{"id":"https://openalex.org/W7214207406","doi":"https://doi.org/10.64898/2026.09.21.753221","title":"Dietary fiber-type-specific gut microbiome preconditioning drives differential susceptibility to sporadic colon cancer development","display_name":"Dietary fiber-type-specific gut microbiome preconditioning drives differential susceptibility to sporadic colon cancer development","publication_year":2026,"publication_date":"2026-09-24","ids":{"openalex":"https://openalex.org/W7214207406","doi":"https://doi.org/10.64898/2026.09.21.753221"},"language":"en","primary_location":{"id":"doi:10.64898/2026.09.21.753221","doi":"https://doi.org/10.64898/2026.09.21.753221","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.21.753221","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/24/2026.09.21.753221.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/24/2026.09.21.753221.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054109507","display_name":"Sangshan Tian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sangshan Tian","raw_affiliation_strings":["Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA, USA","One Health Microbiome Center, Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA, USA","institution_ids":["https://openalex.org/I130769515"]},{"raw_affiliation_string":"One Health Microbiome Center, Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA, USA","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064410113","display_name":"Sumudu Rajakaruna","orcid":"https://orcid.org/0000-0003-1836-3726","observed_orcids":["https://orcid.org/0000-0003-1836-3726"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]},{"id":"https://openalex.org/I4405268258","display_name":"Penn State Cancer Institute","ror":"https://ror.org/00bzx1854","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4405268258"]},{"id":"https://openalex.org/I82783531","display_name":"Penn State Milton S. Hershey Medical Center","ror":"https://ror.org/01h22ap11","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I82783531"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sumudu Rajakaruna","raw_affiliation_strings":["Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA, USA","One Health Microbiome Center, Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA, USA","Penn State Cancer Institute, Hershey, PA, USA"],"raw_orcid":"https://orcid.org/0000-0003-1836-3726","affiliations":[{"raw_affiliation_string":"Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA, USA","institution_ids":["https://openalex.org/I130769515"]},{"raw_affiliation_string":"One Health Microbiome Center, Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA, USA","institution_ids":["https://openalex.org/I130769515"]},{"raw_affiliation_string":"Penn State Cancer Institute, Hershey, PA, USA","institution_ids":["https://openalex.org/I4405268258","https://openalex.org/I82783531"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5117550364","display_name":"Gopi Yalavarthi","orcid":"https://orcid.org/0009-0001-8929-445X","observed_orcids":["https://orcid.org/0009-0001-8929-445X"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gopi Yalavarthi","raw_affiliation_strings":["Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA, USA","One Health Microbiome Center, Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA, USA","institution_ids":["https://openalex.org/I130769515"]},{"raw_affiliation_string":"One Health Microbiome Center, Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA, USA","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042635575","display_name":"Umesh Kumar Goand","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Umesh K Goand","raw_affiliation_strings":["Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA, USA","One Health Microbiome Center, Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA, USA","institution_ids":["https://openalex.org/I130769515"]},{"raw_affiliation_string":"One Health Microbiome Center, Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA, USA","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057003909","display_name":"Tinghua Chen","orcid":"https://orcid.org/0000-0002-6152-3804","observed_orcids":["https://orcid.org/0000-0002-6152-3804"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tinghua Chen","raw_affiliation_strings":["College of Information Sciences and Technology, The Pennsylvania State University, University Park, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Information Sciences and Technology, The Pennsylvania State University, University Park, PA, USA","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042847207","display_name":"Won Gu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Won Gu","raw_affiliation_strings":["Department of Statistics, The Pennsylvania State University, University Park, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Statistics, The Pennsylvania State University, University Park, PA, USA","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5137614496","display_name":"Justin Silverman","orcid":"https://orcid.org/0000-0002-3063-2098","observed_orcids":["https://orcid.org/0000-0002-3063-2098"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Justin Silverman","raw_affiliation_strings":["College of Information Sciences and Technology, The Pennsylvania State University, University Park, PA, USA","One Health Microbiome Center, Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Information Sciences and Technology, The Pennsylvania State University, University Park, PA, USA","institution_ids":["https://openalex.org/I130769515"]},{"raw_affiliation_string":"One Health Microbiome Center, Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA, USA","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024289786","display_name":"Fuhua Hao","orcid":"https://orcid.org/0000-0002-0865-5269","observed_orcids":["https://orcid.org/0000-0002-0865-5269"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fuhua Hao","raw_affiliation_strings":["Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA, USA","One Health Microbiome Center, Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA, USA","institution_ids":["https://openalex.org/I130769515"]},{"raw_affiliation_string":"One Health Microbiome Center, Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA, USA","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055363459","display_name":"Seth R. Bordenstein","orcid":"https://orcid.org/0000-0001-7346-0954","observed_orcids":["https://orcid.org/0000-0001-7346-0954"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Seth R. Bordenstein","raw_affiliation_strings":["Department of Biology, The Pennsylvania State University, University Park, PA, USA","Departments of Biology and Entomology, The Pennsylvania State University, University Park, PA, USA","One Health Microbiome Center, Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, The Pennsylvania State University, University Park, PA, USA","institution_ids":["https://openalex.org/I130769515"]},{"raw_affiliation_string":"Departments of Biology and Entomology, The Pennsylvania State University, University Park, PA, USA","institution_ids":["https://openalex.org/I130769515"]},{"raw_affiliation_string":"One Health Microbiome Center, Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA, USA","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068812632","display_name":"Jordan E. Bisanz","orcid":"https://orcid.org/0000-0002-8649-1706","observed_orcids":["https://orcid.org/0000-0002-8649-1706"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jordan E. Bisanz","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA, USA","One Health Microbiome Center, Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA, USA","institution_ids":["https://openalex.org/I130769515"]},{"raw_affiliation_string":"One Health Microbiome Center, Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA, USA","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004261103","display_name":"Amit Kumar Tiwari","orcid":"https://orcid.org/0000-0002-7427-7155","observed_orcids":["https://orcid.org/0000-0002-7427-7155"]},"institutions":[{"id":"https://openalex.org/I79620101","display_name":"University of Arkansas for Medical Sciences","ror":"https://ror.org/00xcryt71","country_code":"US","type":"education","lineage":["https://openalex.org/I79620101"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amit K. Tiwari","raw_affiliation_strings":["College of Pharmacy, University of Arkansas for Medical Sciences, Arkansas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, University of Arkansas for Medical Sciences, Arkansas, USA","institution_ids":["https://openalex.org/I79620101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5152589984","display_name":"Andrew D Patterson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]},{"id":"https://openalex.org/I4405268258","display_name":"Penn State Cancer Institute","ror":"https://ror.org/00bzx1854","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4405268258"]},{"id":"https://openalex.org/I82783531","display_name":"Penn State Milton S. Hershey Medical Center","ror":"https://ror.org/01h22ap11","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I82783531"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew D. Patterson","raw_affiliation_strings":["Department of Biology, The Pennsylvania State University, University Park, PA, USA","Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA, USA","Penn State Cancer Institute, Hershey, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, The Pennsylvania State University, University Park, PA, USA","institution_ids":["https://openalex.org/I130769515"]},{"raw_affiliation_string":"Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA, USA","institution_ids":["https://openalex.org/I130769515"]},{"raw_affiliation_string":"Penn State Cancer Institute, Hershey, PA, USA","institution_ids":["https://openalex.org/I4405268258","https://openalex.org/I82783531"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101637234","display_name":"Vishal Singh","orcid":"https://orcid.org/0000-0003-3577-1713","observed_orcids":["https://orcid.org/0000-0003-3577-1713"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]},{"id":"https://openalex.org/I4405268258","display_name":"Penn State Cancer Institute","ror":"https://ror.org/00bzx1854","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4405268258"]},{"id":"https://openalex.org/I82783531","display_name":"Penn State Milton S. Hershey Medical Center","ror":"https://ror.org/01h22ap11","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I82783531"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Vishal Singh","raw_affiliation_strings":["Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA, USA","One Health Microbiome Center, Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA, USA","Penn State Cancer Institute, Hershey, PA, USA"],"raw_orcid":"https://orcid.org/0000-0003-3577-1713","affiliations":[{"raw_affiliation_string":"Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA, USA","institution_ids":["https://openalex.org/I130769515"]},{"raw_affiliation_string":"One Health Microbiome Center, Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA, USA","institution_ids":["https://openalex.org/I130769515"]},{"raw_affiliation_string":"Penn State Cancer Institute, Hershey, PA, USA","institution_ids":["https://openalex.org/I4405268258","https://openalex.org/I82783531"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5101637234"],"corresponding_institution_ids":["https://openalex.org/I130769515","https://openalex.org/I4405268258","https://openalex.org/I82783531"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12489","display_name":"Microbial Metabolites in Food Biotechnology","score":0.010300000198185444,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10866","display_name":"Nutritional Studies and Diet","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dietary-fiber","display_name":"dietary fiber","score":0.9929999709129333},{"id":"https://openalex.org/keywords/colon-cancer","display_name":"colon cancer","score":0.7699999809265137},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.8880000114440918},{"id":"https://openalex.org/keywords/inulin","display_name":"inulin","score":0.9179999828338623},{"id":"https://openalex.org/keywords/azoxymethane","display_name":"azoxymethane","score":0.7599999904632568},{"id":"https://openalex.org/keywords/short-chain-fatty-acids","display_name":"short-chain fatty acids","score":0.9020000100135803},{"id":"https://openalex.org/keywords/microbial-fermentation","display_name":"microbial fermentation","score":0.6069999933242798},{"id":"https://openalex.org/keywords/amino-acid-metabolism","display_name":"amino acid metabolism","score":0.9110000133514404},{"id":"https://openalex.org/keywords/succinic-acid","display_name":"succinic acid","score":0.671999990940094},{"id":"https://openalex.org/keywords/fumarate","display_name":"fumarate","score":0.6919999718666077},{"id":"https://openalex.org/keywords/lactate","display_name":"lactate","score":0.953000009059906},{"id":"https://openalex.org/keywords/microbiome-metabolome-interactions","display_name":"microbiome-metabolome interactions","score":0.8339999914169312},{"id":"https://openalex.org/keywords/co-occurrence-networks","display_name":"co-occurrence networks","score":0.7509999871253967},{"id":"https://openalex.org/keywords/carcinogen-susceptibility","display_name":"carcinogen susceptibility","score":0.42100000381469727},{"id":"https://openalex.org/keywords/cellulose","display_name":"cellulose","score":0.6430000066757202},{"id":"https://openalex.org/keywords/agar","display_name":"agar","score":0.8040000200271606},{"id":"https://openalex.org/keywords/pectin","display_name":"pectin","score":1.0}],"concepts":[{"id":"https://openalex.org/C143121216","wikidata":"https://www.wikidata.org/wiki/Q1330402","display_name":"Microbiome","level":2,"score":0.7117000222206116},{"id":"https://openalex.org/C2778452354","wikidata":"https://www.wikidata.org/wiki/Q794084","display_name":"Azoxymethane","level":4,"score":0.6632999777793884},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6159999966621399},{"id":"https://openalex.org/C2775980262","wikidata":"https://www.wikidata.org/wiki/Q218870","display_name":"Prebiotic","level":2,"score":0.6033999919891357},{"id":"https://openalex.org/C2776979534","wikidata":"https://www.wikidata.org/wiki/Q193213","display_name":"Butyrate","level":3,"score":0.5655999779701233},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.5559999942779541},{"id":"https://openalex.org/C135870905","wikidata":"https://www.wikidata.org/wiki/Q903667","display_name":"Metabolome","level":3,"score":0.5537999868392944},{"id":"https://openalex.org/C539455810","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut flora","level":2,"score":0.541100025177002},{"id":"https://openalex.org/C21565614","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolomics","level":2,"score":0.5236999988555908},{"id":"https://openalex.org/C100544194","wikidata":"https://www.wikidata.org/wiki/Q41760","display_name":"Fermentation","level":2,"score":0.4747999906539917},{"id":"https://openalex.org/C2777695942","wikidata":"https://www.wikidata.org/wiki/Q149075","display_name":"Firmicutes","level":4,"score":0.47269999980926514},{"id":"https://openalex.org/C114246631","wikidata":"https://www.wikidata.org/wiki/Q187661","display_name":"Carcinogen","level":2,"score":0.414900004863739},{"id":"https://openalex.org/C61716771","wikidata":"https://www.wikidata.org/wiki/Q496","display_name":"Feces","level":2,"score":0.4043999910354614},{"id":"https://openalex.org/C2779742124","wikidata":"https://www.wikidata.org/wiki/Q201552","display_name":"Inulin","level":2,"score":0.3889999985694885},{"id":"https://openalex.org/C2992741425","wikidata":"https://www.wikidata.org/wiki/Q215210","display_name":"Dietary fiber","level":2,"score":0.3659999966621399},{"id":"https://openalex.org/C3019978661","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut microbiome","level":3,"score":0.36039999127388},{"id":"https://openalex.org/C2776633847","wikidata":"https://www.wikidata.org/wiki/Q574416","display_name":"Resistant starch","level":3,"score":0.34360000491142273},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.33739998936653137},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.33219999074935913},{"id":"https://openalex.org/C117717151","wikidata":"https://www.wikidata.org/wiki/Q3589155","display_name":"Epigenome","level":5,"score":0.33090001344680786},{"id":"https://openalex.org/C2780305828","wikidata":"https://www.wikidata.org/wiki/Q132656","display_name":"Bifidobacterium","level":4,"score":0.32919999957084656},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.32109999656677246},{"id":"https://openalex.org/C179264091","wikidata":"https://www.wikidata.org/wiki/Q410862","display_name":"Mucin","level":2,"score":0.3174999952316284},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.3174999952316284},{"id":"https://openalex.org/C2780423288","wikidata":"https://www.wikidata.org/wiki/Q7242440","display_name":"Prevotella","level":3,"score":0.30630001425743103},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.30329999327659607},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.30219998955726624},{"id":"https://openalex.org/C2780014933","wikidata":"https://www.wikidata.org/wiki/Q422956","display_name":"Propionate","level":2,"score":0.2906999886035919},{"id":"https://openalex.org/C3020179232","wikidata":"https://www.wikidata.org/wiki/Q11083","display_name":"Distal colon","level":2,"score":0.28949999809265137},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2863999903202057},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.28630000352859497},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2800000011920929},{"id":"https://openalex.org/C2778168646","wikidata":"https://www.wikidata.org/wiki/Q133186","display_name":"Bacteroides","level":3,"score":0.27399998903274536},{"id":"https://openalex.org/C2776258521","wikidata":"https://www.wikidata.org/wiki/Q4117942","display_name":"Diet and cancer","level":3,"score":0.273499995470047},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.2563999891281128},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2524999976158142}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.09.21.753221","doi":"https://doi.org/10.64898/2026.09.21.753221","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.21.753221","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/24/2026.09.21.753221.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.09.21.753221","doi":"https://doi.org/10.64898/2026.09.21.753221","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.21.753221","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/24/2026.09.21.753221.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9789000153541565,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320333182","display_name":"Huck Institutes of the Life Sciences","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7214207406.pdf","grobid_xml":"https://content.openalex.org/works/W7214207406.grobid-xml"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W1771974095","https://openalex.org/W1994687037","https://openalex.org/W2056279562","https://openalex.org/W2070863659","https://openalex.org/W2082565035","https://openalex.org/W2089532303","https://openalex.org/W2154480592","https://openalex.org/W2159675211","https://openalex.org/W2167496295","https://openalex.org/W2302003756","https://openalex.org/W2403901761","https://openalex.org/W2462303459","https://openalex.org/W2470512478","https://openalex.org/W2506843120","https://openalex.org/W2550084345","https://openalex.org/W2729285740","https://openalex.org/W2755653983","https://openalex.org/W2774486220","https://openalex.org/W2789789405","https://openalex.org/W2790478543","https://openalex.org/W2807564673","https://openalex.org/W2896926952","https://openalex.org/W2904251687","https://openalex.org/W2949004447","https://openalex.org/W2953937749","https://openalex.org/W2970045605","https://openalex.org/W2987653794","https://openalex.org/W2991479199","https://openalex.org/W3026296114","https://openalex.org/W3080270089","https://openalex.org/W3101477379","https://openalex.org/W3128646645","https://openalex.org/W3191012379","https://openalex.org/W4289111344","https://openalex.org/W4294216483","https://openalex.org/W4308432360","https://openalex.org/W4310467132","https://openalex.org/W4377116085","https://openalex.org/W4385230781","https://openalex.org/W4386600142","https://openalex.org/W4390584479","https://openalex.org/W4392755126","https://openalex.org/W4392984046","https://openalex.org/W4403484112","https://openalex.org/W4405738161","https://openalex.org/W4406705045","https://openalex.org/W4410974032","https://openalex.org/W7117702998","https://openalex.org/W7133294239","https://openalex.org/W7138971007","https://openalex.org/W7160533409"],"related_works":["https://openalex.org/W2400862818","https://openalex.org/W4387745809","https://openalex.org/W7170661897","https://openalex.org/W4385230781","https://openalex.org/W4387472583","https://openalex.org/W7107944803","https://openalex.org/W4308271409","https://openalex.org/W2325378878","https://openalex.org/W2094696314","https://openalex.org/W2790034894"],"abstract_inverted_index":{"ABSTRACT":[0],"Dietary":[1,257,529],"fiber":[2,15,233,258,530],"intake":[3,522],"is":[4,251,262,296],"broadly":[5],"associated":[6,264],"with":[7,121,180,265,328,409],"reduced":[8,267],"colorectal":[9,270,323,405,512,524,546],"cancer":[10,271,406,525,547],"(CRC)":[11],"risk,":[12],"yet":[13],"processed":[14,53,499],"supplements":[16],"exert":[17],"inconsistent":[18],"and":[19,82,104,126,151,155,160,167,172,219,238,285,295,332,356,359,364,372,377,481,501,523,539],"occasionally":[20],"opposing":[21],"effects":[22],"on":[23,67,145,254,349,457],"colon":[24,116],"tumorigenesis.":[25],"How":[26,453],"structurally":[27,46,196,449],"distinct":[28,47,304],"dietary":[29,48,305,504],"fibers":[30,49,306],"differentially":[31,307],"shape":[32,308],"the":[33,208,309,315,400,418,461,492,507,518],"gut":[34,209,293,301,310,468],"microbiome\u2013metabolome":[35,105,311],"axis":[36],"to":[37,52],"influence":[38],"carcinogenic":[39,338,465],"susceptibility":[40],"remains":[41],"poorly":[42],"understood.":[43],"We":[44],"compared":[45,120,327,408],"commonly":[50],"added":[51],"foods":[54,261,500],"in":[55,183,193,432,436,460,498,536],"an":[56],"experimental":[57],"model":[58],"of":[59,149,157,241,247,269,354,361,388,402,476,495,510],"sporadic":[60],"CRC.":[61],"Four-week-old":[62],"male":[63],"mice":[64,131,398],"were":[65,93,190,429],"maintained":[66],"low-fiber":[68],"control":[69,333],"or":[70,77],"fiber-supplemented":[71,331],"diets":[72],"(7.5%w/w:":[73],"cellulose,":[74],"agar,":[75],"pectin,":[76],"inulin)":[78],"for":[79,542],"28":[80],"weeks":[81],"received":[83],"eight":[84],"intraperitoneal":[85],"azoxymethane":[86],"injections":[87],"(AOM;":[88],"7.5mg/kg).":[89],"Temporal":[90],"fecal":[91],"microbiomes":[92],"profiled":[94],"by":[95,101,108],"16S-rRNA":[96],"sequencing,":[97],"cecal":[98,127],"metabolites":[99],"quantified":[100],"\u00b9H-NMR":[102],"spectroscopy,":[103],"interactions":[106],"assessed":[107],"co-occurrence":[109,188,427],"networks.":[110],"Refined":[111,318],"inulin":[112,205,319,497,521],"supplementation":[113,206,320],"markedly":[114],"elevated":[115,322,545],"tumor":[117,324,423],"incidence":[118,509],"(\u223c70%)":[119,326],"all":[122,329],"other":[123,330],"groups":[124,334],"(\u223c10\u201320%),":[125],"extracts":[128,395,410],"from":[129,259,396,411],"inulin-fed":[130,397],"promoted":[132],"HT29":[133],"cancer-cell":[134],"proliferation.":[135],"Longitudinal":[136,340],"microbiome":[137,210,341,469],"profiling":[138,342],"identified":[139,191,343,430],"36":[140,344],"inulin-specific":[141,345],"microbial":[142,346],"signatures":[143,347],"converging":[144,348],"two":[146,350],"axes:":[147,352],"depletion":[148,175,353],"SCFA-producing":[150,355],"fermentation":[152,217,479],"cross-feeding":[153,357],"taxa":[154,294],"reprogramming":[156,360],"amino":[158,173,221,362,378],"acid":[159,174,222,363,379],"nitrogen":[161,365],"metabolism.":[162,366],"Metabolomics":[163],"confirmed":[164,369],"succinate,":[165,370],"fumarate,":[166,371],"lactate":[168,373],"accumulation":[169,374],"alongside":[170,375,506],"propionate":[171,376],"exclusively":[176,192,381,431],"under":[177,336,382],"AOM":[178,383],"conditions,":[179,384,466],"no":[181],"differences":[182],"carcinogen-naive":[184,437],"animals.":[185],"Two":[186],"stable":[187],"hubs":[189,428],"AOM-treated":[194,433],"animals,":[195,434],"integrating":[197],"both":[198,281],"functional":[199,415],"axes.":[200],"These":[201],"findings":[202],"demonstrate":[203],"that":[204,224,417,440],"preconditions":[207],"toward":[211],"a":[212,229,236,266,274,282,286,389,448,472,488,503],"latent":[213],"metabolic":[214,391],"vulnerability,":[215],"disrupted":[216],"throughput":[218],"reprogrammed":[220],"metabolism,":[223],"carcinogen":[225,441],"exposure":[226,442],"amplifies":[227],"into":[228,447],"tumor-promoting":[230,451],"ecosystem,":[231],"establishing":[232,385],"structure":[234],"as":[235,280,299,487,502],"critical":[237],"underappreciated":[239],"determinant":[240],"CRC":[242],"susceptibility.":[243],"Graphical":[244],"abstract":[245],"Significance":[246],"this":[248,255],"study":[249],"What":[250,313],"already":[252],"known":[253],"subject?":[256],"whole":[260],"consistently":[263],"risk":[268,526],"(CRC).":[272],"Inulin,":[273],"highly":[275],"fermentable":[276],"fructan":[277],"used":[278],"widely":[279],"prebiotic":[283,489],"supplement":[284,540],"food":[287],"additive,":[288],"selectively":[289],"expands":[290],"putatively":[291],"beneficial":[292],"generally":[297],"regarded":[298],"promoting":[300],"health.":[302],"Structurally":[303],"axis.":[312],"are":[314,527],"new":[316],"findings?":[317],"dramatically":[321],"prevalence":[325],"(\u223c10\u201320%)":[335],"AOM-induced":[337],"conditions.":[339],"primary":[351],"taxa,":[358],"Cecal":[367,393],"metabolomics":[368],"depletion,":[380],"carcinogen-dependent":[386],"amplification":[387],"diet-preconditioned":[390],"vulnerability.":[392],"content":[394],"increased":[399],"proliferation":[401],"human":[403,515],"HT-29":[404],"cells":[407],"cellulose-fed":[412],"mice,":[413],"providing":[414],"evidence":[416],"inulin-conditioned":[419],"luminal":[420],"environment":[421],"supports":[422],"growth.":[424],"Stable":[425],"microbiome-metabolome":[426],"absent":[435],"counterparts,":[438],"demonstrating":[439],"consolidates":[443],"inulin-driven":[444,467],"community":[445],"restructuring":[446,470],"defined":[450],"ecosystem.":[452],"might":[454],"it":[455],"impact":[456],"clinical":[458,537],"practice":[459],"foreseeable":[462],"future?":[463],"Under":[464],"reveals":[471],"broader":[473],"dysbiotic":[474],"context":[475],"depleted":[477],"protective":[478],"capacity":[480],"oncometabolite":[482],"accumulation,":[483],"challenging":[484],"its":[485],"framing":[486],"benefit.":[490],"Given":[491],"increasing":[493],"use":[494],"isolated":[496],"supplement,":[505],"rising":[508],"early-onset":[511],"cancer,":[513],"prospective":[514],"studies":[516],"examining":[517],"association":[519],"between":[520],"warranted.":[528],"type":[531],"specificity":[532],"should":[533],"be":[534],"considered":[535],"recommendations":[538],"guidance":[541],"individuals":[543],"at":[544],"risk.":[548]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-09-25T00:00:00"}
