{"id":"https://openalex.org/W7214119760","doi":"https://doi.org/10.3390/biology15191695","title":"Comparative Genomics of NGF, NTRK1, and NGFR Across Chordates: Joint Gene Recovery and Region-Specific Constraint","display_name":"Comparative Genomics of NGF, NTRK1, and NGFR Across Chordates: Joint Gene Recovery and Region-Specific Constraint","publication_year":2026,"publication_date":"2026-09-23","ids":{"openalex":"https://openalex.org/W7214119760","doi":"https://doi.org/10.3390/biology15191695","pmid":"https://pubmed.ncbi.nlm.nih.gov/42883368","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13663574"},"language":"en","primary_location":{"id":"doi:10.3390/biology15191695","doi":"https://doi.org/10.3390/biology15191695","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biology15191695","pdf_url":null,"source":{"id":"https://openalex.org/S153489431","display_name":"Biology","issn_l":"2079-7737","issn":["2079-7737"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/biology15191695","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100446636","display_name":"Zhimin Li","orcid":"https://orcid.org/0000-0003-0833-0023","observed_orcids":["https://orcid.org/0000-0003-0833-0023"]},"institutions":[{"id":"https://openalex.org/I4210087107","display_name":"Jiangsu Academy of Agricultural Sciences","ror":"https://ror.org/001f9e125","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210087107"]},{"id":"https://openalex.org/I4210151987","display_name":"Ministry of Agriculture and Rural Affairs","ror":"https://ror.org/05ckt8b96","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210127390","https://openalex.org/I4210151987"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhimin Li","raw_affiliation_strings":["Institute of Veterinary Medicine, Jiangsu Academy of Agricultural Sciences, Key Laboratory of Veterinary Biologicals Engineering and Technology, Ministry of Agriculture and Rural Affairs, National Center for Engineering Research of Veterinary Bio-Products, Nanjing 210014, China"],"raw_orcid":"https://orcid.org/0000-0003-0833-0023","affiliations":[{"raw_affiliation_string":"Institute of Veterinary Medicine, Jiangsu Academy of Agricultural Sciences, Key Laboratory of Veterinary Biologicals Engineering and Technology, Ministry of Agriculture and Rural Affairs, National Center for Engineering Research of Veterinary Bio-Products, Nanjing 210014, China","institution_ids":["https://openalex.org/I4210087107","https://openalex.org/I4210151987"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100338496","display_name":"Xiaojie Liu","orcid":"https://orcid.org/0000-0001-9843-1674","observed_orcids":["https://orcid.org/0000-0001-9843-1674"]},"institutions":[{"id":"https://openalex.org/I152031979","display_name":"Nanjing Normal University","ror":"https://ror.org/036trcv74","country_code":"CN","type":"education","lineage":["https://openalex.org/I152031979"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaojie Liu","raw_affiliation_strings":["School of Marine Science and Engineering, Nanjing Normal University, Nanjing 210023, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Marine Science and Engineering, Nanjing Normal University, Nanjing 210023, China","institution_ids":["https://openalex.org/I152031979"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100342823","display_name":"Ya Zhang","orcid":"https://orcid.org/0000-0002-2158-0660","observed_orcids":["https://orcid.org/0000-0002-2158-0660"]},"institutions":[{"id":"https://openalex.org/I4210087107","display_name":"Jiangsu Academy of Agricultural Sciences","ror":"https://ror.org/001f9e125","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210087107"]},{"id":"https://openalex.org/I4210151987","display_name":"Ministry of Agriculture and Rural Affairs","ror":"https://ror.org/05ckt8b96","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210127390","https://openalex.org/I4210151987"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ya Zhang","raw_affiliation_strings":["Institute of Veterinary Medicine, Jiangsu Academy of Agricultural Sciences, Key Laboratory of Veterinary Biologicals Engineering and Technology, Ministry of Agriculture and Rural Affairs, National Center for Engineering Research of Veterinary Bio-Products, Nanjing 210014, China"],"raw_orcid":"https://orcid.org/0000-0002-2158-0660","affiliations":[{"raw_affiliation_string":"Institute of Veterinary Medicine, Jiangsu Academy of Agricultural Sciences, Key Laboratory of Veterinary Biologicals Engineering and Technology, Ministry of Agriculture and Rural Affairs, National Center for Engineering Research of Veterinary Bio-Products, Nanjing 210014, China","institution_ids":["https://openalex.org/I4210087107","https://openalex.org/I4210151987"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076610694","display_name":"Yeping Tan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087107","display_name":"Jiangsu Academy of Agricultural Sciences","ror":"https://ror.org/001f9e125","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210087107"]},{"id":"https://openalex.org/I4210151987","display_name":"Ministry of Agriculture and Rural Affairs","ror":"https://ror.org/05ckt8b96","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210127390","https://openalex.org/I4210151987"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yeping Tan","raw_affiliation_strings":["Institute of Veterinary Medicine, Jiangsu Academy of Agricultural Sciences, Key Laboratory of Veterinary Biologicals Engineering and Technology, Ministry of Agriculture and Rural Affairs, National Center for Engineering Research of Veterinary Bio-Products, Nanjing 210014, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Veterinary Medicine, Jiangsu Academy of Agricultural Sciences, Key Laboratory of Veterinary Biologicals Engineering and Technology, Ministry of Agriculture and Rural Affairs, National Center for Engineering Research of Veterinary Bio-Products, Nanjing 210014, China","institution_ids":["https://openalex.org/I4210087107","https://openalex.org/I4210151987"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5076610694"],"corresponding_institution_ids":["https://openalex.org/I4210087107","https://openalex.org/I4210151987"],"apc_list":{"value":2700,"currency":"CHF","value_usd":3258},"apc_paid":{"value":2700,"currency":"CHF","value_usd":3258},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.5856858,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"15","issue":"19","first_page":"1695","last_page":"1695"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.9253000020980835,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.9253000020980835,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.022700000554323196,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10483","display_name":"Nerve injury and regeneration","score":0.013700000010430813,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nerve-growth-factor","display_name":"nerve growth factor","score":0.9990000128746033},{"id":"https://openalex.org/keywords/ntrk1","display_name":"NTRK1","score":0.9879999756813049},{"id":"https://openalex.org/keywords/nerve-growth-factor-receptor","display_name":"nerve growth factor receptor","score":0.8820000290870667},{"id":"https://openalex.org/keywords/p75-neurotrophin-receptor","display_name":"p75 neurotrophin receptor","score":0.8930000066757202},{"id":"https://openalex.org/keywords/neurotrophins","display_name":"neurotrophins","score":0.9430000185966492},{"id":"https://openalex.org/keywords/trk-receptors","display_name":"Trk receptors","score":0.9089999794960022},{"id":"https://openalex.org/keywords/gene-family-evolution","display_name":"gene family evolution","score":0.5299999713897705},{"id":"https://openalex.org/keywords/chordate-phylogeny","display_name":"chordate phylogeny","score":0.6769999861717224},{"id":"https://openalex.org/keywords/purifying-selection","display_name":"purifying selection","score":0.7120000123977661},{"id":"https://openalex.org/keywords/dn-ds-ratio","display_name":"dN/dS ratio","score":0.7260000109672546},{"id":"https://openalex.org/keywords/protein-structure-conservation","display_name":"protein structure conservation","score":0.3400000035762787},{"id":"https://openalex.org/keywords/gnathostomes","display_name":"gnathostomes","score":0.7279999852180481},{"id":"https://openalex.org/keywords/sensory-neurons","display_name":"sensory neurons","score":0.3970000147819519},{"id":"https://openalex.org/keywords/pain-signaling","display_name":"pain signaling","score":0.8450000286102295}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9193999767303467},{"id":"https://openalex.org/C134139212","wikidata":"https://www.wikidata.org/wiki/Q24719927","display_name":"Trk receptor","level":4,"score":0.84170001745224},{"id":"https://openalex.org/C92020748","wikidata":"https://www.wikidata.org/wiki/Q420457","display_name":"Neurotrophin","level":3,"score":0.5809999704360962},{"id":"https://openalex.org/C105176652","wikidata":"https://www.wikidata.org/wiki/Q1147112","display_name":"Comparative genomics","level":5,"score":0.5710999965667725},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.5394999980926514},{"id":"https://openalex.org/C132538176","wikidata":"https://www.wikidata.org/wiki/Q24768287","display_name":"Semaphorin","level":3,"score":0.49300000071525574},{"id":"https://openalex.org/C84597430","wikidata":"https://www.wikidata.org/wiki/Q106227","display_name":"Locus (genetics)","level":3,"score":0.4708999991416931},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4675000011920929},{"id":"https://openalex.org/C2778423431","wikidata":"https://www.wikidata.org/wiki/Q417782","display_name":"Nerve growth factor","level":3,"score":0.4187999963760376},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4090999960899353},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.40220001339912415},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.39579999446868896},{"id":"https://openalex.org/C189206191","wikidata":"https://www.wikidata.org/wiki/Q222046","display_name":"Genomics","level":4,"score":0.3702999949455261},{"id":"https://openalex.org/C149904235","wikidata":"https://www.wikidata.org/wiki/Q7049620","display_name":"Nonsynonymous substitution","level":4,"score":0.34369999170303345},{"id":"https://openalex.org/C160539049","wikidata":"https://www.wikidata.org/wiki/Q3064187","display_name":"Neurotrophic factors","level":3,"score":0.32260000705718994},{"id":"https://openalex.org/C194583182","wikidata":"https://www.wikidata.org/wiki/Q21114084","display_name":"Alternative splicing","level":4,"score":0.31200000643730164},{"id":"https://openalex.org/C161078062","wikidata":"https://www.wikidata.org/wiki/Q1068690","display_name":"Functional genomics","level":5,"score":0.2867000102996826},{"id":"https://openalex.org/C2778794669","wikidata":"https://www.wikidata.org/wiki/Q43054","display_name":"Neuron","level":2,"score":0.28029999136924744},{"id":"https://openalex.org/C195221683","wikidata":"https://www.wikidata.org/wiki/Q5000649","display_name":"Bursting","level":2,"score":0.27959999442100525},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2773999869823456},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.2685000002384186},{"id":"https://openalex.org/C138025448","wikidata":"https://www.wikidata.org/wiki/Q7662597","display_name":"Synonymous substitution","level":5,"score":0.2578999996185303},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.25519999861717224}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3390/biology15191695","doi":"https://doi.org/10.3390/biology15191695","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biology15191695","pdf_url":null,"source":{"id":"https://openalex.org/S153489431","display_name":"Biology","issn_l":"2079-7737","issn":["2079-7737"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13663574","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13663574/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13663574/pdf/biology-15-01695.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biology (Basel)","raw_type":"Text"},{"id":"pmid:42883368","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42883368","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:c6af2bc7d5ae49d6a3837fe5847dd4a8","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/c6af2bc7d5ae49d6a3837fe5847dd4a8","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biology, Vol 15, Iss 19, p 1695 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/biology15191695","doi":"https://doi.org/10.3390/biology15191695","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biology15191695","pdf_url":null,"source":{"id":"https://openalex.org/S153489431","display_name":"Biology","issn_l":"2079-7737","issn":["2079-7737"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320309870","display_name":"Jiangsu Agricultural Science and Technology Innovation Fund","ror":"https://ror.org/0335n2618"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7214119760.pdf","grobid_xml":"https://content.openalex.org/works/W7214119760.grobid-xml"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W1877097897","https://openalex.org/W1919497317","https://openalex.org/W2007539627","https://openalex.org/W2010562878","https://openalex.org/W2011207394","https://openalex.org/W2012423618","https://openalex.org/W2025788832","https://openalex.org/W2039677400","https://openalex.org/W2042912378","https://openalex.org/W2047405437","https://openalex.org/W2058286067","https://openalex.org/W2059218765","https://openalex.org/W2061041720","https://openalex.org/W2063420395","https://openalex.org/W2063695629","https://openalex.org/W2066577103","https://openalex.org/W2067296006","https://openalex.org/W2073611916","https://openalex.org/W2088010752","https://openalex.org/W2093089884","https://openalex.org/W2110065044","https://openalex.org/W2110335151","https://openalex.org/W2115888213","https://openalex.org/W2119628780","https://openalex.org/W2132926880","https://openalex.org/W2138122982","https://openalex.org/W2139565721","https://openalex.org/W2160378127","https://openalex.org/W2195302323","https://openalex.org/W2281531600","https://openalex.org/W2299441997","https://openalex.org/W2609354761","https://openalex.org/W2936330600","https://openalex.org/W2970147901","https://openalex.org/W3005235420","https://openalex.org/W3162264013","https://openalex.org/W3184440907","https://openalex.org/W3194902694","https://openalex.org/W4206079600","https://openalex.org/W4220860296","https://openalex.org/W4238448866","https://openalex.org/W4308616062","https://openalex.org/W4309506674","https://openalex.org/W4378908138","https://openalex.org/W4391132111","https://openalex.org/W4394818993","https://openalex.org/W4400353742","https://openalex.org/W4402800197","https://openalex.org/W4409386888","https://openalex.org/W4417178792","https://openalex.org/W7151224350"],"related_works":["https://openalex.org/W2042912378","https://openalex.org/W4249091248","https://openalex.org/W2084212915","https://openalex.org/W4409386888","https://openalex.org/W2059218765","https://openalex.org/W2326058873","https://openalex.org/W4388309970","https://openalex.org/W2119628780","https://openalex.org/W7096614647","https://openalex.org/W2081589840"],"abstract_inverted_index":{"Nerve":[0],"growth":[1],"factor":[2,39],"(NGF)":[3],"is":[4,51],"a":[5,33,170,250],"neurotrophin":[6,24,267],"central":[7],"to":[8,123,131,179],"sensory":[9],"neuron":[10],"biology":[11],"and":[12,16,25,47,65,83,90,98,107,115,127,163,220,242,256],"pain":[13],"signaling.":[14],"NGF":[15,168],"NTRK1":[17,60],"are":[18,56],"gnathostome":[19],"paralogs":[20],"within":[21,264],"the":[22,36,69,80,136,175,186,198,201,205,212,265],"older":[23,266],"Trk":[26,70,239],"families,":[27],"respectively,":[28],"whereas":[29],"NGFR":[30,48,66],"encodes":[31],"p75NTR,":[32],"member":[34],"of":[35,44,79,174,177,253],"tumor":[37],"necrosis":[38],"receptor":[40,71,91],"superfamily.":[41],"Orthology":[42],"assessment":[43],"NGF,":[45],"NTRK1,":[46],"across":[49],"vertebrates":[50],"challenging":[52],"because":[53],"mature":[54],"neurotrophins":[55],"short,":[57],"cysteine-rich":[58],"ligands,":[59],"has":[61],"closely":[62],"related":[63],"paralogs,":[64],"lies":[67],"outside":[68],"family.":[72],"We":[73],"assessed":[74],"species-level":[75],"joint":[76,147,153],"genomic":[77],"recovery":[78,101,133,255],"three":[81,137],"genes":[82],"compared":[84],"evolutionary":[85,125],"constraint":[86,259],"among":[87],"predefined":[88],"ligand":[89],"regions.":[92,245],"The":[93,217],"analysis":[94],"covered":[95],"94":[96],"chordates":[97],"combined":[99],"graded":[100],"evidence":[102,158],"with":[103,160],"family":[104],"phylogenies,":[105],"locus":[106],"domain":[108],"evidence,":[109],"codon":[110],"models,":[111],"amino":[112],"acid":[113],"conservation,":[114],"structural":[116,207],"mapping.":[117],"Sixteen":[118],"non-gnathostome":[119,262],"species":[120],"were":[121,128,195],"included":[122],"provide":[124,249],"context":[126],"not":[129,224],"used":[130],"calculate":[132],"rates":[134,182],"for":[135],"focal":[138],"genes.":[139],"Among":[140],"78":[141],"sampled":[142],"gnathostomes,":[143],"52":[144],"had":[145,150,156,169],"high-confidence":[146],"recovery,":[148,154],"eight":[149],"supported":[151],"provisional":[152],"four":[155],"component-level":[157],"consistent":[159],"possible":[161],"co-recovery,":[162],"14":[164],"remained":[165],"incomplete.":[166],"Mature":[167],"numerically":[171],"lower":[172],"estimate":[173],"ratio":[176],"nonsynonymous":[178],"synonymous":[180],"substitution":[181],"(dN/dS,":[183],"\u03c9)":[184],"than":[185],"pro-domain":[187],"(0.067":[188],"versus":[189],"0.352).":[190],"All":[191],"six":[192],"scaffold":[193,203],"cysteines":[194],"invariant;":[196],"in":[197,238],"residue-class":[199],"comparison,":[200],"cysteine":[202],"was":[204],"only":[206],"class":[208],"that":[209,228],"differed":[210],"from":[211,227],"coordinate-resolved":[213],"background":[214,229],"after":[215,230],"correction.":[216,231],"dimer-interface,":[218],"TrkA-contact,":[219],"p75NTR-contact":[221],"classes":[222],"did":[223],"differ":[225],"significantly":[226],"Receptor":[232],"analyses":[233],"yielded":[234],"low":[235],"\u03c9":[236],"estimates":[237],"kinase":[240],"domains":[241],"p75NTR":[243],"intracellular":[244],"Together,":[246],"these":[247],"results":[248],"confidence-graded":[251],"map":[252],"focal-gene":[254],"regional":[257],"purifying":[258],"while":[260],"placing":[261],"homologs":[263],"system.":[268]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-09-24T00:00:00"}
