{"id":"https://openalex.org/W7214218508","doi":"https://doi.org/10.64898/2026.09.23.26363372","title":"Circulating extracellular vesicle lipidomics identifies distinct signatures of amyotrophic lateral sclerosis and spinal muscular atrophy","display_name":"Circulating extracellular vesicle lipidomics identifies distinct signatures of amyotrophic lateral sclerosis and spinal muscular atrophy","publication_year":2026,"publication_date":"2026-09-24","ids":{"openalex":"https://openalex.org/W7214218508","doi":"https://doi.org/10.64898/2026.09.23.26363372"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.23.26363372","doi":"https://doi.org/10.64898/2026.09.23.26363372","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.23.26363372","pdf_url":null,"source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.64898/2026.09.23.26363372","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007778912","display_name":"Valeria Ricotti","orcid":"https://orcid.org/0000-0003-1800-1987","observed_orcids":["https://orcid.org/0000-0003-1800-1987"]},"institutions":[{"id":"https://openalex.org/I4387152181","display_name":"NIHR Great Ormond Street Hospital Biomedical Research Centre","ror":"https://ror.org/033rx1153","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2800129641","https://openalex.org/I2800349819","https://openalex.org/I34931013","https://openalex.org/I4387152181"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Valeria Ricotti","raw_affiliation_strings":["NIHR Great Ormond Street Hospital Biomedical Research Centre, University College London, London, UK","Vesalic Limited, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NIHR Great Ormond Street Hospital Biomedical Research Centre, University College London, London, UK","institution_ids":["https://openalex.org/I4387152181","https://openalex.org/I45129253"]},{"raw_affiliation_string":"Vesalic Limited, London, UK","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5117371684","display_name":"Antigone Fogel","orcid":"https://orcid.org/0009-0004-7142-4406","observed_orcids":["https://orcid.org/0009-0004-7142-4406"]},"institutions":[{"id":"https://openalex.org/I4210126463","display_name":"UK Dementia Research Institute","ror":"https://ror.org/02wedp412","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210126463"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Antigone Fogel","raw_affiliation_strings":["Care Research and Technology Centre, UK Dementia Research Institute, London, UK","Imperial College London, London, UK","Vesalic Limited, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Care Research and Technology Centre, UK Dementia Research Institute, London, UK","institution_ids":["https://openalex.org/I4210126463"]},{"raw_affiliation_string":"Imperial College London, London, UK","institution_ids":["https://openalex.org/I47508984"]},{"raw_affiliation_string":"Vesalic Limited, London, UK","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056947461","display_name":"Michiel Vandenbosch","orcid":"https://orcid.org/0000-0002-0427-416X","observed_orcids":["https://orcid.org/0000-0002-0427-416X"]},"institutions":[{"id":"https://openalex.org/I34352273","display_name":"Maastricht University","ror":"https://ror.org/02jz4aj89","country_code":"NL","type":"education","lineage":["https://openalex.org/I34352273"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Michiel Vandenbosch","raw_affiliation_strings":["Maastricht University, Maastricht, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Maastricht University, Maastricht, the Netherlands","institution_ids":["https://openalex.org/I34352273"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104670109","display_name":"Federica Cerri","orcid":"https://orcid.org/0009-0003-1619-2019","observed_orcids":["https://orcid.org/0009-0003-1619-2019"]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]},{"id":"https://openalex.org/I4210111425","display_name":"Centro Clinico Nemo","ror":"https://ror.org/01xht6a47","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210111425"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Federica Cerri","raw_affiliation_strings":["Universit\u00e0 degli Studi di Milano / Centro Clinico NeMO, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e0 degli Studi di Milano / Centro Clinico NeMO, Milan, Italy","institution_ids":["https://openalex.org/I189158943","https://openalex.org/I4210111425"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018775365","display_name":"Pierpaolo Ala","orcid":"https://orcid.org/0000-0001-9410-0085","observed_orcids":["https://orcid.org/0000-0001-9410-0085"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pierpaolo Ala","raw_affiliation_strings":["Vesalic Limited, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vesalic Limited, London, UK","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037077476","display_name":"Alexander Capstick","orcid":"https://orcid.org/0000-0002-3884-8045","observed_orcids":["https://orcid.org/0000-0002-3884-8045"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Alexander Capstick","raw_affiliation_strings":["Imperial College London, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Imperial College London, London, UK","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010755895","display_name":"Rachele Rossi","orcid":"https://orcid.org/0000-0001-8264-4798","observed_orcids":["https://orcid.org/0000-0001-8264-4798"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rachele Rossi","raw_affiliation_strings":["Vesalic Limited, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vesalic Limited, London, UK","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090414042","display_name":"Federica Gerardi","orcid":"https://orcid.org/0000-0001-5548-2017","observed_orcids":["https://orcid.org/0000-0001-5548-2017"]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]},{"id":"https://openalex.org/I4210111425","display_name":"Centro Clinico Nemo","ror":"https://ror.org/01xht6a47","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210111425"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Francesca Gerardi","raw_affiliation_strings":["Universit\u00e0 degli Studi di Milano / Centro Clinico NeMO, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e0 degli Studi di Milano / Centro Clinico NeMO, Milan, Italy","institution_ids":["https://openalex.org/I189158943","https://openalex.org/I4210111425"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114175078","display_name":"Ruben Jacobs","orcid":"https://orcid.org/0009-0002-5933-936X","observed_orcids":["https://orcid.org/0009-0002-5933-936X"]},"institutions":[{"id":"https://openalex.org/I34352273","display_name":"Maastricht University","ror":"https://ror.org/02jz4aj89","country_code":"NL","type":"education","lineage":["https://openalex.org/I34352273"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Ruben Jacobs","raw_affiliation_strings":["Maastricht University, Maastricht, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Maastricht University, Maastricht, the Netherlands","institution_ids":["https://openalex.org/I34352273"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042269980","display_name":"Eugenio Maria Mercuri","orcid":"https://orcid.org/0000-0002-9851-5365","observed_orcids":["https://orcid.org/0000-0002-9851-5365","https://orcid.org/0000-0002-1005-3443"]},"institutions":[{"id":"https://openalex.org/I103320735","display_name":"Universit\u00e0 Cattolica del Sacro Cuore","ror":"https://ror.org/03h7r5v07","country_code":"IT","type":"education","lineage":["https://openalex.org/I103320735"]},{"id":"https://openalex.org/I2802557943","display_name":"Agostino Gemelli University Polyclinic","ror":"https://ror.org/00rg70c39","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2802557943"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Eugenio Mercuri","raw_affiliation_strings":["Pediatric Neurology, Catholic University of the Sacred Heart, Rome, Italy","Pediatric Neurology, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatric Neurology, Catholic University of the Sacred Heart, Rome, Italy","institution_ids":["https://openalex.org/I103320735"]},{"raw_affiliation_string":"Pediatric Neurology, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy","institution_ids":["https://openalex.org/I2802557943"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Valeria Sansone","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]},{"id":"https://openalex.org/I4210111425","display_name":"Centro Clinico Nemo","ror":"https://ror.org/01xht6a47","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210111425"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Valeria Sansone","raw_affiliation_strings":["Universit\u00e0 degli Studi di Milano / Centro Clinico NeMO, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e0 degli Studi di Milano / Centro Clinico NeMO, Milan, Italy","institution_ids":["https://openalex.org/I189158943","https://openalex.org/I4210111425"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087727224","display_name":"Pamela J. Shaw","orcid":"https://orcid.org/0000-0002-8925-2567","observed_orcids":["https://orcid.org/0000-0002-8925-2567"]},"institutions":[{"id":"https://openalex.org/I4210102902","display_name":"Sheffield Teaching Hospitals NHS Foundation Trust","ror":"https://ror.org/018hjpz25","country_code":"GB","type":"funder","lineage":["https://openalex.org/I4210102902"]},{"id":"https://openalex.org/I4405269778","display_name":"NIHR Sheffield Biomedical Research Centre","ror":"https://ror.org/055qwb732","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4405269778"]},{"id":"https://openalex.org/I91136226","display_name":"University of Sheffield","ror":"https://ror.org/05krs5044","country_code":"GB","type":"education","lineage":["https://openalex.org/I91136226"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Pamela J. Shaw","raw_affiliation_strings":["NIHR Sheffield Biomedical Research Centre, Sheffield Teaching Hospitals NHS Foundation Trust, Glossop Road, Sheffield S10 2JF, UK","Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, Sheffield, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NIHR Sheffield Biomedical Research Centre, Sheffield Teaching Hospitals NHS Foundation Trust, Glossop Road, Sheffield S10 2JF, UK","institution_ids":["https://openalex.org/I4210102902","https://openalex.org/I4405269778"]},{"raw_affiliation_string":"Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, Sheffield, UK","institution_ids":["https://openalex.org/I91136226"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056157061","display_name":"Payam Mamaani Barnaghi","orcid":"https://orcid.org/0000-0001-8591-9638","observed_orcids":["https://orcid.org/0000-0001-8591-9638"]},"institutions":[{"id":"https://openalex.org/I2800129641","display_name":"Great Ormond Street Hospital","ror":"https://ror.org/00zn2c847","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800129641","https://openalex.org/I2800349819"]},{"id":"https://openalex.org/I4210126463","display_name":"UK Dementia Research Institute","ror":"https://ror.org/02wedp412","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210126463"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Payam Barnaghi","raw_affiliation_strings":["Care Research and Technology Centre, UK Dementia Research Institute, London, UK","Data Research, Innovation and Virtual Environments (DRIVE) Unit, Great Ormond Street Hospital, London, UK","Imperial College London, London, UK"],"raw_orcid":"https://orcid.org/0000-0001-8591-9638","affiliations":[{"raw_affiliation_string":"Care Research and Technology Centre, UK Dementia Research Institute, London, UK","institution_ids":["https://openalex.org/I4210126463"]},{"raw_affiliation_string":"Data Research, Innovation and Virtual Environments (DRIVE) Unit, Great Ormond Street Hospital, London, UK","institution_ids":["https://openalex.org/I2800129641"]},{"raw_affiliation_string":"Imperial College London, London, UK","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111444457","display_name":"Thomas Vo\u00eft","orcid":"https://orcid.org/0000-0002-7424-5401","observed_orcids":["https://orcid.org/0000-0002-7424-5401"]},"institutions":[{"id":"https://openalex.org/I4387152181","display_name":"NIHR Great Ormond Street Hospital Biomedical Research Centre","ror":"https://ror.org/033rx1153","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2800129641","https://openalex.org/I2800349819","https://openalex.org/I34931013","https://openalex.org/I4387152181"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Thomas Voit","raw_affiliation_strings":["NIHR Great Ormond Street Hospital Biomedical Research Centre, University College London, London, UK","Vesalic Limited, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NIHR Great Ormond Street Hospital Biomedical Research Centre, University College London, London, UK","institution_ids":["https://openalex.org/I4387152181","https://openalex.org/I45129253"]},{"raw_affiliation_string":"Vesalic Limited, London, UK","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":13,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.7914999723434448,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.7914999723434448,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":0.1949000060558319,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amyotrophic-lateral-sclerosis","display_name":"amyotrophic lateral sclerosis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/spinal-muscular-atrophy","display_name":"spinal muscular atrophy","score":1.0},{"id":"https://openalex.org/keywords/extracellular-vesicles","display_name":"extracellular vesicles","score":0.9729999899864197},{"id":"https://openalex.org/keywords/lipidomics","display_name":"lipidomics","score":0.8669999837875366},{"id":"https://openalex.org/keywords/circulating-biomarkers","display_name":"circulating biomarkers","score":0.8140000104904175},{"id":"https://openalex.org/keywords/blood-based-diagnostics","display_name":"blood-based diagnosis","score":0.5849999785423279},{"id":"https://openalex.org/keywords/tofersen","display_name":"tofersen","score":0.8320000171661377},{"id":"https://openalex.org/keywords/membrane-remodeling","display_name":"membrane remodeling","score":0.9589999914169312},{"id":"https://openalex.org/keywords/neuromuscular-disorders","display_name":"neuromuscular disorders","score":0.7689999938011169},{"id":"https://openalex.org/keywords/disease-stratification","display_name":"disease stratification","score":0.8370000123977661}],"concepts":[{"id":"https://openalex.org/C2780596555","wikidata":"https://www.wikidata.org/wiki/Q206901","display_name":"Amyotrophic lateral sclerosis","level":3,"score":0.9038000106811523},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.7050999999046326},{"id":"https://openalex.org/C58017582","wikidata":"https://www.wikidata.org/wiki/Q6556376","display_name":"Lipidomics","level":2,"score":0.690500020980835},{"id":"https://openalex.org/C2778558090","wikidata":"https://www.wikidata.org/wiki/Q580290","display_name":"Spinal muscular atrophy","level":3,"score":0.6089000105857849},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5437999963760376},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.539900004863739},{"id":"https://openalex.org/C2781172350","wikidata":"https://www.wikidata.org/wiki/Q194520","display_name":"Atrophy","level":2,"score":0.5188000202178955},{"id":"https://openalex.org/C2992929900","wikidata":"https://www.wikidata.org/wiki/Q21097485","display_name":"Extracellular vesicles","level":2,"score":0.46700000762939453},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.42809998989105225},{"id":"https://openalex.org/C124535831","wikidata":"https://www.wikidata.org/wiki/Q4915074","display_name":"Biomarker discovery","level":4,"score":0.4133000075817108},{"id":"https://openalex.org/C2908689518","wikidata":"https://www.wikidata.org/wiki/Q21097485","display_name":"Extracellular vesicle","level":5,"score":0.3968000113964081},{"id":"https://openalex.org/C58471807","wikidata":"https://www.wikidata.org/wiki/Q327120","display_name":"Receiver operating characteristic","level":2,"score":0.38600000739097595},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.36800000071525574},{"id":"https://openalex.org/C2780640218","wikidata":"https://www.wikidata.org/wiki/Q8277","display_name":"Multiple sclerosis","level":2,"score":0.36070001125335693},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3522999882698059},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3418000042438507},{"id":"https://openalex.org/C4733338","wikidata":"https://www.wikidata.org/wiki/Q2792936","display_name":"Lipid metabolism","level":2,"score":0.30169999599456787},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.2935999929904938},{"id":"https://openalex.org/C2780241833","wikidata":"https://www.wikidata.org/wiki/Q6556375","display_name":"Lipidome","level":3,"score":0.2856000065803528},{"id":"https://openalex.org/C45664433","wikidata":"https://www.wikidata.org/wiki/Q17029420","display_name":"Imaging biomarker","level":3,"score":0.27570000290870667},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.26820001006126404},{"id":"https://openalex.org/C2776356578","wikidata":"https://www.wikidata.org/wiki/Q2246789","display_name":"Neuromuscular disease","level":3,"score":0.2587999999523163}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.09.23.26363372","doi":"https://doi.org/10.64898/2026.09.23.26363372","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.23.26363372","pdf_url":null,"source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.09.23.26363372","doi":"https://doi.org/10.64898/2026.09.23.26363372","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.23.26363372","pdf_url":null,"source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W1784444703","https://openalex.org/W1963604250","https://openalex.org/W1972978214","https://openalex.org/W1980477780","https://openalex.org/W2032708696","https://openalex.org/W2041282815","https://openalex.org/W2052461624","https://openalex.org/W2069856306","https://openalex.org/W2108381339","https://openalex.org/W2116810060","https://openalex.org/W2152311269","https://openalex.org/W2178618172","https://openalex.org/W2295598076","https://openalex.org/W2528264181","https://openalex.org/W2556818673","https://openalex.org/W2592442004","https://openalex.org/W2790705492","https://openalex.org/W2799345117","https://openalex.org/W2809921225","https://openalex.org/W2889223700","https://openalex.org/W2922573905","https://openalex.org/W2933081937","https://openalex.org/W2999615587","https://openalex.org/W3011415530","https://openalex.org/W3015136087","https://openalex.org/W3040840440","https://openalex.org/W3049067609","https://openalex.org/W3175016977","https://openalex.org/W4210427531","https://openalex.org/W4211041983","https://openalex.org/W4252684946","https://openalex.org/W4289755145","https://openalex.org/W4295896242","https://openalex.org/W4297094269","https://openalex.org/W4384264172","https://openalex.org/W4386592991","https://openalex.org/W4392374045","https://openalex.org/W4396854324","https://openalex.org/W4401940240","https://openalex.org/W4411494230","https://openalex.org/W4411570119","https://openalex.org/W4413306636","https://openalex.org/W4415737143","https://openalex.org/W7171378282","https://openalex.org/W7203772428"],"related_works":["https://openalex.org/W4318215092","https://openalex.org/W3192785280","https://openalex.org/W2904034429","https://openalex.org/W4417173739","https://openalex.org/W4407590762","https://openalex.org/W3105826555","https://openalex.org/W4401049606","https://openalex.org/W4225148516","https://openalex.org/W4385335099","https://openalex.org/W7212186783"],"abstract_inverted_index":{"ABSTRACT":[0],"Amyotrophic":[1],"lateral":[2],"sclerosis":[3],"(ALS)":[4],"is":[5],"a":[6,108,121,136],"heterogeneous":[7],"neurodegenerative":[8],"disorder":[9],"lacking":[10],"established":[11],"biomarkers":[12],"of":[13,22,63,125],"underlying":[14],"disease":[15,118],"biology.":[16],"Here,":[17],"we":[18,45],"identify":[19],"lipidomic":[20],"signatures":[21,134],"circulating":[23],"extracellular":[24],"vesicles":[25],"(EVs)":[26],"that":[27,113],"distinguish":[28],"ALS":[29,47,142],"from":[30,49,112],"neurologically":[31],"healthy":[32,50],"controls":[33,51],"and":[34,42,77,145],"related":[35],"neuromuscular":[36],"diseases.":[37],"Using":[38],"mass":[39],"spectrometry-based":[40],"profiling":[41],"multivariate":[43],"modelling,":[44],"separate":[46],"(n=77)":[48],"(n=89)":[52],"with":[53,97,102,148],"an":[54,81],"area":[55],"under":[56],"the":[57],"receiver":[58],"operating":[59],"characteristic":[60],"curve":[61],"(AUROC)":[62],"0.90":[64],"(95%":[65],"CI":[66],"0.85\u20130.94),":[67],"rising":[68],"to":[69],"0.92":[70],"(0.89-0.96)":[71],"when":[72],"low-confidence":[73],"predictions":[74],"are":[75],"withheld,":[76],"retaining":[78],"performance":[79],"in":[80,95,115],"independent":[82],"cohort":[83],"(n=119;":[84],"AUROC":[85],"0.78,":[86],"0.70-0.86).":[87],"In":[88],"Tofersen-treated":[89],"SOD1-ALS":[90],"patients,":[91],"biomarker":[92,139],"trajectories":[93],"change":[94],"parallel":[96],"clinical":[98],"measures":[99],"while":[100],"individuals":[101],"spinal":[103],"muscular":[104],"atrophy":[105],"(n=50)":[106],"exhibit":[107],"lipid":[109,133,151],"fingerprint":[110],"distinct":[111,150],"observed":[114],"ALS,":[116],"supporting":[117],"specificity":[119],"within":[120],"shared":[122],"systemic":[123,127],"framework":[124],"abnormal":[126],"lipogenesis.":[128],"These":[129],"findings":[130],"establish":[131],"EV-associated":[132],"as":[135],"systemic,":[137],"blood-based":[138],"platform":[140],"for":[141],"diagnosis,":[143],"stratification,":[144],"treatment":[146],"monitoring,":[147],"structurally":[149],"species":[152],"indicating":[153],"widespread":[154],"membrane":[155],"remodelling.":[156]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2026-09-25T00:00:00"}
