{"id":"https://openalex.org/W7214237290","doi":"https://doi.org/10.26434/chemrxiv.15009392/v1","title":"\u03bc-Oxo-Bridged Iodine(III) Reagents Enable Catalyst- and Light-Free Fluoro(halo)methyl Radical Generation","display_name":"\u03bc-Oxo-Bridged Iodine(III) Reagents Enable Catalyst- and Light-Free Fluoro(halo)methyl Radical Generation","publication_year":2026,"publication_date":"2026-09-23","ids":{"openalex":"https://openalex.org/W7214237290","doi":"https://doi.org/10.26434/chemrxiv.15009392/v1"},"language":"en","primary_location":{"id":"doi:10.26434/chemrxiv.15009392/v1","doi":"https://doi.org/10.26434/chemrxiv.15009392/v1","is_oa":true,"landing_page_url":"https://doi.org/10.26434/chemrxiv.15009392/v1","pdf_url":"https://chemrxiv.org/doi/pdf/10.26434/chemrxiv.15009392/v1","source":{"id":"https://openalex.org/S4393918830","display_name":"ChemRxiv","issn_l":"2573-2293","issn":["2573-2293"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://chemrxiv.org/doi/pdf/10.26434/chemrxiv.15009392/v1","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084153695","display_name":"Anupam Das","orcid":"https://orcid.org/0000-0002-8166-6482","observed_orcids":["https://orcid.org/0000-0002-8166-6482"]},"institutions":[{"id":"https://openalex.org/I4405272566","display_name":"National Institute of Research and Innovation","ror":"https://ror.org/04bjckx48","country_code":"LV","type":"facility","lineage":["https://openalex.org/I4405272566"]}],"countries":["LV"],"is_corresponding":false,"raw_author_name":"Anupam Das","raw_affiliation_strings":["National Institute of Research and Innovation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute of Research and Innovation","institution_ids":["https://openalex.org/I4405272566"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055669438","display_name":"Nagarajan Ramkumar","orcid":"https://orcid.org/0000-0002-6452-532X","observed_orcids":["https://orcid.org/0000-0002-6452-532X"]},"institutions":[{"id":"https://openalex.org/I4405272566","display_name":"National Institute of Research and Innovation","ror":"https://ror.org/04bjckx48","country_code":"LV","type":"facility","lineage":["https://openalex.org/I4405272566"]}],"countries":["LV"],"is_corresponding":false,"raw_author_name":"Nagarajan Ramkumar","raw_affiliation_strings":["National Institute of Research and Innovation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute of Research and Innovation","institution_ids":["https://openalex.org/I4405272566"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018720752","display_name":"Artis Kin\u0113ns","orcid":"https://orcid.org/0000-0003-1992-525X","observed_orcids":["https://orcid.org/0000-0003-1992-525X"]},"institutions":[{"id":"https://openalex.org/I4405272566","display_name":"National Institute of Research and Innovation","ror":"https://ror.org/04bjckx48","country_code":"LV","type":"facility","lineage":["https://openalex.org/I4405272566"]}],"countries":["LV"],"is_corresponding":false,"raw_author_name":"Artis Kin\u0113ns","raw_affiliation_strings":["National Institute of Research and Innovation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute of Research and Innovation","institution_ids":["https://openalex.org/I4405272566"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5152699829","display_name":"Sergey Belyakov","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405272566","display_name":"National Institute of Research and Innovation","ror":"https://ror.org/04bjckx48","country_code":"LV","type":"facility","lineage":["https://openalex.org/I4405272566"]}],"countries":["LV"],"is_corresponding":false,"raw_author_name":"Sergey Belyakov","raw_affiliation_strings":["National Institute of Research and Innovation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute of Research and Innovation","institution_ids":["https://openalex.org/I4405272566"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029655311","display_name":"Andris Antuzevi\u010d\u0161","orcid":"https://orcid.org/0000-0001-7387-7207","observed_orcids":["https://orcid.org/0000-0001-7387-7207"]},"institutions":[{"id":"https://openalex.org/I91123046","display_name":"University of Latvia","ror":"https://ror.org/05g3mes96","country_code":"LV","type":"education","lineage":["https://openalex.org/I91123046"]}],"countries":["LV"],"is_corresponding":false,"raw_author_name":"Andris Antuzevi\u010ds","raw_affiliation_strings":["Institute of Solid State Physics","University of Latvia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Solid State Physics","institution_ids":[]},{"raw_affiliation_string":"University of Latvia","institution_ids":["https://openalex.org/I91123046"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081131664","display_name":"Janis Veliks","orcid":"https://orcid.org/0000-0003-0955-8257","observed_orcids":["https://orcid.org/0000-0003-0955-8257"]},"institutions":[{"id":"https://openalex.org/I4405272566","display_name":"National Institute of Research and Innovation","ror":"https://ror.org/04bjckx48","country_code":"LV","type":"facility","lineage":["https://openalex.org/I4405272566"]}],"countries":["LV"],"is_corresponding":false,"raw_author_name":"Janis Veliks","raw_affiliation_strings":["National Institute of Research and Innovation"],"raw_orcid":"https://orcid.org/0000-0003-0955-8257","affiliations":[{"raw_affiliation_string":"National Institute of Research and Innovation","institution_ids":["https://openalex.org/I4405272566"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10947","display_name":"Fluorine in Organic Chemistry","score":0.8730000257492065,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10947","display_name":"Fluorine in Organic Chemistry","score":0.8730000257492065,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10701","display_name":"Radical Photochemical Reactions","score":0.057100001722574234,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11989","display_name":"Oxidative Organic Chemistry Reactions","score":0.04729999974370003,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fluoroalkylation","display_name":"fluoroalkylation","score":0.7680000066757202},{"id":"https://openalex.org/keywords/cascade-cyclization","display_name":"tandem cyclization","score":0.7559999823570251},{"id":"https://openalex.org/keywords/methacrylamide","display_name":"methacrylamide","score":0.9860000014305115},{"id":"https://openalex.org/keywords/pyrazolones","display_name":"pyrazolone derivatives","score":0.8759999871253967},{"id":"https://openalex.org/keywords/natural-product-derivatives","display_name":"natural product derivatives","score":0.4569999873638153}],"concepts":[{"id":"https://openalex.org/C40875361","wikidata":"https://www.wikidata.org/wiki/Q2356542","display_name":"Reagent","level":2,"score":0.8682000041007996},{"id":"https://openalex.org/C139066938","wikidata":"https://www.wikidata.org/wiki/Q185056","display_name":"Radical","level":2,"score":0.8585000038146973},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7578999996185303},{"id":"https://openalex.org/C149997192","wikidata":"https://www.wikidata.org/wiki/Q2630168","display_name":"Lability","level":2,"score":0.6571999788284302},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.6097999811172485},{"id":"https://openalex.org/C116569031","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Ligand (biochemistry)","level":3,"score":0.5322999954223633},{"id":"https://openalex.org/C2777289219","wikidata":"https://www.wikidata.org/wiki/Q7632154","display_name":"Substrate (aquarium)","level":2,"score":0.4156000018119812},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.41119998693466187},{"id":"https://openalex.org/C75473681","wikidata":"https://www.wikidata.org/wiki/Q188651","display_name":"Photochemistry","level":1,"score":0.40310001373291016},{"id":"https://openalex.org/C2778074193","wikidata":"https://www.wikidata.org/wiki/Q3498942","display_name":"Carboxylate","level":2,"score":0.3758000135421753},{"id":"https://openalex.org/C34146451","wikidata":"https://www.wikidata.org/wiki/Q5048094","display_name":"Cascade","level":2,"score":0.357699990272522},{"id":"https://openalex.org/C45849291","wikidata":"https://www.wikidata.org/wiki/Q17166058","display_name":"Photoredox catalysis","level":4,"score":0.28060001134872437}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.26434/chemrxiv.15009392/v1","doi":"https://doi.org/10.26434/chemrxiv.15009392/v1","is_oa":true,"landing_page_url":"https://doi.org/10.26434/chemrxiv.15009392/v1","pdf_url":"https://chemrxiv.org/doi/pdf/10.26434/chemrxiv.15009392/v1","source":{"id":"https://openalex.org/S4393918830","display_name":"ChemRxiv","issn_l":"2573-2293","issn":["2573-2293"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.26434/chemrxiv.15009392/v1","doi":"https://doi.org/10.26434/chemrxiv.15009392/v1","is_oa":true,"landing_page_url":"https://doi.org/10.26434/chemrxiv.15009392/v1","pdf_url":"https://chemrxiv.org/doi/pdf/10.26434/chemrxiv.15009392/v1","source":{"id":"https://openalex.org/S4393918830","display_name":"ChemRxiv","issn_l":"2573-2293","issn":["2573-2293"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3665386545","display_name":null,"funder_award_id":"1.1.1.5/2/24/A/001","funder_id":"https://openalex.org/F4320335322","funder_display_name":"European Regional Development Fund"},{"id":"https://openalex.org/G4495442504","display_name":null,"funder_award_id":"1.1.1.5","funder_id":"https://openalex.org/F4320335322","funder_display_name":"European Regional Development Fund"}],"funders":[{"id":"https://openalex.org/F4320335322","display_name":"European Regional Development Fund","ror":"https://ror.org/00k4n6c32"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7214237290.pdf","grobid_xml":"https://content.openalex.org/works/W7214237290.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7117368090","https://openalex.org/W4317871248","https://openalex.org/W2950438038","https://openalex.org/W2290609323","https://openalex.org/W4408540030","https://openalex.org/W4402723208","https://openalex.org/W4248564742","https://openalex.org/W2199686122","https://openalex.org/W3161286897","https://openalex.org/W7220838325"],"abstract_inverted_index":{"While":[0],"conventional":[1],"radical":[2],"fluoroalkylation":[3],"typically":[4],"requires":[5],"exogenous":[6],"catalysts":[7],"or":[8,33],"photoactivation":[9],"to":[10,45],"overcome":[11],"significant":[12],"kinetic":[13],"barriers,":[14],"here":[15],"we":[16],"report":[17],"bench-stable":[18],"\u03bc-oxo-bridged":[19],"iodine(III)":[20,61,109],"reagents":[21],"that":[22],"release":[23],"fluoro(halo)methyl":[24],"radicals":[25,37,129],"upon":[26,98],"heating":[27],"without":[28],"an":[29],"external":[30],"catalyst,":[31],"additive,":[32],"light.":[34],"The":[35,85],"resulting":[36],"initiate":[38],"cascade":[39],"cyclizations":[40],"of":[41,54,67,126],"methacrylamides":[42],"and":[43,50,77,92,95,121,124],"methacrylohydrazides":[44],"afford":[46],"fluorinated":[47,56,127],"oxindoles,":[48],"pyrazolones,":[49],"related":[51],"heterocycles.":[52],"Variation":[53],"the":[55,60,65,68,102,108,118],"carboxylate":[57],"ligand":[58],"within":[59],"reagent":[62,83],"framework":[63],"controls":[64],"identity":[66],"transferred":[69],"C1":[70,128],"fragment,":[71],"thereby":[72],"providing":[73],"chlorofluoromethyl,":[74],"bromofluoromethyl,":[75],"difluoromethyl,":[76],"monofluoromethyl":[78],"products":[79],"from":[80],"a":[81,114],"common":[82],"architecture.":[84],"transformation":[86],"is":[87],"compatible":[88],"with":[89],"structurally":[90],"diverse":[91],"natural-product-derived":[93],"substrates":[94],"proceeds":[96],"efficiently":[97],"scale-up.":[99],"By":[100],"encoding":[101],"required":[103],"bond":[104],"lability":[105],"directly":[106],"into":[107,130],"framework,":[110],"this":[111],"strategy":[112],"establishes":[113],"general":[115],"platform":[116],"for":[117],"catalyst-,":[119],"additive-,":[120],"light-free":[122],"generation":[123],"incorporation":[125],"complex":[131],"molecular":[132],"frameworks.":[133]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-09-25T00:00:00"}