{"id":"https://openalex.org/W7214115484","doi":"https://doi.org/10.1016/j.ajps.2026.101203","title":"Spatiotemporally stratified nanoassemblies for precisely halting the immunothrombotic vicious cycle in acute lung inflammation","display_name":"Spatiotemporally stratified nanoassemblies for precisely halting the immunothrombotic vicious cycle in acute lung inflammation","publication_year":2026,"publication_date":"2026-09-23","ids":{"openalex":"https://openalex.org/W7214115484","doi":"https://doi.org/10.1016/j.ajps.2026.101203","pmid":"https://pubmed.ncbi.nlm.nih.gov/42953335","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13715425"},"language":"en","primary_location":{"id":"doi:10.1016/j.ajps.2026.101203","doi":"https://doi.org/10.1016/j.ajps.2026.101203","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ajps.2026.101203","pdf_url":"https://www.sciencedirect.com/science/article/pii/S1818087626000899/pdf","source":{"id":"https://openalex.org/S2764650913","display_name":"Asian Journal of Pharmaceutical Sciences","issn_l":"1818-0876","issn":["1818-0876","2221-285X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Asian Journal of Pharmaceutical Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.sciencedirect.com/science/article/pii/S1818087626000899/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5141267242","display_name":"Cong Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118803816","display_name":"Liaoning University","ror":"https://ror.org/03xpwj629","country_code":"CN","type":"education","lineage":["https://openalex.org/I118803816"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Cong Li","raw_affiliation_strings":["Liaoning Key Laboratory of New Drug Research & Development, Liaoning University, Shenyang, 110036, China","School of Pharmaceutical Science, Liaoning University, Shenyang 110036, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Liaoning Key Laboratory of New Drug Research & Development, Liaoning University, Shenyang, 110036, China","institution_ids":["https://openalex.org/I118803816"]},{"raw_affiliation_string":"School of Pharmaceutical Science, Liaoning University, Shenyang 110036, China","institution_ids":["https://openalex.org/I118803816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5134296297","display_name":"Yuqing Ni","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118803816","display_name":"Liaoning University","ror":"https://ror.org/03xpwj629","country_code":"CN","type":"education","lineage":["https://openalex.org/I118803816"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuqing Ni","raw_affiliation_strings":["School of Pharmaceutical Science, Liaoning University, Shenyang 110036, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmaceutical Science, Liaoning University, Shenyang 110036, China","institution_ids":["https://openalex.org/I118803816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5134315686","display_name":"Jianqiang Huang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118803816","display_name":"Liaoning University","ror":"https://ror.org/03xpwj629","country_code":"CN","type":"education","lineage":["https://openalex.org/I118803816"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jianqiang Huang","raw_affiliation_strings":["School of Pharmaceutical Science, Liaoning University, Shenyang 110036, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmaceutical Science, Liaoning University, Shenyang 110036, China","institution_ids":["https://openalex.org/I118803816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5152558590","display_name":"Jing Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118803816","display_name":"Liaoning University","ror":"https://ror.org/03xpwj629","country_code":"CN","type":"education","lineage":["https://openalex.org/I118803816"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing Li","raw_affiliation_strings":["School of Pharmaceutical Science, Liaoning University, Shenyang 110036, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmaceutical Science, Liaoning University, Shenyang 110036, China","institution_ids":["https://openalex.org/I118803816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5134292764","display_name":"Yuqing Zheng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118803816","display_name":"Liaoning University","ror":"https://ror.org/03xpwj629","country_code":"CN","type":"education","lineage":["https://openalex.org/I118803816"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuqing Zheng","raw_affiliation_strings":["School of Pharmaceutical Science, Liaoning University, Shenyang 110036, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmaceutical Science, Liaoning University, Shenyang 110036, China","institution_ids":["https://openalex.org/I118803816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100376938","display_name":"Yifan Zhang","orcid":"https://orcid.org/0000-0002-5908-9164","observed_orcids":["https://orcid.org/0000-0002-5908-9164"]},"institutions":[{"id":"https://openalex.org/I118803816","display_name":"Liaoning University","ror":"https://ror.org/03xpwj629","country_code":"CN","type":"education","lineage":["https://openalex.org/I118803816"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yifan Zhang","raw_affiliation_strings":["School of Pharmaceutical Science, Liaoning University, Shenyang 110036, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmaceutical Science, Liaoning University, Shenyang 110036, China","institution_ids":["https://openalex.org/I118803816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048218488","display_name":"Lianrui Cao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118803816","display_name":"Liaoning University","ror":"https://ror.org/03xpwj629","country_code":"CN","type":"education","lineage":["https://openalex.org/I118803816"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lianrui Cao","raw_affiliation_strings":["School of Pharmaceutical Science, Liaoning University, Shenyang 110036, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmaceutical Science, Liaoning University, Shenyang 110036, China","institution_ids":["https://openalex.org/I118803816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100379695","display_name":"Zeyu Wang","orcid":"https://orcid.org/0000-0002-6675-5399","observed_orcids":["https://orcid.org/0000-0002-6675-5399"]},"institutions":[{"id":"https://openalex.org/I118803816","display_name":"Liaoning University","ror":"https://ror.org/03xpwj629","country_code":"CN","type":"education","lineage":["https://openalex.org/I118803816"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zeyu Wang","raw_affiliation_strings":["School of Pharmaceutical Science, Liaoning University, Shenyang 110036, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmaceutical Science, Liaoning University, Shenyang 110036, China","institution_ids":["https://openalex.org/I118803816"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008884564","display_name":"Lijiang Chen","orcid":"https://orcid.org/0000-0001-6168-5419","observed_orcids":["https://orcid.org/0000-0001-6168-5419"]},"institutions":[{"id":"https://openalex.org/I118803816","display_name":"Liaoning University","ror":"https://ror.org/03xpwj629","country_code":"CN","type":"education","lineage":["https://openalex.org/I118803816"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Lijiang Chen","raw_affiliation_strings":["Liaoning Key Laboratory of New Drug Research & Development, Liaoning University, Shenyang, 110036, China","School of Pharmaceutical Science, Liaoning University, Shenyang 110036, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Liaoning Key Laboratory of New Drug Research & Development, Liaoning University, Shenyang, 110036, China","institution_ids":["https://openalex.org/I118803816"]},{"raw_affiliation_string":"School of Pharmaceutical Science, Liaoning University, Shenyang 110036, China","institution_ids":["https://openalex.org/I118803816"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5008884564","https://openalex.org/A5141267242"],"corresponding_institution_ids":["https://openalex.org/I118803816"],"apc_list":{"value":0,"currency":"USD","value_usd":0},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.53346146,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"21","issue":"5","first_page":"101203","last_page":"101203"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11651","display_name":"Inhalation and Respiratory Drug Delivery","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-lung-injury","display_name":"acute lung injury","score":0.9100000262260437},{"id":"https://openalex.org/keywords/acute-respiratory-distress-syndrome","display_name":"acute respiratory distress syndrome","score":0.9190000295639038},{"id":"https://openalex.org/keywords/pulmonary-thrombosis","display_name":"pulmonary thrombosis","score":0.8399999737739563},{"id":"https://openalex.org/keywords/tannic-acid","display_name":"tannic acid","score":0.8709999918937683},{"id":"https://openalex.org/keywords/tlr4","display_name":"TLR4","score":0.9539999961853027},{"id":"https://openalex.org/keywords/macrophage-targeting","display_name":"macrophage targeting","score":0.8019999861717224},{"id":"https://openalex.org/keywords/dexamethasone","display_name":"dexamethasone","score":0.8090000152587891},{"id":"https://openalex.org/keywords/glucocorticoid-receptor","display_name":"glucocorticoid receptor","score":0.8349999785423279},{"id":"https://openalex.org/keywords/fe3-fe2-redox","display_name":"Fe2+/Fe3+ redox","score":0.8309999704360962},{"id":"https://openalex.org/keywords/proton-sponge-effect","display_name":"proton sponge effect","score":0.7940000295639038},{"id":"https://openalex.org/keywords/neutrophil-extracellular-traps","display_name":"neutrophil extracellular traps","score":0.871999979019165},{"id":"https://openalex.org/keywords/neutrophil-activation","display_name":"neutrophil activation","score":0.800000011920929},{"id":"https://openalex.org/keywords/cytokine-storm","display_name":"cytokine storm","score":0.6480000019073486},{"id":"https://openalex.org/keywords/nanoplatforms","display_name":"nanoplatforms","score":0.4429999887943268}],"concepts":[{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.6833999752998352},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5996000170707703},{"id":"https://openalex.org/C134897094","wikidata":"https://www.wikidata.org/wiki/Q7003141","display_name":"Neutrophil extracellular traps","level":3,"score":0.5519000291824341},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.5318999886512756},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.43849998712539673},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4237000048160553},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.41350001096725464},{"id":"https://openalex.org/C2778382381","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Coagulation","level":2,"score":0.40860000252723694},{"id":"https://openalex.org/C2780401358","wikidata":"https://www.wikidata.org/wiki/Q422252","display_name":"Dexamethasone","level":2,"score":0.4065000116825104},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.3880000114440918},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.38510000705718994},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3822000026702881},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3779999911785126},{"id":"https://openalex.org/C2780868729","wikidata":"https://www.wikidata.org/wiki/Q261327","display_name":"Thrombosis","level":2,"score":0.36980000138282776},{"id":"https://openalex.org/C2777292125","wikidata":"https://www.wikidata.org/wiki/Q409166","display_name":"Thrombin","level":3,"score":0.36399999260902405},{"id":"https://openalex.org/C2779559532","wikidata":"https://www.wikidata.org/wiki/Q1076369","display_name":"Cytokine storm","level":5,"score":0.35830000042915344},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.33180001378059387},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.33090001344680786},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.31869998574256897},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.3165000081062317},{"id":"https://openalex.org/C123012128","wikidata":"https://www.wikidata.org/wiki/Q5376430","display_name":"Endothelial stem cell","level":3,"score":0.3068999946117401},{"id":"https://openalex.org/C3018697912","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Platelet activation","level":3,"score":0.3057999908924103},{"id":"https://openalex.org/C2781362458","wikidata":"https://www.wikidata.org/wiki/Q1588755","display_name":"Thrombus","level":2,"score":0.2955000102519989},{"id":"https://openalex.org/C9418649","wikidata":"https://www.wikidata.org/wiki/Q5275407","display_name":"Diffuse alveolar damage","level":4,"score":0.29350000619888306},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.29260000586509705},{"id":"https://openalex.org/C2776992346","wikidata":"https://www.wikidata.org/wiki/Q111140","display_name":"Endothelium","level":2,"score":0.29249998927116394},{"id":"https://openalex.org/C2780545709","wikidata":"https://www.wikidata.org/wiki/Q21130552","display_name":"HMGB1","level":3,"score":0.2919999957084656},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.2904999852180481},{"id":"https://openalex.org/C2107291","wikidata":"https://www.wikidata.org/wiki/Q14886885","display_name":"Mediator","level":2,"score":0.2840000092983246},{"id":"https://openalex.org/C2776348555","wikidata":"https://www.wikidata.org/wiki/Q344873","display_name":"ARDS","level":3,"score":0.27900001406669617},{"id":"https://openalex.org/C2781156865","wikidata":"https://www.wikidata.org/wiki/Q827023","display_name":"Lesion","level":2,"score":0.27730000019073486},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.2653000056743622},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.26420000195503235},{"id":"https://openalex.org/C141983124","wikidata":"https://www.wikidata.org/wiki/Q188008","display_name":"Respiratory distress","level":2,"score":0.2540999948978424}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1016/j.ajps.2026.101203","doi":"https://doi.org/10.1016/j.ajps.2026.101203","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ajps.2026.101203","pdf_url":"https://www.sciencedirect.com/science/article/pii/S1818087626000899/pdf","source":{"id":"https://openalex.org/S2764650913","display_name":"Asian Journal of Pharmaceutical Sciences","issn_l":"1818-0876","issn":["1818-0876","2221-285X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Asian Journal of Pharmaceutical Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13715425","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13715425/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13715425/pdf/main.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Asian J Pharm Sci","raw_type":"Text"},{"id":"pmid:42953335","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42953335","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Asian journal of pharmaceutical sciences","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:ef82c3704d72459b8691fde0f65d3e65","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/ef82c3704d72459b8691fde0f65d3e65","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Asian Journal of Pharmaceutical Sciences, Vol 21, Iss 5, Pp 101203- (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.ajps.2026.101203","doi":"https://doi.org/10.1016/j.ajps.2026.101203","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ajps.2026.101203","pdf_url":"https://www.sciencedirect.com/science/article/pii/S1818087626000899/pdf","source":{"id":"https://openalex.org/S2764650913","display_name":"Asian Journal of Pharmaceutical Sciences","issn_l":"1818-0876","issn":["1818-0876","2221-285X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Asian Journal of Pharmaceutical Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1270982222","display_name":null,"funder_award_id":"2024JH2/102500018","funder_id":"https://openalex.org/F4320327473","funder_display_name":"Department of Science and Technology of Liaoning Province"},{"id":"https://openalex.org/G2935699696","display_name":null,"funder_award_id":"2023-BS-086","funder_id":"https://openalex.org/F4320327473","funder_display_name":"Department of Science and Technology of Liaoning Province"},{"id":"https://openalex.org/G4082459584","display_name":null,"funder_award_id":"JYTQN2023188","funder_id":"https://openalex.org/F4320324560","funder_display_name":"Department of Education of Liaoning Province"},{"id":"https://openalex.org/G4741986130","display_name":null,"funder_award_id":"LNUYJS017","funder_id":"https://openalex.org/F4320324783","funder_display_name":"Liaoning University"},{"id":"https://openalex.org/G629836668","display_name":null,"funder_award_id":"LJ212410140022","funder_id":"https://openalex.org/F4320324560","funder_display_name":"Department of Education of Liaoning Province"}],"funders":[{"id":"https://openalex.org/F4320324560","display_name":"Department of Education of Liaoning Province","ror":"https://ror.org/0022v2454"},{"id":"https://openalex.org/F4320324783","display_name":"Liaoning University","ror":"https://ror.org/03xpwj629"},{"id":"https://openalex.org/F4320327473","display_name":"Department of Science and Technology of Liaoning Province","ror":"https://ror.org/02f09cx53"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7214115484.pdf","grobid_xml":"https://content.openalex.org/works/W7214115484.grobid-xml"},"referenced_works_count":69,"referenced_works":["https://openalex.org/W1519600901","https://openalex.org/W1804398254","https://openalex.org/W1973419152","https://openalex.org/W2091970332","https://openalex.org/W2467345325","https://openalex.org/W2769886493","https://openalex.org/W2894291739","https://openalex.org/W2901055023","https://openalex.org/W2914542421","https://openalex.org/W2963114940","https://openalex.org/W3036581531","https://openalex.org/W3124318210","https://openalex.org/W3135444181","https://openalex.org/W3157841475","https://openalex.org/W3162787232","https://openalex.org/W3163838535","https://openalex.org/W3165704088","https://openalex.org/W3194738017","https://openalex.org/W3199661018","https://openalex.org/W4205813232","https://openalex.org/W4210382886","https://openalex.org/W4220815932","https://openalex.org/W4221066773","https://openalex.org/W4221080581","https://openalex.org/W4223955255","https://openalex.org/W4250801983","https://openalex.org/W4281683632","https://openalex.org/W4281715437","https://openalex.org/W4281911095","https://openalex.org/W4281978555","https://openalex.org/W4308555404","https://openalex.org/W4320482591","https://openalex.org/W4366241063","https://openalex.org/W4376630097","https://openalex.org/W4382502013","https://openalex.org/W4382725546","https://openalex.org/W4382934316","https://openalex.org/W4386000936","https://openalex.org/W4388641627","https://openalex.org/W4390378411","https://openalex.org/W4391283747","https://openalex.org/W4392316411","https://openalex.org/W4394763195","https://openalex.org/W4396809209","https://openalex.org/W4396856587","https://openalex.org/W4403117317","https://openalex.org/W4403711941","https://openalex.org/W4403965880","https://openalex.org/W4405256076","https://openalex.org/W4406811602","https://openalex.org/W4406920613","https://openalex.org/W4407071481","https://openalex.org/W4407924156","https://openalex.org/W4407948288","https://openalex.org/W4408467114","https://openalex.org/W4408665810","https://openalex.org/W4408884667","https://openalex.org/W4409327267","https://openalex.org/W4410587209","https://openalex.org/W4411023029","https://openalex.org/W4411900465","https://openalex.org/W4412001376","https://openalex.org/W4412088787","https://openalex.org/W4412418436","https://openalex.org/W4412882519","https://openalex.org/W4414104052","https://openalex.org/W4414140357","https://openalex.org/W7127145383","https://openalex.org/W7155702218"],"related_works":["https://openalex.org/W2132587838","https://openalex.org/W2963299979","https://openalex.org/W4410587209","https://openalex.org/W2991483990","https://openalex.org/W3150271790","https://openalex.org/W1999059810","https://openalex.org/W4406973247","https://openalex.org/W1604909258","https://openalex.org/W7214191988","https://openalex.org/W4391374136"],"abstract_inverted_index":{"ABSTRACT":[0],"Acute":[1],"lung":[2,228,244],"injury":[3,229],"and":[4,28,49,53,85,149,169,195,203,219,247,258,265],"acute":[5,227],"respiratory":[6],"distress":[7],"syndrome":[8],"have":[9],"high":[10],"mortality.":[11],"Extensive":[12],"pulmonary":[13,119],"microvascular":[14],"thrombosis":[15,29],"occurs":[16],"in":[17],"over":[18],"80%":[19],"of":[20,226,242],"patients":[21],"who":[22],"die":[23],"from":[24,167],"severe":[25],"pneumonia.":[26],"Inflammation":[27],"mutually":[30],"aggravate":[31],"each":[32],"other,":[33],"forming":[34],"a":[35,90,97,223,256],"vicious":[36],"cycle":[37],"that":[38],"accelerates":[39],"disease":[40],"progression.":[41],"Nevertheless,":[42],"it":[43],"remains":[44],"challenging":[45],"to":[46,82],"achieve":[47],"safe":[48],"balanced":[50],"anti-inflammatory":[51],"treatment":[52],"systemic":[54],"anticoagulation.":[55,134],"These":[56],"two":[57],"pathological":[58],"processes":[59],"are":[60,73,157,179],"spatially":[61],"separated,":[62],"coagulation":[63],"arises":[64],"on":[65,116,160],"the":[66,110,117,122,144,161,173,182,212,240,243],"vascular":[67],"endothelial":[68,220],"surface,":[69],"while":[70],"inflammatory":[71],"signals":[72],"confined":[74],"inside":[75],"immune":[76],"cells.":[77],"Current":[78],"therapeutic":[79],"strategies":[80],"fail":[81],"realize":[83],"simultaneous":[84],"precise":[86,257],"dual":[87],"regulation":[88,210],"within":[89],"single":[91],"delivery":[92],"system.":[93],"Therefore,":[94],"we":[95],"developed":[96],"spatiotemporally":[98],"hierarchical":[99],"responsive":[100],"nanoplatform":[101,234],"called":[102],"Hep-PBA/Dex@TAF.":[103],"The":[104,135,189],"outer":[105],"Hep-PBA":[106,131],"layer":[107],"accumulates":[108],"at":[109],"lesion":[111],"sites":[112],"by":[113,141,215,231],"targeting":[114],"P-selectin":[115],"inflamed":[118],"endothelium.":[120],"In":[121,222,251],"weakly":[123],"acidic":[124],"local":[125,133],"microenvironment,":[126],"boronate-ester":[127],"bonds":[128],"break,":[129],"releasing":[130],"for":[132,262],"exposed":[136],"Dex@TAF":[137],"core":[138],"is":[139,170],"internalized":[140],"macrophages":[142],"through":[143],"recognition":[145],"between":[146],"tannic":[147],"acid":[148],"toll-like":[150],"receptor":[151],"4.":[152],"Subsequently,":[153],"intracellular":[154],"metal-polyphenol":[155],"networks":[156],"disassembled.":[158],"Relying":[159],"proton":[162],"sponge":[163],"effect,":[164],"dexamethasone":[165,191],"escapes":[166],"lysosomes":[168],"released":[171,190],"into":[172],"cytoplasm,":[174],"whereas":[175],"reactive":[176],"oxygen":[177],"species":[178],"eliminated":[180],"via":[181],"Fe":[183],"2+":[184],"/Fe":[185],"3+":[186],"redox":[187],"cycle.":[188],"activates":[192],"glucocorticoid":[193],"receptors":[194],"suppresses":[196],"proinflammatory":[197],"transcription,":[198],"further":[199],"reducing":[200],"neutrophil":[201,204],"activation":[202,218],"extracellular":[205],"trap":[206],"production.":[207],"This":[208],"synergistic":[209],"blocks":[211],"inflammation-thrombosis":[213],"cascade":[214],"alleviating":[216],"platelet":[217],"injury.":[221],"mouse":[224],"model":[225],"complicated":[230],"thrombosis,":[232],"this":[233],"markedly":[235],"alleviated":[236],"cytokine":[237],"storms,":[238],"preserved":[239],"integrity":[241],"tissue":[245],"structure,":[246],"inhibited":[248],"microthrombus":[249],"formation.":[250],"conclusion,":[252],"Hep-PBA/Dex@TAF":[253],"serves":[254],"as":[255],"dual-functional":[259],"intervention":[260],"strategy":[261],"comorbid":[263],"inflammation":[264],"thrombosis.":[266]},"counts_by_year":[],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2026-09-24T00:00:00"}