{"id":"https://openalex.org/W7214380417","doi":"https://doi.org/10.3390/cancers18193112","title":"Efficacy and Safety of Daraxonrasib (RMC-6236) in Previously Treated Metastatic RAS-Mutated Pancreatic Ductal Adenocarcinoma: A Systematic Review","display_name":"Efficacy and Safety of Daraxonrasib (RMC-6236) in Previously Treated Metastatic RAS-Mutated Pancreatic Ductal Adenocarcinoma: A Systematic Review","publication_year":2026,"publication_date":"2026-09-25","ids":{"openalex":"https://openalex.org/W7214380417","doi":"https://doi.org/10.3390/cancers18193112","pmid":"https://pubmed.ncbi.nlm.nih.gov/42882807","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13664388"},"language":"en","primary_location":{"id":"doi:10.3390/cancers18193112","doi":"https://doi.org/10.3390/cancers18193112","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cancers18193112","pdf_url":null,"source":{"id":"https://openalex.org/S168415115","display_name":"Cancers","issn_l":"2072-6694","issn":["2072-6694"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/cancers18193112","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5098674307","display_name":"Natalia Gierulska","orcid":"https://orcid.org/0009-0005-8136-9997","observed_orcids":["https://orcid.org/0009-0005-8136-9997"]},"institutions":[{"id":"https://openalex.org/I121032520","display_name":"Medical University of Lublin","ror":"https://ror.org/016f61126","country_code":"PL","type":"education","lineage":["https://openalex.org/I121032520"]}],"countries":["PL"],"is_corresponding":true,"raw_author_name":"Natalia Gierulska","raw_affiliation_strings":["Student Scientific Society, Department of Clinical Oncology and Chemotherapy, Medical University of Lublin, 20-059 Lublin, Poland"],"raw_orcid":"https://orcid.org/0009-0005-8136-9997","affiliations":[{"raw_affiliation_string":"Student Scientific Society, Department of Clinical Oncology and Chemotherapy, Medical University of Lublin, 20-059 Lublin, Poland","institution_ids":["https://openalex.org/I121032520"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5140880269","display_name":"Nina Jankowska","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121032520","display_name":"Medical University of Lublin","ror":"https://ror.org/016f61126","country_code":"PL","type":"education","lineage":["https://openalex.org/I121032520"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Nina Jankowska","raw_affiliation_strings":["Student Scientific Society, Department of Clinical Oncology and Chemotherapy, Medical University of Lublin, 20-059 Lublin, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Student Scientific Society, Department of Clinical Oncology and Chemotherapy, Medical University of Lublin, 20-059 Lublin, Poland","institution_ids":["https://openalex.org/I121032520"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068413842","display_name":"Zuzanna D\u0105browska","orcid":"https://orcid.org/0009-0000-6632-4938","observed_orcids":["https://orcid.org/0009-0000-6632-4938"]},"institutions":[{"id":"https://openalex.org/I121032520","display_name":"Medical University of Lublin","ror":"https://ror.org/016f61126","country_code":"PL","type":"education","lineage":["https://openalex.org/I121032520"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Zuzanna D\u0105browska","raw_affiliation_strings":["Student Scientific Society, Department of Clinical Oncology and Chemotherapy, Medical University of Lublin, 20-059 Lublin, Poland"],"raw_orcid":"https://orcid.org/0009-0000-6632-4938","affiliations":[{"raw_affiliation_string":"Student Scientific Society, Department of Clinical Oncology and Chemotherapy, Medical University of Lublin, 20-059 Lublin, Poland","institution_ids":["https://openalex.org/I121032520"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5094271387","display_name":"Julia Piekarz","orcid":"https://orcid.org/0009-0007-2211-1413","observed_orcids":["https://orcid.org/0009-0007-2211-1413"]},"institutions":[{"id":"https://openalex.org/I121032520","display_name":"Medical University of Lublin","ror":"https://ror.org/016f61126","country_code":"PL","type":"education","lineage":["https://openalex.org/I121032520"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Julia Piekarz","raw_affiliation_strings":["Student Scientific Society, Department of Clinical Oncology and Chemotherapy, Medical University of Lublin, 20-059 Lublin, Poland"],"raw_orcid":"https://orcid.org/0009-0007-2211-1413","affiliations":[{"raw_affiliation_string":"Student Scientific Society, Department of Clinical Oncology and Chemotherapy, Medical University of Lublin, 20-059 Lublin, Poland","institution_ids":["https://openalex.org/I121032520"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041657138","display_name":"Magdalena Sk\u00f3rzewska","orcid":"https://orcid.org/0000-0002-5004-9940","observed_orcids":["https://orcid.org/0000-0002-5004-9940"]},"institutions":[{"id":"https://openalex.org/I121032520","display_name":"Medical University of Lublin","ror":"https://ror.org/016f61126","country_code":"PL","type":"education","lineage":["https://openalex.org/I121032520"]}],"countries":["PL"],"is_corresponding":true,"raw_author_name":"Magdalena Sk\u00f3rzewska","raw_affiliation_strings":["Department of Clinical Oncology and Chemotherapy, Medical University of Lublin, 20-059 Lublin, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Oncology and Chemotherapy, Medical University of Lublin, 20-059 Lublin, Poland","institution_ids":["https://openalex.org/I121032520"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5041657138","https://openalex.org/A5098674307"],"corresponding_institution_ids":["https://openalex.org/I121032520"],"apc_list":{"value":2900,"currency":"CHF","value_usd":3499},"apc_paid":{"value":2900,"currency":"CHF","value_usd":3499},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.49806992,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"18","issue":"19","first_page":"3112","last_page":"3112"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10760","display_name":"Pancreatitis Pathology and Treatment","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/daraxonrasib","display_name":"daraxonrasib","score":0.9890000224113464},{"id":"https://openalex.org/keywords/rmc-6236","display_name":"RMC-6236","score":0.9940000176429749},{"id":"https://openalex.org/keywords/ras-inhibition","display_name":"RAS inhibition","score":0.7289999723434448},{"id":"https://openalex.org/keywords/cyclophilin-a","display_name":"cyclophilin A","score":0.8360000252723694},{"id":"https://openalex.org/keywords/kras","display_name":"KRAS","score":0.5720000267028809},{"id":"https://openalex.org/keywords/nras","display_name":"NRAS","score":0.925000011920929},{"id":"https://openalex.org/keywords/hras","display_name":"HRAS","score":0.9869999885559082},{"id":"https://openalex.org/keywords/previously-treated-patients","display_name":"previously treated patients","score":0.6790000200271606},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.7910000085830688},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.9269999861717224},{"id":"https://openalex.org/keywords/objective-response-rate","display_name":"objective response rate","score":0.9549999833106995},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.5490000247955322},{"id":"https://openalex.org/keywords/quality-of-life","display_name":"quality of life","score":0.6480000019073486}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8773999810218811},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.6381000280380249},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6349999904632568},{"id":"https://openalex.org/C2776478404","wikidata":"https://www.wikidata.org/wiki/Q1105187","display_name":"Cochrane Library","level":3,"score":0.4772000014781952},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.43619999289512634},{"id":"https://openalex.org/C2992026798","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic ductal adenocarcinoma","level":4,"score":0.4361000061035156},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.42890000343322754},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.4278999865055084},{"id":"https://openalex.org/C189708586","wikidata":"https://www.wikidata.org/wiki/Q1504425","display_name":"Systematic review","level":3,"score":0.414000004529953},{"id":"https://openalex.org/C1167327","wikidata":"https://www.wikidata.org/wiki/Q14884140","display_name":"HRAS","level":5,"score":0.39820000529289246},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.38929998874664307},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.35429999232292175},{"id":"https://openalex.org/C2776283816","wikidata":"https://www.wikidata.org/wiki/Q332823","display_name":"Survival rate","level":2,"score":0.3440000116825104},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.3334999978542328},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.29829999804496765},{"id":"https://openalex.org/C3019894029","wikidata":"https://www.wikidata.org/wiki/Q332823","display_name":"Overall survival","level":2,"score":0.29429998993873596},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.28999999165534973},{"id":"https://openalex.org/C31760486","wikidata":"https://www.wikidata.org/wiki/Q7180990","display_name":"Phases of clinical research","level":3,"score":0.2849000096321106},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.2759000062942505},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.26759999990463257},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.26409998536109924}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.3390/cancers18193112","doi":"https://doi.org/10.3390/cancers18193112","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cancers18193112","pdf_url":null,"source":{"id":"https://openalex.org/S168415115","display_name":"Cancers","issn_l":"2072-6694","issn":["2072-6694"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13664388","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13664388/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13664388/pdf/cancers-18-03112.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers (Basel)","raw_type":"Text"},{"id":"pmid:42882807","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42882807","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3390/cancers18193112","doi":"https://doi.org/10.3390/cancers18193112","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cancers18193112","pdf_url":null,"source":{"id":"https://openalex.org/S168415115","display_name":"Cancers","issn_l":"2072-6694","issn":["2072-6694"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7214380417.pdf","grobid_xml":"https://content.openalex.org/works/W7214380417.grobid-xml"},"referenced_works_count":28,"referenced_works":["https://openalex.org/W2793938850","https://openalex.org/W2947826965","https://openalex.org/W2984359187","https://openalex.org/W3092802874","https://openalex.org/W3108145357","https://openalex.org/W3118615836","https://openalex.org/W3210474759","https://openalex.org/W3214810781","https://openalex.org/W3216329808","https://openalex.org/W4285386328","https://openalex.org/W4307842183","https://openalex.org/W4386157319","https://openalex.org/W4386529421","https://openalex.org/W4389623119","https://openalex.org/W4390661935","https://openalex.org/W4391166506","https://openalex.org/W4392403685","https://openalex.org/W4394858706","https://openalex.org/W4401729078","https://openalex.org/W4401904657","https://openalex.org/W4407789762","https://openalex.org/W4413056082","https://openalex.org/W4413334942","https://openalex.org/W4415878065","https://openalex.org/W7117115001","https://openalex.org/W7140297268","https://openalex.org/W7160408317","https://openalex.org/W7162952636"],"related_works":["https://openalex.org/W7212801727","https://openalex.org/W7160408317","https://openalex.org/W4410816009","https://openalex.org/W7167672052","https://openalex.org/W7163156740","https://openalex.org/W7214194264","https://openalex.org/W7213235776","https://openalex.org/W7154728896","https://openalex.org/W7163317289","https://openalex.org/W7162000091"],"abstract_inverted_index":{"Introduction:":[0],"Pancreatic":[1],"ductal":[2],"adenocarcinoma":[3],"(PDAC)":[4],"is":[5,29,42,341],"associated":[6],"with":[7,61,96,106,205,256,274,298,308,319,328,372],"a":[8,30,43,159,201,285,350],"poor":[9],"prognosis,":[10],"and":[11,67,74,88,121,129,138,148,180,228,239,246,295,304,315,367],"RAS":[12,27,207,275,330,364],"gene":[13,365],"mutations":[14],"are":[15,360],"present":[16],"in":[17,92,104,116,200,248,272,279,324,355],"more":[18],"than":[19,307],"90%":[20],"of":[21,49,53,70,79,90,119,161,166,203,244,250,291,301,369],"cases.":[22],"For":[23],"this":[24,80,356],"reason,":[25],"direct":[26],"inhibition":[28],"promising,":[31],"but":[32],"thus":[33],"far":[34],"difficult":[35],"to":[36,84],"achieve,":[37],"therapeutic":[38],"strategy.":[39],"Daraxonrasib":[40,283,311],"(RMC-6236)":[41],"first-in-class,":[44],"oral,":[45],"non-covalent,":[46],"multiselective":[47],"inhibitor":[48],"the":[50,71,86,107,135,141,149,171,177,181,191,206,242,257,280,333,337,370],"active":[51],"form":[52],"RAS.":[54,374],"It":[55],"forms":[56,368],"an":[57,320],"intracellular":[58],"trimeric":[59],"complex":[60],"cyclophilin":[62],"A,":[63],"blocking":[64],"both":[65],"mutant":[66],"wild-type":[68,373],"variants":[69,366],"KRAS,":[72],"NRAS,":[73],"HRAS":[75],"genes.":[76],"The":[77,164],"aim":[78],"systematic":[81,112],"review":[82,101],"was":[83,102,114,168],"evaluate":[85],"efficacy":[87,318],"safety":[89,322],"daraxonrasib":[91,195],"previously":[93,325],"treated":[94,278,326],"patients":[95,204,273,327],"RAS-mutated":[97],"PDAC.":[98],"Methods:":[99],"This":[100],"conducted":[103,115],"accordance":[105],"PRISMA":[108],"2020":[109,128],"guidelines.":[110],"A":[111],"search":[113],"PubMed,":[117],"Web":[118],"Science,":[120],"ClinicalTrials.gov":[122],"for":[123,176,184,335],"studies":[124,133,359],"published":[125],"between":[126],"January":[127],"July":[130],"2026.":[131],"Two":[132],"met":[134],"inclusion":[136],"criteria":[137],"were":[139,254],"analyzed:":[140],"Phase":[142,150],"1\u20132":[143,293],"RMC-6236-001":[144,259],"(n":[145,155],"=":[146,156],"168)":[147],"3":[151],"RASolute":[152,192],"302":[153,193],"trial":[154,179],"500),":[157],"involving":[158],"total":[160],"668":[162],"patients.":[163],"risk":[165],"bias":[167],"assessed":[169],"using":[170],"Cochrane":[172],"RoB":[173],"2.0":[174],"tool":[175],"randomized":[178,339],"Methodological":[182],"Index":[183],"Non-Randomized":[185],"Studies":[186],"(MINORS)":[187],"tool.":[188],"Results:":[189],"In":[190],"trial,":[194],"out":[196],"performed":[197],"investigator-selected":[198],"chemotherapy":[199],"population":[202,334],"G12":[208,276],"mutation,":[209],"improving":[210],"median":[211,266],"overall":[212,267],"survival":[213,221,268],"(13.2":[214],"vs.":[215,223,233],"6.6":[216],"months;":[217,225],"HR":[218,226],"0.40),":[219],"progression-free":[220],"(7.3":[222],"3.5":[224],"0.45),":[227],"objective":[229],"response":[230,262],"rate":[231,263],"(33.2%":[232],"11.8%;":[234],"all":[235],"p":[236],"<":[237],"0.001),":[238],"also":[240],"delayed":[241],"onset":[243],"pain":[245],"deterioration":[247],"quality":[249],"life.":[251],"These":[252,344],"results":[253],"consistent":[255],"earlier":[258],"study":[260],"(objective":[261],"[ORR]":[264],"35%,":[265],"[OS]":[269],"13.1":[270],"months":[271],"mutation":[277],"second-line":[281],"setting).":[282],"exhibited":[284],"predictable":[286],"toxicity":[287,303],"profile,":[288],"consisting":[289],"mainly":[290],"Grade":[292],"dermatologic":[294],"gastrointestinal":[296],"symptoms,":[297],"lower":[299],"rates":[300],"hematologic":[302],"treatment":[305,353],"discontinuation":[306],"chemotherapy.":[309],"Conclusions:":[310],"demonstrates":[312],"clinically":[313],"relevant":[314],"statistically":[316],"significant":[317],"acceptable":[321],"profile":[323],"metastatic":[329],"G12-mutated":[331],"PDAC,":[332],"which":[336],"strongest":[338],"evidence":[340],"currently":[342],"available.":[343],"findings":[345],"support":[346],"its":[347],"potential":[348],"as":[349],"promising":[351],"new":[352],"option":[354],"setting.":[357],"Further":[358],"needed":[361],"regarding":[362],"rare":[363],"disease":[371]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-09-26T00:00:00"}