{"id":"https://openalex.org/W7214218586","doi":"https://doi.org/10.3390/jpm16100494","title":"PAMORAs in Cancer and Non-Cancer Opioid-Induced Constipation: A Systematic Review, Meta-Analysis, and Personalized Value-Based Evaluation Integrating Clinical and Patient-Reported Outcomes","display_name":"PAMORAs in Cancer and Non-Cancer Opioid-Induced Constipation: A Systematic Review, Meta-Analysis, and Personalized Value-Based Evaluation Integrating Clinical and Patient-Reported Outcomes","publication_year":2026,"publication_date":"2026-09-24","ids":{"openalex":"https://openalex.org/W7214218586","doi":"https://doi.org/10.3390/jpm16100494","pmid":"https://pubmed.ncbi.nlm.nih.gov/42930769","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13705715"},"language":"en","primary_location":{"id":"doi:10.3390/jpm16100494","doi":"https://doi.org/10.3390/jpm16100494","is_oa":true,"landing_page_url":"https://doi.org/10.3390/jpm16100494","pdf_url":null,"source":{"id":"https://openalex.org/S2736780684","display_name":"Journal of Personalized Medicine","issn_l":"2075-4426","issn":["2075-4426"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","erih-plus","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Personalized Medicine","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/jpm16100494","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078787825","display_name":"Francesco Fiorica","orcid":"https://orcid.org/0000-0002-9404-3655","observed_orcids":["https://orcid.org/0000-0002-9404-3655"]},"institutions":[{"id":"https://openalex.org/I4405263059","display_name":"Azienda ULSS 9 Scaligera","ror":"https://ror.org/01yfn9570","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4405263059"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Francesco Fiorica","raw_affiliation_strings":["Department of Oncology, Azienda ULSS 9 Scaligera, Via Gianella 1, 37045 Legnago, Italy"],"raw_orcid":"https://orcid.org/0000-0002-9404-3655","affiliations":[{"raw_affiliation_string":"Department of Oncology, Azienda ULSS 9 Scaligera, Via Gianella 1, 37045 Legnago, Italy","institution_ids":["https://openalex.org/I4405263059"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084341908","display_name":"Maria Viviana Candela","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maria Viviana Candela","raw_affiliation_strings":["Business and Law, High School of Sciences, Luigi Einaudi, 44121 Ferrara, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Business and Law, High School of Sciences, Luigi Einaudi, 44121 Ferrara, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044009241","display_name":"Jacopo Giuliani","orcid":"https://orcid.org/0000-0003-4096-2514","observed_orcids":["https://orcid.org/0000-0003-4096-2514"]},"institutions":[{"id":"https://openalex.org/I4405263059","display_name":"Azienda ULSS 9 Scaligera","ror":"https://ror.org/01yfn9570","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4405263059"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Jacopo Giuliani","raw_affiliation_strings":["Department of Oncology, Azienda ULSS 9 Scaligera, Via Gianella 1, 37045 Legnago, Italy"],"raw_orcid":"https://orcid.org/0000-0003-4096-2514","affiliations":[{"raw_affiliation_string":"Department of Oncology, Azienda ULSS 9 Scaligera, Via Gianella 1, 37045 Legnago, Italy","institution_ids":["https://openalex.org/I4405263059"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025473156","display_name":"Umberto Tebano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405263059","display_name":"Azienda ULSS 9 Scaligera","ror":"https://ror.org/01yfn9570","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4405263059"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Umberto Tebano","raw_affiliation_strings":["Department of Oncology, Azienda ULSS 9 Scaligera, Via Gianella 1, 37045 Legnago, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Azienda ULSS 9 Scaligera, Via Gianella 1, 37045 Legnago, Italy","institution_ids":["https://openalex.org/I4405263059"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051055114","display_name":"Marta Mandar\u00e0","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405263059","display_name":"Azienda ULSS 9 Scaligera","ror":"https://ror.org/01yfn9570","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4405263059"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Marta Mandar\u00e0","raw_affiliation_strings":["Department of Oncology, Azienda ULSS 9 Scaligera, Via Gianella 1, 37045 Legnago, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Azienda ULSS 9 Scaligera, Via Gianella 1, 37045 Legnago, Italy","institution_ids":["https://openalex.org/I4405263059"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019967406","display_name":"Milena Gabbani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405263059","display_name":"Azienda ULSS 9 Scaligera","ror":"https://ror.org/01yfn9570","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4405263059"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Milena Gabbani","raw_affiliation_strings":["Department of Oncology, Azienda ULSS 9 Scaligera, Via Gianella 1, 37045 Legnago, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Azienda ULSS 9 Scaligera, Via Gianella 1, 37045 Legnago, Italy","institution_ids":["https://openalex.org/I4405263059"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5152605493","display_name":"Giuseppe Napoli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405263059","display_name":"Azienda ULSS 9 Scaligera","ror":"https://ror.org/01yfn9570","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4405263059"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giuseppe Napoli","raw_affiliation_strings":["Department of Oncology, Azienda ULSS 9 Scaligera, Via Gianella 1, 37045 Legnago, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Azienda ULSS 9 Scaligera, Via Gianella 1, 37045 Legnago, Italy","institution_ids":["https://openalex.org/I4405263059"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033577712","display_name":"Navdeep Singh","orcid":"https://orcid.org/0000-0001-9290-6448","observed_orcids":["https://orcid.org/0000-0001-9290-6448"]},"institutions":[{"id":"https://openalex.org/I4405263059","display_name":"Azienda ULSS 9 Scaligera","ror":"https://ror.org/01yfn9570","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4405263059"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Navdeep Singh","raw_affiliation_strings":["Department of Oncology, Azienda ULSS 9 Scaligera, Via Gianella 1, 37045 Legnago, Italy"],"raw_orcid":"https://orcid.org/0000-0001-9290-6448","affiliations":[{"raw_affiliation_string":"Department of Oncology, Azienda ULSS 9 Scaligera, Via Gianella 1, 37045 Legnago, Italy","institution_ids":["https://openalex.org/I4405263059"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026618047","display_name":"Eliana Ivaldi","orcid":"https://orcid.org/0000-0001-9784-8996","observed_orcids":["https://orcid.org/0000-0001-9784-8996"]},"institutions":[{"id":"https://openalex.org/I4210111911","display_name":"Azienda Sanitaria Locale di Asti","ror":"https://ror.org/019z87133","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210111911"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Eliana Ivaldi","raw_affiliation_strings":["SS Hospice and Palliative Care, 14100 Asti, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SS Hospice and Palliative Care, 14100 Asti, Italy","institution_ids":["https://openalex.org/I4210111911"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040430785","display_name":"Paolo Rappa Verona","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210111911","display_name":"Azienda Sanitaria Locale di Asti","ror":"https://ror.org/019z87133","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210111911"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Paolo Rappa Verona","raw_affiliation_strings":["SS Hospice and Palliative Care, 14100 Asti, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SS Hospice and Palliative Care, 14100 Asti, Italy","institution_ids":["https://openalex.org/I4210111911"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5152740823","display_name":"Nadia Torchio","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210111911","display_name":"Azienda Sanitaria Locale di Asti","ror":"https://ror.org/019z87133","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210111911"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Nadia Torchio","raw_affiliation_strings":["SS Hospice and Palliative Care, 14100 Asti, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SS Hospice and Palliative Care, 14100 Asti, Italy","institution_ids":["https://openalex.org/I4210111911"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5135142901","display_name":"Chiara Boero","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chiara Boero","raw_affiliation_strings":["Home-Based Palliative Care, 14100 Asti, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Home-Based Palliative Care, 14100 Asti, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5152612411","display_name":"Manuela Cazzulo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Manuela Cazzulo","raw_affiliation_strings":["Hospice, Valle Belbo, 14049 Piemonte, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospice, Valle Belbo, 14049 Piemonte, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040093565","display_name":"Delia Lavagnolo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210111911","display_name":"Azienda Sanitaria Locale di Asti","ror":"https://ror.org/019z87133","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210111911"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Delia Lavagnolo","raw_affiliation_strings":["Medical Oncology, Cardinal Massaia Hospital, 14100 Asti, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Oncology, Cardinal Massaia Hospital, 14100 Asti, Italy","institution_ids":["https://openalex.org/I4210111911"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074901651","display_name":"Francesco Pinta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210111911","display_name":"Azienda Sanitaria Locale di Asti","ror":"https://ror.org/019z87133","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210111911"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Francesco Pinta","raw_affiliation_strings":["SS Hospice and Palliative Care, 14100 Asti, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SS Hospice and Palliative Care, 14100 Asti, Italy","institution_ids":["https://openalex.org/I4210111911"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102738119","display_name":"Marcello Tucci","orcid":"https://orcid.org/0000-0002-4977-116X","observed_orcids":["https://orcid.org/0000-0002-4977-116X"]},"institutions":[{"id":"https://openalex.org/I4210111911","display_name":"Azienda Sanitaria Locale di Asti","ror":"https://ror.org/019z87133","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210111911"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Marcello Tucci","raw_affiliation_strings":["Medical Oncology, Cardinal Massaia Hospital, 14100 Asti, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Oncology, Cardinal Massaia Hospital, 14100 Asti, Italy","institution_ids":["https://openalex.org/I4210111911"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5044009241"],"corresponding_institution_ids":["https://openalex.org/I4405263059"],"apc_list":{"value":2600,"currency":"CHF","value_usd":3137},"apc_paid":{"value":2600,"currency":"CHF","value_usd":3137},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"16","issue":"10","first_page":"494","last_page":"494"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.9369999766349792,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.9369999766349792,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11199","display_name":"Pain Management and Opioid Use","score":0.03590000048279762,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10576","display_name":"Opioid Use Disorder Treatment","score":0.006300000008195639,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/opioid-induced-constipation","display_name":"opioid-induced constipation","score":0.996999979019165},{"id":"https://openalex.org/keywords/peripherally-acting-mu-opioid-receptor-antagonists","display_name":"peripherally acting mu-opioid receptor antagonists","score":0.9610000252723694},{"id":"https://openalex.org/keywords/cancer-patients","display_name":"cancer patients","score":0.7639999985694885},{"id":"https://openalex.org/keywords/non-cancer-patients","display_name":"non-cancer patients","score":0.9120000004768372},{"id":"https://openalex.org/keywords/spontaneous-bowel-movements","display_name":"spontaneous bowel movements","score":0.9160000085830688},{"id":"https://openalex.org/keywords/health-related-quality-of-life","display_name":"health-related quality of life","score":0.7639999985694885},{"id":"https://openalex.org/keywords/health-utility","display_name":"health utility","score":0.6010000109672546},{"id":"https://openalex.org/keywords/economic-evaluation","display_name":"economic evaluation","score":0.734000027179718},{"id":"https://openalex.org/keywords/value-based-evaluation","display_name":"value-based evaluation","score":0.6800000071525574},{"id":"https://openalex.org/keywords/long-term-opioid-therapy","display_name":"long-term opioid therapy","score":0.6489999890327454},{"id":"https://openalex.org/keywords/treatment-adherence","display_name":"medication adherence","score":0.4959999918937683},{"id":"https://openalex.org/keywords/patient-reported-outcomes","display_name":"patient-reported outcomes","score":0.5690000057220459},{"id":"https://openalex.org/keywords/pac-qol","display_name":"PAC-QOL","score":0.6320000290870667},{"id":"https://openalex.org/keywords/eq-5d","display_name":"EQ-5D","score":0.8420000076293945}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9142000079154968},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.713100016117096},{"id":"https://openalex.org/C2779951463","wikidata":"https://www.wikidata.org/wiki/Q7268788","display_name":"Quality of life (healthcare)","level":2,"score":0.570900022983551},{"id":"https://openalex.org/C2781112942","wikidata":"https://www.wikidata.org/wiki/Q178436","display_name":"Constipation","level":2,"score":0.5655999779701233},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.54339998960495},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.5396999716758728},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.4936999976634979},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.4763999879360199},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.46639999747276306},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.4399000108242035},{"id":"https://openalex.org/C2780820201","wikidata":"https://www.wikidata.org/wiki/Q173235","display_name":"Analgesic","level":2,"score":0.4325000047683716},{"id":"https://openalex.org/C2781063702","wikidata":"https://www.wikidata.org/wiki/Q427523","display_name":"Opioid","level":3,"score":0.3962000012397766},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.384799987077713},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.38359999656677246},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.37610000371932983},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.3732999861240387},{"id":"https://openalex.org/C28804328","wikidata":"https://www.wikidata.org/wiki/Q7623693","display_name":"Strictly standardized mean difference","level":3,"score":0.3237000107765198},{"id":"https://openalex.org/C189708586","wikidata":"https://www.wikidata.org/wiki/Q1504425","display_name":"Systematic review","level":3,"score":0.3138999938964844},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.29100000858306885},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.28780001401901245},{"id":"https://openalex.org/C32220436","wikidata":"https://www.wikidata.org/wiki/Q2072214","display_name":"Personalized medicine","level":2,"score":0.27790001034736633},{"id":"https://openalex.org/C2778904085","wikidata":"https://www.wikidata.org/wiki/Q3712728","display_name":"Cancer pain","level":3,"score":0.2712000012397766}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.3390/jpm16100494","doi":"https://doi.org/10.3390/jpm16100494","is_oa":true,"landing_page_url":"https://doi.org/10.3390/jpm16100494","pdf_url":null,"source":{"id":"https://openalex.org/S2736780684","display_name":"Journal of Personalized Medicine","issn_l":"2075-4426","issn":["2075-4426"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","erih-plus","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Personalized Medicine","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13705715","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13705715/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13705715/pdf/jpm-16-00494.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Pers Med","raw_type":"Text"},{"id":"pmid:42930769","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42930769","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of personalized medicine","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3390/jpm16100494","doi":"https://doi.org/10.3390/jpm16100494","is_oa":true,"landing_page_url":"https://doi.org/10.3390/jpm16100494","pdf_url":null,"source":{"id":"https://openalex.org/S2736780684","display_name":"Journal of Personalized Medicine","issn_l":"2075-4426","issn":["2075-4426"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","erih-plus","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Personalized Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Systematic Review","id":"https://openalex.org/study-designs/systematic-review"},{"display_name":"Meta-Analysis","id":"https://openalex.org/study-designs/meta-analysis"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7214218586.pdf","grobid_xml":"https://content.openalex.org/works/W7214218586.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W1966250447","https://openalex.org/W1972242861","https://openalex.org/W1984091950","https://openalex.org/W1995873856","https://openalex.org/W1996075855","https://openalex.org/W2020351580","https://openalex.org/W2021543354","https://openalex.org/W2053191149","https://openalex.org/W2058539869","https://openalex.org/W2084196341","https://openalex.org/W2106584438","https://openalex.org/W2107328434","https://openalex.org/W2125435699","https://openalex.org/W2143572441","https://openalex.org/W2158281754","https://openalex.org/W2396215196","https://openalex.org/W2473786944","https://openalex.org/W2602941024","https://openalex.org/W2608589775","https://openalex.org/W2617664403","https://openalex.org/W2792218458","https://openalex.org/W2801854693","https://openalex.org/W2884417868","https://openalex.org/W2897189621","https://openalex.org/W2907769961","https://openalex.org/W2916021673","https://openalex.org/W2978829807","https://openalex.org/W3029283443","https://openalex.org/W3029785540","https://openalex.org/W3036652752","https://openalex.org/W3118615836","https://openalex.org/W3178714642","https://openalex.org/W3179447472","https://openalex.org/W4206608028","https://openalex.org/W4387866472","https://openalex.org/W4392355884","https://openalex.org/W4392549777","https://openalex.org/W4402401191","https://openalex.org/W4404123132","https://openalex.org/W4411257200","https://openalex.org/W4413788947"],"related_works":["https://openalex.org/W7169729100","https://openalex.org/W6995672406","https://openalex.org/W2907769961","https://openalex.org/W7163188960","https://openalex.org/W3179447472","https://openalex.org/W3029785540","https://openalex.org/W3029283443","https://openalex.org/W3132362402","https://openalex.org/W3011483023","https://openalex.org/W4206088111"],"abstract_inverted_index":{"Background:":[0],"Opioid-induced":[1],"constipation":[2,349],"(OIC)":[3],"is":[4],"a":[5,38,256,281,402],"frequent":[6],"and":[7,18,26,61,73,94,146,162,187,228,312,336,352,382,398,418],"clinically":[8,282,387],"relevant":[9],"complication":[10],"of":[11,29,54,75,96,133,140,142,292,302,310,317,364,370,376,380,385,393,425],"long-term":[12],"opioid":[13,44],"therapy":[14],"in":[15,84,121,217,233,260,345,361],"both":[16],"cancer":[17,234,351],"non-cancer":[19,113,218,353],"populations,":[20],"negatively":[21],"affecting":[22],"symptoms,":[23],"treatment":[24,212,320,325,407],"adherence,":[25],"health-related":[27],"quality":[28,132,309,363],"life.":[30],"Peripherally":[31],"acting":[32],"\u03bc-opioid":[33],"receptor":[34],"antagonists":[35],"(PAMORAs)":[36],"represent":[37],"mechanism-based":[39],"therapeutic":[40],"approach":[41],"targeting":[42],"peripheral":[43],"effects":[45],"while":[46],"preserving":[47],"analgesic":[48],"activity.":[49],"However,":[50],"the":[51,119,137,171,175,286,289,293,303,367,377,383,410],"overall":[52],"value":[53],"PAMORAs,":[55],"integrating":[56],"clinical":[57,109,290,368,394],"outcomes,":[58,251,395],"patient-reported":[59,308,396],"benefits,":[60],"health-economic":[62,399],"implications,":[63],"has":[64],"not":[65,420],"been":[66],"comprehensively":[67],"assessed.":[68],"Methods:":[69],"A":[70,153],"systematic":[71],"review":[72],"meta-analysis":[74],"randomized":[76],"controlled":[77],"trials":[78,248],"(RCTs)":[79],"comparing":[80],"PAMORAs":[81,193,252,340],"versus":[82,112],"placebo":[83,200,265],"adults":[85],"with":[86,199,255,264,347],"OIC":[87],"was":[88,118,167,214],"performed.":[89],"PubMed,":[90],"Embase,":[91],"Cochrane":[92],"CENTRAL,":[93],"Web":[95],"Science":[97],"were":[98,105,191,253],"searched":[99],"up":[100],"to":[101,108,160,164,169,241,271,331],"June":[102],"2025.":[103],"Studies":[104],"stratified":[106],"according":[107],"setting":[110],"(cancer":[111],"populations).":[114],"The":[115,211,390],"primary":[116],"outcome":[117],"change":[120],"mean":[122],"weekly":[123,196],"spontaneous":[124],"bowel":[125,306,343],"movements":[126],"(SBMs).":[127],"Secondary":[128],"outcomes":[129],"included":[130],"constipation-related":[131,362],"life":[134],"assessed":[135],"by":[136],"Patient":[138],"Assessment":[139],"Constipation\u2013Quality":[141],"Life":[143],"(PAC-QOL)":[144],"questionnaire":[145],"health":[147],"utility":[148],"estimation":[149,316],"through":[150],"EQ-5D":[151,165,313],"mapping.":[152],"two-step":[154],"exploratory":[155,300,391],"framework":[156,404],"linking":[157],"SBM":[158],"improvement":[159,259,279,360],"PAC-QOL":[161,261],"subsequently":[163],"utilities":[166],"applied":[168],"extend":[170],"economic":[172,412],"evaluation":[173],"across":[174,350],"available":[176],"evidence":[177,356],"base.":[178],"Results:":[179],"Nineteen":[180],"RCTs":[181],"including":[182],"5565":[183],"patients":[184,346],"(2785":[185],"PAMORA-treated":[186],"2780":[188],"placebo-treated":[189],"patients)":[190],"included.":[192],"significantly":[194],"increased":[195],"SBMs":[197],"compared":[198,263],"(mean":[201],"difference":[202],"[MD]":[203],"1.49;":[204],"95%":[205,222,238,268],"CI":[206,223,239,269],"1.04\u20131.95;":[207],"p":[208],"<":[209],"0.0001).":[210],"effect":[213,372],"highly":[215],"consistent":[216],"populations":[219,235],"(MD":[220,236,266],"1.28;":[221],"1.10\u20131.46;":[224],"I2":[225,243],"=":[226,244],"0%)":[227],"larger":[229],"but":[230,409],"more":[231],"heterogeneous":[232],"2.67;":[237],"\u22120.001":[240],"5.35;":[242],"93.7%).":[245],"In":[246],"five":[247],"reporting":[249],"quality-of-life":[250],"associated":[254],"statistically":[257],"significant":[258],"scores":[262],"\u22120.25;":[267],"\u22120.41":[270],"\u22120.10);":[272],"however,":[273],"only":[274],"one":[275],"study":[276],"demonstrated":[277],"an":[278,299,359],"approaching":[280],"meaningful":[283,388],"threshold,":[284],"limiting":[285],"certainty":[287],"regarding":[288],"relevance":[291,369],"pooled":[294],"effect.":[295],"Mapping":[296],"analyses":[297],"provided":[298],"estimate":[301],"relationship":[304],"between":[305],"function,":[307],"life,":[311,365],"utilities,":[314],"allowing":[315],"illustrative":[318],"value-based":[319],"thresholds.":[321],"Estimated":[322],"acceptable":[323],"monthly":[324],"costs":[326],"ranged":[327],"from":[328],"approximately":[329],"\u20ac25":[330],"\u20ac101":[332],"depending":[333],"on":[334],"population":[335],"trial":[337],"characteristics.":[338],"Conclusions:":[339],"consistently":[341,386],"improve":[342],"function":[344],"opioid-induced":[348],"settings.":[354],"Available":[355],"also":[357],"suggests":[358],"although":[366],"this":[371],"remains":[373],"uncertain":[374],"because":[375],"limited":[378],"number":[379],"studies":[381],"lack":[384],"changes.":[389],"integration":[392],"measures,":[397],"parameters":[400],"provides":[401],"potential":[403],"for":[405],"personalized":[406],"evaluation,":[408],"estimated":[411],"thresholds":[413],"should":[414,419],"be":[415,421],"interpreted":[416],"cautiously":[417],"considered":[422],"direct":[423],"estimates":[424],"cross-country":[426],"cost-effectiveness.":[427]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-09-25T00:00:00"}