{"id":"https://openalex.org/W7214177602","doi":"https://doi.org/10.1038/s41467-026-77983-2","title":"Unnatural \u03b1-amino acid synthesis enabled by nickel-catalysed enantioselective hydrocarbamoylation of enamides via C\u2012H functionalisation","display_name":"Unnatural \u03b1-amino acid synthesis enabled by nickel-catalysed enantioselective hydrocarbamoylation of enamides via C\u2012H functionalisation","publication_year":2026,"publication_date":"2026-09-24","ids":{"openalex":"https://openalex.org/W7214177602","doi":"https://doi.org/10.1038/s41467-026-77983-2","pmid":"https://pubmed.ncbi.nlm.nih.gov/42928082","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13696686"},"language":"en","primary_location":{"id":"doi:10.1038/s41467-026-77983-2","doi":"https://doi.org/10.1038/s41467-026-77983-2","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-026-77983-2","pdf_url":"https://www.nature.com/articles/s41467-026-77983-2_reference.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41467-026-77983-2_reference.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101909990","display_name":"Xuemeng Chen","orcid":"https://orcid.org/0000-0003-3024-7488","observed_orcids":["https://orcid.org/0000-0003-3024-7488"]},"institutions":[{"id":"https://openalex.org/I96673099","display_name":"Technical University of Denmark","ror":"https://ror.org/04qtj9h94","country_code":"DK","type":"education","lineage":["https://openalex.org/I96673099"]}],"countries":["DK"],"is_corresponding":true,"raw_author_name":"Xuemeng Chen","raw_affiliation_strings":["Department of Chemistry, Technical University of Denmark, Kgs. Lyngby, Denmark. xuech@kemi.dtu.dk"],"raw_orcid":"https://orcid.org/0000-0003-3024-7488","affiliations":[{"raw_affiliation_string":"Department of Chemistry, Technical University of Denmark, Kgs. Lyngby, Denmark. xuech@kemi.dtu.dk","institution_ids":["https://openalex.org/I96673099"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041087516","display_name":"S\u00f8ren Kramer","orcid":"https://orcid.org/0000-0001-6075-9615","observed_orcids":["https://orcid.org/0000-0001-6075-9615"]},"institutions":[{"id":"https://openalex.org/I96673099","display_name":"Technical University of Denmark","ror":"https://ror.org/04qtj9h94","country_code":"DK","type":"education","lineage":["https://openalex.org/I96673099"]}],"countries":["DK"],"is_corresponding":true,"raw_author_name":"S\u00f8ren Kramer","raw_affiliation_strings":["Department of Chemistry, Technical University of Denmark, Kgs. Lyngby, Denmark. sokr@kemi.dtu.dk"],"raw_orcid":"https://orcid.org/0000-0001-6075-9615","affiliations":[{"raw_affiliation_string":"Department of Chemistry, Technical University of Denmark, Kgs. Lyngby, Denmark. sokr@kemi.dtu.dk","institution_ids":["https://openalex.org/I96673099"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5041087516","https://openalex.org/A5101909990"],"corresponding_institution_ids":["https://openalex.org/I96673099"],"apc_list":{"value":6990,"currency":"USD","value_usd":6990},"apc_paid":{"value":6990,"currency":"USD","value_usd":6990},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.57083367,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10013","display_name":"Asymmetric Synthesis and Catalysis","score":0.7026000022888184,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10013","display_name":"Asymmetric Synthesis and Catalysis","score":0.7026000022888184,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10701","display_name":"Radical Photochemical Reactions","score":0.1509999930858612,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12251","display_name":"Synthesis and Catalytic Reactions","score":0.027899999171495438,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/unnatural-amino-acids","display_name":"unnatural amino acids","score":0.8159999847412109},{"id":"https://openalex.org/keywords/alpha-amino-acid-synthesis","display_name":"\u03b1-amino acid synthesis","score":0.8320000171661377},{"id":"https://openalex.org/keywords/nickel-catalysis","display_name":"nickel catalysis","score":0.9869999885559082},{"id":"https://openalex.org/keywords/enamides","display_name":"enamides","score":0.996999979019165},{"id":"https://openalex.org/keywords/c-h-functionalization","display_name":"C\u2013H functionalization","score":0.9240000247955322},{"id":"https://openalex.org/keywords/asymmetric-synthesis","display_name":"asymmetric synthesis","score":0.5180000066757202}],"concepts":[{"id":"https://openalex.org/C146686406","wikidata":"https://www.wikidata.org/wiki/Q898628","display_name":"Enantioselective synthesis","level":3,"score":0.7903000116348267},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6305000185966492},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.4991999864578247},{"id":"https://openalex.org/C114373084","wikidata":"https://www.wikidata.org/wiki/Q273499","display_name":"Chemical synthesis","level":3,"score":0.3691999912261963},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.35910001397132874},{"id":"https://openalex.org/C129694887","wikidata":"https://www.wikidata.org/wiki/Q47455153","display_name":"Stereoisomerism","level":3,"score":0.34529998898506165},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.30970001220703125},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3003000020980835},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.26989999413490295},{"id":"https://openalex.org/C2779809887","wikidata":"https://www.wikidata.org/wiki/Q14864278","display_name":"Peptide synthesis","level":3,"score":0.23970000445842743}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1038/s41467-026-77983-2","doi":"https://doi.org/10.1038/s41467-026-77983-2","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-026-77983-2","pdf_url":"https://www.nature.com/articles/s41467-026-77983-2_reference.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13696686","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13696686/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13696686/pdf/41467_2026_Article_77983.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nat Commun","raw_type":"Text"},{"id":"pmid:42928082","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42928082","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature communications","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:86fba9f3f4454189a72a210ec3610de0","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/86fba9f3f4454189a72a210ec3610de0","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Communications, Vol 17, Iss 1 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41467-026-77983-2","doi":"https://doi.org/10.1038/s41467-026-77983-2","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-026-77983-2","pdf_url":"https://www.nature.com/articles/s41467-026-77983-2_reference.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1842573213","display_name":null,"funder_award_id":"5244-00010B","funder_id":"https://openalex.org/F4320322928","funder_display_name":"Danmarks Frie Forskningsfond"},{"id":"https://openalex.org/G2041187005","display_name":null,"funder_award_id":"NNF21OC0071458","funder_id":"https://openalex.org/F4320325957","funder_display_name":"Novo Nordisk Fonden"}],"funders":[{"id":"https://openalex.org/F4320322436","display_name":"Novo Nordisk","ror":"https://ror.org/0435rc536"},{"id":"https://openalex.org/F4320322928","display_name":"Danmarks Frie Forskningsfond","ror":"https://ror.org/02sptwz63"},{"id":"https://openalex.org/F4320325957","display_name":"Novo Nordisk Fonden","ror":"https://ror.org/04txyc737"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7214177602.pdf","grobid_xml":"https://content.openalex.org/works/W7214177602.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3163961142","https://openalex.org/W2773002248","https://openalex.org/W4360612501","https://openalex.org/W4280609025","https://openalex.org/W2528275019","https://openalex.org/W4289519009","https://openalex.org/W2754178805","https://openalex.org/W4408309662","https://openalex.org/W3044050250","https://openalex.org/W1998579473"],"abstract_inverted_index":{"Enantioselective":[0,143],"construction":[1,131,144],"of":[2,32,64,85,105,123,132,145,176],"unnatural":[3,73,146],"\u03b1-amino":[4,36,74,134,147,180],"acids":[5,75,148],"is":[6,127,149],"highly":[7,150],"desirable":[8,151],"due":[9,152],"to":[10,129,153],"their":[11,154],"widespread":[12,155],"applications":[13,156],"across":[14,157],"biochemistry,":[15,158],"medicinal":[16,159],"industry":[17,160],"and":[18,26,43,51,61,76,108,126,161,170,187,194],"materials":[19,162],"science.":[20,163],"Herein,":[21,164],"we":[22],"report":[23,167],"a":[24,100,120,168],"straightforward":[25,169],"efficient":[27,171],"method":[28,172],"for":[29,103,173],"the":[30,83,86,130,141,165,174],"assembly":[31,175],"structurally":[33,177],"diverse":[34,178],"enantioenriched":[35,133,179],"acid":[37,181],"derivatives":[38,182],"from":[39,183],"readily":[40,184],"accessible":[41,185],"enamides":[42,186],"N,N-dimethylformamide":[44,188],"(DMF)":[45],"by":[46,92,189],"merging":[47,190],"nickel":[48,191],"hydride":[49,192],"catalysis":[50,193],"hydrogen":[52,195],"atom":[53,196],"transfer":[54],"(HAT).":[55],"The":[56],"protocol":[57],"affords":[58],"good":[59],"yields":[60],"high":[62],"enantioselectivities":[63],"products":[65,87],"which":[66],"easily":[67],"can":[68,88],"be":[69,89],"converted":[70],"into":[71],"unprotected":[72],"other":[77],"valuable":[78],"chiral":[79],"building":[80],"blocks.":[81],"Notably,":[82],"enantiopurity":[84],"further":[90],"enhanced":[91],"normal":[93],"flash":[94],"chromatography":[95],"on":[96,140],"silica":[97],"gel,":[98],"providing":[99],"practical":[101],"platform":[102],"enantiopurification":[104],"both":[106],"oily":[107],"solid":[109],"products.":[110],"This":[111],"radical":[112],"cross-coupling":[113],"reaction":[114],"proceeds":[115],"under":[116],"mild":[117],"conditions,":[118],"tolerates":[119],"broad":[121],"range":[122],"functional":[124],"groups":[125],"amenable":[128],"amides":[135],"bearing":[136],"active":[137],"pharmaceutical":[138],"ingredients":[139],"sidechain.":[142],"authors":[166],"transfer.":[197]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-09-25T00:00:00"}