{"id":"https://openalex.org/W7214129194","doi":"https://doi.org/10.7759/cureus.116776","title":"Exophytic Papillary Thyroid Carcinoma With Anaplastic Transformation in a Cervical Lymph Node: A Case Report and Review of the Literature","display_name":"Exophytic Papillary Thyroid Carcinoma With Anaplastic Transformation in a Cervical Lymph Node: A Case Report and Review of the Literature","publication_year":2026,"publication_date":"2026-09-23","ids":{"openalex":"https://openalex.org/W7214129194","doi":"https://doi.org/10.7759/cureus.116776","pmid":"https://pubmed.ncbi.nlm.nih.gov/42921160","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13693443"},"language":"en","primary_location":{"id":"doi:10.7759/cureus.116776","doi":"https://doi.org/10.7759/cureus.116776","is_oa":true,"landing_page_url":"https://doi.org/10.7759/cureus.116776","pdf_url":"https://www.cureus.com/articles/529616-exophytic-papillary-thyroid-carcinoma-with-anaplastic-transformation-in-a-cervical-lymph-node-a-case-report-and-review-of-the-literature.pdf","source":{"id":"https://openalex.org/S2738950867","display_name":"Cureus","issn_l":"2168-8184","issn":["2168-8184"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310316779","host_organization_name":"Cureus, Inc.","host_organization_lineage":["https://openalex.org/P4310316779"],"host_organization_lineage_names":["Cureus, Inc."],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.cureus.com/articles/529616-exophytic-papillary-thyroid-carcinoma-with-anaplastic-transformation-in-a-cervical-lymph-node-a-case-report-and-review-of-the-literature.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5126935363","display_name":"Israel Garc\u00eda Avilan","orcid":"https://orcid.org/0009-0001-5413-9919","observed_orcids":["https://orcid.org/0009-0001-5413-9919"]},"institutions":[{"id":"https://openalex.org/I4210132044","display_name":"Hospital Universitario Dr Jos\u00e9 Eleuterio Gonzalez","ror":"https://ror.org/030ms0x66","country_code":"MX","type":"healthcare","lineage":["https://openalex.org/I4210132044"]}],"countries":["MX"],"is_corresponding":true,"raw_author_name":"Israel Garcia Avil\u00e1n","raw_affiliation_strings":["General Surgery, Hospital Universitario \"Dr. Jos\u00e9 Eleuterio Gonz\u00e1lez\", Monterrey, MEX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"General Surgery, Hospital Universitario \"Dr. Jos\u00e9 Eleuterio Gonz\u00e1lez\", Monterrey, MEX","institution_ids":["https://openalex.org/I4210132044"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5152542023","display_name":"Oscar  R Garcia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210132044","display_name":"Hospital Universitario Dr Jos\u00e9 Eleuterio Gonzalez","ror":"https://ror.org/030ms0x66","country_code":"MX","type":"healthcare","lineage":["https://openalex.org/I4210132044"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Oscar  R Garcia","raw_affiliation_strings":["Oncology, Hospital Universitario \"Dr. Jos\u00e9 Eleuterio Gonz\u00e1lez\", Monterrey, MEX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology, Hospital Universitario \"Dr. Jos\u00e9 Eleuterio Gonz\u00e1lez\", Monterrey, MEX","institution_ids":["https://openalex.org/I4210132044"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5152521640","display_name":"Jesus Delgado","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210132044","display_name":"Hospital Universitario Dr Jos\u00e9 Eleuterio Gonzalez","ror":"https://ror.org/030ms0x66","country_code":"MX","type":"healthcare","lineage":["https://openalex.org/I4210132044"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Jesus Delgado","raw_affiliation_strings":["General Surgery, Hospital Universitario \"Dr. Jos\u00e9 Eleuterio Gonz\u00e1lez\", Monterrey, MEX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"General Surgery, Hospital Universitario \"Dr. Jos\u00e9 Eleuterio Gonz\u00e1lez\", Monterrey, MEX","institution_ids":["https://openalex.org/I4210132044"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5138169693","display_name":"Brandon  A Lopez Alanis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210132044","display_name":"Hospital Universitario Dr Jos\u00e9 Eleuterio Gonzalez","ror":"https://ror.org/030ms0x66","country_code":"MX","type":"healthcare","lineage":["https://openalex.org/I4210132044"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Brandon Lopez Alanis","raw_affiliation_strings":["General Surgery, Hospital Universitario \"Dr. Jos\u00e9 Eleuterio Gonz\u00e1lez\", Monterrey, MEX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"General Surgery, Hospital Universitario \"Dr. Jos\u00e9 Eleuterio Gonz\u00e1lez\", Monterrey, MEX","institution_ids":["https://openalex.org/I4210132044"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5119388311","display_name":"Flor E Ortiz-Villeda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210132044","display_name":"Hospital Universitario Dr Jos\u00e9 Eleuterio Gonzalez","ror":"https://ror.org/030ms0x66","country_code":"MX","type":"healthcare","lineage":["https://openalex.org/I4210132044"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Flor Ortiz Villeda","raw_affiliation_strings":["Pathology, Hospital Universitario \"Dr. Jos\u00e9 Eleuterio Gonz\u00e1lez\", Monterrey, MEX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathology, Hospital Universitario \"Dr. Jos\u00e9 Eleuterio Gonz\u00e1lez\", Monterrey, MEX","institution_ids":["https://openalex.org/I4210132044"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5126935363"],"corresponding_institution_ids":["https://openalex.org/I4210132044"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.66660045,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"18","issue":"9","first_page":"e116776","last_page":"e116776"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11728","display_name":"Thyroid and Parathyroid Surgery","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12631","display_name":"Head and Neck Anomalies","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/papillary-thyroid-carcinoma","display_name":"papillary thyroid carcinoma","score":0.996999979019165},{"id":"https://openalex.org/keywords/anaplastic-transformation","display_name":"anaplastic transformation","score":0.8960000276565552},{"id":"https://openalex.org/keywords/tall-cell-variant","display_name":"tall cell variant","score":0.7770000100135803},{"id":"https://openalex.org/keywords/cervical-lymph-node-metastasis","display_name":"cervical lymph node metastasis","score":0.9909999966621399},{"id":"https://openalex.org/keywords/total-thyroidectomy","display_name":"total thyroidectomy","score":0.7369999885559082},{"id":"https://openalex.org/keywords/radical-neck-dissection","display_name":"radical neck dissection","score":0.9760000109672546},{"id":"https://openalex.org/keywords/internal-jugular-vein-compression","display_name":"internal jugular vein compression","score":0.6959999799728394},{"id":"https://openalex.org/keywords/skin-ulcers","display_name":"skin ulcers","score":0.7139999866485596}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9855999946594238},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.7003999948501587},{"id":"https://openalex.org/C2778549279","wikidata":"https://www.wikidata.org/wiki/Q962200","display_name":"Cervical lymph nodes","level":4,"score":0.5271000266075134},{"id":"https://openalex.org/C2993294228","wikidata":"https://www.wikidata.org/wiki/Q13632630","display_name":"Thyroid carcinoma","level":3,"score":0.515500009059906},{"id":"https://openalex.org/C2778981773","wikidata":"https://www.wikidata.org/wiki/Q4751574","display_name":"Anaplastic carcinoma","level":3,"score":0.4569000005722046},{"id":"https://openalex.org/C2993477687","wikidata":"https://www.wikidata.org/wiki/Q2292945","display_name":"Papillary carcinoma","level":4,"score":0.43790000677108765},{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.3528999984264374},{"id":"https://openalex.org/C31033888","wikidata":"https://www.wikidata.org/wiki/Q752076","display_name":"Malignant transformation","level":2,"score":0.3375999927520752},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.32030001282691956},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.3190000057220459},{"id":"https://openalex.org/C2779720271","wikidata":"https://www.wikidata.org/wiki/Q179422","display_name":"Lymph","level":2,"score":0.31790000200271606},{"id":"https://openalex.org/C2780263296","wikidata":"https://www.wikidata.org/wiki/Q486082","display_name":"Anaplasia","level":2,"score":0.304500013589859},{"id":"https://openalex.org/C2780256643","wikidata":"https://www.wikidata.org/wiki/Q3658382","display_name":"Anaplastic thyroid cancer","level":4,"score":0.29829999804496765},{"id":"https://openalex.org/C2781461381","wikidata":"https://www.wikidata.org/wiki/Q2292945","display_name":"Papillary thyroid cancer","level":4,"score":0.29019999504089355}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.7759/cureus.116776","doi":"https://doi.org/10.7759/cureus.116776","is_oa":true,"landing_page_url":"https://doi.org/10.7759/cureus.116776","pdf_url":"https://www.cureus.com/articles/529616-exophytic-papillary-thyroid-carcinoma-with-anaplastic-transformation-in-a-cervical-lymph-node-a-case-report-and-review-of-the-literature.pdf","source":{"id":"https://openalex.org/S2738950867","display_name":"Cureus","issn_l":"2168-8184","issn":["2168-8184"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310316779","host_organization_name":"Cureus, Inc.","host_organization_lineage":["https://openalex.org/P4310316779"],"host_organization_lineage_names":["Cureus, Inc."],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13693443","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13693443/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13693443/pdf/cureus-0018-00000116776.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"Text"},{"id":"pmid:42921160","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42921160","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"Case Reports"}],"best_oa_location":{"id":"doi:10.7759/cureus.116776","doi":"https://doi.org/10.7759/cureus.116776","is_oa":true,"landing_page_url":"https://doi.org/10.7759/cureus.116776","pdf_url":"https://www.cureus.com/articles/529616-exophytic-papillary-thyroid-carcinoma-with-anaplastic-transformation-in-a-cervical-lymph-node-a-case-report-and-review-of-the-literature.pdf","source":{"id":"https://openalex.org/S2738950867","display_name":"Cureus","issn_l":"2168-8184","issn":["2168-8184"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310316779","host_organization_name":"Cureus, Inc.","host_organization_lineage":["https://openalex.org/P4310316779"],"host_organization_lineage_names":["Cureus, Inc."],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7214129194.pdf","grobid_xml":"https://content.openalex.org/works/W7214129194.grobid-xml"},"referenced_works_count":7,"referenced_works":["https://openalex.org/W2527230395","https://openalex.org/W3031753978","https://openalex.org/W3136581988","https://openalex.org/W4281560401","https://openalex.org/W4407815182","https://openalex.org/W4411335269","https://openalex.org/W4413972333"],"related_works":["https://openalex.org/W3098520547","https://openalex.org/W7119041538","https://openalex.org/W3200928736","https://openalex.org/W3031753978","https://openalex.org/W4285088186","https://openalex.org/W2408448257","https://openalex.org/W4407815182","https://openalex.org/W4403417072","https://openalex.org/W2956453035","https://openalex.org/W3160310797"],"abstract_inverted_index":{"Papillary":[0],"thyroid":[1,12,130,166,174],"carcinoma":[2,175],"(PTC)":[3],"is":[4,225],"the":[5,11,119,159,165,177,200],"most":[6],"common":[7],"malignant":[8],"neoplasm":[9],"of":[10,27,50,118,158,164,176,196,202,218],"and":[13,33,42,58,87,126,136,145,162,198,207,222,231],"generally":[14],"follows":[15],"an":[16,47,151,191],"indolent":[17],"clinical":[18],"course":[19],"with":[20,71,103,114,133,156,180,213],"favorable":[21],"long-term":[22],"survival.":[23],"However,":[24],"a":[25,62,72,80,95,127],"subset":[26],"tumors":[28],"may":[29],"develop":[30],"aggressive":[31,193,219],"histological":[32,220],"locoregional":[34,194],"features,":[35],"including":[36],"tall-cell":[37,178],"morphology,":[38],"extensive":[39,110,152],"extrathyroidal":[40],"extension,":[41],"anaplastic":[43,59,181,223],"transformation.":[44],"We":[45],"report":[46],"unusual":[48],"presentation":[49,195],"PTC":[51,197],"characterized":[52],"by":[53,84],"massive":[54],"exophytic":[55,100],"cervical":[56,64,77,101,112,153,184,215],"growth":[57],"transformation":[60,182,224],"within":[61,183],"metastatic":[63],"lymph":[65,185],"node.":[66],"A":[67],"76-year-old":[68],"man":[69],"presented":[70],"progressively":[73],"enlarging":[74],"right":[75,111,129,146],"lateral":[76],"mass":[78,102,132],"over":[79],"two-year":[81],"history,":[82],"accompanied":[83],"hoarseness,":[85],"dysphonia,":[86],"dyspnea":[88],"on":[89],"moderate":[90],"exertion.":[91],"Physical":[92],"examination":[93,171],"revealed":[94],"15":[96,98],"\u00d7":[97],"cm":[99],"overlying":[104],"skin":[105],"ulceration.":[106],"Computed":[107],"tomography":[108],"demonstrated":[109,172],"lymphadenopathy":[113],"central":[115],"necrosis,":[116],"compression":[117],"ipsilateral":[120],"internal":[121,134],"jugular":[122],"vein,":[123],"airway":[124],"displacement,":[125],"heterogeneous":[128],"lobe":[131],"calcifications":[135],"poorly":[137],"defined":[138],"margins.":[139],"The":[140],"patient":[141],"underwent":[142],"total":[143],"thyroidectomy":[144],"radical":[147],"neck":[148],"dissection.":[149],"Intraoperatively,":[150],"nodal":[154],"conglomerate":[155],"infiltration":[157],"sternocleidomastoid":[160],"muscle":[161],"involvement":[163],"cartilage":[167],"was":[168],"identified.":[169],"Histopathological":[170],"papillary":[173],"subtype":[179],"node":[186],"metastasis.":[187],"This":[188],"case":[189],"highlights":[190],"exceptionally":[192],"emphasizes":[199],"importance":[201],"comprehensive":[203],"clinical,":[204],"radiological,":[205],"surgical,":[206],"histopathological":[208],"assessment":[209],"in":[210],"patients":[211],"presenting":[212],"bulky":[214],"disease.":[216],"Recognition":[217],"features":[221],"essential":[226],"for":[227],"appropriate":[228],"multidisciplinary":[229],"management":[230],"prognostic":[232],"assessment.":[233]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-09-24T00:00:00"}