{"id":"https://openalex.org/W7214101522","doi":"https://doi.org/10.3389/frph.2026.1933266","title":"Oligozoospermic infertile sperm with high ROS are more prone to epigenetic alterations","display_name":"Oligozoospermic infertile sperm with high ROS are more prone to epigenetic alterations","publication_year":2026,"publication_date":"2026-09-23","ids":{"openalex":"https://openalex.org/W7214101522","doi":"https://doi.org/10.3389/frph.2026.1933266","pmid":"https://pubmed.ncbi.nlm.nih.gov/42845961","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13642678"},"language":"en","primary_location":{"id":"doi:10.3389/frph.2026.1933266","doi":"https://doi.org/10.3389/frph.2026.1933266","is_oa":true,"landing_page_url":"https://doi.org/10.3389/frph.2026.1933266","pdf_url":"https://www.frontiersin.org/journals/reproductive-health/articles/10.3389/frph.2026.1933266/pdf","source":{"id":"https://openalex.org/S4210207188","display_name":"Frontiers in Reproductive Health","issn_l":"2673-3153","issn":["2673-3153"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Reproductive Health","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/reproductive-health/articles/10.3389/frph.2026.1933266/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103098416","display_name":"Anamika Kumari","orcid":"https://orcid.org/0000-0001-8431-0951","observed_orcids":["https://orcid.org/0000-0001-8431-0951"]},"institutions":[{"id":"https://openalex.org/I185249246","display_name":"Central Drug Research Institute","ror":"https://ror.org/04t8qjg16","country_code":"IN","type":"facility","lineage":["https://openalex.org/I185249246","https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]},{"id":"https://openalex.org/I99364266","display_name":"Academy of Scientific and Innovative Research","ror":"https://ror.org/053rcsq61","country_code":"IN","type":"education","lineage":["https://openalex.org/I99364266"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Anamika Kumari","raw_affiliation_strings":["Academy of Scientific and Innovative Research (AcSIR)","Central Drug Research Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Academy of Scientific and Innovative Research (AcSIR)","institution_ids":["https://openalex.org/I99364266"]},{"raw_affiliation_string":"Central Drug Research Institute","institution_ids":["https://openalex.org/I185249246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071670082","display_name":"Syed Waseem Andrabi","orcid":"https://orcid.org/0000-0001-8749-9016","observed_orcids":["https://orcid.org/0000-0001-8749-9016"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Syed Waseem Andrabi","raw_affiliation_strings":["Milan, The Fertility Clinic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Milan, The Fertility Clinic","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102964915","display_name":"Rajender Singh","orcid":"https://orcid.org/0000-0002-2918-6035","observed_orcids":["https://orcid.org/0000-0002-2918-6035"]},"institutions":[{"id":"https://openalex.org/I185249246","display_name":"Central Drug Research Institute","ror":"https://ror.org/04t8qjg16","country_code":"IN","type":"facility","lineage":["https://openalex.org/I185249246","https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]},{"id":"https://openalex.org/I99364266","display_name":"Academy of Scientific and Innovative Research","ror":"https://ror.org/053rcsq61","country_code":"IN","type":"education","lineage":["https://openalex.org/I99364266"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Rajender Singh","raw_affiliation_strings":["Academy of Scientific and Innovative Research (AcSIR)","Central Drug Research Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Academy of Scientific and Innovative Research (AcSIR)","institution_ids":["https://openalex.org/I99364266"]},{"raw_affiliation_string":"Central Drug Research Institute","institution_ids":["https://openalex.org/I185249246"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5102964915"],"corresponding_institution_ids":["https://openalex.org/I185249246","https://openalex.org/I99364266"],"apc_list":{"value":2550,"currency":"CHF","value_usd":3077},"apc_paid":{"value":2550,"currency":"CHF","value_usd":3077},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.67362408,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"8","issue":null,"first_page":"1933266","last_page":"1933266"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.012900000438094139,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oligospermia","display_name":"oligozoospermia","score":0.9919999837875366},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.8379999995231628},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9380000233650208},{"id":"https://openalex.org/keywords/sperm-dna-methylation","display_name":"sperm DNA methylation","score":0.9739999771118164},{"id":"https://openalex.org/keywords/epigenetic-modifications","display_name":"epigenetic modifications","score":0.8709999918937683},{"id":"https://openalex.org/keywords/male-infertility","display_name":"male infertility","score":0.8650000095367432},{"id":"https://openalex.org/keywords/sperm-quality","display_name":"semen quality","score":0.7699999809265137},{"id":"https://openalex.org/keywords/differentially-methylated-genes","display_name":"differentially methylated genes","score":0.8309999704360962}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6747000217437744},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.5976999998092651},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.5806999802589417},{"id":"https://openalex.org/C2781087480","wikidata":"https://www.wikidata.org/wiki/Q17145","display_name":"Sperm","level":2,"score":0.5705000162124634},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.5692999958992004},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.5526999831199646},{"id":"https://openalex.org/C2777338322","wikidata":"https://www.wikidata.org/wiki/Q280156","display_name":"Male infertility","level":4,"score":0.47940000891685486},{"id":"https://openalex.org/C3020630785","wikidata":"https://www.wikidata.org/wiki/Q2916689","display_name":"Sperm quality","level":3,"score":0.44040000438690186},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4172999858856201},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.4115999937057495},{"id":"https://openalex.org/C2777358149","wikidata":"https://www.wikidata.org/wiki/Q1876491","display_name":"Oligospermia","level":5,"score":0.36340001225471497},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.3621000051498413},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3393000066280365},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.30059999227523804}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/frph.2026.1933266","doi":"https://doi.org/10.3389/frph.2026.1933266","is_oa":true,"landing_page_url":"https://doi.org/10.3389/frph.2026.1933266","pdf_url":"https://www.frontiersin.org/journals/reproductive-health/articles/10.3389/frph.2026.1933266/pdf","source":{"id":"https://openalex.org/S4210207188","display_name":"Frontiers in Reproductive Health","issn_l":"2673-3153","issn":["2673-3153"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Reproductive Health","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13642678","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13642678/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13642678/pdf/frph-08-1933266.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Reprod Health","raw_type":"Text"},{"id":"pmid:42845961","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42845961","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in reproductive health","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:89dc74ad872940a492340d842eb83eb5","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/89dc74ad872940a492340d842eb83eb5","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Reproductive Health, Vol 8 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/frph.2026.1933266","doi":"https://doi.org/10.3389/frph.2026.1933266","is_oa":true,"landing_page_url":"https://doi.org/10.3389/frph.2026.1933266","pdf_url":"https://www.frontiersin.org/journals/reproductive-health/articles/10.3389/frph.2026.1933266/pdf","source":{"id":"https://openalex.org/S4210207188","display_name":"Frontiers in Reproductive Health","issn_l":"2673-3153","issn":["2673-3153"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Reproductive Health","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320320720","display_name":"Indian Council of Medical Research","ror":"https://ror.org/0492wrx28"},{"id":"https://openalex.org/F4320320721","display_name":"Council of Scientific and Industrial Research, India","ror":"https://ror.org/021wm7p51"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7214101522.pdf","grobid_xml":"https://content.openalex.org/works/W7214101522.grobid-xml"},"referenced_works_count":49,"referenced_works":["https://openalex.org/W1551516145","https://openalex.org/W1561433308","https://openalex.org/W1563868672","https://openalex.org/W1589590998","https://openalex.org/W1844199574","https://openalex.org/W1966010051","https://openalex.org/W1993762503","https://openalex.org/W1996944297","https://openalex.org/W2012603112","https://openalex.org/W2035118720","https://openalex.org/W2042369211","https://openalex.org/W2042379310","https://openalex.org/W2061888284","https://openalex.org/W2071365780","https://openalex.org/W2086300068","https://openalex.org/W2086718560","https://openalex.org/W2098505353","https://openalex.org/W2109929683","https://openalex.org/W2134726260","https://openalex.org/W2137983089","https://openalex.org/W2138116401","https://openalex.org/W2153362478","https://openalex.org/W2153523586","https://openalex.org/W2157592222","https://openalex.org/W2159804309","https://openalex.org/W2163670586","https://openalex.org/W2416750831","https://openalex.org/W2507689999","https://openalex.org/W2762895841","https://openalex.org/W2782121984","https://openalex.org/W2786780539","https://openalex.org/W2790759837","https://openalex.org/W2898334176","https://openalex.org/W2899391662","https://openalex.org/W2908571759","https://openalex.org/W2922063450","https://openalex.org/W2946041267","https://openalex.org/W3112995340","https://openalex.org/W3119121173","https://openalex.org/W3163080226","https://openalex.org/W4210365842","https://openalex.org/W4223453984","https://openalex.org/W4311862208","https://openalex.org/W4317242299","https://openalex.org/W4388880148","https://openalex.org/W4399269190","https://openalex.org/W4407181044","https://openalex.org/W4408134648","https://openalex.org/W7128244133"],"related_works":["https://openalex.org/W2761299592","https://openalex.org/W2016859940","https://openalex.org/W1541838037","https://openalex.org/W4297871165","https://openalex.org/W2153523586","https://openalex.org/W6957820296","https://openalex.org/W4405321494","https://openalex.org/W2899391662","https://openalex.org/W2765414766","https://openalex.org/W7163415170"],"abstract_inverted_index":{"Introduction:":[0],"Oxidative":[1],"stress":[2],"has":[3],"been":[4],"found":[5],"to":[6,36,125,159,177],"play":[7],"a":[8,28,109,132,165,193],"critical":[9],"role":[10],"in":[11,34,45,75,123],"sperm":[12,176],"quality":[13],"and":[14,49,55,64,86,99,105],"function.":[15],"In":[16],"this":[17],"study,":[18],"we":[19],"asked":[20],"if":[21],"oligozoospermic":[22,50,83,87,104,144,148,175,187],"samples":[23,52,60,73,107,188],"with":[24,53,189],"high":[25,54,81,88,120,145,190,194],"ROS":[26,57,70,85,89,121,129,146,150,191],"display":[27],"higher":[29],"degree":[30,195],"of":[31,112,135,156,163,174,196],"methylation":[32,44,96,197],"alterations":[33],"comparison":[35,102,124,151],"normozoospermic":[37,46,77,80,106,119,127],"samples.":[38],"Methods:":[39],"We":[40,184],"investigated":[41],"genome-wide":[42,94],"DNA":[43,95],"(presumptive":[47],"fertile)":[48],"infertile":[51],"low":[56,78,84,110,128,149],"levels.":[58,71],"Fifty":[59],"each":[61,74],"for":[62,68,93],"oligozoospermia":[63],"normozoospermia":[65],"were":[66,91],"analyzed":[67],"their":[69],"Two":[72],"the":[76,126,141,153,172],"ROS,":[79,82],"categories":[90],"selected":[92],"profiling.":[97],"Results":[98],"discussion:":[100],"A":[101],"between":[103],"showed":[108,131,152],"number":[111,134,155],"differentially":[113,136,161],"methylated":[114,137],"genes":[115,138,157],"(about":[116],"100).":[117],"The":[118],"group":[122,130],"moderate":[133],"(538).":[139],"On":[140],"other":[142],"hand,":[143],"versus":[147],"highest":[154],"(1,755)":[158],"be":[160],"methylated,":[162],"which":[164],"majority":[166],"displayed":[167],"hypomethylation.":[168],"These":[169],"findings":[170],"underscore":[171],"vulnerability":[173],"epigenetic":[178],"disruptions":[179],"induced":[180],"by":[181],"oxidative":[182],"stress.":[183],"conclude":[185],"that":[186],"carry":[192],"alterations.":[198]},"counts_by_year":[],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2026-09-24T00:00:00"}
