{"id":"https://openalex.org/W7214220179","doi":"https://doi.org/10.1128/msystems.00839-26","title":"Synthesis-driven reverse metabolomics reveals 3-hydroxy N -acyl amides as gut microbial molecules","display_name":"Synthesis-driven reverse metabolomics reveals 3-hydroxy N -acyl amides as gut microbial molecules","publication_year":2026,"publication_date":"2026-09-24","ids":{"openalex":"https://openalex.org/W7214220179","doi":"https://doi.org/10.1128/msystems.00839-26","pmid":"https://pubmed.ncbi.nlm.nih.gov/41542415","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12803199"},"language":"en","primary_location":{"id":"doi:10.1128/msystems.00839-26","doi":"https://doi.org/10.1128/msystems.00839-26","is_oa":true,"landing_page_url":"https://doi.org/10.1128/msystems.00839-26","pdf_url":null,"source":{"id":"https://openalex.org/S4210181942","display_name":"mSystems","issn_l":"2379-5077","issn":["2379-5077"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"mSystems","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1128/msystems.00839-26","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5114503360","display_name":"Victoria Deleray","orcid":"https://orcid.org/0009-0002-3201-2578","observed_orcids":["https://orcid.org/0009-0002-3201-2578"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Victoria Deleray","raw_affiliation_strings":["Collaborative Mass Spectrometry Innovation Center, University of California San Diego","Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego"],"raw_orcid":"https://orcid.org/0009-0002-3201-2578","affiliations":[{"raw_affiliation_string":"Collaborative Mass Spectrometry Innovation Center, University of California San Diego","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085873057","display_name":"Vincent Charron\u2010Lamoureux","orcid":"https://orcid.org/0000-0001-9440-7036","observed_orcids":["https://orcid.org/0000-0001-9440-7036"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vincent Charron-Lamoureux","raw_affiliation_strings":["Collaborative Mass Spectrometry Innovation Center, University of California San Diego","Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Collaborative Mass Spectrometry Innovation Center, University of California San Diego","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114503361","display_name":"Kyle Vittali","orcid":"https://orcid.org/0009-0008-4799-8564","observed_orcids":["https://orcid.org/0009-0008-4799-8564"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kyle Vittali","raw_affiliation_strings":["Department of Chemistry and Biochemistry, University of California San Diego, Gilman Drive"],"raw_orcid":"https://orcid.org/0009-0008-4799-8564","affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of California San Diego, Gilman Drive","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062784330","display_name":"Helena Mannochio-Russo","orcid":"https://orcid.org/0000-0002-4961-2353","observed_orcids":["https://orcid.org/0000-0002-4961-2353"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Helena Mannochio-Russo","raw_affiliation_strings":["Collaborative Mass Spectrometry Innovation Center, University of California San Diego","Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego"],"raw_orcid":"https://orcid.org/0000-0002-4961-2353","affiliations":[{"raw_affiliation_string":"Collaborative Mass Spectrometry Innovation Center, University of California San Diego","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090861813","display_name":"Crystal X. Wang","orcid":"https://orcid.org/0000-0002-0525-809X","observed_orcids":["https://orcid.org/0000-0002-0525-809X"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Crystal X. Wang","raw_affiliation_strings":["Department of Psychiatry, University of California San Diego, Gilman Drive"],"raw_orcid":"https://orcid.org/0000-0002-0525-809X","affiliations":[{"raw_affiliation_string":"Department of Psychiatry, University of California San Diego, Gilman Drive","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109798988","display_name":"Corinn Walker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Corinn Walker","raw_affiliation_strings":["Department of Pediatrics, University of California, San Diego"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of California, San Diego","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072461088","display_name":"Karsten Zengler","orcid":"https://orcid.org/0000-0002-8062-3296","observed_orcids":["https://orcid.org/0000-0002-8062-3296"]},"institutions":[{"id":"https://openalex.org/I150209017","display_name":"Scripps Institution of Oceanography","ror":"https://ror.org/04v7hvq31","country_code":"US","type":"facility","lineage":["https://openalex.org/I150209017","https://openalex.org/I36258959"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karsten Zengler","raw_affiliation_strings":["Center for Microbiome Innovation, University of California, San Diego","Department of Bioengineering, University of California, San Diego","Department of Pediatrics, University of California, San Diego","Program in Materials Science and Engineering, University of California, San Diego, Gilman Drive","Soil Health Center, Scripps Institution of Oceanography, University of California San Diego, Gilman Drive"],"raw_orcid":"https://orcid.org/0000-0002-8062-3296","affiliations":[{"raw_affiliation_string":"Center for Microbiome Innovation, University of California, San Diego","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Department of Bioengineering, University of California, San Diego","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Department of Pediatrics, University of California, San Diego","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Program in Materials Science and Engineering, University of California, San Diego, Gilman Drive","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Soil Health Center, Scripps Institution of Oceanography, University of California San Diego, Gilman Drive","institution_ids":["https://openalex.org/I150209017","https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111287013","display_name":"Dionicio Siegel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dionicio Siegel","raw_affiliation_strings":["Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082720301","display_name":"Pieter C. Dorrestein","orcid":"https://orcid.org/0000-0002-3003-1030","observed_orcids":["https://orcid.org/0000-0002-3003-1030"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Pieter C. Dorrestein","raw_affiliation_strings":["Collaborative Mass Spectrometry Innovation Center, University of California San Diego","Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego"],"raw_orcid":"https://orcid.org/0000-0002-3003-1030","affiliations":[{"raw_affiliation_string":"Collaborative Mass Spectrometry Innovation Center, University of California San Diego","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego","institution_ids":["https://openalex.org/I36258959"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5082720301"],"corresponding_institution_ids":["https://openalex.org/I36258959"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":{"value":3500,"currency":"USD","value_usd":3500},"fwci":2.6903,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.8613593,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":96},"biblio":{"volume":"11","issue":"10","first_page":"e0083926","last_page":"e0083926"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bioactive-lipids","display_name":"bioactive lipids","score":0.8479999899864197},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.6629999876022339},{"id":"https://openalex.org/keywords/microbial-metabolite-production","display_name":"microbial metabolite production","score":0.7580000162124634},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.7049999833106995},{"id":"https://openalex.org/keywords/untargeted-metabolomics","display_name":"untargeted metabolomics","score":0.7990000247955322},{"id":"https://openalex.org/keywords/saliva","display_name":"saliva","score":0.5659999847412109},{"id":"https://openalex.org/keywords/feces","display_name":"feces","score":0.7289999723434448},{"id":"https://openalex.org/keywords/skin","display_name":"skin","score":0.8759999871253967},{"id":"https://openalex.org/keywords/host-microbe-interactions","display_name":"host-microbe interactions","score":0.5759999752044678},{"id":"https://openalex.org/keywords/novel-metabolites","display_name":"novel metabolites","score":0.3709999918937683}],"concepts":[{"id":"https://openalex.org/C21565614","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolomics","level":2,"score":0.9106000065803528},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5627999901771545},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5181000232696533},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4986000061035156},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.45669999718666077},{"id":"https://openalex.org/C135870905","wikidata":"https://www.wikidata.org/wiki/Q903667","display_name":"Metabolome","level":3,"score":0.42820000648498535},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4140999913215637},{"id":"https://openalex.org/C192989942","wikidata":"https://www.wikidata.org/wiki/Q68685","display_name":"Metabolic pathway","level":3,"score":0.40209999680519104},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.38589999079704285},{"id":"https://openalex.org/C2987857752","wikidata":"https://www.wikidata.org/wiki/Q12147","display_name":"Human health","level":2,"score":0.37119999527931213},{"id":"https://openalex.org/C539455810","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut flora","level":2,"score":0.35569998621940613},{"id":"https://openalex.org/C9927688","wikidata":"https://www.wikidata.org/wiki/Q4915012","display_name":"Biological pathway","level":4,"score":0.34150001406669617},{"id":"https://openalex.org/C2983668108","wikidata":"https://www.wikidata.org/wiki/Q280453","display_name":"Spectral analysis","level":3,"score":0.3327000141143799},{"id":"https://openalex.org/C116073593","wikidata":"https://www.wikidata.org/wiki/Q864491","display_name":"Biological activity","level":3,"score":0.31380000710487366},{"id":"https://openalex.org/C161624437","wikidata":"https://www.wikidata.org/wiki/Q1988322","display_name":"Small molecule","level":2,"score":0.3052999973297119},{"id":"https://openalex.org/C131779359","wikidata":"https://www.wikidata.org/wiki/Q471875","display_name":"Amine gas treating","level":2,"score":0.29499998688697815},{"id":"https://openalex.org/C3020134792","wikidata":"https://www.wikidata.org/wiki/Q79749","display_name":"Human plasma","level":2,"score":0.2587999999523163}],"mesh":[],"locations_count":7,"locations":[{"id":"doi:10.1128/msystems.00839-26","doi":"https://doi.org/10.1128/msystems.00839-26","is_oa":true,"landing_page_url":"https://doi.org/10.1128/msystems.00839-26","pdf_url":null,"source":{"id":"https://openalex.org/S4210181942","display_name":"mSystems","issn_l":"2379-5077","issn":["2379-5077"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"mSystems","raw_type":"journal-article"},{"id":"doi:10.64898/2026.01.07.698252","doi":"https://doi.org/10.64898/2026.01.07.698252","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.01.07.698252","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/01/08/2026.01.07.698252.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:13712783","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13712783/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13712783/pdf/msystems.00839-26.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"mSystems","raw_type":"Text"},{"id":"pmid:41542415","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41542415","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Journal Article"},{"id":"pmid:42782158","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42782158","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"mSystems","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12803199","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12803199/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:80e20355c4c84ef19ad57e210ea92b2b","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/80e20355c4c84ef19ad57e210ea92b2b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"mSystems, Vol 11, Iss 10 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1128/msystems.00839-26","doi":"https://doi.org/10.1128/msystems.00839-26","is_oa":true,"landing_page_url":"https://doi.org/10.1128/msystems.00839-26","pdf_url":null,"source":{"id":"https://openalex.org/S4210181942","display_name":"mSystems","issn_l":"2379-5077","issn":["2379-5077"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"mSystems","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4614686555","display_name":"Linking Mass Spectrometry Computational Ecosystems to Enhance Biological Insights of Publicly-Available Data","funder_award_id":"2152526","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G8645747324","display_name":null,"funder_award_id":"598938","funder_id":"https://openalex.org/F4320334593","funder_display_name":"Natural Sciences and Engineering Research Council of Canada"},{"id":"https://openalex.org/G9000868323","display_name":"Reverse Metabolomics for the Discovery of Disease Associated Microbial Molecules","funder_award_id":"R01DK136117","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000868334","display_name":"Unified Computation Tools for Natural Products research","funder_award_id":"R01GM107550","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000880441","display_name":"HIV Neurobehavioral Research Center","funder_award_id":"P30MH062512","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G945507648","display_name":"Bourses postdoctorales (citoyens canadiens et r\u00e9sidents permanents) \u2014 Bact\u00e9ries, M\u00e9tabolisme (Organismes vivants)","funder_award_id":"335368","funder_id":"https://openalex.org/F4320334618","funder_display_name":"Fonds de Recherche du Qu\u00e9bec - Sant\u00e9"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320334593","display_name":"Natural Sciences and Engineering Research Council of Canada","ror":"https://ror.org/01h531d29"},{"id":"https://openalex.org/F4320334618","display_name":"Fonds de Recherche du Qu\u00e9bec - Sant\u00e9","ror":"https://ror.org/02eqrsj93"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7214220179.pdf","grobid_xml":"https://content.openalex.org/works/W7214220179.grobid-xml"},"referenced_works_count":46,"referenced_works":["https://openalex.org/W1970862953","https://openalex.org/W2010644245","https://openalex.org/W2058091027","https://openalex.org/W2059327215","https://openalex.org/W2068652603","https://openalex.org/W2081465448","https://openalex.org/W2098290877","https://openalex.org/W2126176053","https://openalex.org/W2128307328","https://openalex.org/W2128769815","https://openalex.org/W2131191824","https://openalex.org/W2333667353","https://openalex.org/W2504691963","https://openalex.org/W2578218195","https://openalex.org/W2767808924","https://openalex.org/W2809403187","https://openalex.org/W2922522932","https://openalex.org/W2954681652","https://openalex.org/W2963667293","https://openalex.org/W2997345427","https://openalex.org/W3023444868","https://openalex.org/W3176586111","https://openalex.org/W4206447491","https://openalex.org/W4224436908","https://openalex.org/W4225962903","https://openalex.org/W4296035824","https://openalex.org/W4297225858","https://openalex.org/W4307468223","https://openalex.org/W4322739219","https://openalex.org/W4386069909","https://openalex.org/W4387764752","https://openalex.org/W4389333849","https://openalex.org/W4391543451","https://openalex.org/W4391744095","https://openalex.org/W4396516765","https://openalex.org/W4396922121","https://openalex.org/W4404299477","https://openalex.org/W4408029127","https://openalex.org/W4410706574","https://openalex.org/W4411178803","https://openalex.org/W4413427729","https://openalex.org/W4415749009","https://openalex.org/W4416354948","https://openalex.org/W7102773087","https://openalex.org/W7118177416","https://openalex.org/W7138917148"],"related_works":["https://openalex.org/W4404012548","https://openalex.org/W4411178803","https://openalex.org/W4389333849","https://openalex.org/W7127899384","https://openalex.org/W4391527815","https://openalex.org/W7220800944","https://openalex.org/W4416354948","https://openalex.org/W4408029127","https://openalex.org/W3217304250","https://openalex.org/W7138913954"],"abstract_inverted_index":{"ABSTRACT":[0],"3-Hydroxy":[1],"N":[2,48,175,243,255,313],"-acyl":[3,49,176,244,256,314],"amides":[4,177,257],"are":[5,16,25],"bioactive":[6],"lipids":[7],"with":[8,56,156],"reported":[9,110],"anti-obesity":[10],"and":[11,67,122,127,137,181,186,197,220,276,279,294,304,328,330],"glucose-regulating":[12],"effects,":[13],"yet":[14],"they":[15,24],"rarely":[17],"detected":[18,102],"in":[19,85,93,118,133,139,154,166,199,217,325,341],"untargeted":[20,86,200,262],"metabolomics":[21,73,87,201,263],"studies":[22],"because":[23],"largely":[26],"absent":[27],"from":[28],"existing":[29],"spectral":[30,41,78,105,190,235],"reference":[31],"libraries.":[32],"To":[33],"address":[34],"this":[35,161,332],"gap,":[36],"we":[37,75],"synthesized":[38],"an":[39,214,238],"MS/MS":[40,104,189,234],"resource":[42,191,334],"comprising":[43],"436":[44],"structurally":[45],"diverse":[46],"3-hydroxy":[47,174,254,312],"amides,":[50],"spanning":[51],"3-":[52],"to":[53,207,284],"18-carbon":[54],"chains":[55],"a":[57,70,179,232],"wide":[58],"range":[59],"of":[60,141,210,225,237,241,251,260,270,300,307,310,338],"amine":[61],"headgroups,":[62],"such":[63,226],"as":[64,178],"ornithine,":[65],"valine,":[66],"dopamine.":[68],"Using":[69],"synthesis-driven":[71],"reverse":[72],"approach,":[74],"found":[76,266,305],"161,626":[77],"matches":[79],"across":[80],"54,744":[81],"publicly":[82],"available":[83],"files":[84],"data":[88,135],"sets,":[89],"revealing":[90],"widespread":[91],"occurrences":[92],"biological":[94,111],"samples,":[95],"including":[96],"human-derived":[97,142,301],"specimens.":[98],"Of":[99],"these":[100,171,271,320,339],"molecules":[101,289],"through":[103],"matching,":[106],"334":[107],"represent":[108],"newly":[109],"entities.":[112],"We":[113,230,265,297],"further":[114],"confirmed":[115],"their":[116,194],"presence":[117,250],"human":[119,167,218,291,326],"saliva,":[120,293],"stool,":[121],"skin":[123,295],"using":[124],"retention":[125],"time":[126],"ion":[128],"mobility":[129],"measurements.":[130],"Frequent":[131],"detection":[132,337],"microbial":[134,146],"sets":[136],"validation":[138,282],"communities":[140,299],"gut":[143,302],"bacteria":[144,303],"support":[145],"production.":[147],"Several":[148],"metabolites":[149,211,227,272,321,340],"also":[150],"showed":[151],"altered":[152],"abundance":[153],"individuals":[155],"diabetes":[157],"mellitus,":[158],"showing":[159],"that":[160,212,319],"lipid":[162,184],"class":[163,240],"is":[164],"modulated":[165],"metabolic":[168],"disease.":[169],"Together,":[170],"findings":[172],"establish":[173],"distinct":[180],"biologically":[182],"relevant":[183],"class,":[185],"the":[187,208,223,249,336],"accompanying":[188],"will":[192],"enable":[193],"broader":[195],"recognition":[196],"study":[198,247],"data.":[202],"IMPORTANCE":[203],"Microbe-host":[204],"interactions":[205],"lead":[206],"production":[209,309],"play":[213,322],"important":[215,323],"role":[216],"health":[219],"disease,":[221,329],"though":[222],"annotation":[224],"remains":[228],"scarce.":[229],"created":[231],"re-usable":[233],"library":[236],"underrepresented":[239],"compounds\u20143-hydroxy":[242],"amides.":[245,315],"Our":[246,316],"characterized":[248],"over":[252,267],"400":[253],"among":[258],"thousands":[259],"public":[261],"datasets.":[264],"100,000":[268],"instances":[269],"within":[273,290],"microbial,":[274],"plant,":[275],"animal":[277],"data,":[278],"used":[280],"orthogonal":[281],"methods":[283],"confirm":[285],"nine":[286],"previously":[287],"unreported":[288],"feces,":[292],"samples.":[296],"cultured":[298],"evidence":[306],"bacterial":[308],"four":[311],"results":[317],"suggest":[318],"roles":[324],"metabolism":[327],"sharing":[331],"curated":[333],"enables":[335],"future":[342],"studies.":[343]},"counts_by_year":[{"year":2026,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2026-09-25T00:00:00"}
