{"id":"https://openalex.org/W7214359125","doi":"https://doi.org/10.64898/2026.09.23.26363640","title":"Effects of Reimbursement Policy Change on Utilization of Injectable Semaglutide for Type 2 Diabetes and on Glycemic Control Among Discontinuers: A Danish Nationwide Cohort Study","display_name":"Effects of Reimbursement Policy Change on Utilization of Injectable Semaglutide for Type 2 Diabetes and on Glycemic Control Among Discontinuers: A Danish Nationwide Cohort Study","publication_year":2026,"publication_date":"2026-09-25","ids":{"openalex":"https://openalex.org/W7214359125","doi":"https://doi.org/10.64898/2026.09.23.26363640"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.23.26363640","doi":"https://doi.org/10.64898/2026.09.23.26363640","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.23.26363640","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2026/09/25/2026.09.23.26363640.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.medrxiv.org/content/medrxiv/early/2026/09/25/2026.09.23.26363640.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067939447","display_name":"Emma Simonsen","orcid":"https://orcid.org/0000-0002-0254-0479","observed_orcids":["https://orcid.org/0000-0002-0254-0479"]},"institutions":[{"id":"https://openalex.org/I177969490","display_name":"University of Southern Denmark","ror":"https://ror.org/03yrrjy16","country_code":"DK","type":"education","lineage":["https://openalex.org/I177969490"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Emma Simonsen","raw_affiliation_strings":["Clinical Pharmacology, Pharmacy and Environmental Medicine, Department of Public Health, University of Southern Denmark, Odense, Denmark"],"raw_orcid":"https://orcid.org/0000-0002-0254-0479","affiliations":[{"raw_affiliation_string":"Clinical Pharmacology, Pharmacy and Environmental Medicine, Department of Public Health, University of Southern Denmark, Odense, Denmark","institution_ids":["https://openalex.org/I177969490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056150399","display_name":"Martin Ernst","orcid":"https://orcid.org/0000-0001-9003-3823","observed_orcids":["https://orcid.org/0000-0001-9003-3823"]},"institutions":[{"id":"https://openalex.org/I177969490","display_name":"University of Southern Denmark","ror":"https://ror.org/03yrrjy16","country_code":"DK","type":"education","lineage":["https://openalex.org/I177969490"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Martin Thomsen Ernst","raw_affiliation_strings":["Clinical Pharmacology, Pharmacy and Environmental Medicine, Department of Public Health, University of Southern Denmark, Odense, Denmark"],"raw_orcid":"https://orcid.org/0000-0001-9003-3823","affiliations":[{"raw_affiliation_string":"Clinical Pharmacology, Pharmacy and Environmental Medicine, Department of Public Health, University of Southern Denmark, Odense, Denmark","institution_ids":["https://openalex.org/I177969490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060864688","display_name":"Diana Hedevang Christensen","orcid":"https://orcid.org/0000-0002-2693-5651","observed_orcids":["https://orcid.org/0000-0002-2693-5651"]},"institutions":[{"id":"https://openalex.org/I204337017","display_name":"Aarhus University","ror":"https://ror.org/01aj84f44","country_code":"DK","type":"education","lineage":["https://openalex.org/I204337017"]},{"id":"https://openalex.org/I2802335433","display_name":"Aarhus University Hospital","ror":"https://ror.org/040r8fr65","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802335433"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Diana Hedevang Christensen","raw_affiliation_strings":["Department of Clinical Epidemiology, Aarhus University and Aarhus University Hospital, Aarhus, Denmark","Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark"],"raw_orcid":"https://orcid.org/0000-0002-2693-5651","affiliations":[{"raw_affiliation_string":"Department of Clinical Epidemiology, Aarhus University and Aarhus University Hospital, Aarhus, Denmark","institution_ids":["https://openalex.org/I204337017","https://openalex.org/I2802335433"]},{"raw_affiliation_string":"Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark","institution_ids":["https://openalex.org/I2802335433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033390335","display_name":"Helene Kildegaard","orcid":"https://orcid.org/0000-0003-1930-5851","observed_orcids":["https://orcid.org/0000-0003-1930-5851"]},"institutions":[{"id":"https://openalex.org/I177969490","display_name":"University of Southern Denmark","ror":"https://ror.org/03yrrjy16","country_code":"DK","type":"education","lineage":["https://openalex.org/I177969490"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Helene Kildegaard","raw_affiliation_strings":["Clinical Pharmacology, Pharmacy and Environmental Medicine, Department of Public Health, University of Southern Denmark, Odense, Denmark"],"raw_orcid":"https://orcid.org/0000-0003-1930-5851","affiliations":[{"raw_affiliation_string":"Clinical Pharmacology, Pharmacy and Environmental Medicine, Department of Public Health, University of Southern Denmark, Odense, Denmark","institution_ids":["https://openalex.org/I177969490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059577837","display_name":"Jens S\u00f8ndergaard","orcid":"https://orcid.org/0000-0002-1629-1864","observed_orcids":["https://orcid.org/0000-0002-1629-1864"]},"institutions":[{"id":"https://openalex.org/I177969490","display_name":"University of Southern Denmark","ror":"https://ror.org/03yrrjy16","country_code":"DK","type":"education","lineage":["https://openalex.org/I177969490"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Jens S\u00f8ndergaard","raw_affiliation_strings":["Research Unit of General Practice, Department of Public Health, University of Southern Denmark, Odense, Denmark"],"raw_orcid":"https://orcid.org/0000-0002-1629-1864","affiliations":[{"raw_affiliation_string":"Research Unit of General Practice, Department of Public Health, University of Southern Denmark, Odense, Denmark","institution_ids":["https://openalex.org/I177969490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056029496","display_name":"Reimar Wernich Thomsen","orcid":"https://orcid.org/0000-0001-9135-3474","observed_orcids":["https://orcid.org/0000-0001-9135-3474"]},"institutions":[{"id":"https://openalex.org/I204337017","display_name":"Aarhus University","ror":"https://ror.org/01aj84f44","country_code":"DK","type":"education","lineage":["https://openalex.org/I204337017"]},{"id":"https://openalex.org/I2802335433","display_name":"Aarhus University Hospital","ror":"https://ror.org/040r8fr65","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802335433"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Reimar W. Thomsen","raw_affiliation_strings":["Department of Clinical Epidemiology, Aarhus University and Aarhus University Hospital, Aarhus, Denmark"],"raw_orcid":"https://orcid.org/0000-0001-9135-3474","affiliations":[{"raw_affiliation_string":"Department of Clinical Epidemiology, Aarhus University and Aarhus University Hospital, Aarhus, Denmark","institution_ids":["https://openalex.org/I204337017","https://openalex.org/I2802335433"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072859924","display_name":"Anton Potteg\u00e5rd","orcid":"https://orcid.org/0000-0001-9314-5679","observed_orcids":["https://orcid.org/0000-0001-9314-5679"]},"institutions":[{"id":"https://openalex.org/I177969490","display_name":"University of Southern Denmark","ror":"https://ror.org/03yrrjy16","country_code":"DK","type":"education","lineage":["https://openalex.org/I177969490"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Anton Potteg\u00e5rd","raw_affiliation_strings":["Clinical Pharmacology, Pharmacy and Environmental Medicine, Department of Public Health, University of Southern Denmark, Odense, Denmark"],"raw_orcid":"https://orcid.org/0000-0001-9314-5679","affiliations":[{"raw_affiliation_string":"Clinical Pharmacology, Pharmacy and Environmental Medicine, Department of Public Health, University of Southern Denmark, Odense, Denmark","institution_ids":["https://openalex.org/I177969490"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11792","display_name":"Pharmaceutical Economics and Policy","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2002","display_name":"Economics and Econometrics"},"field":{"id":"https://openalex.org/fields/20","display_name":"Economics, Econometrics and Finance"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/semaglutide","display_name":"semaglutide","score":0.9129999876022339},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.8309999704360962},{"id":"https://openalex.org/keywords/reimbursement-policy","display_name":"reimbursement policy","score":0.7049999833106995},{"id":"https://openalex.org/keywords/glp-1-receptor-agonists","display_name":"GLP-1 receptor agonists","score":0.8970000147819519},{"id":"https://openalex.org/keywords/medication-discontinuation","display_name":"drug discontinuation","score":0.6610000133514404},{"id":"https://openalex.org/keywords/glycemic-control","display_name":"glycemic control","score":0.7979999780654907},{"id":"https://openalex.org/keywords/hba1c","display_name":"HbA1c","score":0.9769999980926514},{"id":"https://openalex.org/keywords/sglt2-inhibitors","display_name":"SGLT2 inhibitors","score":0.906000018119812},{"id":"https://openalex.org/keywords/treatment-switching","display_name":"treatment switching","score":0.8059999942779541},{"id":"https://openalex.org/keywords/medication-utilization","display_name":"medication utilization","score":0.3449999988079071},{"id":"https://openalex.org/keywords/cardiovascular-risk","display_name":"cardiovascular risk","score":0.6029999852180481},{"id":"https://openalex.org/keywords/denmark","display_name":"Denmark","score":0.675000011920929},{"id":"https://openalex.org/keywords/health-policy-impact","display_name":"health policy impact","score":0.3630000054836273},{"id":"https://openalex.org/keywords/diabetes-self-management-education","display_name":"diabetes self-management education","score":0.33799999952316284}],"concepts":[{"id":"https://openalex.org/C2909862629","wikidata":"https://www.wikidata.org/wiki/Q27261089","display_name":"Semaglutide","level":5,"score":0.9918000102043152},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8212000131607056},{"id":"https://openalex.org/C2779703844","wikidata":"https://www.wikidata.org/wiki/Q760125","display_name":"Reimbursement","level":3,"score":0.6754000186920166},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.6560999751091003},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.4821000099182129},{"id":"https://openalex.org/C2780473172","wikidata":"https://www.wikidata.org/wiki/Q5572518","display_name":"Glycemic","level":3,"score":0.4659999907016754},{"id":"https://openalex.org/C164622146","wikidata":"https://www.wikidata.org/wiki/Q9035","display_name":"Danish","level":2,"score":0.4641000032424927},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.41679999232292175},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.3517000079154968},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.33250001072883606},{"id":"https://openalex.org/C86941820","wikidata":"https://www.wikidata.org/wiki/Q6865391","display_name":"Minimisation (clinical trials)","level":2,"score":0.3025999963283539},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.29649999737739563}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.09.23.26363640","doi":"https://doi.org/10.64898/2026.09.23.26363640","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.23.26363640","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2026/09/25/2026.09.23.26363640.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.09.23.26363640","doi":"https://doi.org/10.64898/2026.09.23.26363640","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.23.26363640","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2026/09/25/2026.09.23.26363640.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320323799","display_name":"Syddansk Universitet","ror":"https://ror.org/03yrrjy16"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7214359125.pdf","grobid_xml":"https://content.openalex.org/works/W7214359125.grobid-xml"},"referenced_works_count":19,"referenced_works":["https://openalex.org/W1978670003","https://openalex.org/W1986696888","https://openalex.org/W2123946565","https://openalex.org/W2163278718","https://openalex.org/W2219591537","https://openalex.org/W2416547532","https://openalex.org/W2528292047","https://openalex.org/W2541013163","https://openalex.org/W2916296804","https://openalex.org/W2963090082","https://openalex.org/W3025861706","https://openalex.org/W3109517929","https://openalex.org/W3120821309","https://openalex.org/W4220656413","https://openalex.org/W4323356536","https://openalex.org/W4399023579","https://openalex.org/W4399423348","https://openalex.org/W4401505899","https://openalex.org/W4404704796"],"related_works":["https://openalex.org/W7126059234","https://openalex.org/W4410031675","https://openalex.org/W4388013824","https://openalex.org/W4402333886","https://openalex.org/W4327719375","https://openalex.org/W4410392889","https://openalex.org/W7130437636","https://openalex.org/W4411477059","https://openalex.org/W7125152466","https://openalex.org/W3114726363"],"abstract_inverted_index":{"Abstract":[0],"Objectives":[1],"To":[2],"evaluate":[3],"the":[4,71,78,90,109,136,163,300,311,438],"impact":[5],"of":[6,94,140,177,207,219,316,361,470,501],"reimbursement":[7,173,392,414],"restrictions":[8,393],"for":[9,15,50,368,427,473],"glucagon-like":[10],"peptide-1":[11],"receptor":[12,363,396],"agonists":[13,397],"(GLP-1RAs)":[14],"type":[16],"2":[17,97],"diabetes,":[18,428],"introduced":[19],"in":[20,22,64,89,299,336,416,421,456,480],"Denmark":[21],"November":[23,115,195],"2024,":[24,196],"on":[25,352,394],"injectable":[26,48,65,141,317,366,425,471],"semaglutide":[27,49,66,75,106,142,153,189,237,249,318,367,426,461,472],"(Ozempic\u00ae)":[28],"utilization":[29],"patterns":[30,63,400],"and":[31,69,100,117,127,180,194,239,332,358,385,401,429],"subsequent":[32,118],"HbA1c":[33,125,229,242,253,271,337,481],"changes":[34,126],"among":[35,430],"discontinuers.":[36,202],"Design":[37],"Nationwide":[38],"registry-based":[39],"cohort":[40],"study.":[41],"Setting":[42],"Denmark.":[43],"Participants":[44],"Adults":[45],"treated":[46],"with":[47,187,226],"diabetes":[51,369,474],"(January":[52],"2018":[53],"to":[54,114,210,257,285,343,375,379,490,504],"December":[55],"2025).":[56],"Main":[57],"outcome":[58],"measures":[59],"We":[60,104],"described":[61],"temporal":[62],"use":[67,99,139,179,315],"before":[68,145,234,321],"after":[70,77,246,404,467],"policy":[72,79,110,137,312],"change.":[73],"Among":[74,121,148,184,224],"continuers":[76],"change,":[80,138,313],"we":[81,123],"assessed":[82],"whether":[83],"continuation":[84],"met":[85,170],"a":[86,171,188,412,478,497],"key":[87,172],"criterion":[88,174],"new":[91],"policy:":[92],"non-feasibility":[93,176],"sodium-glucose":[95],"cotransporter":[96],"inhibitor":[98],"high":[101,181,359],"cardiovascular":[102,182],"risk.":[103],"characterized":[105],"discontinuers":[107,208,220,325,444,458],"around":[108],"implementation":[111],"(March":[112],"2024":[113,193],"2024)":[116],"treatment":[119,399,405,508],"switches.":[120],"discontinuers,":[122],"evaluated":[124],"performed":[128],"interrupted":[129],"time":[130],"series":[131],"(ITS)":[132],"analyses.":[133],"Results":[134],"Following":[135,310,411],"declined":[143,319],"modestly":[144,320],"subsequently":[146],"increasing.":[147],"61,120":[149],"individuals":[150,186,225],"classified":[151,200],"as":[152,201],"continuers,":[154],"27,143":[155],"(44%)":[156],"were":[157,199,437],"already":[158,350],"using":[159],"an":[160,227,240,334,505],"SGLT2i.":[161],"Of":[162],"remaining":[164],"33,977":[165],"(56%),":[166],"only":[167],"1,862":[168],"(5.5%)":[169],"(i.e.,":[175],"SGLT2i":[178],"risk).":[183],"79,305":[185],"fill":[190],"between":[191],"March":[192],"22,096":[197],"(28%)":[198],"Within":[203],"six":[204,280,452,465],"months,":[205,495],"\u223c40%":[206],"switched":[209,433],"other":[211],"glucose-lowering":[212,330,449,507],"therapies,":[213],"most":[214,439,443],"commonly":[215],"SGLT2is":[216],"(24%).":[217],"37%":[218],"later":[221],"reinitiated":[222,459],"semaglutide.":[223],"on-treatment":[228],"measurement":[230,243],"(within":[231],"12":[232,292],"months":[233,245,281,466],"their":[235,247,460],"last":[236,248],"fill)":[238,250],"off-treatment":[241],"(6-12":[244],"(n=13,017),":[251],"mean":[252],"increased":[254,272],"from":[255],"49":[256],"57":[258],"mmol/mol":[259,275,287],"(mean":[260],"change":[261],"+7.4":[262],"mmol/mol,":[263],"95%":[264],"CI":[265,277,289],"7.2-7.6).":[266],"ITS":[267,301],"analysis":[268],"showed":[269],"that":[270,338],"by":[273,477],"5.9":[274],"(95%":[276,288],"5.1-6.7)":[278],"at":[279,291],"post-discontinuation,":[282],"which":[283],"attenuated":[284],"3.1":[286],"2.2-4.1)":[290],"months;":[293],"raw":[294],"monthly":[295],"means":[296],"(not":[297],"included":[298],"model)":[302],"suggested":[303],"this":[304,353,408],"persisted":[305],"through":[306],"18":[307,494],"months.":[308,453],"Conclusions":[309],"population-level":[314],"increasing":[322],"again.":[323],"Most":[324],"did":[326,339,445,487],"not":[327,340,446,488],"initiate":[328,447],"another":[329,448],"therapy":[331,462],"experienced":[333],"increase":[335],"fully":[341],"return":[342,489],"pre-discontinuation":[344,491],"levels":[345,492],"during":[346],"follow-up.":[347],"What":[348,407],"is":[349,388],"known":[351,389],"topic":[354],"The":[355],"rapid":[356],"uptake":[357],"costs":[360],"GLP-1":[362,395],"agonists,":[364],"including":[365],"(Ozempic\u00ae),":[370],"have":[371],"prompted":[372],"health":[373],"systems":[374],"consider":[376],"how":[377,391],"access":[378,503],"these":[380],"treatments":[381],"should":[382],"be":[383],"prioritized":[384],"reimbursed.":[386],"Little":[387],"about":[390],"influence":[398],"glycemic":[402],"control":[403],"discontinuation.":[406],"study":[409],"adds":[410],"national":[413],"restriction":[415],"Denmark,":[417],"more":[418,463],"than":[419,464],"one":[420,455],"four":[422],"patients":[423],"discontinued":[424],"those":[431],"who":[432],"treatment,":[434],"SGLT2":[435],"inhibitors":[436],"common":[440],"alternative,":[441],"while":[442],"drug":[450],"within":[451],"Approximately":[454],"three":[457],"stopping.":[468],"Discontinuation":[469],"was":[475],"followed":[476],"rise":[479],"that,":[482],"despite":[483],"improvement":[484],"over":[485,493],"time,":[486],"highlighting":[496],"potential":[498],"clinical":[499],"consequence":[500],"restricting":[502],"effective":[506],"option.":[509]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-09-26T00:00:00"}