{"id":"https://openalex.org/W7214220641","doi":"https://doi.org/10.64898/2026.09.22.753507","title":"FoxP transcription factors are required for peripheral nervous system development","display_name":"FoxP transcription factors are required for peripheral nervous system development","publication_year":2026,"publication_date":"2026-09-24","ids":{"openalex":"https://openalex.org/W7214220641","doi":"https://doi.org/10.64898/2026.09.22.753507"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.22.753507","doi":"https://doi.org/10.64898/2026.09.22.753507","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.22.753507","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/24/2026.09.22.753507.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nd","license_id":"https://openalex.org/licenses/cc-by-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/24/2026.09.22.753507.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007784155","display_name":"Hanna Yeliseyeva","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Hanna Yeliseyeva","raw_affiliation_strings":["Department of Molecular Life Sciences, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland","Neuroscience Center Zurich, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland","University Research Priority Program Adaptive Brain Circuits in Development and Learning (URPP AdaBD), University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Life Sciences, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland","institution_ids":["https://openalex.org/I202697423"]},{"raw_affiliation_string":"Neuroscience Center Zurich, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland","institution_ids":["https://openalex.org/I202697423"]},{"raw_affiliation_string":"University Research Priority Program Adaptive Brain Circuits in Development and Learning (URPP AdaBD), University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland","institution_ids":["https://openalex.org/I202697423"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078478374","display_name":"Nikita Vladimirov","orcid":"https://orcid.org/0000-0002-1159-0689","observed_orcids":["https://orcid.org/0000-0002-1159-0689"]},"institutions":[{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Nikita Vladimirov","raw_affiliation_strings":["University Research Priority Program Adaptive Brain Circuits in Development and Learning (URPP AdaBD), University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland"],"raw_orcid":"https://orcid.org/0000-0002-1159-0689","affiliations":[{"raw_affiliation_string":"University Research Priority Program Adaptive Brain Circuits in Development and Learning (URPP AdaBD), University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland","institution_ids":["https://openalex.org/I202697423"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037912688","display_name":"Esther T. Stoeckli","orcid":"https://orcid.org/0000-0002-8485-0648","observed_orcids":["https://orcid.org/0000-0002-8485-0648"]},"institutions":[{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Esther T. Stoeckli","raw_affiliation_strings":["Department of Molecular Life Sciences, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland","Neuroscience Center Zurich, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland","University Research Priority Program Adaptive Brain Circuits in Development and Learning (URPP AdaBD), University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland"],"raw_orcid":"https://orcid.org/0000-0002-8485-0648","affiliations":[{"raw_affiliation_string":"Department of Molecular Life Sciences, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland","institution_ids":["https://openalex.org/I202697423"]},{"raw_affiliation_string":"Neuroscience Center Zurich, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland","institution_ids":["https://openalex.org/I202697423"]},{"raw_affiliation_string":"University Research Priority Program Adaptive Brain Circuits in Development and Learning (URPP AdaBD), University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland","institution_ids":["https://openalex.org/I202697423"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5037912688"],"corresponding_institution_ids":["https://openalex.org/I202697423"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.5054000020027161,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.5054000020027161,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12061","display_name":"Axon Guidance and Neuronal Signaling","score":0.17329999804496765,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.13529999554157257,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/foxp1","display_name":"FOXP1","score":0.9909999966621399},{"id":"https://openalex.org/keywords/foxp2","display_name":"FOXP2","score":1.0},{"id":"https://openalex.org/keywords/foxp4","display_name":"FOXP4","score":0.9990000128746033},{"id":"https://openalex.org/keywords/peripheral-nervous-system-development","display_name":"peripheral nervous system development","score":0.9860000014305115},{"id":"https://openalex.org/keywords/autism-spectrum-disorder","display_name":"autism spectrum disorder","score":0.9390000104904175},{"id":"https://openalex.org/keywords/motor-axon-guidance","display_name":"motor axon guidance","score":0.7680000066757202},{"id":"https://openalex.org/keywords/neural-crest-migration","display_name":"neural crest migration","score":0.9879999756813049},{"id":"https://openalex.org/keywords/dorsal-root-ganglia","display_name":"dorsal root ganglia","score":0.9860000014305115},{"id":"https://openalex.org/keywords/neural-circuit-formation","display_name":"neural circuit formation","score":0.9520000219345093},{"id":"https://openalex.org/keywords/cerebellum","display_name":"cerebellum","score":0.7670000195503235}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7128000259399414},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6502000093460083},{"id":"https://openalex.org/C69125201","wikidata":"https://www.wikidata.org/wiki/Q2034716","display_name":"Axon guidance","level":3,"score":0.6341999769210815},{"id":"https://openalex.org/C545706735","wikidata":"https://www.wikidata.org/wiki/Q9404","display_name":"Nervous system","level":2,"score":0.588699996471405},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.5684999823570251},{"id":"https://openalex.org/C118403218","wikidata":"https://www.wikidata.org/wiki/Q43283","display_name":"Biological neural network","level":2,"score":0.5008999705314636},{"id":"https://openalex.org/C94487597","wikidata":"https://www.wikidata.org/wiki/Q11101","display_name":"Sensory system","level":2,"score":0.48339998722076416},{"id":"https://openalex.org/C207259873","wikidata":"https://www.wikidata.org/wiki/Q227241","display_name":"FOXP2","level":4,"score":0.44119998812675476},{"id":"https://openalex.org/C126749454","wikidata":"https://www.wikidata.org/wiki/Q1348455","display_name":"Neural crest","level":3,"score":0.43799999356269836},{"id":"https://openalex.org/C461258","wikidata":"https://www.wikidata.org/wiki/Q1345738","display_name":"Neural development","level":3,"score":0.4268999993801117},{"id":"https://openalex.org/C2776281502","wikidata":"https://www.wikidata.org/wiki/Q1395415","display_name":"Dorsal root ganglion","level":3,"score":0.42570000886917114},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.40560001134872437},{"id":"https://openalex.org/C132538176","wikidata":"https://www.wikidata.org/wiki/Q24768287","display_name":"Semaphorin","level":3,"score":0.40230000019073486},{"id":"https://openalex.org/C2779652256","wikidata":"https://www.wikidata.org/wiki/Q130983","display_name":"Cerebellum","level":2,"score":0.39169999957084656},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.39100000262260437},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.382999986410141},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.36629998683929443},{"id":"https://openalex.org/C545314008","wikidata":"https://www.wikidata.org/wiki/Q169953","display_name":"Peripheral nervous system","level":3,"score":0.33329999446868896},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.31709998846054077},{"id":"https://openalex.org/C205778803","wikidata":"https://www.wikidata.org/wiki/Q38404","display_name":"Autism","level":2,"score":0.3041999936103821},{"id":"https://openalex.org/C2780196419","wikidata":"https://www.wikidata.org/wiki/Q1762173","display_name":"Nerve net","level":2,"score":0.30149999260902405},{"id":"https://openalex.org/C2779296341","wikidata":"https://www.wikidata.org/wiki/Q1500732","display_name":"Interneuron","level":3,"score":0.3010999858379364},{"id":"https://openalex.org/C2780600689","wikidata":"https://www.wikidata.org/wiki/Q14864821","display_name":"EGR1","level":4,"score":0.29820001125335693},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.2777999937534332},{"id":"https://openalex.org/C551621295","wikidata":"https://www.wikidata.org/wiki/Q182228","display_name":"Brainstem","level":2,"score":0.26010000705718994},{"id":"https://openalex.org/C2775908076","wikidata":"https://www.wikidata.org/wiki/Q3142126","display_name":"Sensory neuron","level":3,"score":0.25519999861717224},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2500999867916107}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.09.22.753507","doi":"https://doi.org/10.64898/2026.09.22.753507","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.22.753507","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/24/2026.09.22.753507.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nd","license_id":"https://openalex.org/licenses/cc-by-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.09.22.753507","doi":"https://doi.org/10.64898/2026.09.22.753507","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.22.753507","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/24/2026.09.22.753507.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nd","license_id":"https://openalex.org/licenses/cc-by-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320323874","display_name":"Universit\u00e4t Z\u00fcrich","ror":"https://ror.org/02crff812"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7214220641.pdf","grobid_xml":"https://content.openalex.org/works/W7214220641.grobid-xml"},"referenced_works_count":57,"referenced_works":["https://openalex.org/W1514688353","https://openalex.org/W1580285551","https://openalex.org/W1940237148","https://openalex.org/W1969855284","https://openalex.org/W1971341839","https://openalex.org/W1972741966","https://openalex.org/W1976422431","https://openalex.org/W1976862716","https://openalex.org/W1980443338","https://openalex.org/W1981147791","https://openalex.org/W1990448590","https://openalex.org/W2001574193","https://openalex.org/W2004578012","https://openalex.org/W2009209656","https://openalex.org/W2011146811","https://openalex.org/W2029301458","https://openalex.org/W2030936530","https://openalex.org/W2032756435","https://openalex.org/W2043905106","https://openalex.org/W2069161633","https://openalex.org/W2069789709","https://openalex.org/W2072808488","https://openalex.org/W2077937161","https://openalex.org/W2080531567","https://openalex.org/W2085583998","https://openalex.org/W2089231778","https://openalex.org/W2107555020","https://openalex.org/W2109603175","https://openalex.org/W2113020073","https://openalex.org/W2137801136","https://openalex.org/W2140034535","https://openalex.org/W2151363218","https://openalex.org/W2153654111","https://openalex.org/W2402845798","https://openalex.org/W2415803194","https://openalex.org/W2525969670","https://openalex.org/W2611673124","https://openalex.org/W2739464038","https://openalex.org/W2766920569","https://openalex.org/W2789634291","https://openalex.org/W2912872771","https://openalex.org/W2944467201","https://openalex.org/W2967355849","https://openalex.org/W2973461991","https://openalex.org/W2992171527","https://openalex.org/W3003409042","https://openalex.org/W3005129665","https://openalex.org/W3093132239","https://openalex.org/W3097927022","https://openalex.org/W4224215475","https://openalex.org/W4307426726","https://openalex.org/W4308185912","https://openalex.org/W4377011691","https://openalex.org/W4387340432","https://openalex.org/W4393233092","https://openalex.org/W4397024267","https://openalex.org/W4413290822"],"related_works":["https://openalex.org/W7203749129","https://openalex.org/W2806955236","https://openalex.org/W2914161539","https://openalex.org/W1768523798","https://openalex.org/W2762946595","https://openalex.org/W4407813013","https://openalex.org/W7095585600","https://openalex.org/W2769636270","https://openalex.org/W2885913364","https://openalex.org/W7036231726"],"abstract_inverted_index":{"Abstract":[0],"The":[1],"FoxP":[2,113,129],"family":[3],"of":[4,42,48,56,67,73,79,110,123,128,149,173],"transcription":[5,114],"factors":[6,115],"has":[7,40,62],"been":[8,41,63],"linked":[9],"to":[10,186],"neurodevelopmental":[11],"disorders.":[12],"FoxP1":[13],"and":[14,28,103,135,153],"FoxP2":[15],"were":[16],"identified":[17],"as":[18],"genes":[19,130],"associated":[20],"with":[21,168],"autism":[22],"spectrum":[23],"disorders":[24],"(ASD).":[25],"FoxP1,":[26],"FoxP2,":[27],"FoxP4":[29],"are":[30,165,184],"expressed":[31],"in":[32,45,53,97,101,104,116,120,143,146,155,158,166,178,190],"many":[33],"brain":[34],"regions,":[35],"including":[36],"the":[37,46,54,57,68,87,98,121,124,159,169,174,191],"cerebellum":[38],"that":[39,70,83,171],"particular":[43],"interest":[44],"context":[47],"ASD.":[49],"However,":[50],"their":[51],"role":[52,109],"development":[55],"peripheral":[58],"nervous":[59,89],"system":[60],"(PNS)":[61],"neglected.":[64],"In":[65],"view":[66],"fact":[69],"a":[71,108],"majority":[72],"ASD":[74,179],"patients":[75],"show":[76],"some":[77,172],"signs":[78],"sensory":[80,175],"perception":[81,176],"deficits":[82,154,177],"could":[84],"go":[85],"beyond":[86],"central":[88],"system,":[90],"we":[91],"focused":[92],"on":[93],"neural":[94,117,138,156,188],"circuit":[95,118],"formation":[96,119,148],"PNS.":[99,160,192],"Our":[100],"vivo":[102],"vitro":[105],"studies":[106],"revealed":[107],"all":[111],"three":[112],"hindlimb":[122],"chicken":[125],"embryo.":[126],"Silencing":[127],"altered":[131],"motor":[132],"axon":[133],"guidance":[134],"also":[136],"impacted":[137],"crest":[139],"cell":[140],"migration.":[141],"This":[142],"turn":[144],"resulted":[145],"aberrant":[147,187],"dorsal":[150],"root":[151],"ganglia":[152],"circuits":[157,189],"Taken":[161],"together,":[162],"our":[163],"results":[164],"line":[167],"hypothesis":[170],"patients,":[180],"either":[181],"hyper-or":[182],"hyposensitivity,":[183],"due":[185]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2026-09-25T00:00:00"}
