{"id":"https://openalex.org/W7214220177","doi":"https://doi.org/10.1038/s41467-026-77833-1","title":"Multimodal hydrogel modulation of extracellular vesicle cargo to arrest post-traumatic osteoarthritis in murine models","display_name":"Multimodal hydrogel modulation of extracellular vesicle cargo to arrest post-traumatic osteoarthritis in murine models","publication_year":2026,"publication_date":"2026-09-24","ids":{"openalex":"https://openalex.org/W7214220177","doi":"https://doi.org/10.1038/s41467-026-77833-1","pmid":"https://pubmed.ncbi.nlm.nih.gov/42928352","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13696705"},"language":"en","primary_location":{"id":"doi:10.1038/s41467-026-77833-1","doi":"https://doi.org/10.1038/s41467-026-77833-1","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-026-77833-1","pdf_url":"https://www.nature.com/articles/s41467-026-77833-1_reference.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41467-026-77833-1_reference.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5152616229","display_name":"Xudong Zhang","orcid":"https://orcid.org/0009-0004-7203-8427","observed_orcids":["https://orcid.org/0009-0004-7203-8427"]},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]},{"id":"https://openalex.org/I126520041","display_name":"University of Science and Technology of China","ror":"https://ror.org/04c4dkn09","country_code":"CN","type":"education","lineage":["https://openalex.org/I126520041","https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210128175","display_name":"Shanghai East Hospital","ror":"https://ror.org/038xmzj21","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210128175"]},{"id":"https://openalex.org/I4210132741","display_name":"Shanghai Tenth People's Hospital","ror":"https://ror.org/03vjkf643","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210132741"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xudong Zhang","raw_affiliation_strings":["Department of Orthopedics, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China","Department of Orthopedics, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China","Department of Orthopedics, State Key Laboratory of Immune Response and Immunotherapy, Centre for Leading Medicine and Advanced Technologies of IHM, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China"],"raw_orcid":"https://orcid.org/0009-0004-7203-8427","affiliations":[{"raw_affiliation_string":"Department of Orthopedics, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China","institution_ids":["https://openalex.org/I116953780","https://openalex.org/I4210128175"]},{"raw_affiliation_string":"Department of Orthopedics, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China","institution_ids":["https://openalex.org/I116953780","https://openalex.org/I4210132741"]},{"raw_affiliation_string":"Department of Orthopedics, State Key Laboratory of Immune Response and Immunotherapy, Centre for Leading Medicine and Advanced Technologies of IHM, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China","institution_ids":["https://openalex.org/I126520041"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5152671458","display_name":"Wei Zhu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I184681353","display_name":"Anhui University of Science and Technology","ror":"https://ror.org/00q9atg80","country_code":"CN","type":"education","lineage":["https://openalex.org/I184681353"]},{"id":"https://openalex.org/I4210144482","display_name":"Shanghai Sixth People's Hospital","ror":"https://ror.org/049zrh188","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210144482"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Wei Zhu","raw_affiliation_strings":["Department of Orthopedics, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Jiao Tong University, Shanghai, China. zhuwanbo@sjtu.edu.cn","Department of Orthopedics, The First Affiliated Hospital of Anhui University of Science and Technology, Huainan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Jiao Tong University, Shanghai, China. zhuwanbo@sjtu.edu.cn","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210144482"]},{"raw_affiliation_string":"Department of Orthopedics, The First Affiliated Hospital of Anhui University of Science and Technology, Huainan, China","institution_ids":["https://openalex.org/I184681353"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159708909","display_name":"Huajun Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I159948400","display_name":"Jinan University","ror":"https://ror.org/02xe5ns62","country_code":"CN","type":"education","lineage":["https://openalex.org/I159948400"]},{"id":"https://openalex.org/I4210162753","display_name":"First Affiliated Hospital of Jinan University","ror":"https://ror.org/05d5vvz89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210162753"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huajun Wang","raw_affiliation_strings":["Department of Sports Medicine, State Key Laboratory of Frigid Zone Cardiovascular Diseases, The Guangzhou Key Laboratory of Precision Orthopedics and Regenerative Medicine, Guangdong Provincial Key Laboratory of Speed Capability, The First Affiliated Hospital, Jinan University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Sports Medicine, State Key Laboratory of Frigid Zone Cardiovascular Diseases, The Guangzhou Key Laboratory of Precision Orthopedics and Regenerative Medicine, Guangdong Provincial Key Laboratory of Speed Capability, The First Affiliated Hospital, Jinan University, Guangzhou, China","institution_ids":["https://openalex.org/I159948400","https://openalex.org/I4210162753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100350016","display_name":"Yingjie Wang","orcid":"https://orcid.org/0000-0003-1005-7900","observed_orcids":["https://orcid.org/0000-0003-1005-7900"]},"institutions":[{"id":"https://openalex.org/I253932293","display_name":"Anhui University of Traditional Chinese Medicine","ror":"https://ror.org/0139j4p80","country_code":"CN","type":"education","lineage":["https://openalex.org/I253932293"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yingjie Wang","raw_affiliation_strings":["Department of Orthopedics, The Second Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, The Second Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, China","institution_ids":["https://openalex.org/I253932293"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000858965","display_name":"Ziheng Bu","orcid":"https://orcid.org/0000-0001-6591-1014","observed_orcids":["https://orcid.org/0000-0001-6591-1014"]},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]},{"id":"https://openalex.org/I4210132741","display_name":"Shanghai Tenth People's Hospital","ror":"https://ror.org/03vjkf643","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210132741"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ziheng Bu","raw_affiliation_strings":["Department of Orthopedics, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China","institution_ids":["https://openalex.org/I116953780","https://openalex.org/I4210132741"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159665197","display_name":"Wei Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]},{"id":"https://openalex.org/I4210128175","display_name":"Shanghai East Hospital","ror":"https://ror.org/038xmzj21","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210128175"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Liu","raw_affiliation_strings":["Department of Orthopedics, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China","institution_ids":["https://openalex.org/I116953780","https://openalex.org/I4210128175"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159659959","display_name":"Junchao Huang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]},{"id":"https://openalex.org/I4210128175","display_name":"Shanghai East Hospital","ror":"https://ror.org/038xmzj21","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210128175"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Junchao Huang","raw_affiliation_strings":["Department of Orthopedics, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China","institution_ids":["https://openalex.org/I116953780","https://openalex.org/I4210128175"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087393043","display_name":"Jiawei Mei","orcid":"https://orcid.org/0000-0001-6241-8953","observed_orcids":["https://orcid.org/0000-0001-6241-8953"]},"institutions":[{"id":"https://openalex.org/I126520041","display_name":"University of Science and Technology of China","ror":"https://ror.org/04c4dkn09","country_code":"CN","type":"education","lineage":["https://openalex.org/I126520041","https://openalex.org/I19820366"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiawei Mei","raw_affiliation_strings":["Department of Orthopedics, State Key Laboratory of Immune Response and Immunotherapy, Centre for Leading Medicine and Advanced Technologies of IHM, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, State Key Laboratory of Immune Response and Immunotherapy, Centre for Leading Medicine and Advanced Technologies of IHM, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China","institution_ids":["https://openalex.org/I126520041"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159581525","display_name":"Quan Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126520041","display_name":"University of Science and Technology of China","ror":"https://ror.org/04c4dkn09","country_code":"CN","type":"education","lineage":["https://openalex.org/I126520041","https://openalex.org/I19820366"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Quan Liu","raw_affiliation_strings":["Department of Orthopedics, State Key Laboratory of Immune Response and Immunotherapy, Centre for Leading Medicine and Advanced Technologies of IHM, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, State Key Laboratory of Immune Response and Immunotherapy, Centre for Leading Medicine and Advanced Technologies of IHM, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China","institution_ids":["https://openalex.org/I126520041"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113316639","display_name":"Jiachang Hong","orcid":"https://orcid.org/0009-0003-9267-3340","observed_orcids":["https://orcid.org/0009-0003-9267-3340"]},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]},{"id":"https://openalex.org/I4210128175","display_name":"Shanghai East Hospital","ror":"https://ror.org/038xmzj21","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210128175"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiachang Hong","raw_affiliation_strings":["Department of Orthopedics, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China","institution_ids":["https://openalex.org/I116953780","https://openalex.org/I4210128175"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5152489395","display_name":"Jianing Yu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]},{"id":"https://openalex.org/I4210132741","display_name":"Shanghai Tenth People's Hospital","ror":"https://ror.org/03vjkf643","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210132741"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jianing Yu","raw_affiliation_strings":["Department of Orthopedics, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China","institution_ids":["https://openalex.org/I116953780","https://openalex.org/I4210132741"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111277489","display_name":"Jinxi An","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]},{"id":"https://openalex.org/I4210128175","display_name":"Shanghai East Hospital","ror":"https://ror.org/038xmzj21","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210128175"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"JinXi An","raw_affiliation_strings":["Department of Orthopedics, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China","institution_ids":["https://openalex.org/I116953780","https://openalex.org/I4210128175"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159601425","display_name":"Sudan Xu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210135742","display_name":"Shanghai First People's Hospital","ror":"https://ror.org/04a46mh28","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210135742"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Sudan Xu","raw_affiliation_strings":["Department of Geriatric, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. so.phie1986@163.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Geriatric, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. so.phie1986@163.com","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210135742"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159641553","display_name":"Chen Zhu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126520041","display_name":"University of Science and Technology of China","ror":"https://ror.org/04c4dkn09","country_code":"CN","type":"education","lineage":["https://openalex.org/I126520041","https://openalex.org/I19820366"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Chen Zhu","raw_affiliation_strings":["Department of Orthopedics, State Key Laboratory of Immune Response and Immunotherapy, Centre for Leading Medicine and Advanced Technologies of IHM, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China. zhuchena@ustc.edu.cn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, State Key Laboratory of Immune Response and Immunotherapy, Centre for Leading Medicine and Advanced Technologies of IHM, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China. zhuchena@ustc.edu.cn","institution_ids":["https://openalex.org/I126520041"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063875947","display_name":"Wanbo Zhu","orcid":"https://orcid.org/0000-0003-3457-3432","observed_orcids":["https://orcid.org/0000-0003-3457-3432"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I184681353","display_name":"Anhui University of Science and Technology","ror":"https://ror.org/00q9atg80","country_code":"CN","type":"education","lineage":["https://openalex.org/I184681353"]},{"id":"https://openalex.org/I4210144482","display_name":"Shanghai Sixth People's Hospital","ror":"https://ror.org/049zrh188","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210144482"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Wanbo Zhu","raw_affiliation_strings":["Department of Orthopedics, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Jiao Tong University, Shanghai, China. zhuwanbo@sjtu.edu.cn","Department of Orthopedics, The First Affiliated Hospital of Anhui University of Science and Technology, Huainan, China"],"raw_orcid":"https://orcid.org/0000-0003-3457-3432","affiliations":[{"raw_affiliation_string":"Department of Orthopedics, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Jiao Tong University, Shanghai, China. zhuwanbo@sjtu.edu.cn","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210144482"]},{"raw_affiliation_string":"Department of Orthopedics, The First Affiliated Hospital of Anhui University of Science and Technology, Huainan, China","institution_ids":["https://openalex.org/I184681353"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5159698932","display_name":"Peng Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]},{"id":"https://openalex.org/I4210128175","display_name":"Shanghai East Hospital","ror":"https://ror.org/038xmzj21","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210128175"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Peng Wu","raw_affiliation_strings":["Department of Orthopedics, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China. 1700019@tongji.edu.cn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China. 1700019@tongji.edu.cn","institution_ids":["https://openalex.org/I116953780","https://openalex.org/I4210128175"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":11,"corresponding_author_ids":["https://openalex.org/A5063875947","https://openalex.org/A5152671458","https://openalex.org/A5159601425","https://openalex.org/A5159641553","https://openalex.org/A5159698932"],"corresponding_institution_ids":["https://openalex.org/I116953780","https://openalex.org/I126520041","https://openalex.org/I183067930","https://openalex.org/I184681353","https://openalex.org/I4210128175","https://openalex.org/I4210135742","https://openalex.org/I4210144482"],"apc_list":{"value":6990,"currency":"USD","value_usd":6990},"apc_paid":{"value":6990,"currency":"USD","value_usd":6990},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.7237169,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.004399999976158142,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/post-traumatic-osteoarthritis","display_name":"post-traumatic osteoarthritis","score":0.9419999718666077},{"id":"https://openalex.org/keywords/hydrogels","display_name":"hydrogels","score":0.5249999761581421},{"id":"https://openalex.org/keywords/extracellular-vesicles","display_name":"extracellular vesicles","score":0.8040000200271606},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.7900000214576721},{"id":"https://openalex.org/keywords/hexosamine-biosynthesis-pathway","display_name":"hexosamine biosynthetic pathway","score":0.8429999947547913},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.8539999723434448},{"id":"https://openalex.org/keywords/nanocomplexes","display_name":"nanocomplexes","score":0.7120000123977661},{"id":"https://openalex.org/keywords/xiap","display_name":"XIAP","score":0.7590000033378601},{"id":"https://openalex.org/keywords/otulin","display_name":"OTULIN","score":0.9909999966621399},{"id":"https://openalex.org/keywords/cartilage-regeneration","display_name":"cartilage regeneration","score":0.8420000076293945},{"id":"https://openalex.org/keywords/joint-lubrication","display_name":"joint lubrication","score":0.7689999938011169},{"id":"https://openalex.org/keywords/mechanical-loading","display_name":"mechanical loading","score":0.6389999985694885},{"id":"https://openalex.org/keywords/intra-articular-delivery","display_name":"intra-articular delivery","score":0.5609999895095825}],"concepts":[{"id":"https://openalex.org/C2776164576","wikidata":"https://www.wikidata.org/wiki/Q62736","display_name":"Osteoarthritis","level":3,"score":0.7373999953269958},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7167999744415283},{"id":"https://openalex.org/C2780550940","wikidata":"https://www.wikidata.org/wiki/Q502730","display_name":"Cartilage","level":2,"score":0.6345000267028809},{"id":"https://openalex.org/C77255625","wikidata":"https://www.wikidata.org/wiki/Q402093","display_name":"Reprogramming","level":3,"score":0.5667999982833862},{"id":"https://openalex.org/C17172800","wikidata":"https://www.wikidata.org/wiki/Q7263707","display_name":"Pyroptosis","level":4,"score":0.5644999742507935},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.5273000001907349},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.505299985408783},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.48730000853538513},{"id":"https://openalex.org/C2781403057","wikidata":"https://www.wikidata.org/wiki/Q775480","display_name":"Chondrocyte","level":3,"score":0.45559999346733093},{"id":"https://openalex.org/C2779638656","wikidata":"https://www.wikidata.org/wiki/Q6043166","display_name":"Integrated stress response","level":5,"score":0.4544000029563904},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.40290001034736633},{"id":"https://openalex.org/C2908689518","wikidata":"https://www.wikidata.org/wiki/Q21097485","display_name":"Extracellular vesicle","level":5,"score":0.3456000089645386},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.3386000096797943},{"id":"https://openalex.org/C4001165","wikidata":"https://www.wikidata.org/wiki/Q6804689","display_name":"Mechanosensitive channels","level":4,"score":0.3375999927520752},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.3084000051021576},{"id":"https://openalex.org/C130316041","wikidata":"https://www.wikidata.org/wiki/Q189206","display_name":"Vesicle","level":3,"score":0.2987000048160553},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.28299999237060547},{"id":"https://openalex.org/C2909674901","wikidata":"https://www.wikidata.org/wiki/Q938793","display_name":"Cartilage damage","level":5,"score":0.2809000015258789},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.28029999136924744},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.2628999948501587},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.25290000438690186}],"mesh":[{"descriptor_ui":"D000067128","descriptor_name":"Extracellular Vesicles","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D000067128","descriptor_name":"Extracellular Vesicles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002358","descriptor_name":"Cartilage, Articular","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002358","descriptor_name":"Cartilage, Articular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002358","descriptor_name":"Cartilage, Articular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006595","descriptor_name":"Hexosamines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010003","descriptor_name":"Osteoarthritis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D010003","descriptor_name":"Osteoarthritis","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D010003","descriptor_name":"Osteoarthritis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010003","descriptor_name":"Osteoarthritis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D013314","descriptor_name":"Stress, Mechanical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019902","descriptor_name":"Chondrocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019902","descriptor_name":"Chondrocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020100","descriptor_name":"Hydrogels","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D020100","descriptor_name":"Hydrogels","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1038/s41467-026-77833-1","doi":"https://doi.org/10.1038/s41467-026-77833-1","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-026-77833-1","pdf_url":"https://www.nature.com/articles/s41467-026-77833-1_reference.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},{"id":"pmid:42928352","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42928352","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature communications","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13696705","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13696705/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nat Commun","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:9fd6ebaf90ea484987e74d6c2c4145ba","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/9fd6ebaf90ea484987e74d6c2c4145ba","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Communications, Vol 17, Iss 1 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41467-026-77833-1","doi":"https://doi.org/10.1038/s41467-026-77833-1","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-026-77833-1","pdf_url":"https://www.nature.com/articles/s41467-026-77833-1_reference.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1408679397","display_name":null,"funder_award_id":"2023YJXYSA004","funder_id":"https://openalex.org/F4320322665","funder_display_name":"Natural Science Foundation of Jiangxi Province"},{"id":"https://openalex.org/G1803815770","display_name":null,"funder_award_id":"82272512","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G2910294387","display_name":null,"funder_award_id":"20252BAC240483","funder_id":"https://openalex.org/F4320322665","funder_display_name":"Natural Science Foundation of Jiangxi Province"},{"id":"https://openalex.org/G5922802526","display_name":null,"funder_award_id":"SHDC22024242","funder_id":"https://openalex.org/F4320325338","funder_display_name":"Shanghai Hospital Development Center"},{"id":"https://openalex.org/G6385848642","display_name":null,"funder_award_id":"YD9110002053","funder_id":"https://openalex.org/F4320325599","funder_display_name":"University of Science and Technology of China"},{"id":"https://openalex.org/G8533229303","display_name":null,"funder_award_id":"82472463","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G9000378371","display_name":null,"funder_award_id":"82272512,82472463","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320317789","display_name":"Shanghai Municipal Health Commission","ror":null},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321885","display_name":"Science and Technology Commission of Shanghai Municipality","ror":"https://ror.org/03kt66j61"},{"id":"https://openalex.org/F4320322665","display_name":"Natural Science Foundation of Jiangxi Province","ror":null},{"id":"https://openalex.org/F4320325338","display_name":"Shanghai Hospital Development Center","ror":"https://ror.org/02zrtve16"},{"id":"https://openalex.org/F4320325599","display_name":"University of Science and Technology of China","ror":"https://ror.org/04c4dkn09"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7214220177.pdf","grobid_xml":"https://content.openalex.org/works/W7214220177.grobid-xml"},"referenced_works_count":58,"referenced_works":["https://openalex.org/W2106571851","https://openalex.org/W2507683743","https://openalex.org/W2608687752","https://openalex.org/W2809262584","https://openalex.org/W2884481535","https://openalex.org/W2892467853","https://openalex.org/W2956139918","https://openalex.org/W2965642174","https://openalex.org/W2985172752","https://openalex.org/W3016091053","https://openalex.org/W3022311903","https://openalex.org/W3036835022","https://openalex.org/W3047446200","https://openalex.org/W3095202855","https://openalex.org/W3119413560","https://openalex.org/W3128022084","https://openalex.org/W3128854552","https://openalex.org/W3131879536","https://openalex.org/W3134249721","https://openalex.org/W3135203598","https://openalex.org/W3157784033","https://openalex.org/W3182300858","https://openalex.org/W3213197915","https://openalex.org/W3214070903","https://openalex.org/W3216974417","https://openalex.org/W4205419579","https://openalex.org/W4206521993","https://openalex.org/W4221045395","https://openalex.org/W4223477006","https://openalex.org/W4223902582","https://openalex.org/W4280623026","https://openalex.org/W4283795205","https://openalex.org/W4291511795","https://openalex.org/W4327620359","https://openalex.org/W4362613559","https://openalex.org/W4376604878","https://openalex.org/W4378212976","https://openalex.org/W4380871794","https://openalex.org/W4384559189","https://openalex.org/W4386202961","https://openalex.org/W4387611097","https://openalex.org/W4389832343","https://openalex.org/W4392086957","https://openalex.org/W4394687496","https://openalex.org/W4394726663","https://openalex.org/W4394932754","https://openalex.org/W4396214672","https://openalex.org/W4396722434","https://openalex.org/W4399929119","https://openalex.org/W4400746458","https://openalex.org/W4403081067","https://openalex.org/W4405943419","https://openalex.org/W4409051850","https://openalex.org/W4409249616","https://openalex.org/W4409316643","https://openalex.org/W4409402519","https://openalex.org/W4410554967","https://openalex.org/W4410794002"],"related_works":["https://openalex.org/W7131644844","https://openalex.org/W4408165520","https://openalex.org/W4403146222","https://openalex.org/W4392360707","https://openalex.org/W4391023016","https://openalex.org/W4220843661","https://openalex.org/W4415396861","https://openalex.org/W4412710404","https://openalex.org/W4404553073","https://openalex.org/W4412487777"],"abstract_inverted_index":{"Effective":[0],"prophylactic":[1],"interventions":[2],"for":[3,35,195],"exercise-induced":[4],"joint":[5,37,168],"damage":[6,183],"and":[7,25,39,64,87,104,115,122,151,184],"preclinical":[8,109],"osteoarthritis":[9,197],"remain":[10],"elusive,":[11],"as":[12,96],"abnormal":[13],"mechanical":[14,53],"loading":[15],"drives":[16],"pathology":[17],"through":[18],"a":[19,30,47,145,159,192],"dual":[20],"pyroptotic":[21],"loop":[22],"between":[23],"chondrocytes":[24],"macrophages.":[26],"We":[27],"present":[28],"PMUC,":[29],"mechano-responsive":[31,160],"lubricating":[32,161],"hydrogel":[33,162],"engineered":[34],"graded":[36],"protection":[38],"repair.":[40],"Mimicking":[41],"native":[42],"lubrication,":[43],"intra-articular":[44],"PMUC":[45,118,136],"forms":[46],"persistent":[48],"hydration":[49],"layer":[50],"that":[51,99,135,163],"dissipates":[52],"stress.":[54],"Under":[55],"pathological":[56],"load,":[57],"stress-induced":[58],"reactive":[59],"oxygen":[60],"species":[61],"trigger":[62],"mannose":[63],"nanocomplex":[65],"release.":[66],"This":[67],"cascade":[68],"activates":[69],"the":[70,101,156,172],"hexosamine":[71],"biosynthetic":[72],"pathway,":[73],"suppressing":[74],"Caspase-3/GSDME-mediated":[75],"chondrocyte":[76],"pyroptosis":[77],"while":[78],"concurrently":[79],"reprogramming":[80],"macrophage-derived":[81],"extracellular":[82,93],"vesicles.":[83],"Enriched":[84],"with":[85,126,140],"XIAP":[86],"OTULIN":[88],"proteins,":[89],"these":[90],"in":[91],"situ-generated":[92],"vesicles":[94],"act":[95],"intercellular":[97],"messengers":[98],"disrupt":[100],"inflammatory":[102,173],"cycle":[103,174],"facilitate":[105],"matrix":[106],"regeneration.":[107],"In":[108,177],"rat":[110,178],"models":[111],"of":[112],"high-load":[113],"exercise":[114],"post-traumatic":[116],"OA,":[117],"prevents":[119,181],"cartilage":[120,182],"erosion":[121],"achieves":[123],"full":[124],"regeneration":[125],"restored":[127],"locomotion":[128],"within":[129,188],"eight":[130,189],"weeks.":[131],"Here":[132],"we":[133],"show":[134],"integrates":[137],"adaptive":[138],"lubrication":[139],"stress-triggered":[141],"immune-metabolic":[142],"modulation,":[143],"offering":[144,191],"first\u2011in\u2011class":[146],"strategy":[147,194],"to":[148,170],"protect":[149],"joints":[150],"alleviate":[152],"early":[153,196],"OA.":[154],"Here,":[155],"authors":[157],"develop":[158],"releases":[164],"bioactive":[165],"molecules":[166],"under":[167],"stress":[169],"interrupt":[171],"is":[175],"osteoarthritis.":[176],"models,":[179],"it":[180],"restores":[185],"motor":[186],"function":[187],"weeks,":[190],"potential":[193],"intervention.":[198]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-09-25T00:00:00"}
