol\u00f3gica, Universidad Aut\u00f3noma de Occidente, Av. del Mar 1200, Col. Teller\u00eda, Mazatl\u00e1n C.P. 82100, Sinaloa, Mexico"],"raw_orcid":"https://orcid.org/0000-0002-3390-7683","affiliations":[{"raw_affiliation_string":"Unidad Regional Mazatl\u00e1n, Laboratorio de Investigaci\u00f3n Biom\u00e9dica y Biotecnol\u00f3gica, Universidad Aut\u00f3noma de Occidente, Av. del Mar 1200, Col. Teller\u00eda, Mazatl\u00e1n C.P. 82100, Sinaloa, Mexico","institution_ids":["https://openalex.org/I4210095594"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037046723","display_name":"Geovanni Romero-Quintana","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I196375840","display_name":"Universidad Aut\u00f3noma de Sinaloa","ror":"https://ror.org/05g1mh260","country_code":"MX","type":"education","lineage":["https://openalex.org/I196375840"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Geovanni Romero-Quintana","raw_affiliation_strings":["Facultad de Ciencias Qu\u00edmico-Biol\u00f3gicas, Universidad Aut\u00f3noma de Sinaloa, Ciudad Universitaria, Calz. de las Am\u00e9ricas Nte. 2771, Col. Bur\u00f3crata, Culiac\u00e1n Rosales C.P. 80030, Sinaloa, Mexico"],"raw_orcid":"https://orcid.org/0000-0003-2646-106X","affiliations":[{"raw_affiliation_string":"Facultad de Ciencias Qu\u00edmico-Biol\u00f3gicas, Universidad Aut\u00f3noma de Sinaloa, Ciudad Universitaria, Calz. de las Am\u00e9ricas Nte. 2771, Col. Bur\u00f3crata, Culiac\u00e1n Rosales C.P. 80030, Sinaloa, Mexico","institution_ids":["https://openalex.org/I196375840"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032545180","display_name":"Jes\u00fas Ricardo Parra\u2010Unda","orcid":"https://orcid.org/0000-0001-5291-6879","observed_orcids":["https://orcid.org/0000-0001-5291-6879"]},"institutions":[{"id":"https://openalex.org/I196375840","display_name":"Universidad Aut\u00f3noma de Sinaloa","ror":"https://ror.org/05g1mh260","country_code":"MX","type":"education","lineage":["https://openalex.org/I196375840"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Jes\u00fas Parra-Unda","raw_affiliation_strings":["Unidad de Investigaciones en Salud P\u00fablica \u201cDra. Kaethe Willms\u201d, Facultad de Ciencias Qu\u00edmico-Biol\u00f3gicas, Universidad Aut\u00f3noma de Sinaloa, Ciudad Universitaria, Culiac\u00e1n Rosales C.P. 80013, Sinaloa, Mexico"],"raw_orcid":"https://orcid.org/0000-0001-5291-6879","affiliations":[{"raw_affiliation_string":"Unidad de Investigaciones en Salud P\u00fablica \u201cDra. Kaethe Willms\u201d, Facultad de Ciencias Qu\u00edmico-Biol\u00f3gicas, Universidad Aut\u00f3noma de Sinaloa, Ciudad Universitaria, Culiac\u00e1n Rosales C.P. 80013, Sinaloa, Mexico","institution_ids":["https://openalex.org/I196375840"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049062188","display_name":"Lennin Isaac Garrido-Palazuelos","orcid":"https://orcid.org/0000-0002-2353-9047","observed_orcids":["https://orcid.org/0000-0002-2353-9047"]},"institutions":[{"id":"https://openalex.org/I4210095594","display_name":"Universidad Aut\u00f3noma de Occidente","ror":"https://ror.org/009m7cp22","country_code":"MX","type":"education","lineage":["https://openalex.org/I4210095594"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Lennin Garrido-Palazuelos","raw_affiliation_strings":["Unidad Regional Los Mochis, Departamento Acad\u00e9mico de Ciencias de la Salud, Universidad Aut\u00f3noma de Occidente, Blvd. Macario Gaxiola y Carretera Internacional M\u00e9xico 15, Los Mochis C.P. 81223, Sinaloa, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unidad Regional Los Mochis, Departamento Acad\u00e9mico de Ciencias de la Salud, Universidad Aut\u00f3noma de Occidente, Blvd. Macario Gaxiola y Carretera Internacional M\u00e9xico 15, Los Mochis C.P. 81223, Sinaloa, Mexico","institution_ids":["https://openalex.org/I4210095594"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001676726","display_name":"Mart\u00edn Irigoyen Arredondo","orcid":"https://orcid.org/0000-0001-7024-7963","observed_orcids":["https://orcid.org/0000-0001-7024-7963"]},"institutions":[{"id":"https://openalex.org/I4210095594","display_name":"Universidad Aut\u00f3noma de Occidente","ror":"https://ror.org/009m7cp22","country_code":"MX","type":"education","lineage":["https://openalex.org/I4210095594"]}],"countries":["MX"],"is_corresponding":true,"raw_author_name":"Mart\u00edn Irigoyen Arredondo","raw_affiliation_strings":["Unidad Regional Mazatl\u00e1n, Laboratorio de Investigaci\u00f3n Biom\u00e9dica y Biotecnol\u00f3gica, Universidad Aut\u00f3noma de Occidente, Av. del Mar 1200, Col. Teller\u00eda, Mazatl\u00e1n C.P. 82100, Sinaloa, Mexico"],"raw_orcid":"https://orcid.org/0000-0001-7024-7963","affiliations":[{"raw_affiliation_string":"Unidad Regional Mazatl\u00e1n, Laboratorio de Investigaci\u00f3n Biom\u00e9dica y Biotecnol\u00f3gica, Universidad Aut\u00f3noma de Occidente, Av. del Mar 1200, Col. Teller\u00eda, Mazatl\u00e1n C.P. 82100, Sinaloa, Mexico","institution_ids":["https://openalex.org/I4210095594"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5001676726"],"corresponding_institution_ids":["https://openalex.org/I4210095594"],"apc_list":{"value":2900,"currency":"CHF","value_usd":3499},"apc_paid":{"value":2900,"currency":"CHF","value_usd":3499},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.64900693,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"27","issue":"18","first_page":"8316","last_page":"8316"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9810000061988831,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9810000061988831,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.012799999676644802,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.9430000185966492},{"id":"https://openalex.org/keywords/indolent-prostate-cancer","display_name":"indolent prostate cancer","score":0.7820000052452087},{"id":"https://openalex.org/keywords/genomic-instability","display_name":"genomic instability","score":0.8830000162124634},{"id":"https://openalex.org/keywords/copy-number-alterations","display_name":"copy number alterations","score":0.7710000276565552},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.5350000262260437},{"id":"https://openalex.org/keywords/pten-deletion","display_name":"PTEN deletion","score":0.753000020980835},{"id":"https://openalex.org/keywords/fga","display_name":"FGA","score":0.6489999890327454},{"id":"https://openalex.org/keywords/differentially-expressed-genes","display_name":"differentially expressed genes","score":0.7639999985694885},{"id":"https://openalex.org/keywords/tumor-purity","display_name":"tumor purity","score":0.3269999921321869},{"id":"https://openalex.org/keywords/molecular-heterogeneity","display_name":"molecular heterogeneity","score":0.5339999794960022}],"concepts":[{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.8062999844551086},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.777999997138977},{"id":"https://openalex.org/C2777609662","wikidata":"https://www.wikidata.org/wiki/Q416356","display_name":"PTEN","level":4,"score":0.6194999814033508},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.5638999938964844},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5212000012397766},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4997999966144562},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.44269999861717224},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.42719998955726624},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.42559999227523804},{"id":"https://openalex.org/C178169997","wikidata":"https://www.wikidata.org/wiki/Q2892636","display_name":"Genome instability","level":4,"score":0.387800008058548},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3368000090122223},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32019999623298645},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.31679999828338623},{"id":"https://openalex.org/C2777008409","wikidata":"https://www.wikidata.org/wiki/Q4914714","display_name":"Biochemical recurrence","level":5,"score":0.3091000020503998},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.304500013589859},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.2955999970436096},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.2944999933242798},{"id":"https://openalex.org/C189206191","wikidata":"https://www.wikidata.org/wiki/Q222046","display_name":"Genomics","level":4,"score":0.29269999265670776},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.28540000319480896},{"id":"https://openalex.org/C2779767149","wikidata":"https://www.wikidata.org/wiki/Q488212","display_name":"Microsatellite instability","level":5,"score":0.2728999853134155},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.26660001277923584},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.2639000117778778},{"id":"https://openalex.org/C205003668","wikidata":"https://www.wikidata.org/wiki/Q17113442","display_name":"Chromoplexy","level":5,"score":0.2615000009536743},{"id":"https://openalex.org/C3018260909","wikidata":"https://www.wikidata.org/wiki/Q1322871","display_name":"Exploratory analysis","level":2,"score":0.2581000030040741},{"id":"https://openalex.org/C145741570","wikidata":"https://www.wikidata.org/wiki/Q7251534","display_name":"Proteogenomics","level":5,"score":0.25209999084472656}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042822","descriptor_name":"Genomic Instability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051059","descriptor_name":"PTEN Phosphohydrolase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D056915","descriptor_name":"DNA Copy Number Variations","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.3390/ijms27188316","doi":"https://doi.org/10.3390/ijms27188316","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms27188316","pdf_url":null,"source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},{"id":"pmid:42794743","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42794743","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular sciences","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13607054","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13607054/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Mol Sci","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3390/ijms27188316","doi":"https://doi.org/10.3390/ijms27188316","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms27188316","pdf_url":null,"source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":49,"referenced_works":["https://openalex.org/W1972266686","https://openalex.org/W1998343146","https://openalex.org/W2016661249","https://openalex.org/W2103912979","https://openalex.org/W2126525177","https://openalex.org/W2136850043","https://openalex.org/W2144656637","https://openalex.org/W2151494814","https://openalex.org/W2153056550","https://openalex.org/W2159675211","https://openalex.org/W2161112598","https://openalex.org/W2214074259","https://openalex.org/W2345356016","https://openalex.org/W2580185643","https://openalex.org/W2783667606","https://openalex.org/W2788783025","https://openalex.org/W2789900707","https://openalex.org/W2885738092","https://openalex.org/W2891405227","https://openalex.org/W2928665623","https://openalex.org/W2958658309","https://openalex.org/W3007837833","https://openalex.org/W3014088197","https://openalex.org/W3102147110","https://openalex.org/W3111149356","https://openalex.org/W3145969289","https://openalex.org/W3176654394","https://openalex.org/W3184537515","https://openalex.org/W3200317384","https://openalex.org/W3211402536","https://openalex.org/W3217589610","https://openalex.org/W4224095112","https://openalex.org/W4307425304","https://openalex.org/W4322502897","https://openalex.org/W4360826379","https://openalex.org/W4383105300","https://openalex.org/W4388014730","https://openalex.org/W4403110854","https://openalex.org/W4405965660","https://openalex.org/W4409360594","https://openalex.org/W4411236241","https://openalex.org/W4412379344","https://openalex.org/W4413012691","https://openalex.org/W4414948008","https://openalex.org/W4415354958","https://openalex.org/W7132830154","https://openalex.org/W7135388471","https://openalex.org/W7141174637","https://openalex.org/W7153296006"],"related_works":["https://openalex.org/W4362540502","https://openalex.org/W3122376210","https://openalex.org/W2585053957","https://openalex.org/W1847790984","https://openalex.org/W4297859003","https://openalex.org/W3017508752","https://openalex.org/W1988428525","https://openalex.org/W4297821405","https://openalex.org/W3007305601","https://openalex.org/W1684904284"],"abstract_inverted_index":{"Prostate":[0,57],"cancer":[1],"(PCa)":[2],"is":[3],"a":[4,98,178],"highly":[5],"heterogeneous":[6],"disease,":[7],"and":[8,32,49,97,147,165,169,174,177],"the":[9,25,144,183,197],"molecular":[10,26,194],"features":[11],"underlying":[12],"differences":[13,27,195],"in":[14],"tumor":[15],"aggressiveness":[16],"remain":[17],"incompletely":[18],"understood.":[19],"This":[20],"study":[21],"aimed":[22],"to":[23],"characterize":[24],"between":[28,196],"young":[29],"aggressive":[30],"(YA)":[31],"old":[33],"indolence-associated":[34],"(OI)":[35],"prostate":[36],"tumors":[37,64,80,93],"using":[38],"an":[39],"integrative":[40,119],"multi-omics":[41],"approach.":[42],"RNA":[43],"sequencing,":[44],"copy":[45],"number":[46],"alteration":[47],"(CNA),":[48],"clinical":[50],"data":[51],"from":[52],"The":[53],"Cancer":[54],"Genome":[55],"Atlas":[56],"Adenocarcinoma":[58],"(TCGA-PRAD)":[59],"cohort":[60],"were":[61,76],"analyzed.":[62],"YA":[63,92],"(age":[65,81],"\u2264":[66,87],"58":[67],"years,":[68,84],"Gleason":[69,85],"score":[70,86],"\u2265":[71,82],"8;":[72],"n":[73,89],"=":[74,90],"30)":[75],"compared":[77],"with":[78,107],"OI":[79],"67":[83],"7;":[88],"41).":[91],"exhibited":[94],"higher":[95],"FGA":[96],"greater":[99],"nominal":[100],"frequency":[101],"of":[102,128,139],"homozygous":[103],"PTEN":[104],"deletion,":[105],"consistent":[106],"increased":[108],"genomic":[109],"instability.":[110],"Transcriptomic":[111],"analysis":[112,121],"identified":[113,172],"1083":[114],"differentially":[115],"expressed":[116],"genes,":[117,126],"whereas":[118,153],"RNA-CNA":[120],"prioritized":[122,185],"40":[123,140],"exploratory":[124,191],"concordant":[125],"35":[127],"which":[129],"showed":[130,136],"copy-number":[131],"loss-associated":[132],"downregulation.":[133],"Sensitivity":[134],"analyses":[135,171],"that":[137],"8":[138],"genes":[141],"retained":[142,157],"both":[143,158],"predefined":[145,199],"FDR":[146],"effect-size":[148],"criteria":[149,159],"after":[150,160],"tumor-purity":[151],"adjustment,":[152],"only":[154],"one":[155],"gene":[156,186],"additional":[161],"adjustment":[162],"for":[163],"pT":[164],"N.":[166],"Functional":[167],"enrichment":[168],"network":[170],"metabolic":[173],"homeostatic":[175],"programs":[176],"central":[179],"interaction":[180],"module":[181],"within":[182],"original":[184],"set.":[187],"These":[188],"findings":[189],"provide":[190],"hypotheses":[192],"regarding":[193],"two":[198],"extreme":[200],"phenotypes.":[201]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2026-09-27T00:00:00"}
