{"id":"https://openalex.org/W7214430993","doi":"https://doi.org/10.1093/gerona/glag240","title":"Exploring epigenetic aging and cognitive change in middle adulthood","display_name":"Exploring epigenetic aging and cognitive change in middle adulthood","publication_year":2026,"publication_date":"2026-09-25","ids":{"openalex":"https://openalex.org/W7214430993","doi":"https://doi.org/10.1093/gerona/glag240","pmid":"https://pubmed.ncbi.nlm.nih.gov/42799693","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13644642"},"language":"en","primary_location":{"id":"doi:10.1093/gerona/glag240","doi":"https://doi.org/10.1093/gerona/glag240","is_oa":false,"landing_page_url":"https://doi.org/10.1093/gerona/glag240","pdf_url":null,"source":{"id":"https://openalex.org/S969433497","display_name":"The Journals of Gerontology Series A","issn_l":"1079-5006","issn":["1079-5006","1758-535X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","erih-plus","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journals of Gerontology, Series A: Biological Sciences and Medical Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13644642/pdf/nihms-2212805.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005015732","display_name":"Daisy V. Zavala","orcid":"https://orcid.org/0000-0002-9689-5616","observed_orcids":["https://orcid.org/0000-0002-9689-5616"]},"institutions":[{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daisy V Zavala","raw_affiliation_strings":["Department of Psychology, Stony Brook University , Stony Brook, New York,"],"raw_orcid":"https://orcid.org/0000-0002-9689-5616","affiliations":[{"raw_affiliation_string":"Department of Psychology, Stony Brook University , Stony Brook, New York,","institution_ids":["https://openalex.org/I59553526"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Sharon H Kim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sharon H Kim","raw_affiliation_strings":["Department of Human Development and Family Studies, The Pennsylvania State University, University Park , Pennsylvania,","Department of Social Data Analytics, The Pennsylvania State University , University Park, Pennsylvania,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Development and Family Studies, The Pennsylvania State University, University Park , Pennsylvania,","institution_ids":["https://openalex.org/I130769515"]},{"raw_affiliation_string":"Department of Social Data Analytics, The Pennsylvania State University , University Park, Pennsylvania,","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008261817","display_name":"John Michael Felt","orcid":"https://orcid.org/0000-0002-7334-6489","observed_orcids":["https://orcid.org/0000-0002-7334-6489"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John M Felt","raw_affiliation_strings":["Center for Healthy Aging, The Pennsylvania State University , University Park, Pennsylvania,"],"raw_orcid":"https://orcid.org/0000-0002-7334-6489","affiliations":[{"raw_affiliation_string":"Center for Healthy Aging, The Pennsylvania State University , University Park, Pennsylvania,","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009667479","display_name":"Zita Oravecz","orcid":"https://orcid.org/0000-0002-9070-3329","observed_orcids":["https://orcid.org/0000-0002-9070-3329"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zita Oravecz","raw_affiliation_strings":["Center for Healthy Aging, The Pennsylvania State University , University Park, Pennsylvania,","Department of Human Development and Family Studies, The Pennsylvania State University, University Park , Pennsylvania,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Healthy Aging, The Pennsylvania State University , University Park, Pennsylvania,","institution_ids":["https://openalex.org/I130769515"]},{"raw_affiliation_string":"Department of Human Development and Family Studies, The Pennsylvania State University, University Park , Pennsylvania,","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075873735","display_name":"Martin J. Sliwinski","orcid":"https://orcid.org/0000-0002-9611-7558","observed_orcids":["https://orcid.org/0000-0002-9611-7558"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Martin J Sliwinski","raw_affiliation_strings":["Center for Healthy Aging, The Pennsylvania State University , University Park, Pennsylvania,","Department of Human Development and Family Studies, The Pennsylvania State University, University Park , Pennsylvania,"],"raw_orcid":"https://orcid.org/0000-0002-9611-7558","affiliations":[{"raw_affiliation_string":"Center for Healthy Aging, The Pennsylvania State University , University Park, Pennsylvania,","institution_ids":["https://openalex.org/I130769515"]},{"raw_affiliation_string":"Department of Human Development and Family Studies, The Pennsylvania State University, University Park , Pennsylvania,","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039035377","display_name":"Jennifer E. Graham\u2010Engeland","orcid":"https://orcid.org/0000-0002-9940-2856","observed_orcids":["https://orcid.org/0000-0002-9940-2856"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer E Graham-Engeland","raw_affiliation_strings":["Center for Healthy Aging, The Pennsylvania State University , University Park, Pennsylvania,","Department of Biobehavioral Health, The Pennsylvania State University , University Park, Pennsylvania,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Healthy Aging, The Pennsylvania State University , University Park, Pennsylvania,","institution_ids":["https://openalex.org/I130769515"]},{"raw_affiliation_string":"Department of Biobehavioral Health, The Pennsylvania State University , University Park, Pennsylvania,","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103168923","display_name":"Christopher G. Engeland","orcid":"https://orcid.org/0000-0002-1073-373X","observed_orcids":["https://orcid.org/0000-0002-1073-373X"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher G Engeland","raw_affiliation_strings":["Center for Healthy Aging, The Pennsylvania State University , University Park, Pennsylvania,","Department of Biobehavioral Health, The Pennsylvania State University , University Park, Pennsylvania,","Ross and Carol Nese College of Nursing, The Pennsylvania State University , University Park, Pennsylvania,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Healthy Aging, The Pennsylvania State University , University Park, Pennsylvania,","institution_ids":["https://openalex.org/I130769515"]},{"raw_affiliation_string":"Department of Biobehavioral Health, The Pennsylvania State University , University Park, Pennsylvania,","institution_ids":["https://openalex.org/I130769515"]},{"raw_affiliation_string":"Ross and Carol Nese College of Nursing, The Pennsylvania State University , University Park, Pennsylvania,","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077002680","display_name":"Kristin Bernard","orcid":"https://orcid.org/0000-0003-2421-8453","observed_orcids":["https://orcid.org/0000-0003-2421-8453"]},"institutions":[{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kristin Bernard","raw_affiliation_strings":["Department of Psychology, Stony Brook University , Stony Brook, New York,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychology, Stony Brook University , Stony Brook, New York,","institution_ids":["https://openalex.org/I59553526"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075133785","display_name":"Krishna R. Veeramah","orcid":"https://orcid.org/0000-0002-6768-4000","observed_orcids":["https://orcid.org/0000-0002-6768-4000"]},"institutions":[{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Krishna R Veeramah","raw_affiliation_strings":["Department of Ecology and Evolution, Stony Brook University , Stony Brook, New York,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ecology and Evolution, Stony Brook University , Stony Brook, New York,","institution_ids":["https://openalex.org/I59553526"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048046796","display_name":"Stacey Scott","orcid":"https://orcid.org/0000-0002-7060-4964","observed_orcids":["https://orcid.org/0000-0002-7060-4964"]},"institutions":[{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Stacey B Scott","raw_affiliation_strings":["Department of Psychology, Stony Brook University , Stony Brook, New York,"],"raw_orcid":"https://orcid.org/0000-0002-7060-4964","affiliations":[{"raw_affiliation_string":"Department of Psychology, Stony Brook University , Stony Brook, New York,","institution_ids":["https://openalex.org/I59553526"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5048046796"],"corresponding_institution_ids":["https://openalex.org/I59553526"],"apc_list":{"value":4408,"currency":"USD","value_usd":4408},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.69330572,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"81","issue":"11","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11577","display_name":"Cognitive Abilities and Testing","score":0.45899999141693115,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T11577","display_name":"Cognitive Abilities and Testing","score":0.45899999141693115,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T11265","display_name":"Aging and Gerontology Research","score":0.3521000146865845,"subfield":{"id":"https://openalex.org/subfields/3204","display_name":"Developmental and Educational Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.06870000064373016,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epigenetic-aging","display_name":"epigenetic aging","score":0.972000002861023},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.7960000038146973},{"id":"https://openalex.org/keywords/biological-age","display_name":"biological age","score":0.7400000095367432},{"id":"https://openalex.org/keywords/cognitive-aging","display_name":"cognitive aging","score":0.6240000128746033},{"id":"https://openalex.org/keywords/midlife","display_name":"midlife","score":0.847000002861023},{"id":"https://openalex.org/keywords/processing-speed","display_name":"processing speed","score":0.9300000071525574},{"id":"https://openalex.org/keywords/working-memory","display_name":"working memory","score":0.9990000128746033},{"id":"https://openalex.org/keywords/forgetting","display_name":"forgetting","score":0.7570000290870667},{"id":"https://openalex.org/keywords/intra-individual-variability","display_name":"within-person variability","score":0.9879999756813049},{"id":"https://openalex.org/keywords/peak-performance","display_name":"peak performance","score":0.6430000066757202},{"id":"https://openalex.org/keywords/chronological-age","display_name":"chronological age","score":0.7570000290870667},{"id":"https://openalex.org/keywords/dunedinpace","display_name":"DunedinPACE","score":0.7400000095367432},{"id":"https://openalex.org/keywords/phenoage","display_name":"PhenoAge","score":0.9860000014305115},{"id":"https://openalex.org/keywords/grimage","display_name":"GrimAge","score":0.9580000042915344}],"concepts":[{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.7394999861717224},{"id":"https://openalex.org/C2986811735","wikidata":"https://www.wikidata.org/wiki/Q4692577","display_name":"Cognitive aging","level":3,"score":0.7251999974250793},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.6334999799728394},{"id":"https://openalex.org/C7149132","wikidata":"https://www.wikidata.org/wiki/Q1377840","display_name":"Forgetting","level":2,"score":0.5676000118255615},{"id":"https://openalex.org/C205545832","wikidata":"https://www.wikidata.org/wiki/Q17156455","display_name":"Young adult","level":2,"score":0.5138999819755554},{"id":"https://openalex.org/C138496976","wikidata":"https://www.wikidata.org/wiki/Q175002","display_name":"Developmental psychology","level":1,"score":0.477400004863739},{"id":"https://openalex.org/C6057870","wikidata":"https://www.wikidata.org/wiki/Q5141248","display_name":"Cognitive test","level":3,"score":0.45969998836517334},{"id":"https://openalex.org/C2984863031","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Cognitive decline","level":4,"score":0.42910000681877136},{"id":"https://openalex.org/C185711340","wikidata":"https://www.wikidata.org/wiki/Q5347381","display_name":"Effects of sleep deprivation on cognitive performance","level":3,"score":0.376800000667572},{"id":"https://openalex.org/C198531522","wikidata":"https://www.wikidata.org/wiki/Q485146","display_name":"Sample (material)","level":2,"score":0.3506999909877777},{"id":"https://openalex.org/C2991747559","wikidata":"https://www.wikidata.org/wiki/Q4915075","display_name":"Biological age","level":2,"score":0.34459999203681946},{"id":"https://openalex.org/C134290984","wikidata":"https://www.wikidata.org/wiki/Q5141241","display_name":"Cognitive skill","level":3,"score":0.33329999446868896},{"id":"https://openalex.org/C2777895361","wikidata":"https://www.wikidata.org/wiki/Q1758614","display_name":"Longitudinal study","level":2,"score":0.33250001072883606},{"id":"https://openalex.org/C21963081","wikidata":"https://www.wikidata.org/wiki/Q11337567","display_name":"Working memory","level":3,"score":0.3158000111579895},{"id":"https://openalex.org/C88576662","wikidata":"https://www.wikidata.org/wiki/Q18646","display_name":"Episodic memory","level":3,"score":0.31459999084472656},{"id":"https://openalex.org/C107673813","wikidata":"https://www.wikidata.org/wiki/Q812534","display_name":"Bayesian probability","level":2,"score":0.3025999963283539},{"id":"https://openalex.org/C2986834420","wikidata":"https://www.wikidata.org/wiki/Q5932254","display_name":"Age groups","level":2,"score":0.2985999882221222},{"id":"https://openalex.org/C3020318244","wikidata":"https://www.wikidata.org/wiki/Q4812187","display_name":"Large sample","level":2,"score":0.2980000078678131},{"id":"https://openalex.org/C2780176501","wikidata":"https://www.wikidata.org/wiki/Q5690755","display_name":"Health and Retirement Study","level":2,"score":0.28369998931884766},{"id":"https://openalex.org/C4661277","wikidata":"https://www.wikidata.org/wiki/Q1054157","display_name":"Cog","level":2,"score":0.2687000036239624},{"id":"https://openalex.org/C2993830578","wikidata":"https://www.wikidata.org/wiki/Q5370791","display_name":"Early adulthood","level":3,"score":0.26429998874664307},{"id":"https://openalex.org/C2779758577","wikidata":"https://www.wikidata.org/wiki/Q1202615","display_name":"Middle age","level":2,"score":0.2630999982357025}],"mesh":[{"descriptor_ui":"D000094725","descriptor_name":"Processing Speed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":true},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003071","descriptor_name":"Cognition","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008570","descriptor_name":"Memory, Short-Term","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009483","descriptor_name":"Neuropsychological Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1093/gerona/glag240","doi":"https://doi.org/10.1093/gerona/glag240","is_oa":false,"landing_page_url":"https://doi.org/10.1093/gerona/glag240","pdf_url":null,"source":{"id":"https://openalex.org/S969433497","display_name":"The Journals of Gerontology Series A","issn_l":"1079-5006","issn":["1079-5006","1758-535X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","erih-plus","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journals of Gerontology, Series A: Biological Sciences and Medical Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13644642","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13644642/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13644642/pdf/nihms-2212805.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Gerontol A Biol Sci Med Sci","raw_type":"Text"},{"id":"pmid:42799693","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42799693","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The journals of gerontology. Series A, Biological sciences and medical sciences","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:13644642","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13644642/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13644642/pdf/nihms-2212805.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Gerontol A Biol Sci Med Sci","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.4043000042438507,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G1217729389","display_name":"Chronic Stress as a Pathway to Health Disparities","funder_award_id":"R03AG050798","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G4152302242","display_name":"Inflammatory Mediators of Stress and Cognitive Aging","funder_award_id":"R01AG042595","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G6990823261","display_name":"Stress, Unconstructive Repetitive Thought and Cognitive Aging","funder_award_id":"R01AG039409","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320331904","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7214430993.pdf","grobid_xml":"https://content.openalex.org/works/W7214430993.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4410457540","https://openalex.org/W4405969774","https://openalex.org/W4366758709","https://openalex.org/W7118064474","https://openalex.org/W7062716703","https://openalex.org/W7155095402","https://openalex.org/W4308913666","https://openalex.org/W2998585838","https://openalex.org/W7214067996","https://openalex.org/W2098447741"],"abstract_inverted_index":{"Greater":[0],"age":[1,9,166,188],"deviation":[2],"(AgeDev),":[3],"in":[4,58,71,169,182,199,215,237],"which":[5],"a":[6,43,80,116,216],"person's":[7],"biological":[8,243],"is":[10,16],"older":[11],"than":[12],"their":[13],"chronological":[14,144,165,187,241],"age,":[15,224],"associated":[17,239],"with":[18,139,148,175,194,240],"worse":[19],"cognitive":[20,28,53,170,211],"performance.":[21,212],"Most":[22],"findings,":[23],"however,":[24],"rely":[25],"on":[26],"lab-administered":[27],"measures":[29],"and":[30,66,95,110,119,143,151,159],"do":[31],"not":[32,190],"account":[33],"for":[34,137],"time-ordered":[35],"effects":[36],"of":[37,52,82,207,210,234],"practice.":[38],"The":[39],"present":[40],"study":[41],"leveraged":[42],"measurement":[44],"burst":[45],"dataset":[46],"to":[47],"examine":[48],"6":[49],"distinct":[50],"features":[51,73],"performance":[54,134],"(peak":[55],"performance,":[56,60],"change":[57,171],"peak":[59,133],"intraindividual":[61,180],"variability,":[62],"forgetting,":[63],"retest-related":[64,156],"gains),":[65],"explored":[67],"whether":[68],"individual":[69],"differences":[70,168],"these":[72],"can":[74],"be":[75],"predicted":[76,167],"by":[77],"AgeDev.":[78],"In":[79],"sample":[81,217],"139":[83],"adults":[84],"aged":[85],"25-65,":[86],"baseline":[87,132],"AgeDev":[88,150,163,177],"(Horvath1,":[89],"Horvath2,":[90],"Hannum,":[91],"PhenoAge,":[92],"GrimAge),":[93],"DunedinPACE,":[94,142],"SystemsAge":[96],"were":[97,113],"derived":[98],"from":[99],"DNA":[100],"methylation.":[101],"Across":[102],"4":[103],"annual":[104],"high-frequency":[105],"assessment":[106],"bursts,":[107],"processing":[108,183],"speed":[109],"working":[111],"memory":[112],"assessed":[114],"via":[115],"Symbol":[117],"Search":[118],"N-Back":[120],"task,":[121],"respectively.":[122],"Using":[123],"Bayesian":[124],"Double":[125],"Exponential":[126],"Models":[127],"(BDEMs),":[128],"we":[129],"found":[130],"that":[131],"was":[135,192],"lower":[136],"individuals":[138,147],"greater":[140,149,155,176,186],"AgeDev,":[141],"age.":[145],"Interestingly,":[146],"faster":[152],"DunedinPACE":[153],"showed":[154,178],"gains":[157],"within":[158],"across":[160,172],"bursts.":[161],"Neither":[162],"nor":[164],"time.":[173],"Individuals":[174],"more":[179,195],"variability":[181],"speed.":[184],"Finally,":[185],"(but":[189],"AgeDev)":[191],"linked":[193],"forgetting":[196],"between":[197],"bursts":[198],"both":[200],"tasks.":[201],"These":[202],"findings":[203],"underscore":[204],"the":[205,232],"value":[206],"multidimensional":[208],"indices":[209,226],"Importantly,":[213],"even":[214],"spanning":[218],"young":[219],"adulthood":[220],"through":[221],"early":[222],"old":[223],"such":[225],"may":[227],"provide":[228],"unique":[229],"information":[230],"regarding":[231],"nature":[233],"longitudinal":[235],"patterns":[236],"cognition":[238],"or":[242],"aging.":[244]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2026-09-27T00:00:00"}