{"id":"https://openalex.org/W7214433814","doi":"https://doi.org/10.64898/2026.09.24.753785","title":"Mouse Neural Organoids Model the Mature In Vivo Synaptic Proteome","display_name":"Mouse Neural Organoids Model the Mature In Vivo Synaptic Proteome","publication_year":2026,"publication_date":"2026-09-25","ids":{"openalex":"https://openalex.org/W7214433814","doi":"https://doi.org/10.64898/2026.09.24.753785"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.24.753785","doi":"https://doi.org/10.64898/2026.09.24.753785","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.24.753785","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/25/2026.09.24.753785.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/25/2026.09.24.753785.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020193931","display_name":"Stefano L. Giandomenico","orcid":"https://orcid.org/0000-0003-4235-8353","observed_orcids":["https://orcid.org/0000-0003-4235-8353"]},"institutions":[{"id":"https://openalex.org/I4210127408","display_name":"Max Planck Institute for Brain Research","ror":"https://ror.org/02h1nk258","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210127408"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Stefano L. Giandomenico","raw_affiliation_strings":["Max Planck Institute for Brain Research, Max von Laue Strasse 4, 60438 Frankfurt, Germany"],"raw_orcid":"https://orcid.org/0000-0003-4235-8353","affiliations":[{"raw_affiliation_string":"Max Planck Institute for Brain Research, Max von Laue Strasse 4, 60438 Frankfurt, Germany","institution_ids":["https://openalex.org/I4210127408"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046163178","display_name":"Marc van Oostrum","orcid":"https://orcid.org/0000-0001-8747-9787","observed_orcids":["https://orcid.org/0000-0001-8747-9787"]},"institutions":[{"id":"https://openalex.org/I1850255","display_name":"University of Basel","ror":"https://ror.org/02s6k3f65","country_code":"CH","type":"education","lineage":["https://openalex.org/I1850255"]},{"id":"https://openalex.org/I4210127408","display_name":"Max Planck Institute for Brain Research","ror":"https://ror.org/02h1nk258","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210127408"]}],"countries":["CH","DE"],"is_corresponding":false,"raw_author_name":"Marc van Oostrum","raw_affiliation_strings":["Biozentrum, University of Basel, Basel, Switzerland","Max Planck Institute for Brain Research, Max von Laue Strasse 4, 60438 Frankfurt, Germany"],"raw_orcid":"https://orcid.org/0000-0001-8747-9787","affiliations":[{"raw_affiliation_string":"Biozentrum, University of Basel, Basel, Switzerland","institution_ids":["https://openalex.org/I1850255"]},{"raw_affiliation_string":"Max Planck Institute for Brain Research, Max von Laue Strasse 4, 60438 Frankfurt, Germany","institution_ids":["https://openalex.org/I4210127408"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064995138","display_name":"Quinn Waselenchuk","orcid":"https://orcid.org/0009-0005-9198-7924","observed_orcids":["https://orcid.org/0009-0005-9198-7924"]},"institutions":[{"id":"https://openalex.org/I4210124035","display_name":"Max Planck Institute of Biophysics","ror":"https://ror.org/02panr271","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210124035"]},{"id":"https://openalex.org/I4210127408","display_name":"Max Planck Institute for Brain Research","ror":"https://ror.org/02h1nk258","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210127408"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Quinn Waselenchuk","raw_affiliation_strings":["Max Planck Institute for Brain Research, Max von Laue Strasse 4, 60438 Frankfurt, Germany","Max Planck Institute of Biophysics, Max von Laue Strasse 3, 60438 Frankfurt, Germany"],"raw_orcid":"https://orcid.org/0009-0005-9198-7924","affiliations":[{"raw_affiliation_string":"Max Planck Institute for Brain Research, Max von Laue Strasse 4, 60438 Frankfurt, Germany","institution_ids":["https://openalex.org/I4210127408"]},{"raw_affiliation_string":"Max Planck Institute of Biophysics, Max von Laue Strasse 3, 60438 Frankfurt, Germany","institution_ids":["https://openalex.org/I4210124035"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042089651","display_name":"Irene Dalla Costa","orcid":"https://orcid.org/0000-0002-0924-383X","observed_orcids":["https://orcid.org/0000-0002-0924-383X"]},"institutions":[{"id":"https://openalex.org/I4210127408","display_name":"Max Planck Institute for Brain Research","ror":"https://ror.org/02h1nk258","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210127408"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Irene Dalla Costa","raw_affiliation_strings":["Max Planck Institute for Brain Research, Max von Laue Strasse 4, 60438 Frankfurt, Germany"],"raw_orcid":"https://orcid.org/0000-0002-0924-383X","affiliations":[{"raw_affiliation_string":"Max Planck Institute for Brain Research, Max von Laue Strasse 4, 60438 Frankfurt, Germany","institution_ids":["https://openalex.org/I4210127408"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035071340","display_name":"Julian D. Langer","orcid":"https://orcid.org/0000-0002-5190-577X","observed_orcids":["https://orcid.org/0000-0002-5190-577X"]},"institutions":[{"id":"https://openalex.org/I4210124035","display_name":"Max Planck Institute of Biophysics","ror":"https://ror.org/02panr271","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210124035"]},{"id":"https://openalex.org/I4210127408","display_name":"Max Planck Institute for Brain Research","ror":"https://ror.org/02h1nk258","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210127408"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Julian D. Langer","raw_affiliation_strings":["Max Planck Institute for Brain Research, Max von Laue Strasse 4, 60438 Frankfurt, Germany","Max Planck Institute of Biophysics, Max von Laue Strasse 3, 60438 Frankfurt, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Max Planck Institute for Brain Research, Max von Laue Strasse 4, 60438 Frankfurt, Germany","institution_ids":["https://openalex.org/I4210127408"]},{"raw_affiliation_string":"Max Planck Institute of Biophysics, Max von Laue Strasse 3, 60438 Frankfurt, Germany","institution_ids":["https://openalex.org/I4210124035"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015863270","display_name":"Erin Margaret Schuman","orcid":"https://orcid.org/0000-0002-7053-1005","observed_orcids":["https://orcid.org/0000-0002-7053-1005"]},"institutions":[{"id":"https://openalex.org/I145872427","display_name":"Radboud University Nijmegen","ror":"https://ror.org/016xsfp80","country_code":"NL","type":"education","lineage":["https://openalex.org/I145872427"]},{"id":"https://openalex.org/I4210127408","display_name":"Max Planck Institute for Brain Research","ror":"https://ror.org/02h1nk258","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210127408"]},{"id":"https://openalex.org/I4405261313","display_name":"Donders Institute for Brain, Cognition and Behaviour","ror":"https://ror.org/053sba816","country_code":"NL","type":"facility","lineage":["https://openalex.org/I145872427","https://openalex.org/I4405261313"]}],"countries":["DE","NL"],"is_corresponding":true,"raw_author_name":"Erin M. Schuman","raw_affiliation_strings":["Max Planck Institute for Brain Research, Max von Laue Strasse 4, 60438 Frankfurt, Germany","Radboud University, Donders Institute for Brain, Cognition and Behaviour; Nijmegen, 6525 EN, Netherlands"],"raw_orcid":"https://orcid.org/0000-0002-7053-1005","affiliations":[{"raw_affiliation_string":"Max Planck Institute for Brain Research, Max von Laue Strasse 4, 60438 Frankfurt, Germany","institution_ids":["https://openalex.org/I4210127408"]},{"raw_affiliation_string":"Radboud University, Donders Institute for Brain, Cognition and Behaviour; Nijmegen, 6525 EN, Netherlands","institution_ids":["https://openalex.org/I145872427","https://openalex.org/I4405261313"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5015863270"],"corresponding_institution_ids":["https://openalex.org/I145872427","https://openalex.org/I4210127408","https://openalex.org/I4405261313"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.4675000011920929,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.4675000011920929,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.19949999451637268,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.11349999904632568,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/brain-organoids","display_name":"brain organoids","score":0.9990000128746033},{"id":"https://openalex.org/keywords/synapse-proteome","display_name":"synapse proteome","score":0.7319999933242798},{"id":"https://openalex.org/keywords/synaptic-proteins","display_name":"synaptic proteins","score":0.6060000061988831},{"id":"https://openalex.org/keywords/forebrain-organoids","display_name":"forebrain organoids","score":0.9330000281333923},{"id":"https://openalex.org/keywords/mouse-embryonic-stem-cells","display_name":"mouse embryonic stem cells","score":0.9279999732971191},{"id":"https://openalex.org/keywords/organoid-maturation","display_name":"organoid maturation","score":0.9150000214576721},{"id":"https://openalex.org/keywords/time-resolved-proteomics","display_name":"time-resolved proteomics","score":0.8799999952316284}],"concepts":[{"id":"https://openalex.org/C31695470","wikidata":"https://www.wikidata.org/wiki/Q11293125","display_name":"Organoid","level":2,"score":0.8780999779701233},{"id":"https://openalex.org/C104397665","wikidata":"https://www.wikidata.org/wiki/Q860947","display_name":"Proteome","level":2,"score":0.7253000140190125},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6462000012397766},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.5708000063896179},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.47929999232292175},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.46129998564720154},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4489000141620636},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.4253999888896942},{"id":"https://openalex.org/C2779715522","wikidata":"https://www.wikidata.org/wiki/Q507027","display_name":"Forebrain","level":3,"score":0.42100000381469727},{"id":"https://openalex.org/C136834591","wikidata":"https://www.wikidata.org/wiki/Q2944097","display_name":"Neural stem cell","level":3,"score":0.39469999074935913},{"id":"https://openalex.org/C118403218","wikidata":"https://www.wikidata.org/wiki/Q43283","display_name":"Biological neural network","level":2,"score":0.37880000472068787},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.35519999265670776},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.3310999870300293},{"id":"https://openalex.org/C200170125","wikidata":"https://www.wikidata.org/wiki/Q969316","display_name":"Neurotransmission","level":3,"score":0.3199999928474426},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.31060001254081726},{"id":"https://openalex.org/C98229152","wikidata":"https://www.wikidata.org/wiki/Q1551556","display_name":"Synaptic plasticity","level":3,"score":0.30959999561309814},{"id":"https://openalex.org/C103072069","wikidata":"https://www.wikidata.org/wiki/Q5058372","display_name":"Cellular neuroscience","level":2,"score":0.29760000109672546},{"id":"https://openalex.org/C127445978","wikidata":"https://www.wikidata.org/wiki/Q187181","display_name":"Synapse","level":2,"score":0.2955999970436096},{"id":"https://openalex.org/C545706735","wikidata":"https://www.wikidata.org/wiki/Q9404","display_name":"Nervous system","level":2,"score":0.28040000796318054},{"id":"https://openalex.org/C2780196419","wikidata":"https://www.wikidata.org/wiki/Q1762173","display_name":"Nerve net","level":2,"score":0.2759000062942505},{"id":"https://openalex.org/C162746124","wikidata":"https://www.wikidata.org/wiki/Q7002675","display_name":"Neurosphere","level":5,"score":0.2736999988555908},{"id":"https://openalex.org/C2778794669","wikidata":"https://www.wikidata.org/wiki/Q43054","display_name":"Neuron","level":2,"score":0.2603999972343445},{"id":"https://openalex.org/C19843653","wikidata":"https://www.wikidata.org/wiki/Q213907","display_name":"Model organism","level":3,"score":0.2526000142097473},{"id":"https://openalex.org/C2778921374","wikidata":"https://www.wikidata.org/wiki/Q7662055","display_name":"Synaptosome","level":3,"score":0.25099998712539673}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.64898/2026.09.24.753785","doi":"https://doi.org/10.64898/2026.09.24.753785","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.24.753785","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/25/2026.09.24.753785.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:publikationen.ub.uni-frankfurt.de:100387","doi":null,"is_oa":true,"landing_page_url":"http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/100387","pdf_url":null,"source":{"id":"https://openalex.org/S4306400432","display_name":"Publication Server of Goethe University Frankfurt am Main (Goethe University Frankfurt)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114090438","host_organization_name":"Goethe University Frankfurt","host_organization_lineage":["https://openalex.org/I114090438"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"preprint"},{"id":"pmh:oai:publikationen.ub.uni-frankfurt.de:100556","doi":null,"is_oa":true,"landing_page_url":"http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/100556","pdf_url":null,"source":{"id":"https://openalex.org/S4306400432","display_name":"Publication Server of Goethe University Frankfurt am Main (Goethe University Frankfurt)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114090438","host_organization_name":"Goethe University Frankfurt","host_organization_lineage":["https://openalex.org/I114090438"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"preprint"}],"best_oa_location":{"id":"doi:10.64898/2026.09.24.753785","doi":"https://doi.org/10.64898/2026.09.24.753785","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.24.753785","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/25/2026.09.24.753785.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320320924","display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","ror":"https://ror.org/00yjd3n13"},{"id":"https://openalex.org/F4320322434","display_name":"Max-Planck-Gesellschaft","ror":"https://ror.org/01hhn8329"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7214433814.pdf","grobid_xml":"https://content.openalex.org/works/W7214433814.grobid-xml"},"referenced_works_count":59,"referenced_works":["https://openalex.org/W1553983967","https://openalex.org/W1966255973","https://openalex.org/W1967232661","https://openalex.org/W1979142448","https://openalex.org/W1984678540","https://openalex.org/W2008370035","https://openalex.org/W2018286352","https://openalex.org/W2033877733","https://openalex.org/W2062859898","https://openalex.org/W2100591877","https://openalex.org/W2114165700","https://openalex.org/W2124348590","https://openalex.org/W2138340289","https://openalex.org/W2144447780","https://openalex.org/W2195294260","https://openalex.org/W2409259228","https://openalex.org/W2512007269","https://openalex.org/W2512022815","https://openalex.org/W2584287700","https://openalex.org/W2609844460","https://openalex.org/W2756780707","https://openalex.org/W2912027715","https://openalex.org/W2914346216","https://openalex.org/W2923019381","https://openalex.org/W2949410666","https://openalex.org/W2970454553","https://openalex.org/W3087046884","https://openalex.org/W3112094576","https://openalex.org/W3183726003","https://openalex.org/W3197619341","https://openalex.org/W3205234844","https://openalex.org/W3211084271","https://openalex.org/W4205718273","https://openalex.org/W4205967011","https://openalex.org/W4210782186","https://openalex.org/W4281701833","https://openalex.org/W4282931190","https://openalex.org/W4310911230","https://openalex.org/W4318263660","https://openalex.org/W4321180717","https://openalex.org/W4362602490","https://openalex.org/W4386303585","https://openalex.org/W4388141314","https://openalex.org/W4389048048","https://openalex.org/W4395071317","https://openalex.org/W4399803176","https://openalex.org/W4400030605","https://openalex.org/W4403186453","https://openalex.org/W4403509883","https://openalex.org/W4405089709","https://openalex.org/W4405183562","https://openalex.org/W4405801429","https://openalex.org/W4406001182","https://openalex.org/W4409865197","https://openalex.org/W4410616530","https://openalex.org/W7043890906","https://openalex.org/W7118620572","https://openalex.org/W7160837967","https://openalex.org/W7202299664"],"related_works":["https://openalex.org/W7135426678","https://openalex.org/W2948588843","https://openalex.org/W2318955614","https://openalex.org/W7160837967","https://openalex.org/W4393261738","https://openalex.org/W4411450045","https://openalex.org/W2539335834","https://openalex.org/W4415055764","https://openalex.org/W4388141314","https://openalex.org/W4408188403"],"abstract_inverted_index":{"Summary":[0],"Neural":[1],"organoids":[2,39],"represent":[3],"a":[4,33,73],"promising":[5],"approach":[6],"for":[7],"modelling":[8],"neural":[9],"circuits":[10],"and":[11,45,71],"neurological":[12],"disease,":[13],"yet":[14],"their":[15],"utility":[16],"depends":[17],"on":[18],"whether":[19],"they":[20],"can":[21],"recapitulate":[22],"the":[23,51,68],"molecular":[24,89],"complexity":[25],"of":[26,53],"mature":[27,37,87],"brain":[28],"synapses.":[29],"Here,":[30],"we":[31,66],"optimized":[32],"protocol":[34],"to":[35,49],"generate":[36],"forebrain":[38],"from":[40],"mouse":[41],"embryonic":[42],"stem":[43],"cells":[44],"used":[46],"time-resolved":[47],"proteomics":[48],"define":[50],"emergence":[52],"synaptic":[54,80,88],"proteins":[55],"during":[56],"maturation.":[57],"Using":[58],"fluorescence-activated":[59],"synaptosome":[60],"sorting":[61],"coupled":[62],"with":[63,76],"mass":[64],"spectrometry,":[65],"quantified":[67],"synapse-enriched":[69],"proteome":[70],"found":[72],"high":[74],"correlation":[75],"matched":[77],"in":[78,95],"vivo":[79],"proteomes.":[81],"These":[82],"findings":[83],"demonstrate":[84],"that":[85],"complex":[86],"architecture":[90],"is":[91],"present":[92],"within":[93],"an":[94],"vitro":[96],"organoid":[97],"environment.":[98]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-09-27T00:00:00"}
