{"id":"https://openalex.org/W7214236166","doi":"https://doi.org/10.64898/2026.09.20.752755","title":"Maintenance of quantitative genetic variation in regions of restricted recombination via associative overdominance","display_name":"Maintenance of quantitative genetic variation in regions of restricted recombination via associative overdominance","publication_year":2026,"publication_date":"2026-09-24","ids":{"openalex":"https://openalex.org/W7214236166","doi":"https://doi.org/10.64898/2026.09.20.752755","pmid":"https://pubmed.ncbi.nlm.nih.gov/42818142","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13622095"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.20.752755","doi":"https://doi.org/10.64898/2026.09.20.752755","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.20.752755","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/24/2026.09.20.752755.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/24/2026.09.20.752755.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5152640514","display_name":"Yan Zhao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Yan Zhao","raw_affiliation_strings":["Department of Forest and Conservation Science, University of British Columbia, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Forest and Conservation Science, University of British Columbia, Canada","institution_ids":["https://openalex.org/I141945490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5151621597","display_name":"Chaebin Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Chaebin Lee","raw_affiliation_strings":["Department of Forest and Conservation Science, University of British Columbia, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Forest and Conservation Science, University of British Columbia, Canada","institution_ids":["https://openalex.org/I141945490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021476604","display_name":"Parul Johri","orcid":"https://orcid.org/0000-0002-4003-7719","observed_orcids":["https://orcid.org/0000-0002-4003-7719"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Parul Johri","raw_affiliation_strings":["Department of Biology, University of North Carolina at Chapel Hill, USA"],"raw_orcid":"https://orcid.org/0000-0002-4003-7719","affiliations":[{"raw_affiliation_string":"Department of Biology, University of North Carolina at Chapel Hill, USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057234820","display_name":"Brian Charlesworth","orcid":"https://orcid.org/0000-0002-2706-355X","observed_orcids":["https://orcid.org/0000-0002-2706-355X"]},"institutions":[{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Brian Charlesworth","raw_affiliation_strings":["Institute of Evolutionary Biology, University of Edinburgh, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Evolutionary Biology, University of Edinburgh, UK","institution_ids":["https://openalex.org/I98677209"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072787666","display_name":"Tom R. Booker","orcid":"https://orcid.org/0000-0001-8403-6219","observed_orcids":["https://orcid.org/0000-0001-8403-6219"]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Tom R. Booker","raw_affiliation_strings":["Department of Forest and Conservation Science, University of British Columbia, Canada"],"raw_orcid":"https://orcid.org/0000-0001-8403-6219","affiliations":[{"raw_affiliation_string":"Department of Forest and Conservation Science, University of British Columbia, Canada","institution_ids":["https://openalex.org/I141945490"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5072787666"],"corresponding_institution_ids":["https://openalex.org/I141945490"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10594","display_name":"Genetic and phenotypic traits in livestock","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10012","display_name":"Genetic diversity and population structure","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/quantitative-genetic-variation","display_name":"quantitative genetic variation","score":0.7459999918937683},{"id":"https://openalex.org/keywords/additive-genetic-variance","display_name":"additive genetic variance","score":0.7590000033378601},{"id":"https://openalex.org/keywords/mutation-selection-balance","display_name":"mutation-selection balance","score":0.8360000252723694},{"id":"https://openalex.org/keywords/linkage","display_name":"linkage","score":0.46000000834465027},{"id":"https://openalex.org/keywords/recessive-deleterious-alleles","display_name":"recessive deleterious alleles","score":0.8960000276565552},{"id":"https://openalex.org/keywords/heterozygosity","display_name":"heterozygosity","score":0.8119999766349792},{"id":"https://openalex.org/keywords/quantitative-trait-loci","display_name":"quantitative trait loci","score":0.9350000023841858}],"concepts":[{"id":"https://openalex.org/C37233692","wikidata":"https://www.wikidata.org/wiki/Q1066584","display_name":"Overdominance","level":4,"score":0.9391000270843506},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8353999853134155},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6991999745368958},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.5321000218391418},{"id":"https://openalex.org/C68873052","wikidata":"https://www.wikidata.org/wiki/Q349856","display_name":"Genetic variation","level":3,"score":0.5181000232696533},{"id":"https://openalex.org/C81941488","wikidata":"https://www.wikidata.org/wiki/Q853421","display_name":"Quantitative trait locus","level":3,"score":0.5117999911308289},{"id":"https://openalex.org/C81917197","wikidata":"https://www.wikidata.org/wiki/Q628760","display_name":"Selection (genetic algorithm)","level":2,"score":0.5109000205993652},{"id":"https://openalex.org/C143589142","wikidata":"https://www.wikidata.org/wiki/Q2617554","display_name":"Loss of heterozygosity","level":4,"score":0.49070000648498535},{"id":"https://openalex.org/C75268714","wikidata":"https://www.wikidata.org/wiki/Q43478","display_name":"Natural selection","level":3,"score":0.47749999165534973},{"id":"https://openalex.org/C156695909","wikidata":"https://www.wikidata.org/wiki/Q3373825","display_name":"Recombination","level":3,"score":0.4659000039100647},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.45730000734329224},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.4291999936103821},{"id":"https://openalex.org/C139807058","wikidata":"https://www.wikidata.org/wiki/Q352374","display_name":"Adaptation (eye)","level":2,"score":0.38449999690055847},{"id":"https://openalex.org/C51255272","wikidata":"https://www.wikidata.org/wiki/Q550479","display_name":"Quantitative genetics","level":4,"score":0.3700999915599823},{"id":"https://openalex.org/C35605836","wikidata":"https://www.wikidata.org/wiki/Q2064311","display_name":"Linkage disequilibrium","level":5,"score":0.3458000123500824},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.3215000033378601},{"id":"https://openalex.org/C2992519594","wikidata":"https://www.wikidata.org/wiki/Q870433","display_name":"Genetic model","level":3,"score":0.31459999084472656},{"id":"https://openalex.org/C9287583","wikidata":"https://www.wikidata.org/wiki/Q5532883","display_name":"Genetic architecture","level":4,"score":0.310699999332428},{"id":"https://openalex.org/C137848329","wikidata":"https://www.wikidata.org/wiki/Q804635","display_name":"Balancing selection","level":4,"score":0.3018999993801117},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.30140000581741333},{"id":"https://openalex.org/C161890455","wikidata":"https://www.wikidata.org/wiki/Q1503548","display_name":"Heritability","level":2,"score":0.29980000853538513},{"id":"https://openalex.org/C24218269","wikidata":"https://www.wikidata.org/wiki/Q1047416","display_name":"Genetic load","level":4,"score":0.29339998960494995},{"id":"https://openalex.org/C2778334786","wikidata":"https://www.wikidata.org/wiki/Q1586270","display_name":"Variation (astronomy)","level":2,"score":0.2768000066280365},{"id":"https://openalex.org/C2910240311","wikidata":"https://www.wikidata.org/wiki/Q5418641","display_name":"Mutation Accumulation","level":4,"score":0.273499995470047},{"id":"https://openalex.org/C172777353","wikidata":"https://www.wikidata.org/wiki/Q1374271","display_name":"Genetic variability","level":4,"score":0.2619999945163727},{"id":"https://openalex.org/C153471976","wikidata":"https://www.wikidata.org/wiki/Q2873354","display_name":"Heterozygote advantage","level":4,"score":0.257099986076355},{"id":"https://openalex.org/C122995739","wikidata":"https://www.wikidata.org/wiki/Q847051","display_name":"Holarctic","level":3,"score":0.2563999891281128},{"id":"https://openalex.org/C101434241","wikidata":"https://www.wikidata.org/wiki/Q211675","display_name":"Genetic recombination","level":4,"score":0.2533999979496002},{"id":"https://openalex.org/C189206191","wikidata":"https://www.wikidata.org/wiki/Q222046","display_name":"Genomics","level":4,"score":0.2526000142097473}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.64898/2026.09.20.752755","doi":"https://doi.org/10.64898/2026.09.20.752755","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.20.752755","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/24/2026.09.20.752755.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:42818142","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42818142","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13622095","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13622095/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.64898/2026.09.20.752755","doi":"https://doi.org/10.64898/2026.09.20.752755","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.20.752755","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/24/2026.09.20.752755.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G694979907","display_name":null,"funder_award_id":"RGPIN\u20102024\u201004434","funder_id":"https://openalex.org/F4320334593","funder_display_name":"Natural Sciences and Engineering Research Council of Canada"},{"id":"https://openalex.org/G7117131608","display_name":"Jointly modeling the effects of evolutionary processes on genomic variation","funder_award_id":"1r35gm154969-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334593","display_name":"Natural Sciences and Engineering Research Council of Canada","ror":"https://ror.org/01h531d29"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7214236166.pdf","grobid_xml":"https://content.openalex.org/works/W7214236166.grobid-xml"},"referenced_works_count":1,"referenced_works":["https://openalex.org/W4416729254"],"related_works":["https://openalex.org/W2118612333","https://openalex.org/W4307715157","https://openalex.org/W2988462279","https://openalex.org/W2970112352","https://openalex.org/W2997659918","https://openalex.org/W2951837961","https://openalex.org/W7097316272","https://openalex.org/W7124690797","https://openalex.org/W1936408530","https://openalex.org/W1947533230"],"abstract_inverted_index":{"Mutation-selection":[0],"balance":[1],"is":[2,26,115,130],"the":[3,9,30,43,58,118,150],"most":[4],"plausible":[5],"general":[6],"mechanism":[7],"for":[8,19],"maintenance":[10,151],"of":[11,71,120,152],"additive":[12],"genetic":[13,31],"variance":[14],"(":[15],"V":[16,111,128,153],"A":[17,112,129,154],")":[18],"quantitative":[20],"traits":[21,34,126],"in":[22,77,117,158],"natural":[23,167],"populations.":[24],"It":[25],"well":[27],"established":[28],"that":[29,74,99],"variants":[32],"affecting":[33],"(QTLs)":[35],"are":[36,49],"widely":[37],"distributed":[38],"across":[39],"species\u2019":[40],"genomes.":[41],"At":[42],"same":[44],"time,":[45],"unconditionally":[46,121],"deleterious":[47,83,122,138],"mutations":[48],"also":[50],"expected":[51,116],"to":[52,63,89,104,149],"be":[53,64,163],"common,":[54],"with":[55,57],"those":[56],"largest":[59],"fitness":[60],"effects":[61],"tending":[62],"strongly":[65],"recessive.":[66],"Many":[67],"genomes":[68],"possess":[69],"regions":[70,106],"restricted":[72],"recombination":[73],"could":[75],"result":[76],"tight":[78],"linkage":[79],"between":[80],"largely":[81],"recessive":[82,137],"alleles,":[84],"conditions":[85],"which":[86],"can":[87,109],"lead":[88],"elevated":[90],"heterozygosity":[91],"via":[92],"associative":[93],"overdominance":[94],"(AOD).":[95],"Here":[96],"we":[97],"show":[98],"weakly":[100],"selected":[101],"QTLs":[102],"linked":[103],"genomic":[105],"exhibiting":[107],"AOD":[108,146],"elevate":[110],"above":[113],"what":[114],"absence":[119],"mutations.":[123],"Selection":[124],"on":[125],"when":[127],"maintained":[131,157],"by":[132,166],"AOD,":[133],"however,":[134],"may":[135,147,161],"expose":[136],"alleles":[139],"as":[140],"homozygotes,":[141],"reducing":[142],"fitness.":[143],"Thus,":[144],"while":[145],"contribute":[148],",":[155],"variation":[156],"this":[159],"way":[160],"not":[162],"readily":[164],"accessible":[165],"or":[168],"artificial":[169],"selection.":[170]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-09-25T00:00:00"}
