{"id":"https://openalex.org/W7214097085","doi":"https://doi.org/10.3390/diseases14100352","title":"Association of DNA Copy Number Aberrations with Organ-Specific Metastasis in Luminal B HER2-Negative Breast Cancer","display_name":"Association of DNA Copy Number Aberrations with Organ-Specific Metastasis in Luminal B HER2-Negative Breast Cancer","publication_year":2026,"publication_date":"2026-09-23","ids":{"openalex":"https://openalex.org/W7214097085","doi":"https://doi.org/10.3390/diseases14100352","pmid":"https://pubmed.ncbi.nlm.nih.gov/42929979","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13703441"},"language":"en","primary_location":{"id":"doi:10.3390/diseases14100352","doi":"https://doi.org/10.3390/diseases14100352","is_oa":true,"landing_page_url":"https://doi.org/10.3390/diseases14100352","pdf_url":null,"source":{"id":"https://openalex.org/S2736521255","display_name":"Diseases","issn_l":"2079-9721","issn":["2079-9721"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diseases","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/diseases14100352","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090965653","display_name":"Marina Konstantinovna Ibragimova","orcid":"https://orcid.org/0000-0001-8815-2786","observed_orcids":["https://orcid.org/0000-0001-8815-2786"]},"institutions":[{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I196355604","display_name":"National Research Tomsk State University","ror":"https://ror.org/02he2nc27","country_code":"RU","type":"education","lineage":["https://openalex.org/I196355604"]},{"id":"https://openalex.org/I196530094","display_name":"Siberian State Medical University","ror":"https://ror.org/01yecy831","country_code":"RU","type":"education","lineage":["https://openalex.org/I196530094"]},{"id":"https://openalex.org/I4210118499","display_name":"Tomsk National Research Medical Center","ror":"https://ror.org/01z0w8p93","country_code":"RU","type":"healthcare","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210118499"]}],"countries":["RU"],"is_corresponding":true,"raw_author_name":"Marina K. Ibragimova","raw_affiliation_strings":["Biochemistry and Molecular Biology Division, Siberian State Medical University, Moskovsky Trakt 2, Tomsk 634050, Russia","Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, 5 Kooperativny Lane, Tomsk 634050, Russia","Institute of Biology, National Research Tomsk State University, 36 Lenin Ave., Tomsk 634050, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry and Molecular Biology Division, Siberian State Medical University, Moskovsky Trakt 2, Tomsk 634050, Russia","institution_ids":["https://openalex.org/I196530094"]},{"raw_affiliation_string":"Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, 5 Kooperativny Lane, Tomsk 634050, Russia","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210118499"]},{"raw_affiliation_string":"Institute of Biology, National Research Tomsk State University, 36 Lenin Ave., Tomsk 634050, Russia","institution_ids":["https://openalex.org/I196355604"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047964551","display_name":"Matvey Mikhailovich Tsyganov","orcid":"https://orcid.org/0000-0001-7419-4512","observed_orcids":["https://orcid.org/0000-0001-7419-4512"]},"institutions":[{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I196530094","display_name":"Siberian State Medical University","ror":"https://ror.org/01yecy831","country_code":"RU","type":"education","lineage":["https://openalex.org/I196530094"]},{"id":"https://openalex.org/I4210118499","display_name":"Tomsk National Research Medical Center","ror":"https://ror.org/01z0w8p93","country_code":"RU","type":"healthcare","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210118499"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Matvey M. Tsyganov","raw_affiliation_strings":["Biochemistry and Molecular Biology Division, Siberian State Medical University, Moskovsky Trakt 2, Tomsk 634050, Russia","Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, 5 Kooperativny Lane, Tomsk 634050, Russia"],"raw_orcid":"https://orcid.org/0000-0001-7419-4512","affiliations":[{"raw_affiliation_string":"Biochemistry and Molecular Biology Division, Siberian State Medical University, Moskovsky Trakt 2, Tomsk 634050, Russia","institution_ids":["https://openalex.org/I196530094"]},{"raw_affiliation_string":"Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, 5 Kooperativny Lane, Tomsk 634050, Russia","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210118499"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5122888066","display_name":"Arina K. Shagabudinova","orcid":"https://orcid.org/0009-0008-3832-6440","observed_orcids":["https://orcid.org/0009-0008-3832-6440"]},"institutions":[{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I4210118499","display_name":"Tomsk National Research Medical Center","ror":"https://ror.org/01z0w8p93","country_code":"RU","type":"healthcare","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210118499"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Arina K. Shagabudinova","raw_affiliation_strings":["Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, 5 Kooperativny Lane, Tomsk 634050, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, 5 Kooperativny Lane, Tomsk 634050, Russia","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210118499"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059210992","display_name":"Irina Aleksandrovna Tsydenova","orcid":"https://orcid.org/0000-0002-2716-3075","observed_orcids":["https://orcid.org/0000-0002-2716-3075"]},"institutions":[{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I4210118499","display_name":"Tomsk National Research Medical Center","ror":"https://ror.org/01z0w8p93","country_code":"RU","type":"healthcare","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210118499"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Irina A. Tsydenova","raw_affiliation_strings":["Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, 5 Kooperativny Lane, Tomsk 634050, Russia"],"raw_orcid":"https://orcid.org/0000-0002-2716-3075","affiliations":[{"raw_affiliation_string":"Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, 5 Kooperativny Lane, Tomsk 634050, Russia","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210118499"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5117771443","display_name":"Maxim A. Morozovsky","orcid":"https://orcid.org/0009-0001-5841-0606","observed_orcids":["https://orcid.org/0009-0001-5841-0606"]},"institutions":[{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I196530094","display_name":"Siberian State Medical University","ror":"https://ror.org/01yecy831","country_code":"RU","type":"education","lineage":["https://openalex.org/I196530094"]},{"id":"https://openalex.org/I4210118499","display_name":"Tomsk National Research Medical Center","ror":"https://ror.org/01z0w8p93","country_code":"RU","type":"healthcare","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210118499"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Maxim A. Morozovsky","raw_affiliation_strings":["Biochemistry and Molecular Biology Division, Siberian State Medical University, Moskovsky Trakt 2, Tomsk 634050, Russia","Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, 5 Kooperativny Lane, Tomsk 634050, Russia"],"raw_orcid":"https://orcid.org/0009-0001-5841-0606","affiliations":[{"raw_affiliation_string":"Biochemistry and Molecular Biology Division, Siberian State Medical University, Moskovsky Trakt 2, Tomsk 634050, Russia","institution_ids":["https://openalex.org/I196530094"]},{"raw_affiliation_string":"Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, 5 Kooperativny Lane, Tomsk 634050, Russia","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210118499"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017325034","display_name":"\u041d\u0438\u043a\u043e\u043b\u0430\u0439 \u0412\u0430\u0441\u0438\u043b\u044c\u0435\u0432\u0438\u0447 \u041b\u0438\u0442\u0432\u044f\u043a\u043e\u0432","orcid":"https://orcid.org/0000-0002-0714-8927","observed_orcids":["https://orcid.org/0000-0002-0714-8927"]},"institutions":[{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I196355604","display_name":"National Research Tomsk State University","ror":"https://ror.org/02he2nc27","country_code":"RU","type":"education","lineage":["https://openalex.org/I196355604"]},{"id":"https://openalex.org/I4210118499","display_name":"Tomsk National Research Medical Center","ror":"https://ror.org/01z0w8p93","country_code":"RU","type":"healthcare","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210118499"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Nikolai V. Litviakov","raw_affiliation_strings":["Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, 5 Kooperativny Lane, Tomsk 634050, Russia","Institute of Biology, National Research Tomsk State University, 36 Lenin Ave., Tomsk 634050, Russia"],"raw_orcid":"https://orcid.org/0000-0002-0714-8927","affiliations":[{"raw_affiliation_string":"Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, 5 Kooperativny Lane, Tomsk 634050, Russia","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210118499"]},{"raw_affiliation_string":"Institute of Biology, National Research Tomsk State University, 36 Lenin Ave., Tomsk 634050, Russia","institution_ids":["https://openalex.org/I196355604"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5090965653"],"corresponding_institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I196355604","https://openalex.org/I196530094","https://openalex.org/I4210118499"],"apc_list":{"value":1800,"currency":"CHF","value_usd":2172},"apc_paid":{"value":1800,"currency":"CHF","value_usd":2172},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.634076,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"14","issue":"10","first_page":"352","last_page":"352"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.8407999873161316,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.8407999873161316,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.08919999748468399,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":0.020600000396370888,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/luminal-b","display_name":"luminal B","score":0.7710000276565552},{"id":"https://openalex.org/keywords/her2-negative-breast-cancer","display_name":"HER2-negative breast cancer","score":0.9980000257492065},{"id":"https://openalex.org/keywords/dna-copy-number-aberrations","display_name":"DNA copy number aberrations","score":0.9169999957084656},{"id":"https://openalex.org/keywords/organ-specific-metastasis","display_name":"organ-specific metastasis","score":0.9860000014305115},{"id":"https://openalex.org/keywords/organotropism","display_name":"organotropism","score":0.8299999833106995},{"id":"https://openalex.org/keywords/bone-metastases","display_name":"bone metastasis","score":0.9700000286102295},{"id":"https://openalex.org/keywords/liver-metastases","display_name":"liver metastasis","score":0.9639999866485596},{"id":"https://openalex.org/keywords/lung-metastasis","display_name":"lung metastasis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/brain-metastases","display_name":"brain metastases","score":1.0},{"id":"https://openalex.org/keywords/metastatic-heterogeneity","display_name":"metastatic heterogeneity","score":0.6669999957084656}],"concepts":[{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.779699981212616},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.7544999718666077},{"id":"https://openalex.org/C2775930923","wikidata":"https://www.wikidata.org/wiki/Q12859063","display_name":"Metastatic breast cancer","level":4,"score":0.5565999746322632},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.49230000376701355},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4733000099658966},{"id":"https://openalex.org/C2778164965","wikidata":"https://www.wikidata.org/wiki/Q1620196","display_name":"Brain metastasis","level":4,"score":0.44929999113082886},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.43790000677108765},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.40959998965263367},{"id":"https://openalex.org/C2777783956","wikidata":"https://www.wikidata.org/wiki/Q848085","display_name":"Bone metastasis","level":4,"score":0.4023999869823456},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4009000062942505},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.3919999897480011},{"id":"https://openalex.org/C120821319","wikidata":"https://www.wikidata.org/wiki/Q1501491","display_name":"Copy-number variation","level":4,"score":0.3917999863624573},{"id":"https://openalex.org/C186836561","wikidata":"https://www.wikidata.org/wiki/Q1931516","display_name":"Microarray","level":4,"score":0.37209999561309814},{"id":"https://openalex.org/C2780283643","wikidata":"https://www.wikidata.org/wiki/Q2110267","display_name":"Primary tumor","level":4,"score":0.3580000102519989},{"id":"https://openalex.org/C2993589390","wikidata":"https://www.wikidata.org/wiki/Q12859063","display_name":"Breast cancer metastasis","level":5,"score":0.3549000024795532},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3456000089645386},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.3158999979496002},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3095000088214874},{"id":"https://openalex.org/C2778001805","wikidata":"https://www.wikidata.org/wiki/Q189961","display_name":"Mammary gland","level":4,"score":0.29750001430511475},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.2870999872684479},{"id":"https://openalex.org/C2781230642","wikidata":"https://www.wikidata.org/wiki/Q492646","display_name":"Targeted therapy","level":3,"score":0.28610000014305115},{"id":"https://openalex.org/C166608930","wikidata":"https://www.wikidata.org/wiki/Q5169175","display_name":"Copy number analysis","level":5,"score":0.27880001068115234},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.2786000072956085},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.2597000002861023}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3390/diseases14100352","doi":"https://doi.org/10.3390/diseases14100352","is_oa":true,"landing_page_url":"https://doi.org/10.3390/diseases14100352","pdf_url":null,"source":{"id":"https://openalex.org/S2736521255","display_name":"Diseases","issn_l":"2079-9721","issn":["2079-9721"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diseases","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13703441","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13703441/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13703441/pdf/diseases-14-00352.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diseases","raw_type":"Text"},{"id":"pmid:42929979","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42929979","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diseases (Basel, Switzerland)","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:5207e790fe084f0ebb56f39f6ccfe522","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/5207e790fe084f0ebb56f39f6ccfe522","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Diseases, Vol 14, Iss 10, p 352 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/diseases14100352","doi":"https://doi.org/10.3390/diseases14100352","is_oa":true,"landing_page_url":"https://doi.org/10.3390/diseases14100352","pdf_url":null,"source":{"id":"https://openalex.org/S2736521255","display_name":"Diseases","issn_l":"2079-9721","issn":["2079-9721"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diseases","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.979200005531311}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G9000375843","display_name":null,"funder_award_id":"25-25-20045","funder_id":"https://openalex.org/F4320324099","funder_display_name":"Russian Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320324099","display_name":"Russian Science Foundation","ror":"https://ror.org/03y2gwe85"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7214097085.pdf","grobid_xml":"https://content.openalex.org/works/W7214097085.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W1985846755","https://openalex.org/W2140626299","https://openalex.org/W2147268539","https://openalex.org/W2580994437","https://openalex.org/W2593310480","https://openalex.org/W2755561465","https://openalex.org/W2892874888","https://openalex.org/W2910861570","https://openalex.org/W2943993922","https://openalex.org/W2967213355","https://openalex.org/W2967901922","https://openalex.org/W2971280165","https://openalex.org/W3006604612","https://openalex.org/W3097139470","https://openalex.org/W3107885361","https://openalex.org/W3108610721","https://openalex.org/W3113331104","https://openalex.org/W3197899419","https://openalex.org/W3203834970","https://openalex.org/W4220873173","https://openalex.org/W4221048469","https://openalex.org/W4288070148","https://openalex.org/W4311281221","https://openalex.org/W4360998902","https://openalex.org/W4378071964","https://openalex.org/W4387381115","https://openalex.org/W4387973780","https://openalex.org/W4388273185","https://openalex.org/W4391317232","https://openalex.org/W4400802448","https://openalex.org/W4406379563","https://openalex.org/W4411206157","https://openalex.org/W4412581320","https://openalex.org/W7126221353"],"related_works":["https://openalex.org/W2063975380","https://openalex.org/W2040546025","https://openalex.org/W4396934936","https://openalex.org/W2152628477","https://openalex.org/W3108231556","https://openalex.org/W3130704317","https://openalex.org/W4241732417","https://openalex.org/W3182939635","https://openalex.org/W2077098300","https://openalex.org/W4387973780"],"abstract_inverted_index":{"Breast":[0],"cancer":[1,243],"(BC)":[2],"exhibits":[3],"considerable":[4],"metastatic":[5,46,93,102],"heterogeneity":[6],"and":[7,19,45,48,65,72,82,92,111,191,197,215],"distinct":[8],"patterns":[9,60,240],"of":[10,39,145,162,186,206],"organotropism,":[11],"which":[12],"contribute":[13],"to":[14,49,106],"differences":[15],"in":[16,61,147,164,188,208,216,226,241],"patient":[17],"outcomes":[18],"therapeutic":[20],"responses.":[21],"However,":[22],"the":[23,36,107,148,165,189,209,217],"molecular":[24],"mechanisms":[25],"underlying":[26],"this":[27],"organ":[28],"specificity":[29],"remain":[30],"incompletely":[31],"understood.":[32],"Objective:":[33],"To":[34],"investigate":[35],"genetic":[37],"landscape":[38],"primary":[40,101],"breast":[41,62,242],"tumor,":[42],"surgical":[43,74,90],"specimens,":[44],"lesions":[47],"identify":[50,233],"copy":[51],"number":[52],"aberration":[53],"(CNA)":[54],"regions":[55,130,193,235],"associated":[56,132,140,157,181,201,236],"with":[57,79,100,133,141,158,182,202,237],"organ-specific":[58,134,238],"metastatic-site":[59,135,239],"cancer.":[63],"Materials":[64],"methods:":[66],"The":[67,127],"study":[68],"included":[69],"paired":[70],"pretreatment":[71],"post-treatment":[73],"specimens":[75],"from":[76,97],"50":[77],"patients":[78,99],"BC":[80,103],"(T1\u20134N0\u20133M0)":[81],"hematogenous":[83],"metastases.":[84],"In":[85],"addition,":[86],"three":[87],"samples":[88],"(biopsy,":[89],"specimen,":[91],"lesion)":[94],"were":[95,131],"obtained":[96],"four":[98],"(with":[104],"metastasis":[105,138,155,179,199],"bones,":[108],"lungs,":[109],"liver,":[110],"brain).":[112],"Microarray":[113],"analysis":[114],"was":[115,139,156,180,200],"performed":[116],"using":[117],"high-density":[118],"CytoScanTM":[119],"HD":[120],"Array":[121],"DNA":[122],"chips":[123],"(Affymetrix":[124],"(USA)).":[125],"Results:":[126],"following":[128],"CNA":[129,234],"patterns:":[136],"bone":[137],"a":[142,159,183,203],"higher":[143,160,184,204],"frequency":[144,161,185,205],"amplifications":[146,163],"14q32.33":[149],"region":[150,167,211,219],"(p":[151,168,194,212,220],"=":[152,169,195,213,221],"0.0144);":[153],"liver":[154],"17q23.2":[166],"0.0042,":[170],"confirmed":[171,223],"by":[172,224],"validation":[173,225],"on":[174],"an":[175,227],"independent":[176,228],"cohort);":[177],"lung":[178],"deletions":[187,207],"2p13.1":[190],"19p13.12":[192],"0.0449);":[196],"brain":[198],"19q12":[210],"0.0522)":[214],"20q11.22":[218],"0.0089,":[222],"cohort).":[229],"Conclusions:":[230],"Our":[231],"findings":[232],"patients.":[244]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-09-24T00:00:00"}