{"id":"https://openalex.org/W7214434266","doi":"https://doi.org/10.3390/ijms27188310","title":"Genetic Variation in NR1I2 and Palbociclib Safety and Prognosis in Advanced Breast Cancer: An Exploratory Multicenter Study","display_name":"Genetic Variation in NR1I2 and Palbociclib Safety and Prognosis in Advanced Breast Cancer: An Exploratory Multicenter Study","publication_year":2026,"publication_date":"2026-09-18","ids":{"openalex":"https://openalex.org/W7214434266","doi":"https://doi.org/10.3390/ijms27188310","pmid":"https://pubmed.ncbi.nlm.nih.gov/42794737","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13607729"},"language":"en","primary_location":{"id":"doi:10.3390/ijms27188310","doi":"https://doi.org/10.3390/ijms27188310","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms27188310","pdf_url":null,"source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/ijms27188310","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034168282","display_name":"Cristina Arqueros","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123044942","display_name":"Universitat Aut\u00f2noma de Barcelona","ror":"https://ror.org/052g8jq94","country_code":"ES","type":"education","lineage":["https://openalex.org/I123044942"]},{"id":"https://openalex.org/I2801795740","display_name":"Hospital de Sant Pau","ror":"https://ror.org/059n1d175","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I2801795740"]},{"id":"https://openalex.org/I4210163263","display_name":"GEICAM \u2013 Spanish Breast Cancer Group","ror":"https://ror.org/05ygm7711","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I4210163263"]},{"id":"https://openalex.org/I4387155026","display_name":"Institut de Recerca Sant Pau","ror":"https://ror.org/005teat46","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4387153040","https://openalex.org/I4387155026"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Cristina Arqueros","raw_affiliation_strings":["Department of Medical Oncology, Hospital de la Santa Creu i Sant Pau, 08041 Barcelona, Spain","Department of Medicine, Faculty of Medicine, Universitat Aut\u00f2noma de Barcelona, 08035 Barcelona, Spain","Spanish Group for Breast Cancer Research (GEICAM), 08041 Barcelona, Spain","Translational Medical Oncology Laboratory, Institut de Recerca Sant Pau (IR Sant Pau), 08041 Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Hospital de la Santa Creu i Sant Pau, 08041 Barcelona, Spain","institution_ids":["https://openalex.org/I2801795740"]},{"raw_affiliation_string":"Department of Medicine, Faculty of Medicine, Universitat Aut\u00f2noma de Barcelona, 08035 Barcelona, Spain","institution_ids":["https://openalex.org/I123044942"]},{"raw_affiliation_string":"Spanish Group for Breast Cancer Research (GEICAM), 08041 Barcelona, Spain","institution_ids":["https://openalex.org/I4210163263"]},{"raw_affiliation_string":"Translational Medical Oncology Laboratory, Institut de Recerca Sant Pau (IR Sant Pau), 08041 Barcelona, Spain","institution_ids":["https://openalex.org/I4387155026"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5152963447","display_name":"Marta Andr\u00e9s","orcid":"https://orcid.org/0000-0003-3214-1636","observed_orcids":["https://orcid.org/0000-0003-3214-1636"]},"institutions":[{"id":"https://openalex.org/I123044942","display_name":"Universitat Aut\u00f2noma de Barcelona","ror":"https://ror.org/052g8jq94","country_code":"ES","type":"education","lineage":["https://openalex.org/I123044942"]},{"id":"https://openalex.org/I2801795740","display_name":"Hospital de Sant Pau","ror":"https://ror.org/059n1d175","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I2801795740"]},{"id":"https://openalex.org/I4210163263","display_name":"GEICAM \u2013 Spanish Breast Cancer Group","ror":"https://ror.org/05ygm7711","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I4210163263"]},{"id":"https://openalex.org/I4387155026","display_name":"Institut de Recerca Sant Pau","ror":"https://ror.org/005teat46","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4387153040","https://openalex.org/I4387155026"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Marta Andr\u00e9s","raw_affiliation_strings":["Department of Medical Oncology, Hospital de la Santa Creu i Sant Pau, 08041 Barcelona, Spain","Department of Medicine, Faculty of Medicine, Universitat Aut\u00f2noma de Barcelona, 08035 Barcelona, Spain","Spanish Group for Breast Cancer Research (GEICAM), 08041 Barcelona, Spain","Translational Medical Oncology Laboratory, Institut de Recerca Sant Pau (IR Sant Pau), 08041 Barcelona, Spain"],"raw_orcid":"https://orcid.org/0000-0003-3214-1636","affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Hospital de la Santa Creu i Sant Pau, 08041 Barcelona, Spain","institution_ids":["https://openalex.org/I2801795740"]},{"raw_affiliation_string":"Department of Medicine, Faculty of Medicine, Universitat Aut\u00f2noma de Barcelona, 08035 Barcelona, Spain","institution_ids":["https://openalex.org/I123044942"]},{"raw_affiliation_string":"Spanish Group for Breast Cancer Research (GEICAM), 08041 Barcelona, Spain","institution_ids":["https://openalex.org/I4210163263"]},{"raw_affiliation_string":"Translational Medical Oncology Laboratory, Institut de Recerca Sant Pau (IR Sant Pau), 08041 Barcelona, Spain","institution_ids":["https://openalex.org/I4387155026"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006460186","display_name":"S\u00f2nia Servitja","orcid":"https://orcid.org/0000-0001-6988-4519","observed_orcids":["https://orcid.org/0000-0001-6988-4519","https://orcid.org/0009-0007-0758-7202"]},"institutions":[{"id":"https://openalex.org/I170486558","display_name":"Universitat Pompeu Fabra","ror":"https://ror.org/04n0g0b29","country_code":"ES","type":"education","lineage":["https://openalex.org/I170486558"]},{"id":"https://openalex.org/I4210130874","display_name":"Hospital Del Mar","ror":"https://ror.org/03a8gac78","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210130874"]},{"id":"https://openalex.org/I4210156109","display_name":"Hospital del Mar Research Institute","ror":"https://ror.org/042nkmz09","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210156109","https://openalex.org/I4387153040"]},{"id":"https://openalex.org/I4210163263","display_name":"GEICAM \u2013 Spanish Breast Cancer Group","ror":"https://ror.org/05ygm7711","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I4210163263"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"S\u00f2nia Servitja","raw_affiliation_strings":["Department of Medicine and Life Science, Universitat Pompeu Fabra, 08003 Barcelona, Spain","Hospital del Mar Research Institute, 08003 Barcelona, Spain","Medical Oncology, Hospital del Mar, 08003 Barcelona, Spain","Spanish Group for Breast Cancer Research (GEICAM), 08041 Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine and Life Science, Universitat Pompeu Fabra, 08003 Barcelona, Spain","institution_ids":["https://openalex.org/I170486558"]},{"raw_affiliation_string":"Hospital del Mar Research Institute, 08003 Barcelona, Spain","institution_ids":["https://openalex.org/I4210156109"]},{"raw_affiliation_string":"Medical Oncology, Hospital del Mar, 08003 Barcelona, Spain","institution_ids":["https://openalex.org/I4210130874"]},{"raw_affiliation_string":"Spanish Group for Breast Cancer Research (GEICAM), 08041 Barcelona, Spain","institution_ids":["https://openalex.org/I4210163263"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023909137","display_name":"Julia Giner","orcid":"https://orcid.org/0009-0003-1672-0010","observed_orcids":["https://orcid.org/0009-0003-1672-0010"]},"institutions":[{"id":"https://openalex.org/I4210115578","display_name":"Corporaci\u00f3 Sanit\u00e0ria Parc Taul\u00ed","ror":"https://ror.org/02pg81z63","country_code":"ES","type":"other","lineage":["https://openalex.org/I4210115578"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"J\u00falia Giner","raw_affiliation_strings":["Medical Oncology Department, Corporaci\u00f3 Sanit\u00e0ria Parc Taul\u00ed, 08208 Sabadell, Spain"],"raw_orcid":"https://orcid.org/0009-0003-1672-0010","affiliations":[{"raw_affiliation_string":"Medical Oncology Department, Corporaci\u00f3 Sanit\u00e0ria Parc Taul\u00ed, 08208 Sabadell, Spain","institution_ids":["https://openalex.org/I4210115578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056336799","display_name":"Ariadna Tibau","orcid":"https://orcid.org/0000-0003-0229-6987","observed_orcids":["https://orcid.org/0000-0003-0229-6987"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I2801795740","display_name":"Hospital de Sant Pau","ror":"https://ror.org/059n1d175","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I2801795740"]},{"id":"https://openalex.org/I4387155026","display_name":"Institut de Recerca Sant Pau","ror":"https://ror.org/005teat46","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4387153040","https://openalex.org/I4387155026"]}],"countries":["ES","US"],"is_corresponding":false,"raw_author_name":"Ariadna Tibau","raw_affiliation_strings":["Department of Medical Oncology, Hospital de la Santa Creu i Sant Pau, 08041 Barcelona, Spain","Program on Regulation, Therapeutics and Law (PORTAL), Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA 02120, USA","Translational Medical Oncology Laboratory, Institut de Recerca Sant Pau (IR Sant Pau), 08041 Barcelona, Spain"],"raw_orcid":"https://orcid.org/0000-0003-0229-6987","affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Hospital de la Santa Creu i Sant Pau, 08041 Barcelona, Spain","institution_ids":["https://openalex.org/I2801795740"]},{"raw_affiliation_string":"Program on Regulation, Therapeutics and Law (PORTAL), Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA 02120, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Translational Medical Oncology Laboratory, Institut de Recerca Sant Pau (IR Sant Pau), 08041 Barcelona, Spain","institution_ids":["https://openalex.org/I4387155026"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087374714","display_name":"Maria Borrell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210127641","display_name":"Vall d'Hebron Hospital Universitari","ror":"https://ror.org/03ba28x55","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I157913058","https://openalex.org/I4210127641","https://openalex.org/I4210153292"]},{"id":"https://openalex.org/I4387155398","display_name":"Vall d'Hebron Institute of Oncology","ror":"https://ror.org/054xx3904","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4387153040","https://openalex.org/I4387155398"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Maria Borrell","raw_affiliation_strings":["Breast Cancer Group, Vall d\u2019Hebron Institute of Oncology (VHIO), 08035 Barcelona, Spain","Medical Oncology Department, Vall d\u2019Hebron Hospital, 08035 Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Breast Cancer Group, Vall d\u2019Hebron Institute of Oncology (VHIO), 08035 Barcelona, Spain","institution_ids":["https://openalex.org/I4387155398"]},{"raw_affiliation_string":"Medical Oncology Department, Vall d\u2019Hebron Hospital, 08035 Barcelona, Spain","institution_ids":["https://openalex.org/I4210127641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034578061","display_name":"Sergio Mart\u00ednez-Recio","orcid":"https://orcid.org/0000-0001-8056-7100","observed_orcids":["https://orcid.org/0000-0001-8056-7100"]},"institutions":[{"id":"https://openalex.org/I2801795740","display_name":"Hospital de Sant Pau","ror":"https://ror.org/059n1d175","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I2801795740"]},{"id":"https://openalex.org/I4387155026","display_name":"Institut de Recerca Sant Pau","ror":"https://ror.org/005teat46","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4387153040","https://openalex.org/I4387155026"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Sergio Martinez-Recio","raw_affiliation_strings":["Department of Medical Oncology, Hospital de la Santa Creu i Sant Pau, 08041 Barcelona, Spain","Translational Medical Oncology Laboratory, Institut de Recerca Sant Pau (IR Sant Pau), 08041 Barcelona, Spain"],"raw_orcid":"https://orcid.org/0000-0001-8056-7100","affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Hospital de la Santa Creu i Sant Pau, 08041 Barcelona, Spain","institution_ids":["https://openalex.org/I2801795740"]},{"raw_affiliation_string":"Translational Medical Oncology Laboratory, Institut de Recerca Sant Pau (IR Sant Pau), 08041 Barcelona, Spain","institution_ids":["https://openalex.org/I4387155026"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027875773","display_name":"Agust\u00ed Barnadas","orcid":"https://orcid.org/0000-0002-0429-1349","observed_orcids":["https://orcid.org/0000-0002-0429-1349"]},"institutions":[{"id":"https://openalex.org/I2801795740","display_name":"Hospital de Sant Pau","ror":"https://ror.org/059n1d175","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I2801795740"]},{"id":"https://openalex.org/I4387155026","display_name":"Institut de Recerca Sant Pau","ror":"https://ror.org/005teat46","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4387153040","https://openalex.org/I4387155026"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Agust\u00ed Barnadas","raw_affiliation_strings":["Department of Medical Oncology, Hospital de la Santa Creu i Sant Pau, 08041 Barcelona, Spain","Translational Medical Oncology Laboratory, Institut de Recerca Sant Pau (IR Sant Pau), 08041 Barcelona, Spain"],"raw_orcid":"https://orcid.org/0000-0002-0429-1349","affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Hospital de la Santa Creu i Sant Pau, 08041 Barcelona, Spain","institution_ids":["https://openalex.org/I2801795740"]},{"raw_affiliation_string":"Translational Medical Oncology Laboratory, Institut de Recerca Sant Pau (IR Sant Pau), 08041 Barcelona, Spain","institution_ids":["https://openalex.org/I4387155026"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040064906","display_name":"Juliana Salazar","orcid":"https://orcid.org/0000-0002-3581-4499","observed_orcids":["https://orcid.org/0000-0002-3581-4499"]},"institutions":[{"id":"https://openalex.org/I4387155026","display_name":"Institut de Recerca Sant Pau","ror":"https://ror.org/005teat46","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4387153040","https://openalex.org/I4387155026"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Juliana Salazar","raw_affiliation_strings":["Translational Medical Oncology Laboratory, Institut de Recerca Sant Pau (IR Sant Pau), 08041 Barcelona, Spain"],"raw_orcid":"https://orcid.org/0000-0002-3581-4499","affiliations":[{"raw_affiliation_string":"Translational Medical Oncology Laboratory, Institut de Recerca Sant Pau (IR Sant Pau), 08041 Barcelona, Spain","institution_ids":["https://openalex.org/I4387155026"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":12,"corresponding_author_ids":["https://openalex.org/A5034168282","https://openalex.org/A5040064906"],"corresponding_institution_ids":["https://openalex.org/I123044942","https://openalex.org/I2801795740","https://openalex.org/I4210163263","https://openalex.org/I4387155026"],"apc_list":{"value":2900,"currency":"CHF","value_usd":3499},"apc_paid":{"value":2900,"currency":"CHF","value_usd":3499},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.68741871,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"27","issue":"18","first_page":"8310","last_page":"8310"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12829","display_name":"Advanced Breast Cancer Therapies","score":0.5210000276565552,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12829","display_name":"Advanced Breast Cancer Therapies","score":0.5210000276565552,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.40209999680519104,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":0.03359999880194664,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/palbociclib","display_name":"palbociclib","score":0.9929999709129333},{"id":"https://openalex.org/keywords/pregnane-x-receptor","display_name":"pregnane X receptor","score":0.9860000014305115},{"id":"https://openalex.org/keywords/genetic-polymorphism","display_name":"genetic polymorphism","score":0.7160000205039978},{"id":"https://openalex.org/keywords/drug-toxicity","display_name":"drug toxicity","score":0.5189999938011169},{"id":"https://openalex.org/keywords/neutropenia","display_name":"neutropenia","score":0.9789999723434448},{"id":"https://openalex.org/keywords/hr-her2-breast-cancer","display_name":"hormone receptor-positive HER2-negative breast cancer","score":0.8569999933242798},{"id":"https://openalex.org/keywords/metastatic-breast-cancer","display_name":"metastatic breast cancer","score":0.8960000276565552},{"id":"https://openalex.org/keywords/endocrine-therapy","display_name":"endocrine therapy","score":0.75},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7900000214576721},{"id":"https://openalex.org/keywords/cyp3a4","display_name":"CYP3A4","score":0.7699999809265137},{"id":"https://openalex.org/keywords/p-glycoprotein","display_name":"P-glycoprotein","score":0.847000002861023},{"id":"https://openalex.org/keywords/abcg2","display_name":"ABCG2","score":0.8410000205039978},{"id":"https://openalex.org/keywords/sult2a1","display_name":"SULT2A1","score":0.800000011920929},{"id":"https://openalex.org/keywords/por","display_name":"POR","score":0.8949999809265137},{"id":"https://openalex.org/keywords/p27","display_name":"p27","score":0.9509999752044678},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.7919999957084656},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.972000002861023}],"concepts":[{"id":"https://openalex.org/C2779744173","wikidata":"https://www.wikidata.org/wiki/Q15269707","display_name":"Palbociclib","level":5,"score":0.8579999804496765},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8278999924659729},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.7498000264167786},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6452999711036682},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.5263000130653381},{"id":"https://openalex.org/C2775930923","wikidata":"https://www.wikidata.org/wiki/Q12859063","display_name":"Metastatic breast cancer","level":4,"score":0.5004000067710876},{"id":"https://openalex.org/C3019894029","wikidata":"https://www.wikidata.org/wiki/Q332823","display_name":"Overall survival","level":2,"score":0.3919000029563904},{"id":"https://openalex.org/C68873052","wikidata":"https://www.wikidata.org/wiki/Q349856","display_name":"Genetic variation","level":3,"score":0.3492000102996826},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.31779998540878296},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.3156999945640564},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.3073999881744385},{"id":"https://openalex.org/C2780673598","wikidata":"https://www.wikidata.org/wiki/Q285223","display_name":"Genetic testing","level":2,"score":0.3066999912261963},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.29910001158714294},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.2865999937057495},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.2759000062942505},{"id":"https://openalex.org/C2778334786","wikidata":"https://www.wikidata.org/wiki/Q1586270","display_name":"Variation (astronomy)","level":2,"score":0.27480000257492065},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.27090001106262207},{"id":"https://openalex.org/C80227256","wikidata":"https://www.wikidata.org/wiki/Q1124169","display_name":"Genetic counseling","level":2,"score":0.2581000030040741},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.2581000030040741}],"mesh":[{"descriptor_ui":"D000077297","descriptor_name":"Pregnane X Receptor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010879","descriptor_name":"Piperazines","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D010879","descriptor_name":"Piperazines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011725","descriptor_name":"Pyridines","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D011725","descriptor_name":"Pyridines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.3390/ijms27188310","doi":"https://doi.org/10.3390/ijms27188310","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms27188310","pdf_url":null,"source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},{"id":"pmid:42794737","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42794737","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular sciences","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13607729","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13607729/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Mol Sci","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3390/ijms27188310","doi":"https://doi.org/10.3390/ijms27188310","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms27188310","pdf_url":null,"source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":49,"referenced_works":["https://openalex.org/W2010427019","https://openalex.org/W2014001512","https://openalex.org/W2022581050","https://openalex.org/W2024868771","https://openalex.org/W2034802701","https://openalex.org/W2045206092","https://openalex.org/W2052021060","https://openalex.org/W2061818721","https://openalex.org/W2061879307","https://openalex.org/W2068489442","https://openalex.org/W2071333117","https://openalex.org/W2072500831","https://openalex.org/W2076972557","https://openalex.org/W2080240185","https://openalex.org/W2097322998","https://openalex.org/W2098008269","https://openalex.org/W2099016928","https://openalex.org/W2103659790","https://openalex.org/W2141820415","https://openalex.org/W2195359644","https://openalex.org/W2256833355","https://openalex.org/W2290950904","https://openalex.org/W2318725321","https://openalex.org/W2552099557","https://openalex.org/W2730419572","https://openalex.org/W2786784128","https://openalex.org/W2799792097","https://openalex.org/W2886243066","https://openalex.org/W2950856878","https://openalex.org/W3092297775","https://openalex.org/W3158639081","https://openalex.org/W3161806487","https://openalex.org/W3171598956","https://openalex.org/W3189308284","https://openalex.org/W3206671948","https://openalex.org/W4220750897","https://openalex.org/W4223596966","https://openalex.org/W4286560606","https://openalex.org/W4304190250","https://openalex.org/W4321471241","https://openalex.org/W4386850549","https://openalex.org/W4388982112","https://openalex.org/W4399323405","https://openalex.org/W4401272104","https://openalex.org/W4403912600","https://openalex.org/W4407294081","https://openalex.org/W4411371090","https://openalex.org/W4416933731","https://openalex.org/W7125981927"],"related_works":["https://openalex.org/W7159802884","https://openalex.org/W4414545910","https://openalex.org/W4416814225","https://openalex.org/W7129710953","https://openalex.org/W4388982112","https://openalex.org/W7208834457","https://openalex.org/W7171527155","https://openalex.org/W3158639081","https://openalex.org/W3176037701","https://openalex.org/W4294919919"],"abstract_inverted_index":{"Palbociclib":[0],"has":[1],"shown":[2],"survival":[3,118,200,222],"benefits":[4],"in":[5,90,224],"hormone":[6],"receptor":[7,14],"(HR)-positive":[8],"and":[9,55,100,114,117,132,167,191,198,218,221],"human":[10],"epidermal":[11],"growth":[12],"factor":[13],"2":[15],"(HER2)-negative":[16],"locally":[17,66,229],"advanced":[18,67,230],"or":[19,68,231],"metastatic":[20,69,232],"breast":[21,70,233],"cancer.":[22],"At":[23],"present,":[24],"however,":[25],"no":[26],"genetic":[27,48,112],"predictors":[28],"of":[29,41,60,79,138,206],"palbociclib-related":[30],"hematological":[31],"toxicity":[32,54,116,220],"have":[33],"been":[34],"validated":[35],"for":[36,151],"clinical":[37,152],"use.":[38],"The":[39,159,178,204],"aim":[40],"this":[42,207],"study":[43,59,209],"was":[44,84,182],"to":[45,86,106,243],"evaluate":[46],"whether":[47],"variants":[49,89,113,162],"are":[50],"associated":[51,173,183],"with":[52,63,73,174,184,192,226,236],"palbociclib":[53,74,185],"patient":[56],"prognosis.":[57],"Multicenter":[58],"113":[61],"patients":[62,121,225],"HR-positive,":[64,227],"HER2-negative":[65,228],"cancer":[71,234],"treated":[72,235],"plus":[75],"endocrine":[76],"therapy.":[77],"Genotyping":[78],"DNA":[80],"from":[81],"blood":[82],"samples":[83],"performed":[85,105],"determine":[87],"18":[88],"seven":[91],"target":[92],"genes":[93],"(CYP3A4,":[94],"SULT2A1,":[95],"ABCB1,":[96],"ABCG2,":[97],"NR1I2,":[98],"POR,":[99],"CDKN1B).":[101],"Association":[102],"analyses":[103],"were":[104,172],"assess":[107],"the":[108,111,139,147,214],"relationship":[109],"between":[110,213],"treatment-related":[115],"outcomes.":[119],"Sixty-seven":[120],"(59.3%)":[122],"developed":[123],"grade":[124,175],"3/4":[125,176],"neutropenia,":[126],"62":[127],"(54.9%)":[128],"experienced":[129],"disease":[130],"progression,":[131],"43":[133],"(38.1%)":[134],"died.":[135],"Although":[136],"none":[137],"univariate":[140],"associations":[141,212],"remained":[142],"significant":[143,157],"after":[144],"Bonferroni":[145],"correction,":[146],"multivariate":[148],"analysis,":[149],"adjusted":[150],"variables,":[153],"revealed":[154],"several":[155],"nominally":[156],"associations.":[158],"NR1I2":[160,179,215],"gene":[161],"rs6785049":[163,180,216],"(p":[164,169,188,195,201],"=":[165,170,189,196,202],"0.01)":[166],"rs3732360":[168],"0.009)":[171],"neutropenia.":[177],"variant":[181,217],"treatment":[186,219],"interruption":[187],"0.03)":[190],"worse":[193],"progression-free":[194],"0.003)":[197],"overall":[199],"0.02).":[203],"findings":[205,241],"exploratory":[208],"suggest":[210],"potential":[211],"outcomes":[223],"palbociclib.":[237],"However,":[238],"these":[239],"hypothesis-generating":[240],"need":[242],"be":[244],"independently":[245],"validated.":[246]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-09-27T00:00:00"}
