{"id":"https://openalex.org/W7214110562","doi":"https://doi.org/10.3390/ijms27198491","title":"Time to Heal: MicroRNA Temporal Dysregulation in Diabetic Foot Ulcers","display_name":"Time to Heal: MicroRNA Temporal Dysregulation in Diabetic Foot Ulcers","publication_year":2026,"publication_date":"2026-09-23","ids":{"openalex":"https://openalex.org/W7214110562","doi":"https://doi.org/10.3390/ijms27198491","pmid":"https://pubmed.ncbi.nlm.nih.gov/42883745","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13665434"},"language":"en","primary_location":{"id":"doi:10.3390/ijms27198491","doi":"https://doi.org/10.3390/ijms27198491","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms27198491","pdf_url":null,"source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/ijms27198491","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5146832431","display_name":"Lingyu Pan","orcid":"https://orcid.org/0009-0000-0411-7933","observed_orcids":["https://orcid.org/0009-0000-0411-7933"]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I2800091995","display_name":"West China Medical Center of Sichuan University","ror":"https://ror.org/040nggs60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I24185976","https://openalex.org/I2800091995"]},{"id":"https://openalex.org/I4210089761","display_name":"West China Hospital of Sichuan University","ror":"https://ror.org/007mrxy13","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089761"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lingyu Pan","raw_affiliation_strings":["Department of Dermatology and Venereology, West China Hospital, Sichuan University, Chengdu 610041, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology and Venereology, West China Hospital, Sichuan University, Chengdu 610041, China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I2800091995","https://openalex.org/I4210089761"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5152543741","display_name":"Lingyun Zhao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I2800091995","display_name":"West China Medical Center of Sichuan University","ror":"https://ror.org/040nggs60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I24185976","https://openalex.org/I2800091995"]},{"id":"https://openalex.org/I4210089761","display_name":"West China Hospital of Sichuan University","ror":"https://ror.org/007mrxy13","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089761"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lingyun Zhao","raw_affiliation_strings":["Department of Dermatology and Venereology, West China Hospital, Sichuan University, Chengdu 610041, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology and Venereology, West China Hospital, Sichuan University, Chengdu 610041, China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I2800091995","https://openalex.org/I4210089761"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100424761","display_name":"Jinfeng Liu","orcid":"https://orcid.org/0000-0002-0343-8222","observed_orcids":["https://orcid.org/0000-0002-0343-8222","https://orcid.org/0009-0005-9897-2178"]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I2800091995","display_name":"West China Medical Center of Sichuan University","ror":"https://ror.org/040nggs60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I24185976","https://openalex.org/I2800091995"]},{"id":"https://openalex.org/I4210089761","display_name":"West China Hospital of Sichuan University","ror":"https://ror.org/007mrxy13","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089761"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jinfeng Liu","raw_affiliation_strings":["Department of Dermatology and Venereology, West China Hospital, Sichuan University, Chengdu 610041, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology and Venereology, West China Hospital, Sichuan University, Chengdu 610041, China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I2800091995","https://openalex.org/I4210089761"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5152551592","display_name":"You Mou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I2800091995","display_name":"West China Medical Center of Sichuan University","ror":"https://ror.org/040nggs60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I24185976","https://openalex.org/I2800091995"]},{"id":"https://openalex.org/I4210089761","display_name":"West China Hospital of Sichuan University","ror":"https://ror.org/007mrxy13","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089761"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"You Mou","raw_affiliation_strings":["Department of Dermatology and Venereology, West China Hospital, Sichuan University, Chengdu 610041, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology and Venereology, West China Hospital, Sichuan University, Chengdu 610041, China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I2800091995","https://openalex.org/I4210089761"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016220263","display_name":"Kunju Wang","orcid":"https://orcid.org/0000-0001-7400-5603","observed_orcids":["https://orcid.org/0000-0001-7400-5603"]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I2800091995","display_name":"West China Medical Center of Sichuan University","ror":"https://ror.org/040nggs60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I24185976","https://openalex.org/I2800091995"]},{"id":"https://openalex.org/I4210089761","display_name":"West China Hospital of Sichuan University","ror":"https://ror.org/007mrxy13","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089761"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kaili Wang","raw_affiliation_strings":["Department of Dermatology and Venereology, West China Hospital, Sichuan University, Chengdu 610041, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology and Venereology, West China Hospital, Sichuan University, Chengdu 610041, China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I2800091995","https://openalex.org/I4210089761"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5152544451","display_name":"Xinyi Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I2800091995","display_name":"West China Medical Center of Sichuan University","ror":"https://ror.org/040nggs60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I24185976","https://openalex.org/I2800091995"]},{"id":"https://openalex.org/I4210089761","display_name":"West China Hospital of Sichuan University","ror":"https://ror.org/007mrxy13","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089761"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinyi Liu","raw_affiliation_strings":["Department of Dermatology and Venereology, West China Hospital, Sichuan University, Chengdu 610041, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology and Venereology, West China Hospital, Sichuan University, Chengdu 610041, China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I2800091995","https://openalex.org/I4210089761"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070863871","display_name":"Wei Hua","orcid":"https://orcid.org/0000-0002-3061-5749","observed_orcids":["https://orcid.org/0000-0002-3061-5749","https://orcid.org/0000-0002-1678-364X"]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I2800091995","display_name":"West China Medical Center of Sichuan University","ror":"https://ror.org/040nggs60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I24185976","https://openalex.org/I2800091995"]},{"id":"https://openalex.org/I4210089761","display_name":"West China Hospital of Sichuan University","ror":"https://ror.org/007mrxy13","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089761"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Wei Hua","raw_affiliation_strings":["Cosmetics Safety and Efficacy Evaluation Center, West China Hospital, Sichuan University, Chengdu 610041, China","Department of Dermatology and Venereology, West China Hospital, Sichuan University, Chengdu 610041, China"],"raw_orcid":"https://orcid.org/0000-0002-3061-5749","affiliations":[{"raw_affiliation_string":"Cosmetics Safety and Efficacy Evaluation Center, West China Hospital, Sichuan University, Chengdu 610041, China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I4210089761"]},{"raw_affiliation_string":"Department of Dermatology and Venereology, West China Hospital, Sichuan University, Chengdu 610041, China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I2800091995","https://openalex.org/I4210089761"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5070863871"],"corresponding_institution_ids":["https://openalex.org/I24185976","https://openalex.org/I2800091995","https://openalex.org/I4210089761"],"apc_list":{"value":2900,"currency":"CHF","value_usd":3499},"apc_paid":{"value":2900,"currency":"CHF","value_usd":3499},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.57086769,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"27","issue":"19","first_page":"8491","last_page":"8491"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.005799999926239252,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11227","display_name":"Diabetic Foot Ulcer Assessment and Management","score":0.00419999985024333,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/diabetic-foot-ulcer","display_name":"diabetic foot ulcer","score":0.9319999814033508},{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.9340000152587891},{"id":"https://openalex.org/keywords/temporal-gene-expression","display_name":"temporal gene expression","score":0.5199999809265137},{"id":"https://openalex.org/keywords/wound-healing","display_name":"wound healing","score":0.9959999918937683},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.9459999799728394},{"id":"https://openalex.org/keywords/circadian-regulation","display_name":"circadian regulation","score":0.7749999761581421},{"id":"https://openalex.org/keywords/hyperglycemia","display_name":"hyperglycemia","score":0.8550000190734863},{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.9739999771118164},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":1.0},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.8629999756813049},{"id":"https://openalex.org/keywords/granulation-tissue","display_name":"granulation tissue","score":0.6859999895095825},{"id":"https://openalex.org/keywords/vascular-repair","display_name":"vascular repair","score":0.6679999828338623},{"id":"https://openalex.org/keywords/microrna-delivery","display_name":"microRNA delivery","score":0.8130000233650208},{"id":"https://openalex.org/keywords/engineered-vesicles","display_name":"engineered vesicles","score":0.6840000152587891},{"id":"https://openalex.org/keywords/biomaterial-carriers","display_name":"biomaterial carriers","score":0.7670000195503235},{"id":"https://openalex.org/keywords/mirna-mimics-and-inhibitors","display_name":"miRNA mimics and inhibitors","score":0.8619999885559082}],"concepts":[{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.8176000118255615},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.5223000049591064},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5216000080108643},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.5041000247001648},{"id":"https://openalex.org/C2777858829","wikidata":"https://www.wikidata.org/wiki/Q52856","display_name":"Diabetic foot","level":3,"score":0.5005999803543091},{"id":"https://openalex.org/C2780269544","wikidata":"https://www.wikidata.org/wiki/Q1509074","display_name":"Wound healing","level":2,"score":0.49129998683929443},{"id":"https://openalex.org/C20518536","wikidata":"https://www.wikidata.org/wiki/Q6840469","display_name":"Microvesicles","level":4,"score":0.42750000953674316},{"id":"https://openalex.org/C2776055305","wikidata":"https://www.wikidata.org/wiki/Q1543255","display_name":"Granulation tissue","level":3,"score":0.40310001373291016},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.396699994802475},{"id":"https://openalex.org/C149364088","wikidata":"https://www.wikidata.org/wiki/Q185917","display_name":"Translation (biology)","level":4,"score":0.392300009727478},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.37310001254081726},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3702000081539154},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3529999852180481},{"id":"https://openalex.org/C2779368916","wikidata":"https://www.wikidata.org/wiki/Q425022","display_name":"Antagomir","level":4,"score":0.35280001163482666},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.3515999913215637},{"id":"https://openalex.org/C10854531","wikidata":"https://www.wikidata.org/wiki/Q1061415","display_name":"Regenerative medicine","level":3,"score":0.349700003862381},{"id":"https://openalex.org/C128544194","wikidata":"https://www.wikidata.org/wiki/Q474859","display_name":"Translational research","level":2,"score":0.3379000127315521},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.33219999074935913},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.33149999380111694},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.3305000066757202},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.31790000200271606},{"id":"https://openalex.org/C2778144972","wikidata":"https://www.wikidata.org/wiki/Q52859","display_name":"Diabetic foot ulcer","level":4,"score":0.3109999895095825},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.298799991607666},{"id":"https://openalex.org/C3020610862","wikidata":"https://www.wikidata.org/wiki/Q1540285","display_name":"Tissue repair","level":2,"score":0.2842000126838684},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.28290000557899475},{"id":"https://openalex.org/C2778271429","wikidata":"https://www.wikidata.org/wiki/Q1281049","display_name":"Neovascularization","level":3,"score":0.2808000147342682},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.274399995803833},{"id":"https://openalex.org/C109523444","wikidata":"https://www.wikidata.org/wiki/Q424216","display_name":"Matrix metalloproteinase","level":2,"score":0.26980000734329224},{"id":"https://openalex.org/C186836561","wikidata":"https://www.wikidata.org/wiki/Q1931516","display_name":"Microarray","level":4,"score":0.2662999927997589},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.26249998807907104},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.2574000060558319},{"id":"https://openalex.org/C137738243","wikidata":"https://www.wikidata.org/wiki/Q189092","display_name":"Cell migration","level":3,"score":0.2572000026702881},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.25589999556541443},{"id":"https://openalex.org/C49892992","wikidata":"https://www.wikidata.org/wiki/Q1540285","display_name":"Tissue engineering","level":2,"score":0.2524000108242035}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014945","descriptor_name":"Wound Healing","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D017719","descriptor_name":"Diabetic Foot","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D017719","descriptor_name":"Diabetic Foot","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017719","descriptor_name":"Diabetic Foot","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.3390/ijms27198491","doi":"https://doi.org/10.3390/ijms27198491","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms27198491","pdf_url":null,"source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13665434","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13665434/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13665434/pdf/ijms-27-08491.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Mol Sci","raw_type":"Text"},{"id":"pmid:42883745","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42883745","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular sciences","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3390/ijms27198491","doi":"https://doi.org/10.3390/ijms27198491","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms27198491","pdf_url":null,"source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6328108615","display_name":null,"funder_award_id":"82103767","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7214110562.pdf","grobid_xml":"https://content.openalex.org/works/W7214110562.grobid-xml"},"referenced_works_count":146,"referenced_works":["https://openalex.org/W1530925068","https://openalex.org/W1608217646","https://openalex.org/W1974102799","https://openalex.org/W1979364477","https://openalex.org/W1993038214","https://openalex.org/W2001760269","https://openalex.org/W2002393742","https://openalex.org/W2030458665","https://openalex.org/W2037953145","https://openalex.org/W2049772720","https://openalex.org/W2067647130","https://openalex.org/W2075860675","https://openalex.org/W2096407919","https://openalex.org/W2107156571","https://openalex.org/W2111025829","https://openalex.org/W2123943141","https://openalex.org/W2124957695","https://openalex.org/W2129994868","https://openalex.org/W2134161094","https://openalex.org/W2135666474","https://openalex.org/W2163294226","https://openalex.org/W2163716193","https://openalex.org/W2166864763","https://openalex.org/W2171139781","https://openalex.org/W2172693840","https://openalex.org/W2198454761","https://openalex.org/W2222979086","https://openalex.org/W2230281891","https://openalex.org/W2313938778","https://openalex.org/W2353982544","https://openalex.org/W2472286572","https://openalex.org/W2484877107","https://openalex.org/W2549531463","https://openalex.org/W2551343812","https://openalex.org/W2575888567","https://openalex.org/W2605619440","https://openalex.org/W2610590180","https://openalex.org/W2611096724","https://openalex.org/W2767440258","https://openalex.org/W2793035493","https://openalex.org/W2795151696","https://openalex.org/W2885395939","https://openalex.org/W2889277513","https://openalex.org/W2891186860","https://openalex.org/W2892642834","https://openalex.org/W2898378414","https://openalex.org/W2898522810","https://openalex.org/W2901270606","https://openalex.org/W2937261316","https://openalex.org/W2947016510","https://openalex.org/W2949422953","https://openalex.org/W2962904682","https://openalex.org/W2965314815","https://openalex.org/W2965911906","https://openalex.org/W2967786139","https://openalex.org/W2972156753","https://openalex.org/W3004046375","https://openalex.org/W3005783560","https://openalex.org/W3009047637","https://openalex.org/W3022574365","https://openalex.org/W3023903717","https://openalex.org/W3038490524","https://openalex.org/W3041023286","https://openalex.org/W3044416282","https://openalex.org/W3085959729","https://openalex.org/W3094891065","https://openalex.org/W3111799935","https://openalex.org/W3113278288","https://openalex.org/W3128240809","https://openalex.org/W3162290153","https://openalex.org/W3176013631","https://openalex.org/W3187178710","https://openalex.org/W3205920569","https://openalex.org/W4214764335","https://openalex.org/W4220946416","https://openalex.org/W4224231629","https://openalex.org/W4224440218","https://openalex.org/W4226016727","https://openalex.org/W4285592941","https://openalex.org/W4286715888","https://openalex.org/W4291000801","https://openalex.org/W4308131690","https://openalex.org/W4308580168","https://openalex.org/W4312092997","https://openalex.org/W4313816684","https://openalex.org/W4319333879","https://openalex.org/W4320179446","https://openalex.org/W4320496003","https://openalex.org/W4328053116","https://openalex.org/W4377823004","https://openalex.org/W4378347981","https://openalex.org/W4378529685","https://openalex.org/W4378649466","https://openalex.org/W4380367117","https://openalex.org/W4382918816","https://openalex.org/W4385605886","https://openalex.org/W4386015080","https://openalex.org/W4386271739","https://openalex.org/W4386517427","https://openalex.org/W4386705874","https://openalex.org/W4387002564","https://openalex.org/W4387567261","https://openalex.org/W4387747561","https://openalex.org/W4388570184","https://openalex.org/W4388594078","https://openalex.org/W4390954112","https://openalex.org/W4391328658","https://openalex.org/W4392920810","https://openalex.org/W4393144087","https://openalex.org/W4393307030","https://openalex.org/W4395456170","https://openalex.org/W4399009929","https://openalex.org/W4399706107","https://openalex.org/W4399929643","https://openalex.org/W4400080524","https://openalex.org/W4400786151","https://openalex.org/W4401541693","https://openalex.org/W4402537884","https://openalex.org/W4403118697","https://openalex.org/W4403442599","https://openalex.org/W4404568868","https://openalex.org/W4406786313","https://openalex.org/W4406795380","https://openalex.org/W4407932192","https://openalex.org/W4408041825","https://openalex.org/W4408726398","https://openalex.org/W4409828653","https://openalex.org/W4410114022","https://openalex.org/W4412824413","https://openalex.org/W4413773942","https://openalex.org/W4414748962","https://openalex.org/W4414759687","https://openalex.org/W4415104935","https://openalex.org/W4415782579","https://openalex.org/W4415954557","https://openalex.org/W4416235293","https://openalex.org/W4416808838","https://openalex.org/W4417121382","https://openalex.org/W7118942635","https://openalex.org/W7120090179","https://openalex.org/W7124175094","https://openalex.org/W7127631252","https://openalex.org/W7130380039","https://openalex.org/W7134179368","https://openalex.org/W7154251731","https://openalex.org/W7163392370"],"related_works":["https://openalex.org/W4402537884","https://openalex.org/W2891392488","https://openalex.org/W7167622147","https://openalex.org/W2408025807","https://openalex.org/W4408041825","https://openalex.org/W3028782684","https://openalex.org/W4285592941","https://openalex.org/W7205002036","https://openalex.org/W4327979079","https://openalex.org/W4285984959"],"abstract_inverted_index":{"Diabetic":[0],"foot":[1],"ulcers":[2],"(DFUs)":[3],"are":[4],"a":[5,172],"severe":[6],"complication":[7],"of":[8,108,143,171,188],"diabetes":[9],"characterized":[10],"by":[11],"delayed":[12,92],"healing,":[13,21],"infection":[14],"susceptibility,":[15],"and":[16,28,34,49,54,60,74,85,98,117,136,148,193],"tissue":[17,32,119],"necrosis.":[18],"During":[19],"normal":[20],"microRNA":[22],"(miRNA)":[23],"expression":[24],"changes":[25],"over":[26,185],"time":[27],"helps":[29],"regulate":[30],"inflammation,":[31],"formation,":[33],"matrix":[35],"remodeling.":[36],"The":[37,161],"same":[38],"miRNA":[39,68,111,134,144,156,174,183],"can":[40],"serve":[41],"opposing":[42],"roles":[43],"depending":[44],"on":[45],"cell":[46],"type,":[47],"timing,":[48],"wound":[50],"context.":[51],"Hyperglycemia,":[52],"hypoxia,":[53],"oxidative":[55],"stress":[56],"disrupt":[57],"these":[58,126],"processes":[59],"prolong":[61],"inflammation.":[62],"This":[63],"review":[64],"examines":[65],"how":[66,109],"altered":[67],"regulation":[69,122],"may":[70,113,123],"impair":[71,114],"wound-healing":[72],"transitions":[73],"vessel":[75],"maturation":[76],"in":[77,178],"DFUs.":[78,179],"We":[79],"organize":[80],"findings":[81],"from":[82],"experimental":[83],"models":[84],"human":[86,137,162],"samples":[87],"into":[88],"three":[89],"interpretive":[90],"patterns:":[91],"or":[93,101,176],"insufficient":[94],"induction,":[95],"aberrant":[96],"persistence,":[97],"temporal":[99],"inversion":[100],"phase-inappropriate":[102],"expression.":[103],"Angiogenesis":[104],"provides":[105],"an":[106],"example":[107],"disrupted":[110],"timing":[112],"vascular":[115],"repair":[116,159,202],"granulation":[118],"formation.":[120],"Circadian":[121],"further":[124],"influence":[125],"processes,":[127],"although":[128],"direct":[129],"evidence":[130],"linking":[131],"circadian":[132],"regulation,":[133],"dynamics,":[135],"DFUs":[138],"remains":[139],"limited.":[140],"Preclinical":[141],"studies":[142,163],"combinations,":[145],"engineered":[146],"vesicles,":[147],"biomaterial":[149],"carriers":[150],"suggest":[151],"opportunities":[152],"to":[153,195],"coordinate":[154],"local":[155],"delivery":[157,194],"with":[158],"needs.":[160],"reviewed":[164],"here":[165],"do":[166],"not":[167],"establish":[168],"clinical":[169],"efficacy":[170],"defined":[173],"mimic":[175],"inhibitor":[177],"Further":[180],"translation":[181],"requires":[182],"profiling":[184],"time,":[186],"assessment":[187],"the":[189,196,200],"wound's":[190],"biological":[191],"stage,":[192],"relevant":[197],"cells":[198],"during":[199],"appropriate":[201],"window.":[203]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-09-24T00:00:00"}
