{"id":"https://openalex.org/W7214101023","doi":"https://doi.org/10.64898/2026.09.22.753586","title":"PROXINAUT: An Automation Platform for Rapid Hit-to-Degrader Discovery","display_name":"PROXINAUT: An Automation Platform for Rapid Hit-to-Degrader Discovery","publication_year":2026,"publication_date":"2026-09-23","ids":{"openalex":"https://openalex.org/W7214101023","doi":"https://doi.org/10.64898/2026.09.22.753586"},"language":null,"primary_location":{"id":"doi:10.64898/2026.09.22.753586","doi":"https://doi.org/10.64898/2026.09.22.753586","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.22.753586","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/23/2026.09.22.753586.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/23/2026.09.22.753586.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5098778017","display_name":"Sean M. McKenna","orcid":"https://orcid.org/0000-0001-9197-5089","observed_orcids":["https://orcid.org/0000-0001-9197-5089"]},"institutions":[{"id":"https://openalex.org/I4210111138","display_name":"Oncode Institute","ror":"https://ror.org/01n92vv28","country_code":"NL","type":"education","lineage":["https://openalex.org/I4210111138"]},{"id":"https://openalex.org/I4210133171","display_name":"Centre for Human Drug Research","ror":"https://ror.org/044hshx49","country_code":"NL","type":"facility","lineage":["https://openalex.org/I4210133171"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Sean M. McKenna","raw_affiliation_strings":["Leiden Academic Centre for Drug Research, Leiden University, Leiden, 2333 CC, The Netherlands","Oncode Institute; Utrecht, 3521 AL, The Netherlands"],"raw_orcid":"https://orcid.org/0000-0001-9197-5089","affiliations":[{"raw_affiliation_string":"Leiden Academic Centre for Drug Research, Leiden University, Leiden, 2333 CC, The Netherlands","institution_ids":["https://openalex.org/I4210133171"]},{"raw_affiliation_string":"Oncode Institute; Utrecht, 3521 AL, The Netherlands","institution_ids":["https://openalex.org/I4210111138"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034930291","display_name":"Monika T. Gnatzy","orcid":"https://orcid.org/0009-0007-2236-8227","observed_orcids":["https://orcid.org/0009-0007-2236-8227"]},"institutions":[{"id":"https://openalex.org/I4210111138","display_name":"Oncode Institute","ror":"https://ror.org/01n92vv28","country_code":"NL","type":"education","lineage":["https://openalex.org/I4210111138"]},{"id":"https://openalex.org/I4210133171","display_name":"Centre for Human Drug Research","ror":"https://ror.org/044hshx49","country_code":"NL","type":"facility","lineage":["https://openalex.org/I4210133171"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Monika T. Gnatzy","raw_affiliation_strings":["Leiden Academic Centre for Drug Research, Leiden University, Leiden, 2333 CC, The Netherlands","Oncode Institute; Utrecht, 3521 AL, The Netherlands"],"raw_orcid":"https://orcid.org/0009-0007-2236-8227","affiliations":[{"raw_affiliation_string":"Leiden Academic Centre for Drug Research, Leiden University, Leiden, 2333 CC, The Netherlands","institution_ids":["https://openalex.org/I4210133171"]},{"raw_affiliation_string":"Oncode Institute; Utrecht, 3521 AL, The Netherlands","institution_ids":["https://openalex.org/I4210111138"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066775655","display_name":"Edith van der Nol","orcid":"https://orcid.org/0000-0002-0597-8185","observed_orcids":["https://orcid.org/0000-0002-0597-8185"]},"institutions":[{"id":"https://openalex.org/I4210111138","display_name":"Oncode Institute","ror":"https://ror.org/01n92vv28","country_code":"NL","type":"education","lineage":["https://openalex.org/I4210111138"]},{"id":"https://openalex.org/I4210133171","display_name":"Centre for Human Drug Research","ror":"https://ror.org/044hshx49","country_code":"NL","type":"facility","lineage":["https://openalex.org/I4210133171"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Edith van der Nol","raw_affiliation_strings":["Leiden Academic Centre for Drug Research, Leiden University, Leiden, 2333 CC, The Netherlands","Oncode Institute; Utrecht, 3521 AL, The Netherlands"],"raw_orcid":"https://orcid.org/0000-0002-0597-8185","affiliations":[{"raw_affiliation_string":"Leiden Academic Centre for Drug Research, Leiden University, Leiden, 2333 CC, The Netherlands","institution_ids":["https://openalex.org/I4210133171"]},{"raw_affiliation_string":"Oncode Institute; Utrecht, 3521 AL, The Netherlands","institution_ids":["https://openalex.org/I4210111138"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5152521119","display_name":"Femke J. Boxman","orcid":"https://orcid.org/0009-0007-8713-5459","observed_orcids":["https://orcid.org/0009-0007-8713-5459"]},"institutions":[{"id":"https://openalex.org/I4210133171","display_name":"Centre for Human Drug Research","ror":"https://ror.org/044hshx49","country_code":"NL","type":"facility","lineage":["https://openalex.org/I4210133171"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Femke J. Boxman","raw_affiliation_strings":["Leiden Academic Centre for Drug Research, Leiden University, Leiden, 2333 CC, The Netherlands"],"raw_orcid":"https://orcid.org/0009-0007-8713-5459","affiliations":[{"raw_affiliation_string":"Leiden Academic Centre for Drug Research, Leiden University, Leiden, 2333 CC, The Netherlands","institution_ids":["https://openalex.org/I4210133171"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124394659","display_name":"Chenlu Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chenlu Zhang","raw_affiliation_strings":["Department of Chemistry, Northwestern University, Evanston, Illinois, 60208, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Northwestern University, Evanston, Illinois, 60208, USA","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5123047699","display_name":"Xiaokang Jin","orcid":"https://orcid.org/0009-0005-7011-8199","observed_orcids":["https://orcid.org/0009-0005-7011-8199"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaokang Jin","raw_affiliation_strings":["Department of Chemistry, Northwestern University, Evanston, Illinois, 60208, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Northwestern University, Evanston, Illinois, 60208, USA","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050004923","display_name":"Jingming Liu","orcid":"https://orcid.org/0009-0003-1007-1937","observed_orcids":["https://orcid.org/0009-0003-1007-1937"]},"institutions":[{"id":"https://openalex.org/I4210111138","display_name":"Oncode Institute","ror":"https://ror.org/01n92vv28","country_code":"NL","type":"education","lineage":["https://openalex.org/I4210111138"]},{"id":"https://openalex.org/I4210133171","display_name":"Centre for Human Drug Research","ror":"https://ror.org/044hshx49","country_code":"NL","type":"facility","lineage":["https://openalex.org/I4210133171"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Jingming Liu","raw_affiliation_strings":["Leiden Academic Centre for Drug Research, Leiden University, Leiden, 2333 CC, The Netherlands","Oncode Institute; Utrecht, 3521 AL, The Netherlands"],"raw_orcid":"https://orcid.org/0009-0003-1007-1937","affiliations":[{"raw_affiliation_string":"Leiden Academic Centre for Drug Research, Leiden University, Leiden, 2333 CC, The Netherlands","institution_ids":["https://openalex.org/I4210133171"]},{"raw_affiliation_string":"Oncode Institute; Utrecht, 3521 AL, The Netherlands","institution_ids":["https://openalex.org/I4210111138"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086735484","display_name":"Jeroen Kortekaas","orcid":"https://orcid.org/0000-0002-0329-0176","observed_orcids":["https://orcid.org/0000-0002-0329-0176"]},"institutions":[{"id":"https://openalex.org/I4210133171","display_name":"Centre for Human Drug Research","ror":"https://ror.org/044hshx49","country_code":"NL","type":"facility","lineage":["https://openalex.org/I4210133171"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Jeroen Kortekaas","raw_affiliation_strings":["Leiden Academic Centre for Drug Research, Leiden University, Leiden, 2333 CC, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leiden Academic Centre for Drug Research, Leiden University, Leiden, 2333 CC, The Netherlands","institution_ids":["https://openalex.org/I4210133171"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100419397","display_name":"Xiaoyu Zhang","orcid":"https://orcid.org/0000-0002-0951-9664","observed_orcids":["https://orcid.org/0000-0002-0951-9664"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaoyu Zhang","raw_affiliation_strings":["Department of Chemistry, Northwestern University, Evanston, Illinois, 60208, USA"],"raw_orcid":"https://orcid.org/0000-0002-0951-9664","affiliations":[{"raw_affiliation_string":"Department of Chemistry, Northwestern University, Evanston, Illinois, 60208, USA","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028126343","display_name":"Sebastian J. Pomplun","orcid":"https://orcid.org/0000-0003-0905-8551","observed_orcids":["https://orcid.org/0000-0003-0905-8551"]},"institutions":[{"id":"https://openalex.org/I4210111138","display_name":"Oncode Institute","ror":"https://ror.org/01n92vv28","country_code":"NL","type":"education","lineage":["https://openalex.org/I4210111138"]},{"id":"https://openalex.org/I4210133171","display_name":"Centre for Human Drug Research","ror":"https://ror.org/044hshx49","country_code":"NL","type":"facility","lineage":["https://openalex.org/I4210133171"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Sebastian J. Pomplun","raw_affiliation_strings":["Leiden Academic Centre for Drug Research, Leiden University, Leiden, 2333 CC, The Netherlands","Oncode Institute; Utrecht, 3521 AL, The Netherlands"],"raw_orcid":"https://orcid.org/0000-0003-0905-8551","affiliations":[{"raw_affiliation_string":"Leiden Academic Centre for Drug Research, Leiden University, Leiden, 2333 CC, The Netherlands","institution_ids":["https://openalex.org/I4210133171"]},{"raw_affiliation_string":"Oncode Institute; Utrecht, 3521 AL, The Netherlands","institution_ids":["https://openalex.org/I4210111138"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5028126343"],"corresponding_institution_ids":["https://openalex.org/I4210111138","https://openalex.org/I4210133171"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12534","display_name":"Protein Degradation and Inhibitors","score":0.6708999872207642,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12534","display_name":"Protein Degradation and Inhibitors","score":0.6708999872207642,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.32199999690055847,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.0038999998942017555,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bifunctional-degraders","display_name":"bifunctional degraders","score":0.828000009059906},{"id":"https://openalex.org/keywords/brd4","display_name":"BRD4","score":0.9850000143051147},{"id":"https://openalex.org/keywords/fbxo31","display_name":"FBXO31","score":0.859000027179718},{"id":"https://openalex.org/keywords/cereblon","display_name":"cereblon","score":0.753000020980835},{"id":"https://openalex.org/keywords/cyclic-imides","display_name":"cyclic imides","score":0.6919999718666077},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.6869999766349792},{"id":"https://openalex.org/keywords/hit-optimization","display_name":"hit optimization","score":0.4620000123977661},{"id":"https://openalex.org/keywords/e3-ubiquitin-ligase","display_name":"E3 ubiquitin ligase","score":0.5929999947547913}],"concepts":[{"id":"https://openalex.org/C177212765","wikidata":"https://www.wikidata.org/wiki/Q627335","display_name":"Workflow","level":2,"score":0.7840999960899353},{"id":"https://openalex.org/C115901376","wikidata":"https://www.wikidata.org/wiki/Q184199","display_name":"Automation","level":2,"score":0.6632000207901001},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6341999769210815},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.6104999780654907},{"id":"https://openalex.org/C2780443040","wikidata":"https://www.wikidata.org/wiki/Q3737863","display_name":"Bifunctional","level":3,"score":0.48249998688697815},{"id":"https://openalex.org/C197129107","wikidata":"https://www.wikidata.org/wiki/Q1921621","display_name":"Merge (version control)","level":2,"score":0.430400013923645},{"id":"https://openalex.org/C85135244","wikidata":"https://www.wikidata.org/wiki/Q1799487","display_name":"Laboratory automation","level":3,"score":0.4108000099658966},{"id":"https://openalex.org/C2780557392","wikidata":"https://www.wikidata.org/wiki/Q523796","display_name":"Linker","level":2,"score":0.36570000648498535},{"id":"https://openalex.org/C149635348","wikidata":"https://www.wikidata.org/wiki/Q193040","display_name":"Embedded system","level":1,"score":0.36550000309944153},{"id":"https://openalex.org/C2777904410","wikidata":"https://www.wikidata.org/wiki/Q7397","display_name":"Software","level":2,"score":0.32100000977516174},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.3034999966621399},{"id":"https://openalex.org/C118524514","wikidata":"https://www.wikidata.org/wiki/Q173212","display_name":"Computer architecture","level":1,"score":0.3028999865055084},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.29739999771118164},{"id":"https://openalex.org/C191908910","wikidata":"https://www.wikidata.org/wiki/Q862838","display_name":"Synthetic biology","level":2,"score":0.2939999997615814},{"id":"https://openalex.org/C64903051","wikidata":"https://www.wikidata.org/wiki/Q2198549","display_name":"Drug development","level":3,"score":0.29269999265670776},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2912999987602234},{"id":"https://openalex.org/C137981799","wikidata":"https://www.wikidata.org/wiki/Q1369184","display_name":"Reusability","level":3,"score":0.2872999906539917},{"id":"https://openalex.org/C187191949","wikidata":"https://www.wikidata.org/wiki/Q1138496","display_name":"Profiling (computer programming)","level":2,"score":0.2775000035762787},{"id":"https://openalex.org/C147494362","wikidata":"https://www.wikidata.org/wiki/Q2078905","display_name":"Troubleshooting","level":2,"score":0.27320000529289246},{"id":"https://openalex.org/C115903868","wikidata":"https://www.wikidata.org/wiki/Q80993","display_name":"Software engineering","level":1,"score":0.2703999876976013}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.09.22.753586","doi":"https://doi.org/10.64898/2026.09.22.753586","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.22.753586","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/23/2026.09.22.753586.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.09.22.753586","doi":"https://doi.org/10.64898/2026.09.22.753586","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.09.22.753586","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/09/23/2026.09.22.753586.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320310838","display_name":"University of Dundee","ror":"https://ror.org/03h2bxq36"},{"id":"https://openalex.org/F4320331496","display_name":"Oncode Institute","ror":"https://ror.org/01n92vv28"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7214101023.pdf","grobid_xml":"https://content.openalex.org/works/W7214101023.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Abstract":[0],"Massive":[1],"library-based":[2,51],"platforms":[3],"enable":[4],"rapid":[5,101],"early":[6],"hit":[7,11,52,63,82],"discovery,":[8,64],"yet":[9],"subsequent":[10],"resynthesis":[12],"and":[13,67,91,110,199,241],"validation":[14],"remain":[15],"major":[16],"bottlenecks":[17],"in":[18,112,213],"drug":[19],"discovery.":[20],"This":[21,211],"delay":[22],"is":[23],"amplified":[24],"when":[25],"optimizing":[26],"hits,":[27],"or":[28,166],"elaborating":[29],"structures":[30],"towards":[31],"more":[32],"advanced":[33,242],"modalities,":[34],"such":[35],"as":[36,93,138],"chemical":[37],"inducers":[38],"of":[39,127,192],"proximity":[40],"(CIPs).":[41],"Here,":[42],"we":[43,121,223],"report":[44],"PROXINAUT,":[45],"an":[46,55],"end-to-end":[47],"workflow":[48,98],"integrating":[49],"self-encoded":[50],"discovery":[53],"with":[54,115,217,230],"automated":[56,89,175],"parallel":[57,88,185,232],"solid-phase":[58],"synthesis":[59,90,132,191],"platform":[60,176],"to":[61,123,151,179,219,234],"streamline":[62],"validation,":[65],"optimization,":[66],"degrader":[68,243],"development.":[69],"As":[70],"a":[71,74,100,113,135,139,149],"demonstration,":[72],"screening":[73],"176k-member":[75],"benzimidazole":[76],"library":[77,226],"against":[78],"BRD4":[79,215],"yielded":[80],"six":[81],"candidates,":[83],"which":[84],"were":[85],"obtained":[86],"via":[87],"validated":[92,239],"submicromolar":[94],"binders.":[95],"The":[96],"automation":[97,233],"empowered":[99],"structure":[102],"activity":[103],"relationship":[104],"exploration":[105],"around":[106],"the":[107,125,208],"whole":[108],"scaffold":[109],"resulted":[111,212],"variant":[114],"six-fold":[116],"improved":[117],"binding":[118],"affinity.":[119],"Next,":[120],"aimed":[122],"automatize":[124],"development":[126],"bifunctional":[128,194],"degraders.":[129],"Solid":[130],"phase":[131],"typically":[133],"leaves":[134],"C-terminal":[136,164],"amide":[137],"synthetic":[140,181],"artifact":[141],"that":[142],"can":[143,203,228],"compromise":[144],"druglike":[145],"properties.":[146],"We":[147],"developed":[148],"strategy":[150],"repurpose":[152],"this":[153],"resin-attachment":[154],"site,":[155],"converting":[156],"it":[157],"into":[158,238],"functional":[159],"degrons":[160],"featuring":[161],"either":[162],"FBXO31-targeting":[163],"amides":[165],"cereblon-binding":[167],"cyclic":[168],"imides.":[169],"Operating":[170],"without":[171],"human":[172],"intervention,":[173],"our":[174],"executes":[177],"up":[178],"16":[180],"steps":[182],"across":[183],"multiple":[184],"structures,":[186],"enabling":[187],"true":[188],"de":[189],"novo":[190],"full":[193],"scaffolds,":[195],"where":[196],"ligand,":[197],"linker":[198],"E3":[200],"recruiter":[201],"variations":[202],"all":[204],"be":[205],"explored":[206],"within":[207],"same":[209],"workflow.":[210],"cell-active":[214],"degraders":[216],"subnanomolar":[218],"nanomolar":[220],"potency.":[221],"Overall,":[222],"show":[224],"how":[225],"selections":[227],"merge":[229],"multi-step":[231],"convert":[235],"hits":[236],"directly":[237],"leads":[240],"modalities.":[244]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2026-09-24T00:00:00"}